Invitrogen

CD266 Polyclonal Antibody

CD266 Antibody in Immunocytochemistry (ICC/IF)

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CD266 Antibody (PA5-20275) in ICC/IF

Immunofluorescence of Fn14 in Human Liver cells with CD266 Polyclonal Antibody (Product # PA5-20275) at 20 µg/mL.

CD266 Antibody in Immunohistochemistry (IHC)

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产品信息

PA5-20275

应用

建议稀释比

已发表文章

免疫印迹 (WB)

2-4 µg/mL

免疫组化 (IHC)

2.5 µg/mL

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免疫细胞化学 (ICC/IF)

20 µg/mL

产品规格

种属反应

Human

已发表种属

Human

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

a human IgG1 Fc-tagged Fn14 protein.

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS

内含物

0.02% sodium azide

保存条件

Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_11152172

产品详细信息

A suggested positive control is 293 cell lysate.

靶标信息

TWEAK is a member of the TNF family and was first described as a weak inducer of apoptosis in demonstrate that this relatively small molecule is a fully transformed cell lines. Recently, a receptor for TWEAK was isolated by expression cloning from a HUVEC cell cDNA library. TweakR is a small protein belonging to TNF receptor super family. TweakR is capable of intiating a proliferative signal by binding to TRAF1, 2, and 3. TweakR mRNA is upregulated during tissue regeneration in the aorta and liver. It may also play a role in vascular cell migration and angiogenesis.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

Progenitor identification and SARS-CoV-2 infection in human distal lung organoids.

Nature

Salahudeen AA,Choi SS,Rustagi A,Zhu J,van Unen V,de la O SM,Flynn RA,Margalef-Català M,Santos AJM,Ju J,Batish A,Usui T,Zheng GXY,Edwards CE,Wagar LE,Luca V,Anchang B,Nagendran M,Nguyen K,Hart DJ,Terry JM,Belgrader P,Ziraldo SB,Mikkelsen TS,Harbury PB,Glenn JS,Garcia KC,Davis MM,Baric RS,Sabatti C,Amieva MR,Blish CA,Desai TJ,Kuo CJ

PA5-20275 was used in Immunohistochemistry-immunofluorescence to describe the development of a long-term feeder-free, chemically defined culture system for distal lung progenitors as organoids derived from single adult human alveolar epithelial type II (AT2) or KRT5+ basal cells.

Tue Dec 01 00:00:00 EST 2020

Progenitor identification and SARS-CoV-2 infection in long-term human distal lung organoid cultures.

bioRxiv : the preprint server for biology

Salahudeen AA,Choi SS,Rustagi A,Zhu J,de la O SM,Flynn RA,Margalef-Català M,Santos AJM,Ju J,Batish A,van Unen V,Usui T,Zheng GXY,Edwards CE,Wagar LE,Luca V,Anchang B,Nagendran M,Nguyen K,Hart DJ,Terry JM,Belgrader P,Ziraldo SB,Mikkelsen TS,Harbury PB,Glenn JS,Garcia KC,Davis MM,Baric RS,Sabatti C,Amieva MR,Blish CA,Desai TJ,Kuo CJ

PA5-20275 was used in Immunohistochemistry to develop robust feeder-free, chemically-defined culture of distal human lung progenitors as organoids derived clonally from single adult human alveolar epithelial type II (AT2) or KRT5 + basal cells.

Mon Jul 27 00:00:00 EDT 2020

生物信息学

蛋白别名: CD266; FGF-inducible 14; Fibroblast growth factor-inducible immediate-early response protein 14; Tumor necrosis factor receptor superfamily member 12A; tumor necrosis factor receptor superfamily, member 12A; Tweak-receptor; TweakR; type I transmembrane protein Fn14

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基因别名: CD266; FN14; TNFRSF12A; TWEAKR

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UniProt ID: (Human) Q9NP84

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Entrez Gene ID: (Human) 51330

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功能

protein binding transmembrane signal receptor

参与通路

angiogenesis substrate-dependent cell migration, cell attachment to substrate tumor necrosis factor-mediated signaling pathway positive regulation of apoptotic process regulation of angiogenesis positive regulation of axon extension regulation of wound healing extrinsic apoptotic signaling pathway positive regulation of extrinsic apoptotic signaling pathway