Product References
Heterologous vaccination utilizing viral vector and protein platforms confers complete protection against SFTSV.
Scientific reports
Kim JY,Jeon K,Hong JJ,Park SI,Cho H,Park HJ,Kwak HW,Park HJ,Bang YJ,Lee YS,Bae SH,Kim SH,Hwang KA,Jung DI,Cho SH,Seo SH,Kim G,Oh H,Lee HY,Kim KH,Lim HY,Jeon P,Lee JY,Chung J,Lee SM,Ko HL,Song M,Cho NH,Lee YS,Hong SH,Nam JH
Published figure using CD25 monoclonal antibody (Product # 25-0251-82) in Flow Cytometry
Sat May 20 00:00:00 EDT 2023
Regulatory T-cells and IL-5 mediate pain outcomes in a preclinical model of chronic muscle pain.
Molecular pain
Lenert ME,Szabo-Pardi TA,Burton MD
Published figure using CD25 monoclonal antibody (Product # 25-0251-82) in Flow Cytometry
Mon Feb 13 00:00:00 EST 2023
Immunotherapy targeting plasma ASM is protective in a mouse model of Alzheimer's disease.
Nature communications
Choi BJ,Park MH,Park KH,Han WH,Yoon HJ,Jung HY,Hong JY,Chowdhury MR,Kim KY,Lee J,Song IS,Pang M,Choi MK,Gulbins E,Reichel M,Kornhuber J,Hong CW,Kim C,Kim SH,Schuchman EH,Jin HK,Bae JS
Published figure using CD25 monoclonal antibody (Product # 25-0251-82) in Flow Cytometry
Fri Mar 24 00:00:00 EDT 2023
Dexmedetomidine alleviates acute lung injury by promoting Tregs differentiation via activation of AMPK/SIRT1 pathway.
Inflammopharmacology
Zhang ZT,Xie K,Luo RJ,Zhang DY,He ZW,Li KF,Lin SH,Xu F
25-0251-82 was used in Flow cytometry/Cell sorting to explore the anti-inflammatory effect and the potential mechanism of dexmedetomidine in ARDS/ALI.
Wed Feb 01 00:00:00 EST 2023
Group 2 Innate Lymphoid Cells Protect Mice from Abdominal Aortic Aneurysm Formation via IL5 and Eosinophils.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Zhang Y,Liu T,Deng Z,Fang W,Zhang X,Zhang S,Wang M,Luo S,Meng Z,Liu J,Sukhova GK,Li D,McKenzie ANJ,Libby P,Shi GP,Guo J
Published figure using CD25 monoclonal antibody (Product # 25-0251-82) in Flow Cytometry
Wed Mar 01 00:00:00 EST 2023
Aiolos represses CD4+ T cell cytotoxic programming via reciprocal regulation of TFH transcription factors and IL-2 sensitivity.
Nature communications
Read KA,Jones DM,Pokhrel S,Hales EDS,Varkey A,Tuazon JA,Eisele CD,Abdouni O,Saadey A,Leonard MR,Warren RT,Powell MD,Boss JM,Hemann EA,Yount JS,Xin G,Ghoneim HE,Lio CJ,Freud AG,Collins PL,Oestreich KJ
Published figure using CD25 monoclonal antibody (Product # 25-0251-82) in Flow Cytometry
Fri Mar 24 00:00:00 EDT 2023
A hydrogen peroxide economizer for on-demand oxygen production-assisted robust sonodynamic immunotherapy.
Theranostics
Jiang Q,Qiao B,Lin X,Cao J,Zhang N,Guo H,Liu W,Zhu L,Xie X,Wan L,Tang R,Liang B,Wang D,Wang Z,Zhou Y,Ran H,Li P
Published figure using CD25 monoclonal antibody (Product # 25-0251-82) in Flow Cytometry
Mon Mar 07 00:00:00 EST 2022
Glutamine is essential for overcoming the immunosuppressive microenvironment in malignant salivary gland tumors.
Theranostics
Cao S,Hung YW,Wang YC,Chung Y,Qi Y,Ouyang C,Zhong X,Hu W,Coblentz A,Maghami E,Sun Z,Lin HH,Ann DK
Published figure using CD25 monoclonal antibody (Product # 25-0251-82) in Flow Cytometry
Tue Aug 16 00:00:00 EDT 2022
Maternal gut bacteria drive intestinal inflammation in offspring with neurodevelopmental disorders by altering the chromatin landscape of CD4+ T cells.
Immunity
Kim E,Paik D,Ramirez RN,Biggs DG,Park Y,Kwon HK,Choi GB,Huh JR
25-0251-82 was used in Flow cytometry/Cell sorting to investigate intestinal inflammation in children with autism spectrum disorders in response to maternal gut bacteria.
Tue Jan 11 00:00:00 EST 2022
Nucleolin Therapeutic Targeting Decreases Pancreatic Cancer Immunosuppression.
Cancers
Ponzo M,Debesset A,Cossutta M,Chalabi-Dchar M,Houppe C,Pilon C,Nicolas-Boluda A,Meunier S,Raineri F,Thiolat A,Nicolle R,Maione F,Brundu S,Cojocaru CF,Bouvet P,Bousquet C,Gazeau F,Tournigand C,Courty J,Giraudo E,Cohen JL,Cascone I
25-0251-82 was used in Flow cytometry/Cell sorting to show that nucleolin (NCL) inhibition normalizes tumour vessels and impairs PDAC growth.
Wed Aug 31 00:00:00 EDT 2022
RAGE-mediated T cell metabolic reprogramming shapes T cell inflammatory response after stroke.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
Zhang Y,Li F,Chen C,Li Y,Xie W,Huang D,Zhai X,Yu W,Wan J,Li P
25-0251-82 was used in Flow cytometry/Cell sorting to show that sRAGE can serve as a novel immunometabolic modulator that ameliorates ischemic stroke recovery by inhibiting fatty acid synthesis and thus favoring CD4+ T cells polarization toward Treg after cerebral ischemia injury.
Wed Jun 01 00:00:00 EDT 2022
Deletion of Lactate Dehydrogenase-A Impairs Oncogene-Induced Mouse Hepatocellular Carcinoma Development.
Cellular and molecular gastroenterology and hepatology
Serra M,Di Matteo M,Serneels J,Pal R,Cafarello ST,Lanza M,Sanchez-Martin C,Evert M,Castegna A,Calvisi DF,Mazzone M,Columbano A
25-0251-82 was used in Flow cytometry/Cell sorting to investigate whether lactate dehydrogenase-A genetic ablation interferes with metabolic reprogramming and hepatocellular carcinoma development in the mouse.
Mon Aug 29 00:00:00 EDT 2022
Epigenetic modifier SMCHD1 maintains a normal pool of long-term hematopoietic stem cells.
iScience
Kinkel SA,Liu J,Beck T,Breslin KA,Iminitoff M,Hickey P,Blewitt ME
25-0251-82 was used in Flow cytometry/Cell sorting to investigate structural maintenance of chromosomes hinge domain containing 1 in hematopoiesis.
Fri Jul 15 00:00:00 EDT 2022
Stage-specific action of Runx1 and GATA3 controls silencing of PU.1 expression in mouse pro-T cells.
The Journal of experimental medicine
Hosokawa H,Koizumi M,Masuhara K,Romero-Wolf M,Tanaka T,Nakayama T,Rothenberg EV
Published figure using CD25 monoclonal antibody (Product # 25-0251-82) in Flow Cytometry
Mon Aug 02 00:00:00 EDT 2021
TRPM8 channel augments T-cell activation and proliferation.
Cell biology international
Acharya TK,Tiwari A,Majhi RK,Goswami C
Published figure using CD25 monoclonal antibody (Product # 25-0251-82) in Flow Cytometry
Fri Jan 01 00:00:00 EST 2021
MicroRNA‑21‑5p protects melanocytes via targeting STAT3 and modulating Treg/Teff balance to alleviate vitiligo.
Molecular medicine reports
Huo J,Liu T,Li F,Song X,Hou X
Published figure using CD25 monoclonal antibody (Product # 25-0251-82) in Flow Cytometry
Fri Jan 01 00:00:00 EST 2021
Irradiated whole-cell vaccine suppresses hepatocellular carcinoma growth in mice via Th9 cells.
Oncology letters
Chen J,Ding Y,Huang F,Lan R,Wang Z,Huang W,Chen R,Wu B,Fu L,Yang Y,Liu J,Hong J,Zhang W,Zhang L
Published figure using CD25 monoclonal antibody (Product # 25-0251-82) in Flow Cytometry
Sat May 01 00:00:00 EDT 2021
Imbalance between T helper 1 and regulatory T cells plays a detrimental role in experimental Parkinson's disease in mice.
The Journal of international medical research
Li W,Luo Y,Xu H,Ma Q,Yao Q
25-0251-82 was used in Flow cytometry/Cell sorting to investigate if an imbalance between T helper (Th) 1 and regulatory T (Treg) cells is essential in experimental Parkinson''s disease.
Thu Apr 01 00:00:00 EDT 2021
Imbalance between T helper 1 and regulatory T cells plays a detrimental role in experimental Parkinson's disease in mice.
The Journal of international medical research
Li W,Luo Y,Xu H,Ma Q,Yao Q
25-0251-82 was used in Flow cytometry/Cell sorting to investigate if an imbalance between T helper (Th) 1 and regulatory T (Treg) cells is essential in experimental Parkinson''s disease.
Thu Apr 01 00:00:00 EDT 2021
Cell-permeable transgelin-2 as a potent therapeutic for dendritic cell-based cancer immunotherapy.
Journal of hematology & oncology
Kim HR,Park JS,Park JH,Yasmin F,Kim CH,Oh SK,Chung IJ,Jun CD
Published figure using CD25 monoclonal antibody (Product # 25-0251-82) in Flow Cytometry
Wed Mar 17 00:00:00 EDT 2021
Neuroimmune Consequences of eIF4E Phosphorylation on Chemotherapy-Induced Peripheral Neuropathy.
Frontiers in immunology
Agalave NM,Mody PH,Szabo-Pardi TA,Jeong HS,Burton MD
Published figure using CD25 monoclonal antibody (Product # 25-0251-82) in Flow Cytometry
Mon Sep 20 00:00:00 EDT 2021
Aiduqing formula inhibits breast cancer metastasis by suppressing TAM/CXCL1-induced Treg differentiation and infiltration.
Cell communication and signaling : CCS
Li J,Wang S,Wang N,Zheng Y,Yang B,Wang X,Zhang J,Pan B,Wang Z
Published figure using CD25 monoclonal antibody (Product # 25-0251-82) in Flow Cytometry
Mon Aug 30 00:00:00 EDT 2021
The effect of fingolimod on regulatory T cells in a mouse model of brain ischaemia.
Journal of neuroinflammation
Malone K,Diaz Diaz AC,Shearer JA,Moore AC,Waeber C
Published figure using CD25 monoclonal antibody (Product # 25-0251-82) in Flow Cytometry
Sat Jan 30 00:00:00 EST 2021
PI3Kδ coordinates transcriptional, chromatin, and metabolic changes to promote effector CD8+ T cells at the expense of central memory.
Cell reports
Cannons JL,Villarino AV,Kapnick SM,Preite S,Shih HY,Gomez-Rodriguez J,Kaul Z,Shibata H,Reilley JM,Huang B,Handon R,McBain IT,Gossa S,Wu T,Su HC,McGavern DB,O'Shea JJ,McGuire PJ,Uzel G,Schwartzberg PL
Published figure using CD25 monoclonal antibody (Product # 25-0251-82) in Flow Cytometry
Tue Oct 12 00:00:00 EDT 2021
Acacetin ameliorates insulin resistance in obesity mice through regulating Treg/Th17 balance via MiR-23b-3p/NEU1 Axis.
BMC endocrine disorders
Wei Y,Jing J,Peng Z,Liu X,Wang X
Published figure using CD25 monoclonal antibody (Product # 25-0251-82) in Flow Cytometry
Mon Mar 29 00:00:00 EDT 2021
Near-infrared photoimmunotherapy targeting human-EGFR in a mouse tumor model simulating current and future clinical trials.
EBioMedicine
Okada R,Furusawa A,Vermeer DW,Inagaki F,Wakiyama H,Kato T,Nagaya T,Choyke PL,Spanos WC,Allen CT,Kobayashi H
Published figure using CD25 monoclonal antibody (Product # 25-0251-82) in Flow Cytometry
Sat May 01 00:00:00 EDT 2021
Milk-derived extracellular vesicles alleviate ulcerative colitis by regulating the gut immunity and reshaping the gut microbiota.
Theranostics
Tong L,Hao H,Zhang Z,Lv Y,Liang X,Liu Q,Liu T,Gong P,Zhang L,Cao F,Pastorin G,Lee CN,Chen X,Wang JW,Yi H
Published figure using CD25 monoclonal antibody (Product # 25-0251-82) in Flow Cytometry
Fri Jan 28 00:00:00 EST 2022
CD4+ effector T cells accelerate Alzheimer's disease in mice.
Journal of neuroinflammation
Machhi J,Yeapuri P,Lu Y,Foster E,Chikhale R,Herskovitz J,Namminga KL,Olson KE,Abdelmoaty MM,Gao J,Quadros RM,Kiyota T,Jingjing L,Kevadiya BD,Wang X,Liu Y,Poluektova LY,Gurumurthy CB,Mosley RL,Gendelman HE
25-0251-82 was used in Flow Cytometry to investigate the role of effector immunity and how it could affect cellular-level disease pathobiology in an alzheimer's disease animal model.
Fri Nov 19 00:00:00 EST 2021
Sex-specific adipose tissue imprinting of regulatory T cells.
Nature
Vasanthakumar A,Chisanga D,Blume J,Gloury R,Britt K,Henstridge DC,Zhan Y,Torres SV,Liene S,Collins N,Cao E,Sidwell T,Li C,Spallanzani RG,Liao Y,Beavis PA,Gebhardt T,Trevaskis N,Nutt SL,Zajac JD,Davey RA,Febbraio MA,Mathis D,Shi W,Kallies A
25-0251-82 was used in Flow Cytometry to find that sex-specific differences in Treg cells from visceral adipose tissue are determined by the tissue niche in a sex-hormone-dependent manner to limit adipose tissue inflammation.
Sun Mar 01 00:00:00 EST 2020
Hybrid Gene Origination Creates Human-Virus Chimeric Proteins during Infection.
Cell
Ho JSY,Angel M,Ma Y,Sloan E,Wang G,Martinez-Romero C,Alenquer M,Roudko V,Chung L,Zheng S,Chang M,Fstkchyan Y,Clohisey S,Dinan AM,Gibbs J,Gifford R,Shen R,Gu Q,Irigoyen N,Campisi L,Huang C,Zhao N,Jones JD,van Knippenberg I,Zhu Z,Moshkina N,Meyer L,Noel J,Peralta Z,Rezelj V,Kaake R,Rosenberg B,Wang B,Wei J,Paessler S,Wise HM,Johnson J,Vannini A,Amorim MJ,Baillie JK,Miraldi ER,Benner C,Brierley I,Digard P,Łuksza M,Firth AE,Krogan N,Greenbaum BD,MacLeod MK,van Bakel H,Garcìa-Sastre A,Yewdell JW,Hutchinson E,Marazzi I
Published figure using CD25 monoclonal antibody (Product # 25-0251-82) in Flow Cytometry
Thu Jun 25 00:00:00 EDT 2020
Interleukin-17A Serves a Priming Role in Autoimmunity by Recruiting IL-1β-Producing Myeloid Cells that Promote Pathogenic T Cells.
Immunity
McGinley AM,Sutton CE,Edwards SC,Leane CM,DeCourcey J,Teijeiro A,Hamilton JA,Boon L,Djouder N,Mills KHG
25-0251 was used in Flow cytometry/Cell sorting to demonstrate that a key function of IL-17A in central nervous system (CNS) autoimmunity is to recruit IL-1β-secreting myeloid cells that prime pathogenic γδT17 and Th17 cells.
Tue Feb 18 00:00:00 EST 2020
Regulatory T Cell-Derived TGF-β1 Controls Multiple Checkpoints Governing Allergy and Autoimmunity.
Immunity
Turner JA,Stephen-Victor E,Wang S,Rivas MN,Abdel-Gadir A,Harb H,Cui Y,Fanny M,Charbonnier LM,Fong JJH,Benamar M,Wang L,Burton OT,Bansal K,Bry L,Zhu C,Li QZ,Clement RL,Oettgen HC,Crestani E,Rachid R,Sage PT,Chatila TA
25-0251-82 was used in Flow Cytometry to show that Treg cells in food allergy (FA) had decreased expression of transforming growth factor beta 1 (TGF-β1) because of interleukin-4 (IL-4)- and signal transducer and activator of transciription-6 (STAT6)-dependent inhibition of Tgfb1 transcription.
Tue Dec 15 00:00:00 EST 2020
Altered Immunity of Laboratory Mice in the Natural Environment Is Associated with Fungal Colonization.
Cell host & microbe
Yeung F,Chen YH,Lin JD,Leung JM,McCauley C,Devlin JC,Hansen C,Cronkite A,Stephens Z,Drake-Dunn C,Fulmer Y,Shopsin B,Ruggles KV,Round JL,Loke P,Graham AL,Cadwell K
25-0251-82 was used in Flow Cytometry to establish a model to investigate how the natural environment impacts immune development and show that sustained fungal exposure impacts granulocyte numbers.
Wed May 13 00:00:00 EDT 2020
Protein arginine methyltransferase 5 promotes cholesterol biosynthesis-mediated Th17 responses and autoimmunity.
The Journal of clinical investigation
Webb LM,Sengupta S,Edell C,Piedra-Quintero ZL,Amici SA,Miranda JN,Bevins M,Kennemer A,Laliotis G,Tsichlis PN,Guerau-de-Arellano M
Published figure using CD25 monoclonal antibody (Product # 25-0251-82) in Flow Cytometry
Wed Apr 01 00:00:00 EDT 2020
Glufosinate constrains synchronous and metachronous metastasis by promoting anti-tumor macrophages.
EMBO molecular medicine
Menga A,Serra M,Todisco S,Riera-Domingo C,Ammarah U,Ehling M,Palmieri EM,Di Noia MA,Gissi R,Favia M,Pierri CL,Porporato PE,Castegna A,Mazzone M
25-0251 was used in Flow cytometry/Cell sorting to evaluate the pharmacological potential of Glutamine synthetase (GS) inhibitors in targeting metastasis.
Wed Oct 07 00:00:00 EDT 2020
Glufosinate constrains synchronous and metachronous metastasis by promoting anti-tumor macrophages.
EMBO molecular medicine
Menga A,Serra M,Todisco S,Riera-Domingo C,Ammarah U,Ehling M,Palmieri EM,Di Noia MA,Gissi R,Favia M,Pierri CL,Porporato PE,Castegna A,Mazzone M
25-0251 was used in Flow cytometry/Cell sorting to evaluate the pharmacological potential of Glutamine synthetase (GS) inhibitors in targeting metastasis.
Wed Oct 07 00:00:00 EDT 2020
Excessive Costimulation Leads to Dysfunction of Adoptively Transferred T Cells.
Cancer immunology research
Wijewarnasuriya D,Bebernitz C,Lopez AV,Rafiq S,Brentjens RJ
25-0251 was used in Flow cytometry/Cell sorting to show excessive CD28 and 4-1BB co-stimulation can drive chimeric antigen receptor T-cell dysfunction.
Mon Jun 01 00:00:00 EDT 2020
Notch2 complements Notch1 to mediate inductive signaling that initiates early T cell development.
The Journal of cell biology
Romero-Wolf M,Shin B,Zhou W,Koizumi M,Rothenberg EV,Hosokawa H
Published figure using CD25 monoclonal antibody (Product # 25-0251-82) in Flow Cytometry
Mon Oct 05 00:00:00 EDT 2020
Enhanced alleviation of aGVHD by TGF-β1-modified mesenchymal stem cells in mice through shifting MΦ into M2 phenotype and promoting the differentiation of Treg cells.
Journal of cellular and molecular medicine
Wu R,Liu C,Deng X,Chen L,Hao S,Ma L
Published figure using CD25 monoclonal antibody (Product # 25-0251-82) in Flow Cytometry
Wed Jan 01 00:00:00 EST 2020
Immunoprophylactic and immunotherapeutic control of hormone receptor-positive breast cancer.
Nature communications
Buqué A,Bloy N,Perez-Lanzón M,Iribarren K,Humeau J,Pol JG,Levesque S,Mondragon L,Yamazaki T,Sato A,Aranda F,Durand S,Boissonnas A,Fucikova J,Senovilla L,Enot D,Hensler M,Kremer M,Stoll G,Hu Y,Massa C,Formenti SC,Seliger B,Elemento O,Spisek R,André F,Zitvogel L,Delaloge S,Kroemer G,Galluzzi L
25-0251 was used in Flow cytometry/Cell sorting to identify NAM as a potential strategy for the prevention and treatment of HR+ BC.
Thu Jul 30 00:00:00 EDT 2020
Immunoprophylactic and immunotherapeutic control of hormone receptor-positive breast cancer.
Nature communications
Buqué A,Bloy N,Perez-Lanzón M,Iribarren K,Humeau J,Pol JG,Levesque S,Mondragon L,Yamazaki T,Sato A,Aranda F,Durand S,Boissonnas A,Fucikova J,Senovilla L,Enot D,Hensler M,Kremer M,Stoll G,Hu Y,Massa C,Formenti SC,Seliger B,Elemento O,Spisek R,André F,Zitvogel L,Delaloge S,Kroemer G,Galluzzi L
25-0251 was used in Flow cytometry/Cell sorting to identify NAM as a potential strategy for the prevention and treatment of HR+ BC.
Thu Jul 30 00:00:00 EDT 2020
Mitochondrial Pyruvate Carrier 1 Promotes Peripheral T Cell Homeostasis through Metabolic Regulation of Thymic Development.
Cell reports
Ramstead AG,Wallace JA,Lee SH,Bauer KM,Tang WW,Ekiz HA,Lane TE,Cluntun AA,Bettini ML,Round JL,Rutter J,O'Connell RM
Published figure using CD25 monoclonal antibody (Product # 25-0251-82) in Flow Cytometry
Tue Mar 03 00:00:00 EST 2020
PTPN2 Deficiency Enhances Programmed T Cell Expansion and Survival Capacity of Activated T Cells.
Cell reports
Flosbach M,Oberle SG,Scherer S,Zecha J,von Hoesslin M,Wiede F,Chennupati V,Cullen JG,List M,Pauling JK,Baumbach J,Kuster B,Tiganis T,Zehn D
25-0251 was used in Flow cytometry/Cell sorting to show the therapeutic potential of targeting PTPN2 in T cell-based therapies to augment the number and survival capacity of antigen-specific T cells.
Tue Jul 28 00:00:00 EDT 2020
PTPN2 Deficiency Enhances Programmed T Cell Expansion and Survival Capacity of Activated T Cells.
Cell reports
Flosbach M,Oberle SG,Scherer S,Zecha J,von Hoesslin M,Wiede F,Chennupati V,Cullen JG,List M,Pauling JK,Baumbach J,Kuster B,Tiganis T,Zehn D
25-0251 was used in Flow cytometry/Cell sorting to show the therapeutic potential of targeting PTPN2 in T cell-based therapies to augment the number and survival capacity of antigen-specific T cells.
Tue Jul 28 00:00:00 EDT 2020
Artificial Mini Dendritic Cells Boost T Cell-Based Immunotherapy for Ovarian Cancer.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Cheng S,Xu C,Jin Y,Li Y,Zhong C,Ma J,Yang J,Zhang N,Li Y,Wang C,Yang Z,Wang Y
Published figure using CD25 monoclonal antibody (Product # 25-0251-82) in Flow Cytometry
Wed Apr 01 00:00:00 EDT 2020
Distinct actions of the fermented beverage kefir on host behaviour, immunity and microbiome gut-brain modules in the mouse.
Microbiome
van de Wouw M,Walsh AM,Crispie F,van Leuven L,Lyte JM,Boehme M,Clarke G,Dinan TG,Cotter PD,Cryan JF
Published figure using CD25 monoclonal antibody (Product # 25-0251-82) in Flow Cytometry
Mon May 18 00:00:00 EDT 2020
B7-CD28 co-stimulation modulates central tolerance via thymic clonal deletion and Treg generation through distinct mechanisms.
Nature communications
Watanabe M,Lu Y,Breen M,Hodes RJ
Published figure using CD25 monoclonal antibody (Product # 25-0251-82) in Flow Cytometry
Tue Dec 08 00:00:00 EST 2020
KLF10 Deficiency in CD4+ T Cells Triggers Obesity, Insulin Resistance, and Fatty Liver.
Cell reports
Wara AK,Wang S,Wu C,Fang F,Haemmig S,Weber BN,Aydogan CO,Tesmenitsky Y,Aliakbarian H,Hawse JR,Subramaniam M,Zhao L,Sage PT,Tavakkoli A,Garza A,Lynch L,Banks AS,Feinberg MW
25-0251-82 was used in Flow Cytometry to explore the role of KLF10 in high-fat-diet-induced obesity and insulin resistance.
Tue Dec 29 00:00:00 EST 2020
Attenuation of TCR-induced transcription by Bach2 controls regulatory T cell differentiation and homeostasis.
Nature communications
Sidwell T,Liao Y,Garnham AL,Vasanthakumar A,Gloury R,Blume J,Teh PP,Chisanga D,Thelemann C,de Labastida Rivera F,Engwerda CR,Corcoran L,Kometani K,Kurosaki T,Smyth GK,Shi W,Kallies A
25-0251 was used in Flow cytometry/Cell sorting to show homeostasis of thymically-derived and peripherally-derived Treg cells is maintained through the balancing of TCR signaling induced transcriptional activity by Bach2.
Tue Jan 14 00:00:00 EST 2020
IDO1+ Paneth cells promote immune escape of colorectal cancer.
Communications biology
Pflügler S,Svinka J,Scharf I,Crncec I,Filipits M,Charoentong P,Tschurtschenthaler M,Kenner L,Awad M,Stift J,Schernthanner M,Bischl R,Herndler-Brandstetter D,Glitzner E,Moll HP,Casanova E,Timelthaler G,Sibilia M,Gnant M,Lax S,Thaler J,Müller M,Strobl B,Mohr T,Kaser A,Trajanoski Z,Heller G,Eferl R
25-0251 was used in Flow cytometry/Cell sorting to uncover an immune escape mechanism of colorectal cancer (CRC) and identify IDO1+ Paneth cells as a target for immunotherapy.
Fri May 22 00:00:00 EDT 2020
An Id2RFP-Reporter Mouse Redefines Innate Lymphoid Cell Precursor Potentials.
Immunity
Xu W,Cherrier DE,Chea S,Vosshenrich C,Serafini N,Petit M,Liu P,Golub R,Di Santo JP
Published figure using CD25 monoclonal antibody (Product # 25-0251-82) in Flow Cytometry
Tue Apr 16 00:00:00 EDT 2019
Polychromic Reporter Mice Reveal Unappreciated Innate Lymphoid Cell Progenitor Heterogeneity and Elusive ILC3 Progenitors in Bone Marrow.
Immunity
Walker JA,Clark PA,Crisp A,Barlow JL,Szeto A,Ferreira ACF,Rana BMJ,Jolin HE,Rodriguez-Rodriguez N,Sivasubramaniam M,Pannell R,Cruickshank J,Daly M,Haim-Vilmovsky L,Teichmann SA,McKenzie ANJ
Published figure using CD25 monoclonal antibody (Product # 25-0251-82) in Flow Cytometry
Tue Jul 16 00:00:00 EDT 2019
A Mutation in the Transcription Factor Foxp3 Drives T Helper 2 Effector Function in Regulatory T Cells.
Immunity
Van Gool F,Nguyen MLT,Mumbach MR,Satpathy AT,Rosenthal WL,Giacometti S,Le DT,Liu W,Brusko TM,Anderson MS,Rudensky AY,Marson A,Chang HY,Bluestone JA
25-0251 was used in Flow cytometry/Cell sorting to identify an IPEX (immune dysregulation polyendocrinopathy enteropathy X-linked) syndrome patient with a FOXP3 mutation in the domain swap interface of the protein.
Tue Feb 19 00:00:00 EST 2019
Cancer cells induce immune escape via glycocalyx changes controlled by the telomeric protein TRF2.
The EMBO journal
Cherfils-Vicini J,Iltis C,Cervera L,Pisano S,Croce O,Sadouni N,Győrffy B,Collet R,Renault VM,Rey-Millet M,Leonetti C,Zizza P,Allain F,Ghiringhelli F,Soubeiran N,Shkreli M,Vivier E,Biroccio A,Gilson E
25-0251 was used in Flow cytometry/Cell sorting to describe a mechanism by which cancer cells control myeloid-derived suppressor cells in human cancers by upregulating TRF2, a protein required for telomere stability.
Mon Jun 03 00:00:00 EDT 2019
PTCy ameliorates GVHD by restoring regulatory and effector T-cell homeostasis in recipients with PD-1 blockade.
Blood advances
Ikegawa S,Meguri Y,Kondo T,Sugiura H,Sando Y,Nakamura M,Iwamoto M,Maeda Y,Matsuoka KI
25-0251-82 was used in Flow Cytometry to present that the influence of PD-1 blockade differed within T-cell subsets and caused unbalanced reconstitution of T-cell subsets, resulting in severe GVHD. PTCy successfully restored T-cell homeostasis and ameliorated GVHD induced by PD-1-/- donor T cells.
Tue Dec 10 00:00:00 EST 2019
Characterization of immune cell subtypes in three commonly used mouse strains reveals gender and strain-specific variations.
Laboratory investigation; a journal of technical methods and pathology
Hensel JA,Khattar V,Ashton R,Ponnazhagan S
Published figure using CD25 monoclonal antibody (Product # 25-0251-82) in Flow Cytometry
Tue Jan 01 00:00:00 EST 2019
Cyclooxygenase-1 Regulates the Development of Follicular Th Cells via Prostaglandin E2.
Journal of immunology (Baltimore, Md. : 1950)
Liu T,Yang Q,Cao YJ,Yuan WM,Lei AH,Zhou P,Zhou W,Liu YD,Shi MH,Yang Q,Tang JY,Wang HK,Zhang H,Yu Y,Zhou J
25-0251-82 was used in Flow Cytometry to indicate that COX-1 plays an important role in the development of TFH cells.
Thu Aug 15 00:00:00 EDT 2019
Interleukin 10 Gene-Modified Bone Marrow-Derived Dendritic Cells Attenuate Liver Fibrosis in Mice by Inducing Regulatory T Cells and Inhibiting the TGF-β/Smad Signaling Pathway.
Mediators of inflammation
Xu Y,Tang X,Yang M,Zhang S,Li S,Chen Y,Liu M,Guo Y,Lu M
Published figure using CD25 monoclonal antibody (Product # 25-0251-82) in Flow Cytometry
Tue Jun 11 00:00:00 EDT 2019
Antitumor and immunomodulatory effects of a novel multitarget inhibitor, CS2164, in mouse hepatocellular carcinoma models.
Anti-cancer drugs
Zhou Y,Fu C,Kong Y,Pan D,Wang Y,Huang S,Li Z,Ning Z,Lu X,Shan S,Xin L
Published figure using CD25 monoclonal antibody (Product # 25-0251-82) in Flow Cytometry
Tue Oct 01 00:00:00 EDT 2019
Sex Differences in Mouse Popliteal Lymph Nodes.
Scientific reports
Dill-Garlow R,Chen KE,Walker AM
Published figure using CD25 monoclonal antibody (Product # 25-0251-82) in Flow Cytometry
Wed Jan 30 00:00:00 EST 2019
SCGN deficiency results in colitis susceptibility.
eLife
Sifuentes-Dominguez LF,Li H,Llano E,Liu Z,Singla A,Patel AS,Kathania M,Khoury A,Norris N,Rios JJ,Starokadomskyy P,Park JY,Gopal P,Liu Q,Tan S,Chan L,Ross T,Harrison S,Venuprasad K,Baker LA,Jia D,Burstein E
Published figure using CD25 monoclonal antibody (Product # 25-0251-82) in Flow Cytometry
Wed Oct 30 00:00:00 EDT 2019
Anti-IL-6 eluting immunomodulatory biomaterials prolong skin allograft survival.
Scientific reports
Uehara M,Li X,Sheikhi A,Zandi N,Walker B,Saleh B,Banouni N,Jiang L,Ordikhani F,Dai L,Yonar M,Vohra I,Kasinath V,Orgill DP,Khademhosseini A,Annabi N,Abdi R
Published figure using CD25 monoclonal antibody (Product # 25-0251-82) in Flow Cytometry
Thu Apr 25 00:00:00 EDT 2019
A synergistic triad of chemotherapy, immune checkpoint inhibitors, and caloric restriction mimetics eradicates tumors in mice.
Oncoimmunology
Lévesque S,Le Naour J,Pietrocola F,Paillet J,Kremer M,Castoldi F,Baracco EE,Wang Y,Vacchelli E,Stoll G,Jolly A,De La Grange P,Zitvogel L,Kroemer G,Pol JG
25-0251-82 was used in Flow Cytometry to point to the possibility of synergistic interactions among distinct classes of anticancer agents.
Sat Oct 14 00:00:00 EDT 2023
LAP+ Treg is a better biomarker than total Treg in viral myocarditis.
Journal of medical virology
Wang X,Ge J,Chen R
25-0251-82 was used in Flow cytometry/Cell sorting to present the data on the proportion of LAP+ Treg out of CD4+ cells in mice with viral myocarditis, which we believed was more sensitive and specific than that of the ratio of total Treg in CD4+ cells.
Wed May 01 00:00:00 EDT 2019
Hippo Kinases Mst1 and Mst2 Sense and Amplify IL-2R-STAT5 Signaling in Regulatory T Cells to Establish Stable Regulatory Activity.
Immunity
Shi H,Liu C,Tan H,Li Y,Nguyen TM,Dhungana Y,Guy C,Vogel P,Neale G,Rankin S,Feng Y,Peng J,Tao W,Chi H
Published figure using CD25 monoclonal antibody (Product # 25-0251-82) in Flow Cytometry
Tue Nov 20 00:00:00 EST 2018
Critical Role for the Microbiota in CX3CR1+ Intestinal Mononuclear Phagocyte Regulation of Intestinal T Cell Responses.
Immunity
Kim M,Galan C,Hill AA,Wu WJ,Fehlner-Peach H,Song HW,Schady D,Bettini ML,Simpson KW,Longman RS,Littman DR,Diehl GE
25-0251 was used in Flow cytometry/Cell sorting to identify a cellular mechanism by which the microbiota limits intestinal inflammation and promotes tissue homeostasis.
Tue Jul 17 00:00:00 EDT 2018
E3 Ligase VHL Promotes Group 2 Innate Lymphoid Cell Maturation and Function via Glycolysis Inhibition and Induction of Interleukin-33 Receptor.
Immunity
Li Q,Li D,Zhang X,Wan Q,Zhang W,Zheng M,Zou L,Elly C,Lee JH,Liu YC
25-0251 was used in Flow Cytometry to indicate that the VHL-HIF-glycolysis axis is essential for the late-stage maturation and function of ILC2s via targeting IL-33-ST2 pathway.
Tue Feb 20 00:00:00 EST 2018
MTOR signaling is essential for the development of thymic epithelial cells and the induction of central immune tolerance.
Autophagy
Liang Z,Zhang L,Su H,Luan R,Na N,Sun L,Zhao Y,Zhang X,Zhang Q,Li J,Zhang L,Zhao Y
Published figure using CD25 monoclonal antibody (Product # 25-0251-82) in Flow Cytometry
Fri Mar 22 00:00:00 EDT 2019
Quantitative Methods for Measuring Repair Rates and Innate-Immune Cell Responses in Wounded Mouse Skin.
Frontiers in immunology
Li Z,Gothard E,Coles MC,Ambler CA
25-0251 was used in Flow cytometry/Cell sorting to provide methods for measuring wound openness by digital 3D image capture and semi-automated image processing.
Wed Mar 27 00:00:00 EDT 2019
Impact of hyperglycemia on autoimmune pancreatitis and regulatory T-cells.
World journal of gastroenterology
Müller-Graff FT,Fitzner B,Jaster R,Vollmar B,Zechner D
25-0251 was used in Flow cytometry/Cell sorting to evaluate the influence of hyperglycaemia on the progression of autoimmune pancreatitis.
Sat Jul 28 00:00:00 EDT 2018
Granulocyte-macrophage colony-stimulating factor neuroprotective activities in Alzheimer's disease mice.
Journal of neuroimmunology
Kiyota T,Machhi J,Lu Y,Dyavarshetty B,Nemati M,Yokoyama I,Mosley RL,Gendelman HE
Published figure using CD25 monoclonal antibody (Product # 25-0251-82) in Flow Cytometry
Fri Jun 15 00:00:00 EDT 2018
Immunological effects of a low-dose cytarabine, aclarubicin and granulocyte-colony stimulating factor priming regimen on a mouse leukemia model.
Oncology letters
Chen J,Yang N,Liu H,Yao H,Wang J,Yang Y,Zhang W
Published figure using CD25 monoclonal antibody (Product # 25-0251-82) in Flow Cytometry
Sat Sep 01 00:00:00 EDT 2018
Assessment of tumor growth factor-β1 neutralizing antibody in the treatment of allergic rhinitis and asthma.
Experimental and therapeutic medicine
Wei Y,Zhang Z,Wang F,Zhou S
Published figure using CD25 monoclonal antibody (Product # 25-0251-82) in Flow Cytometry
Mon Jan 01 00:00:00 EST 2018
A stochastic epigenetic switch controls the dynamics of T-cell lineage commitment.
eLife
Ng KK,Yui MA,Mehta A,Siu S,Irwin B,Pease S,Hirose S,Elowitz MB,Rothenberg EV,Kueh HY
Published figure using CD25 monoclonal antibody (Product # 25-0251-82) in Flow Cytometry
Tue Nov 20 00:00:00 EST 2018
IL-7 treatment augments and prolongs sepsis-induced expansion of IL-10-producing B lymphocytes and myeloid-derived suppressor cells.
PloS one
Kulkarni U,Herrmenau C,Win SJ,Bauer M,Kamradt T
25-0251 was used in Flow cytometry/Cell sorting to investigate the expansion of immunoregulatory cells as long-term sequelae of sepsis with or without IL-7 treatment.
Mon Apr 09 00:00:00 EDT 2018
Limited Foxp3+ Regulatory T Cells Response During Acute Trypanosoma cruzi Infection Is Required to Allow the Emergence of Robust Parasite-Specific CD8+ T Cell Immunity.
Frontiers in immunology
Araujo Furlan CL,Tosello Boari J,Rodriguez C,Canale FP,Fiocca Vernengo F,Boccardo S,Beccaria CG,Adoue V,Joffre O,Gruppi A,Montes CL,Acosta Rodriguez EV
25-0251 was used in Flow cytometry/Cell sorting to study the role of regulatory T cells during Trypanosoma cruzi infection.
Thu Sep 26 00:00:00 EDT 2019
Stability and function of regulatory T cells expressing the transcription factor T-bet.
Nature
Levine AG,Mendoza A,Hemmers S,Moltedo B,Niec RE,Schizas M,Hoyos BE,Putintseva EV,Chaudhry A,Dikiy S,Fujisawa S,Chudakov DM,Treuting PM,Rudensky AY
Published figure using CD25 monoclonal antibody (Product # 25-0251-82) in Flow Cytometry
Thu Jun 15 00:00:00 EDT 2017
Regulatory Innate Lymphoid Cells Control Innate Intestinal Inflammation.
Cell
Wang S,Xia P,Chen Y,Qu Y,Xiong Z,Ye B,Du Y,Tian Y,Yin Z,Xu Z,Fan Z
25-0251 was used in Flow cytometry/Cell sorting to identify a regulatory subpopulation of innate lymphoid cells that exists in the gut, and harbour a unique gene identity.
Thu Sep 21 00:00:00 EDT 2017
Commensal Microbes and Hair Follicle Morphogenesis Coordinately Drive Treg Migration into Neonatal Skin.
Cell host & microbe
Scharschmidt TC,Vasquez KS,Pauli ML,Leitner EG,Chu K,Truong HA,Lowe MM,Sanchez Rodriguez R,Ali N,Laszik ZG,Sonnenburg JL,Millar SE,Rosenblum MD
Published figure using CD25 monoclonal antibody (Product # 25-0251-82) in Flow Cytometry
Wed Apr 12 00:00:00 EDT 2017
Autoreactive T Cells and Chronic Fungal Infection Drive Esophageal Carcinogenesis.
Cell host & microbe
Zhu F,Willette-Brown J,Song NY,Lomada D,Song Y,Xue L,Gray Z,Zhao Z,Davis SR,Sun Z,Zhang P,Wu X,Zhan Q,Richie ER,Hu Y
Published figure using CD25 monoclonal antibody (Product # 25-0251-82) in Flow Cytometry
Wed Apr 12 00:00:00 EDT 2017
Opposing effects on the cell cycle of T lymphocytes by Fbxo7 via Cdk6 and p27.
Cellular and molecular life sciences : CMLS
Patel SP,Randle SJ,Gibbs S,Cooke A,Laman H
25-0251 was used in Flow cytometry/Cell sorting to test the physiological role of an F-box protein, Fbxo7, in multiple tissues.
Sat Apr 01 00:00:00 EDT 2017
Immunological effects of vaccines combined with granulocyte colony-stimulating factor on a murine WEHI-3 leukemia model.
Oncology letters
Chen J,Zhang M,Zhou F,Wang J,Niu B,Zhang W
Published figure using CD25 monoclonal antibody (Product # 25-0251-82) in Flow Cytometry
Sat Apr 01 00:00:00 EDT 2017
Targeted calcium influx boosts cytotoxic T lymphocyte function in the tumour microenvironment.
Nature communications
Kim KD,Bae S,Capece T,Nedelkovska H,de Rubio RG,Smrcka AV,Jun CD,Jung W,Park B,Kim TI,Kim M
Published figure using CD25 monoclonal antibody (Product # 25-0251-82) in Flow Cytometry
Mon May 15 00:00:00 EDT 2017
Targeted genome editing restores T cell differentiation in a humanized X-SCID pluripotent stem cell disease model.
Scientific reports
Alzubi J,Pallant C,Mussolino C,Howe SJ,Thrasher AJ,Cathomen T
Published figure using CD25 monoclonal antibody (Product # 25-0251-82) in Flow Cytometry
Fri Sep 29 00:00:00 EDT 2017
Tristetraprolin inhibits macrophage IL-27-induced activation of antitumour cytotoxic T cell responses.
Nature communications
Wang Q,Ning H,Peng H,Wei L,Hou R,Hoft DF,Liu J
Published figure using CD25 monoclonal antibody (Product # 25-0251-82) in Flow Cytometry
Wed Oct 11 00:00:00 EDT 2017
Ceramide synthesis regulates T cell activity and GVHD development.
JCI insight
Sofi MH,Heinrichs J,Dany M,Nguyen H,Dai M,Bastian D,Schutt S,Wu Y,Daenthanasanmak A,Gencer S,Zivkovic A,Szulc Z,Stark H,Liu C,Chang YJ,Ogretmen B,Yu XZ
25-0251 was used in Flow cytometry/Cell sorting to define the involvement of ceramides in the T-cell response to alloantigens present after allogeneic haematopoietic cell transplantation.
Thu May 18 00:00:00 EDT 2017
Combined Blockade of T Cell Immunoglobulin and Mucin Domain 3 and Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1 Results in Durable Therapeutic Efficacy in Mice with Intracranial Gliomas.
Medical science monitor : international medical journal of experimental and clinical research
Li J,Liu X,Duan Y,Liu Y,Wang H,Lian S,Zhuang G,Fan Y
25-0251 was used in Flow cytometry/Cell sorting to indicate that combined blockade of T cell immunoglobulin and mucin domain 3 and carcinoembryonic antigen-related cell adhesion molecule 1 generates robust therapeutic efficacy in mice with intracranial tumours.
Mon Jul 24 00:00:00 EDT 2017
Oligodendrocyte death results in immune-mediated CNS demyelination.
Nature neuroscience
Traka M,Podojil JR,McCarthy DP,Miller SD,Popko B
Published figure using CD25 monoclonal antibody (Product # 25-0251-82) in Flow Cytometry
Fri Jan 01 00:00:00 EST 2016
Autophagy deficiency in myeloid cells increases susceptibility to obesity-induced diabetes and experimental colitis.
Autophagy
Lee HY,Kim J,Quan W,Lee JC,Kim MS,Kim SH,Bae JW,Hur KY,Lee MS
Published figure using CD25 monoclonal antibody (Product # 25-0251-82) in Flow Cytometry
Tue Aug 02 00:00:00 EDT 2016
Distinctive Expression of Bcl-2 Factors in Regulatory T Cells Determines a Pharmacological Target to Induce Immunological Tolerance.
Frontiers in immunology
Gabriel SS,Bon N,Chen J,Wekerle T,Bushell A,Fehr T,Cippà PE
25-0251 was used in Flow cytometry/Cell sorting to show that blocking the intrinsic apoptosis pathway with a Bcl-2/Bcl-xL inhibitor (ABT-737) caused a selective depletion of effector T cells and a relative enrichment of Tregs in vivo.
Mon Mar 14 00:00:00 EDT 2016
IL-33-Dependent Group 2 Innate Lymphoid Cells Promote Cutaneous Wound Healing.
The Journal of investigative dermatology
Rak GD,Osborne LC,Siracusa MC,Kim BS,Wang K,Bayat A,Artis D,Volk SW
25-0251 was used in Flow cytometry/Cell sorting to demonstrate that cutaneous injury promotes an IL-33-dependent group 2 ILC (ILC2) response and that abrogation of this response can impair efficient wound closure.
Mon Feb 01 00:00:00 EST 2016
Oligodendroglial TNFR2 Mediates Membrane TNF-Dependent Repair in Experimental Autoimmune Encephalomyelitis by Promoting Oligodendrocyte Differentiation and Remyelination.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Madsen PM,Motti D,Karmally S,Szymkowski DE,Lambertsen KL,Bethea JR,Brambilla R
25-0251 was used in Flow cytometry/Cell sorting to provide evidence that TNFR2 in oligodendrocytes is important for oligodendrocyte differentiation, thereby sustaining tmTNF-dependent repair in neuroimmune disease.
Wed May 04 00:00:00 EDT 2016
Intranasal immunization with heat shock protein 60 induces CD4(+) CD25(+) GARP(+) and type 1 regulatory T cells and inhibits early atherosclerosis.
Clinical and experimental immunology
Zhong Y,Tang H,Wang X,Zeng Q,Liu Y,Zhao XI,Yu K,Shi H,Zhu R,Mao X
Published figure using CD25 monoclonal antibody (Product # 25-0251-82) in Flow Cytometry
Tue Mar 01 00:00:00 EST 2016
Rapamycin ameliorates CCl4-induced liver fibrosis in mice through reciprocal regulation of the Th17/Treg cell balance.
Molecular medicine reports
Gu L,Deng WS,Sun XF,Zhou H,Xu Q
Published figure using CD25 monoclonal antibody (Product # 25-0251-82) in Flow Cytometry
Mon Aug 01 00:00:00 EDT 2016
Genomic and immunologic factors associated with viral pathogenesis in a lethal EV71 infected neonatal mouse model.
Molecular medicine reports
Yue Y,Li P,Song N,Li B,Li Z,Guo Y,Zhang W,Wei MQ,Gai Z,Meng H,Wang J,Qin L
Published figure using CD25 monoclonal antibody (Product # 25-0251-82) in Flow Cytometry
Sun May 01 00:00:00 EDT 2016
Chinese herbal medicine formula Gu-Ben-Fang-Xiao-Tang attenuates airway inflammation by modulating Th17/Treg balance in an ovalbumin-induced murine asthma model.
Experimental and therapeutic medicine
Ruan G,Tao B,Wang D,Li Y,Wu J,Yin G
Published figure using CD25 monoclonal antibody (Product # 25-0251-82) in Flow Cytometry
Thu Sep 01 00:00:00 EDT 2016
PRDM14 promotes RAG-dependent Notch1 driver mutations in mouse T-ALL.
Biology open
Carofino BL,Ayanga B,Tracey LJ,Brooke-Bisschop T,Justice MJ
Published figure using CD25 monoclonal antibody (Product # 25-0251-82) in Flow Cytometry
Sun May 15 00:00:00 EDT 2016
Treg engage lymphotoxin beta receptor for afferent lymphatic transendothelial migration.
Nature communications
Brinkman CC,Iwami D,Hritzo MK,Xiong Y,Ahmad S,Simon T,Hippen KL,Blazar BR,Bromberg JS
Published figure using CD25 monoclonal antibody (Product # 25-0251-82) in Flow Cytometry
Tue Jun 21 00:00:00 EDT 2016
Affinity and dose of TCR engagement yield proportional enhancer and gene activity in CD4+ T cells.
eLife
Allison KA,Sajti E,Collier JG,Gosselin D,Troutman TD,Stone EL,Hedrick SM,Glass CK
Published figure using CD25 monoclonal antibody (Product # 25-0251-82) in Flow Cytometry
Mon Jul 04 00:00:00 EDT 2016
Immunosuppressive effect of mesenchymal stem cell-derived exosomes on a concanavalin A-induced liver injury model.
Inflammation and regeneration
Tamura R,Uemoto S,Tabata Y
Published figure using CD25 monoclonal antibody (Product # 25-0251-82) in Flow Cytometry
Thu Mar 31 00:00:00 EDT 2022
Exploring the induction of preproinsulin-specific Foxp3(+) CD4(+) Treg cells that inhibit CD8(+) T cell-mediated autoimmune diabetes by DNA vaccination.
Scientific reports
Stifter K,Schuster C,Schlosser M,Boehm BO,Schirmbeck R
Published figure using CD25 monoclonal antibody (Product # 25-0251-82) in Flow Cytometry
Mon Jul 11 00:00:00 EDT 2016
Loss of immune tolerance to IL-2 in type 1 diabetes.
Nature communications
Pérol L,Lindner JM,Caudana P,Nunez NG,Baeyens A,Valle A,Sedlik C,Loirat D,Boyer O,Créange A,Cohen JL,Rogner UC,Yamanouchi J,Marchant M,Leber XC,Scharenberg M,Gagnerault MC,Mallone R,Battaglia M,Santamaria P,Hartemann A,Traggiai E,Piaggio E
25-0251 was used in Flow cytometry/Cell sorting to study the role of the loss of immune tolerance to IL-2 in type 1 diabetes.
Thu Oct 06 00:00:00 EDT 2016
Inhibition of the JAK/STAT Signaling Pathway in Regulatory T Cells Reveals a Very Dynamic Regulation of Foxp3 Expression.
PloS one
Goldstein JD,Burlion A,Zaragoza B,Sendeyo K,Polansky JK,Huehn J,Piaggio E,Salomon BL,Marodon G
25-0251 was used in Flow cytometry/Cell sorting to investigate the role of the JAK/STAT pathway in controlling Foxp3 in the short term, showing dynamic regulation of Foxp3 expression.
Thu Aug 25 00:00:00 EDT 2016
4-1BB Signaling in Conventional T Cells Drives IL-2 Production That Overcomes CD4+CD25+FoxP3+ T Regulatory Cell Suppression.
PloS one
Barsoumian HB,Yolcu ES,Shirwan H
25-0251 was used in Flow cytometry/Cell sorting to establish 4-1BB signaling as a key circuit regulating physical and functional equilibrium between Tregs and Tconvs.
Mon Aug 22 00:00:00 EDT 2016
Group 2 innate lymphoid cells promote beiging of white adipose tissue and limit obesity.
Nature
Brestoff JR,Kim BS,Saenz SA,Stine RR,Monticelli LA,Sonnenberg GF,Thome JJ,Farber DL,Lutfy K,Seale P,Artis D
25-0251 was used in Flow cytometry/Cell sorting to study how ILC2s can regulate adipose function and metabolic homeostasis.
Thu Mar 12 00:00:00 EDT 2015
Production of IL-10 by CD4(+) regulatory T cells during the resolution of infection promotes the maturation of memory CD8(+) T cells.
Nature immunology
Laidlaw BJ,Cui W,Amezquita RA,Gray SM,Guan T,Lu Y,Kobayashi Y,Flavell RA,Kleinstein SH,Craft J,Kaech SM
Published figure using CD25 monoclonal antibody (Product # 25-0251-82) in Flow Cytometry
Sat Aug 01 00:00:00 EDT 2015
Blocking stroke-induced immunodeficiency increases CNS antigen-specific autoreactivity but does not worsen functional outcome after experimental stroke.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Römer C,Engel O,Winek K,Hochmeister S,Zhang T,Royl G,Klehmet J,Dirnagl U,Meisel C,Meisel A
25-0251 was used in Flow cytometry/Cell sorting to show that inhibiting stroke-induced immunodepression by pharmacological blockade of body's stress axes increases autoreactive CNS antigen-specific T-cell responses in the brain.
Wed May 20 00:00:00 EDT 2015
The immunosuppressive enzyme IL4I1 promotes FoxP3(+) regulatory T lymphocyte differentiation.
European journal of immunology
Cousin C,Aubatin A,Le Gouvello S,Apetoh L,Castellano F,Molinier-Frenkel V
25-0251 was used in Flow cytometry/Cell sorting to study the effect of IL4I1 on naive CD4+ T cell differentiation.
Mon Jun 01 00:00:00 EDT 2015
Intermuscular and perimuscular fat expansion in obesity correlates with skeletal muscle T cell and macrophage infiltration and insulin resistance.
International journal of obesity (2005)
Khan IM,Perrard XY,Brunner G,Lui H,Sparks LM,Smith SR,Wang X,Shi ZZ,Lewis DE,Wu H,Ballantyne CM
Published figure using CD25 monoclonal antibody (Product # 25-0251-82) in Flow Cytometry
Sun Nov 01 00:00:00 EDT 2015
The MAPK-Activated Kinase MK2 Attenuates Dendritic Cell-Mediated Th1 Differentiation and Autoimmune Encephalomyelitis.
Journal of immunology (Baltimore, Md. : 1950)
Soukup K,Halfmann A,Le Bras M,Sahin E,Vittori S,Poyer F,Schuh C,Luger R,Niederreiter B,Haider T,Stoiber D,Blüml S,Schabbauer G,Kotlyarov A,Gaestel M,Felzmann T,Dohnal AM
25-0251 was used in Flow cytometry/Cell sorting to investigate the role of MK2 in dendritic cells, showing that it attenuates dendritic cell-mediated Th1 differentiation and autoimmune encephalomyelitis.
Wed Jul 15 00:00:00 EDT 2015
A tumor lysate is an effective vaccine antigen for the stimulation of CD4(+) T-cell function and subsequent induction of antitumor immunity mediated by CD8(+) T cells.
Cancer biology & therapy
Kawahara M,Takaku H
Published figure using CD25 monoclonal antibody (Product # 25-0251-82) in Flow Cytometry
Mon Sep 12 00:00:00 EDT 2016
Programmed cell death receptor ligand 1 modulates the regulatory T cells' capacity to repress shock/sepsis-induced indirect acute lung injury by recruiting phosphatase SRC homology region 2 domain-containing phosphatase 1.
Shock (Augusta, Ga.)
Tang L,Bai J,Chung CS,Lomas-Neira J,Chen Y,Huang X,Ayala A
25-0251 was used in Flow cytometry/Cell sorting to investigate the mechanisms by which the programmed cell death receptor 1 ligand suppresses lung injury.
Thu Jan 01 00:00:00 EST 2015
Favorable alteration of tumor microenvironment by immunomodulatory cytokines for efficient T-cell therapy in solid tumors.
PloS one
Tähtinen S,Kaikkonen S,Merisalo-Soikkeli M,Grönberg-Vähä-Koskela S,Kanerva A,Parviainen S,Vähä-Koskela M,Hemminki A
Published figure using CD25 monoclonal antibody (Product # 25-0251-82) in Flow Cytometry
Thu Apr 28 00:00:00 EDT 2016
Prophylaxis with a respiratory syncytial virus (RSV) anti-G protein monoclonal antibody shifts the adaptive immune response to RSV rA2-line19F infection from Th2 to Th1 in BALB/c mice.
Journal of virology
Boyoglu-Barnum S,Chirkova T,Todd SO,Barnum TR,Gaston KA,Jorquera P,Haynes LM,Tripp RA,Moore ML,Anderson LJ
25-0251 was used in Flow cytometry/Cell sorting to suggest that the RSV G protein not only contributes to disease, but also dampens the host immune response to infection.
Mon Sep 01 00:00:00 EDT 2014
Active players in resolution of shock/sepsis induced indirect lung injury: immunomodulatory effects of Tregs and PD-1.
Journal of leukocyte biology
Tang L,Bai J,Chung CS,Lomas-Neira J,Chen Y,Huang X,Ayala A
25-0251 was used in Flow cytometry/Cell sorting to explore the ability of Tregs to modify the innate immune response induced by experimental iALI.
Sat Nov 01 00:00:00 EDT 2014
Tryptophan catabolism restricts IFN-γ-expressing neutrophils and Clostridium difficile immunopathology.
Journal of immunology (Baltimore, Md. : 1950)
El-Zaatari M,Chang YM,Zhang M,Franz M,Shreiner A,McDermott AJ,van der Sluijs KF,Lutter R,Grasberger H,Kamada N,Young VB,Huffnagle GB,Kao JY
25-0251 was used in Flow cytometry/Cell sorting to show tryptophan catabolism restricts IGN-gamma expressing neutrophils and Clostridium difficile immunopathology.
Tue Jul 15 00:00:00 EDT 2014
Macrophage PTEN regulates expression and secretion of arginase I modulating innate and adaptive immune responses.
Journal of immunology (Baltimore, Md. : 1950)
Sahin E,Haubenwallner S,Kuttke M,Kollmann I,Halfmann A,Dohnal AM,Chen L,Cheng P,Hoesel B,Einwallner E,Brunner J,Kral JB,Schrottmaier WC,Thell K,Saferding V,Blüml S,Schabbauer G
25-0251 was used in Flow cytometry/Cell sorting to study the role of extracellular Arginase I in inflammation and immunity.
Fri Aug 15 00:00:00 EDT 2014
High-dose interferon-γ promotes abortion in mice by suppressing Treg and Th17 polarization.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research
Liu HY,Liu ZK,Chao H,Li Z,Song Z,Yang Y,Peng JP
Published figure using CD25 monoclonal antibody (Product # 25-0251-82) in Flow Cytometry
Thu May 01 00:00:00 EDT 2014
Critical role of histone demethylase Jmjd3 in the regulation of CD4+ T-cell differentiation.
Nature communications
Li Q,Zou J,Wang M,Ding X,Chepelev I,Zhou X,Zhao W,Wei G,Cui J,Zhao K,Wang HY,Wang RF
Published figure using CD25 monoclonal antibody (Product # 25-0251-82) in Flow Cytometry
Mon Dec 22 00:00:00 EST 2014
Dual immune modulatory effect of vitamin A in human visceral leishmaniasis.
PloS one
Maciel BL,Valverde JG,Rodrigues-Neto JF,Freire-Neto F,Keesen TS,Jeronimo SM
25-0251 was used in Flow cytometry/Cell sorting to investigate the effect of vitamin A in human visceral leishmaniasis on a subset of Treg cells and monocytes, showing a dual immune modulatory function whereby vitamin A improves the regulatory profile and down modulates IL-10, suggesting that it can be used to improve recovery in VL.
Thu Jun 25 00:00:00 EDT 2015
Self-recognition of the endothelium enables regulatory T-cell trafficking and defines the kinetics of immune regulation.
Nature communications
Fu H,Kishore M,Gittens B,Wang G,Coe D,Komarowska I,Infante E,Ridley AJ,Cooper D,Perretti M,Marelli-Berg FM
25-0251 was used in Flow cytometry/Cell sorting to explain the mechanisms underlying the powerful migratory capacity of Treg cells and their ability to maintain optimal T cell ratios.
Fri Mar 14 00:00:00 EDT 2014
Differential potency of regulatory T cell-mediated immunosuppression in kidney tumors compared to subcutaneous tumors.
Oncoimmunology
Devaud C,Westwood JA,Teng MW,John LB,Yong CS,Duong CP,Smyth MJ,Darcy PK,Kershaw MH
25-0251 was used in Flow cytometry/Cell sorting to provide insights into the immunosuppressive nature of the immune response generated in the kidney microenvironment.
Sat Nov 01 00:00:00 EDT 2014
Enhancing chemotherapy efficacy in Pten-deficient prostate tumors by activating the senescence-associated antitumor immunity.
Cell reports
Toso A,Revandkar A,Di Mitri D,Guccini I,Proietti M,Sarti M,Pinton S,Zhang J,Kalathur M,Civenni G,Jarrossay D,Montani E,Marini C,Garcia-Escudero R,Scanziani E,Grassi F,Pandolfi PP,Catapano CV,Alimonti A
25-0251 was used in Flow cytometry/Cell sorting to demonstrate that immune surveillance of senescent tumour cells can be suppressed in specific genetic backgrounds but also evoked by pharmacological treatments.
Thu Oct 09 00:00:00 EDT 2014
Antiapoptotic Mcl-1 is critical for the survival and niche-filling capacity of Foxp3⁺ regulatory T cells.
Nature immunology
Pierson W,Cauwe B,Policheni A,Schlenner SM,Franckaert D,Berges J,Humblet-Baron S,Schönefeldt S,Herold MJ,Hildeman D,Strasser A,Bouillet P,Lu LF,Matthys P,Freitas AA,Luther RJ,Weaver CT,Dooley J,Gray DH,Liston A
25-0251 was used in Flow cytometry/Cell sorting to study the regulation of the Foxp3+ T cell pool by proliferation and apoptosis, and specifically the role of antiapoptoic Mcl-1 in T cell survival.
Sun Sep 01 00:00:00 EDT 2013
Reciprocal effects of rab7 deletion in activated and neglected T cells.
Autophagy
Roy SG,Stevens MW,So L,Edinger AL
Published figure using CD25 monoclonal antibody (Product # 25-0251-82) in Flow Cytometry
Mon Jul 01 00:00:00 EDT 2013
Genetic deletion of chemokine receptor Ccr7 exacerbates atherogenesis in ApoE-deficient mice.
Cardiovascular research
Wan W,Lionakis MS,Liu Q,Roffê E,Murphy PM
Published figure using CD25 monoclonal antibody (Product # 25-0251-82) in Flow Cytometry
Fri Mar 01 00:00:00 EST 2013
Cell-to-cell variability analysis dissects the plasticity of signaling of common γ chain cytokines in T cells.
Science signaling
Cotari JW,Voisinne G,Dar OE,Karabacak V,Altan-Bonnet G
25-0251 was used in Flow cytometry/Cell sorting to investigate the effects of IL-2Rα on the sensitivity of primary mouse T lymphocytes to cytokines that signal through receptors that have the common γ chain.
Tue Mar 12 00:00:00 EDT 2013
CX(3)CR1(+) macrophages support IL-22 production by innate lymphoid cells during infection with Citrobacter rodentium.
Mucosal immunology
Manta C,Heupel E,Radulovic K,Rossini V,Garbi N,Riedel CU,Niess JH
Published figure using CD25 monoclonal antibody (Product # 25-0251-82) in Flow Cytometry
Tue Jan 01 00:00:00 EST 2013
CD4+ T cell-derived IL-10 promotes Brucella abortus persistence via modulation of macrophage function.
PLoS pathogens
Xavier MN,Winter MG,Spees AM,Nguyen K,Atluri VL,Silva TM,Bäumler AJ,Müller W,Santos RL,Tsolis RM
25-0251 was used in Flow cytometry/Cell sorting to show that Brucella abortus prevents macrophage activation by inducing CD4+ CD25+ T-cells to produce interleukin-10 early during infection.
Fri Jan 17 00:00:00 EST 2014
Tumor-specific CD4+ T cells develop cytotoxic activity and eliminate virus-induced tumor cells in the absence of regulatory T cells.
Cancer immunology, immunotherapy : CII
Akhmetzyanova I,Zelinskyy G,Schimmer S,Brandau S,Altenhoff P,Sparwasser T,Dittmer U
25-0251 was used in Flow cytometry/Cell sorting to explore the role of effector CD4(+) T cells in the immune control of tumours.
Fri Feb 01 00:00:00 EST 2013
CD40 deficiency in mice exacerbates obesity-induced adipose tissue inflammation, hepatic steatosis, and insulin resistance.
American journal of physiology. Endocrinology and metabolism
Guo CA,Kogan S,Amano SU,Wang M,Dagdeviren S,Friedline RH,Aouadi M,Kim JK,Czech MP
Published figure using CD25 monoclonal antibody (Product # 25-0251-82) in Flow Cytometry
Wed May 01 00:00:00 EDT 2013
Parental dietary fat intake alters offspring microbiome and immunity.
Journal of immunology (Baltimore, Md. : 1950)
Myles IA,Fontecilla NM,Janelsins BM,Vithayathil PJ,Segre JA,Datta SK
25-0251 was used in Flow cytometry/Cell sorting to reveal that parental fat consumption can leave a "lard legacy", impacting offspring immunity and health.
Sun Sep 15 00:00:00 EDT 2013
Nod2 activates NF-kB in CD4+ T cells but its expression is dispensable for T cell-induced colitis.
PloS one
Zanello G,Goethel A,Forster K,Geddes K,Philpott DJ,Croitoru K
Published figure using CD25 monoclonal antibody (Product # 25-0251-82) in Flow Cytometry
Thu Jul 31 00:00:00 EDT 2014
IL-2 immunotherapy reveals potential for innate beta cell regeneration in the non-obese diabetic mouse model of autoimmune diabetes.
PloS one
Diaz-de-Durana Y,Lau J,Knee D,Filippi C,Londei M,McNamara P,Nasoff M,DiDonato M,Glynne R,Herman AE
Published figure using CD25 monoclonal antibody (Product # 25-0251-82) in Flow Cytometry
Mon Feb 23 00:00:00 EST 2015
Nucleoside salvage pathway kinases regulate hematopoiesis by linking nucleotide metabolism with replication stress.
The Journal of experimental medicine
Austin WR,Armijo AL,Campbell DO,Singh AS,Hsieh T,Nathanson D,Herschman HR,Phelps ME,Witte ON,Czernin J,Radu CG
25-0251 was used in Flow cytometry/Cell sorting to investigate a functional link between nucleotide deficiency, replication stress, and two enzymes of the nucleoside salvage pathway: deoxycytidine kinase and thymidine kinase.
Mon Nov 19 00:00:00 EST 2012
Fates of CD4+ T cells in a tolerant environment depend on timing and place of antigen exposure.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Burrell BE,Bromberg JS
25-0251 was used in Flow cytometry/Cell sorting to elucidate the key factors that determine the fate of graft reactive T cells.
Thu Mar 01 00:00:00 EST 2012
T cell apoptosis and induction of Foxp3+ regulatory T cells underlie the therapeutic efficacy of CD4 blockade in experimental autoimmune encephalomyelitis.
Journal of immunology (Baltimore, Md. : 1950)
Duarte J,Carrié N,Oliveira VG,Almeida C,Agua-Doce A,Rodrigues L,Simas JP,Mars LT,Graca L
25-0251 was used in Flow cytometry/Cell sorting to investigate the mechanism underlying effective MS prevention, showing that apoptosis of T cells and induction of Foxp3+ Tregs underlie efficacy of CD4 blockade in EAE.
Wed Aug 15 00:00:00 EDT 2012
Prenatal cadmium exposure alters postnatal immune cell development and function.
Toxicology and applied pharmacology
Hanson ML,Holásková I,Elliott M,Brundage KM,Schafer R,Barnett JB
25-0251 was used in Flow cytometry/Cell sorting to investigate the effects of prenatal exposure to Cd on the immune system of offspring, showing that exposure alters postnatal immune cell development and function.
Fri Jun 01 00:00:00 EDT 2012
SA-4-1BBL costimulation inhibits conversion of conventional CD4+ T cells into CD4+ FoxP3+ T regulatory cells by production of IFN-γ.
PloS one
Madireddi S,Schabowsky RH,Srivastava AK,Sharma RK,Yolcu ES,Shirwan H
25-0251 was used in Flow cytometry/Cell sorting to investigate whether 4-1BBL can prevent the conversion of effector CD4+ cells into induced T regulatory cells in tumour settings.
Tue Feb 19 00:00:00 EST 2013
Soluble MOG35-55/I-A(b) dimers ameliorate experimental autoimmune encephalomyelitis by reducing encephalitogenic T cells.
PloS one
Gong Y,Wang Z,Liang Z,Duan H,Ouyang L,Yu Q,Xu Z,Shen G,Weng X,Wu X
25-0251 was used in Flow cytometry/Cell sorting to demonstrate that soluble divalent MHC class II molecules can abrogate pathogenic T cells in experimental autoimmune encephalomyelitis.
Fri Jul 19 00:00:00 EDT 2013
RUNX transcription factor-mediated association of Cd4 and Cd8 enables coordinate gene regulation.
Immunity
Collins A,Hewitt SL,Chaumeil J,Sellars M,Micsinai M,Allinne J,Parisi F,Nora EP,Bolland DJ,Corcoran AE,Kluger Y,Bosselut R,Ellmeier W,Chong MM,Littman DR,Skok JA
25-0251 was used in Flow cytometry/Cell sorting to study how communication between Cd4 and Cd8 appears to enable long-range epigenetic regulation to ensure that expression of one excludes the other in mature CD4 or CD8 single-positive cells.
Fri Mar 25 00:00:00 EDT 2011
Innate lymphoid cells promote lung-tissue homeostasis after infection with influenza virus.
Nature immunology
Monticelli LA,Sonnenberg GF,Abt MC,Alenghat T,Ziegler CG,Doering TA,Angelosanto JM,Laidlaw BJ,Yang CY,Sathaliyawala T,Kubota M,Turner D,Diamond JM,Goldrath AW,Farber DL,Collman RG,Wherry EJ,Artis D
25-0251 was used in Flow cytometry/Cell sorting to demonstrate a critical role for lung ILCs in restoring airway epithelial integrity and tissue homeostasis after viral replication.
Tue Nov 01 00:00:00 EDT 2011
T cell factor 1 regulates thymocyte survival via a RORγt-dependent pathway.
Journal of immunology (Baltimore, Md. : 1950)
Wang R,Xie H,Huang Z,Ma J,Fang X,Ding Y,Sun Z
Published figure using CD25 monoclonal antibody (Product # 25-0251-82) in Flow Cytometry
Thu Dec 01 00:00:00 EST 2011
Knockdown of Fbxo7 reveals its regulatory role in proliferation and differentiation of haematopoietic precursor cells.
Journal of cell science
Meziane el K,Randle SJ,Nelson DE,Lomonosov M,Laman H
25-0251 was used in Flow cytometry/Cell sorting to test the ability of Fbxo7 to transform haematopoietic pro-B cells.
Fri Jul 01 00:00:00 EDT 2011
Seminal fluid regulates accumulation of FOXP3+ regulatory T cells in the preimplantation mouse uterus through expanding the FOXP3+ cell pool and CCL19-mediated recruitment.
Biology of reproduction
Guerin LR,Moldenhauer LM,Prins JR,Bromfield JJ,Hayball JD,Robertson SA
25-0251 was used in Flow cytometry/Cell sorting to confirm the identity of the expanded lymph node population of FOXP3(+) Treg cells and show cell number increase in the uterus.
Mon Aug 01 00:00:00 EDT 2011
Continuous activation of the CD122/STAT-5 signaling pathway during selection of antigen-specific regulatory T cells in the murine thymus.
PloS one
Goldstein JD,Balderas RS,Marodon G
25-0251 was used in Flow cytometry/Cell sorting to report higher levels of phosphorylated STAT-5 in nTreg cells in the murine thymus and, to a lesser extent, in the periphery compared to other CD4(+)CD8(-) subsets.
Tue Apr 26 00:00:00 EDT 2011
Conditional TPM3-ALK and NPM-ALK transgenic mice develop reversible ALK-positive early B-cell lymphoma/leukemia.
Blood
Giuriato S,Foisseau M,Dejean E,Felsher DW,Al Saati T,Demur C,Ragab A,Kruczynski A,Schiff C,Delsol G,Meggetto F
25-0251 was used in Flow cytometry/Cell sorting to develop conditional mouse models for anaplastic lymphoma kinase-induced lymphomagenesis.
Thu May 20 00:00:00 EDT 2010
Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acid.
The Journal of experimental medicine
Sun CM,Hall JA,Blank RB,Bouladoux N,Oukka M,Mora JR,Belkaid Y
25-0251 was used in Flow cytometry/Cell sorting to investigate how the intestinal immune system has evolved a self-contained strategy to promote T reg cell neoconversion.
Mon Aug 06 00:00:00 EDT 2007
Listeria monocytogenes promotes tumor growth via tumor cell toll-like receptor 2 signaling.
Cancer research
Huang B,Zhao J,Shen S,Li H,He KL,Shen GX,Mayer L,Unkeless J,Li D,Yuan Y,Zhang GM,Xiong H,Feng ZH
Tue May 01 00:00:00 EDT 2007
Combination of tumor site-located CTL-associated antigen-4 blockade and systemic regulatory T-cell depletion induces tumor-destructive immune responses.
Cancer research
Tuve S,Chen BM,Liu Y,Cheng TL,Touré P,Sow PS,Feng Q,Kiviat N,Strauss R,Ni S,Li ZY,Roffler SR,Lieber A
Fri Jun 15 00:00:00 EDT 2007
