Product References
Reprogramming of Tumor-reactive Tumor-infiltrating Lymphocytes to Human-induced Pluripotent Stem Cells.
Cancer research communications
Islam SMR,Maeda T,Tamaoki N,Good ML,Kishton RJ,Paria BC,Yu Z,Bosch-Marce M,Bedanova NM,Liu C,Kruhlak MJ,Restifo NP,Vizcardo R
17-9969-42 was used in Flow cytometry/Cell sorting to reprogram exhausted TIL that possess T-cell receptors (TCR) specific for tumor antigens into induced pluripotent stem cells (iPSC) to rejuvenate them for more potent ACT.
Mon May 01 00:00:00 EDT 2023
Reprogramming of Tumor-reactive Tumor-infiltrating Lymphocytes to Human-induced Pluripotent Stem Cells.
Cancer research communications
Islam SMR,Maeda T,Tamaoki N,Good ML,Kishton RJ,Paria BC,Yu Z,Bosch-Marce M,Bedanova NM,Liu C,Kruhlak MJ,Restifo NP,Vizcardo R
17-9969-42 was used in Flow cytometry/Cell sorting to reprogram exhausted TIL that possess T-cell receptors (TCR) specific for tumor antigens into induced pluripotent stem cells (iPSC) to rejuvenate them for more potent ACT.
Mon May 01 00:00:00 EDT 2023
Interaction between HLA-G and NK cell receptor KIR2DL4 orchestrates HER2-positive breast cancer resistance to trastuzumab.
Signal transduction and targeted therapy
Zheng G,Guo Z,Li W,Xi W,Zuo B,Zhang R,Wen W,Yang AG,Jia L
Published figure using CD279 (PD-1) monoclonal antibody (Product # 17-9969-42) in Flow Cytometry
Wed Jun 23 00:00:00 EDT 2021
Construction of Novel lncRNA-miRNA-mRNA Network Associated With Recurrence and Identification of Immune-Related Potential Regulatory Axis in Hepatocellular Carcinoma.
Frontiers in oncology
Zhan T,Gao X,Wang G,Li F,Shen J,Lu C,Xu L,Li Y,Zhang J
Published figure using CD279 (PD-1) monoclonal antibody (Product # 17-9969-42) in Flow Cytometry
Tue Aug 03 00:00:00 EDT 2021
Imaging Changes and Immune-Checkpoint Expression on T Cells in Bronchoalveolar Lavage Fluid from Patients with Pulmonary Sarcoidosis.
Biomedicines
Kotetsu Y,Yanagihara T,Suzuki K,Ando H,Eto D,Hata K,Arimura-Omori M,Yamamoto Y,Harada E,Hamada N
Published figure using CD279 (PD-1) monoclonal antibody (Product # 17-9969-42) in Flow Cytometry
Thu Sep 16 00:00:00 EDT 2021
Bispecific T-Cell Engaging Antibodies Against MUC16 Demonstrate Efficacy Against Ovarian Cancer in Monotherapy and in Combination With PD-1 and VEGF Inhibition.
Frontiers in immunology
Yeku OO,Rao TD,Laster I,Kononenko A,Purdon TJ,Wang P,Cui Z,Liu H,Brentjens RJ,Spriggs D
17-9969-42 was used in Flow Cytometry to show the feasibility and efficacy of human MUC16 ectodomain- specific BiTEDs and provide a basis for the combination with anti-VEGF therapy for ovarian cancer.
Thu Oct 21 00:00:00 EDT 2021
Bispecific T-Cell Engaging Antibodies Against MUC16 Demonstrate Efficacy Against Ovarian Cancer in Monotherapy and in Combination With PD-1 and VEGF Inhibition.
Frontiers in immunology
Yeku OO,Rao TD,Laster I,Kononenko A,Purdon TJ,Wang P,Cui Z,Liu H,Brentjens RJ,Spriggs D
17-9969-42 was used in Flow Cytometry to show the feasibility and efficacy of human MUC16 ectodomain- specific BiTEDs and provide a basis for the combination with anti-VEGF therapy for ovarian cancer.
Thu Oct 21 00:00:00 EDT 2021
PD-1 and BTLA regulate T cell signaling differentially and only partially through SHP1 and SHP2.
The Journal of cell biology
Xu X,Hou B,Fulzele A,Masubuchi T,Zhao Y,Wu Z,Hu Y,Jiang Y,Ma Y,Wang H,Bennett EJ,Fu G,Hui E
Published figure using CD279 (PD-1) monoclonal antibody (Product # 17-9969-42) in Flow Cytometry
Mon Jun 01 00:00:00 EDT 2020
Diacylglycerol kinase ζ limits IL-2-dependent control of PD-1 expression in tumor-infiltrating T lymphocytes.
Journal for immunotherapy of cancer
Arranz-Nicolás J,Martin-Salgado M,Rodríguez-Rodríguez C,Liébana R,Moreno-Ortiz MC,Leitner J,Steinberger P,Ávila-Flores A,Merida I
17-9969 was used in Flow cytometry/Cell sorting to suggest that diacylglycerol kinase ζ plays a role in the control of PD-1 expression, and provides a potential therapeutic target and biomarker of CD8+ T cell dysfunctional states.
Sun Nov 01 00:00:00 EDT 2020
Immunogenic neoantigens derived from gene fusions stimulate T cell responses.
Nature medicine
Yang W,Lee KW,Srivastava RM,Kuo F,Krishna C,Chowell D,Makarov V,Hoen D,Dalin MG,Wexler L,Ghossein R,Katabi N,Nadeem Z,Cohen MA,Tian SK,Robine N,Arora K,Geiger H,Agius P,Bouvier N,Huberman K,Vanness K,Havel JJ,Sims JS,Samstein RM,Mandal R,Tepe J,Ganly I,Ho AL,Riaz N,Wong RJ,Shukla N,Chan TA,Morris LGT
Published figure using CD279 (PD-1) monoclonal antibody (Product # 17-9969-42) in Flow Cytometry
Wed May 01 00:00:00 EDT 2019
PD-1 signaling affects cristae morphology and leads to mitochondrial dysfunction in human CD8+ T lymphocytes.
Journal for immunotherapy of cancer
Ogando J,Sáez ME,Santos J,Nuevo-Tapioles C,Gut M,Esteve-Codina A,Heath S,González-Pérez A,Cuezva JM,Lacalle RA,Mañes S
17-9969 was used in Flow cytometry/Cell sorting to suggest that mitochondria are the main targets of PD-1 inhibitory activity. PD-1 reprograms CD8+ T cell metabolism for efficient use of fatty acid oxidation; this mitochondrial phenotype might explain the long-lived phenotype of PD-1-engaged T cells.
Thu Jun 13 00:00:00 EDT 2019
Malnutrition in HIV-Infected Children Is an Indicator of Severe Disease with an Impaired Response to Antiretroviral Therapy.
AIDS research and human retroviruses
Muenchhoff M,Healy M,Singh R,Roider J,Groll A,Kindra C,Sibaya T,Moonsamy A,McGregor C,Phan MQ,Palma A,Kloverpris H,Leslie A,Bobat R,LaRussa P,Ndung'u T,Goulder P,Sobieszczyk ME,Archary M
17-9969 was used in Flow cytometry/Cell sorting to show HIV-uninfected children have increased microbial translocation, immune activation, and immune exhaustion with severe acute malnutrition, while HIV-infected children on antiretroviral therapy show worse prognosis and impaired immune recovery.
Mon Jan 01 00:00:00 EST 2018
Antigen-Presenting Cell-Intrinsic PD-1 Neutralizes PD-L1 in cis to Attenuate PD-1 Signaling in T Cells.
Cell reports
Zhao Y,Harrison DL,Song Y,Ji J,Huang J,Hui E
Published figure using CD279 (PD-1) monoclonal antibody (Product # 17-9969-42) in Flow Cytometry
Tue Jul 10 00:00:00 EDT 2018
T cell receptor richness in peripheral blood increases after cetuximab therapy and correlates with therapeutic response.
Oncoimmunology
Kansy BA,Shayan G,Jie HB,Gibson SP,Lei YL,Brandau S,Lang S,Schmitt NC,Ding F,Lin Y,Ferris RL
17-9969 was used in Flow cytometry/Cell sorting to investigate differences in T-cell receptor (TCR) sequences between human papillomavirus (HPV)+ and HPV-head and neck cancer patients, and between T cells of peripheral blood mononuclear cells and tumour infiltrating lymphocytes.
Tue Jan 12 00:00:00 EST 2021
Increased levels of CCR7(lo)PD-1(hi) CXCR5+ CD4+ T cells, and associated factors Bcl-6, CXCR5, IL-21 and IL-6 contribute to repeated implantation failure.
Experimental and therapeutic medicine
Gong Q,Zhu Y,Pang N,Ai H,Gong X,La X,Ding J
Published figure using CD279 (PD-1) monoclonal antibody (Product # 17-9969-42) in Flow Cytometry
Fri Dec 01 00:00:00 EST 2017
Nonprogressing HIV-infected children share fundamental immunological features of nonpathogenic SIV infection.
Science translational medicine
Muenchhoff M,Adland E,Karimanzira O,Crowther C,Pace M,Csala A,Leitman E,Moonsamy A,McGregor C,Hurst J,Groll A,Mori M,Sinmyee S,Thobakgale C,Tudor-Williams G,Prendergast AJ,Kloverpris H,Roider J,Leslie A,Shingadia D,Brits T,Daniels S,Frater J,Willberg CB,Walker BD,Ndung'u T,Jooste P,Moore PL,Morris L,Goulder P
Wed Sep 28 00:00:00 EDT 2016
Exhaustion of Activated CD8 T Cells Predicts Disease Progression in Primary HIV-1 Infection.
PLoS pathogens
Hoffmann M,Pantazis N,Martin GE,Hickling S,Hurst J,Meyerowitz J,Willberg CB,Robinson N,Brown H,Fisher M,Kinloch S,Babiker A,Weber J,Nwokolo N,Fox J,Fidler S,Phillips R,Frater J
17-9969 was used in Flow cytometry/Cell sorting to identify CD8 T cell exhaustion markers which correlate with HIV-1 disease progression.
Fri Jul 01 00:00:00 EDT 2016
Activation of Innate and Adaptive Immunity by a Recombinant Human Cytomegalovirus Strain Expressing an NKG2D Ligand.
PLoS pathogens
Tomić A,Varanasi PR,Golemac M,Malić S,Riese P,Borst EM,Mischak-Weissinger E,Guzmán CA,Krmpotić A,Jonjić S,Messerle M
17-9969 was used in Flow cytometry/Cell sorting to investigate a strategy for an HCMV vaccine that aims at the simultaneous activation of innate and adaptive immune responses.
Thu Dec 01 00:00:00 EST 2016
Tumor-infiltrating Tim-3+ T cells proliferate avidly except when PD-1 is co-expressed: Evidence for intracellular cross talk.
Oncoimmunology
Li J,Shayan G,Avery L,Jie HB,Gildener-Leapman N,Schmitt N,Lu BF,Kane LP,Ferris RL
17-9969 was used in Flow cytometry/Cell sorting to investigate the phenotypic and functional characteristics of T cells with differential expression of PD-1 and Tim-3.
Tue Jan 12 00:00:00 EST 2021
CD103+ intraepithelial T cells in high-grade serous ovarian cancer are phenotypically diverse TCRαβ+ CD8αβ+ T cells that can be targeted for cancer immunotherapy.
Oncotarget
Komdeur FL,Wouters MC,Workel HH,Tijans AM,Terwindt AL,Brunekreeft KL,Plat A,Klip HG,Eggink FA,Leffers N,Helfrich W,Samplonius DF,Bremer E,Wisman GB,Daemen T,Duiker EW,Hollema H,Nijman HW,de Bruyn M
17996942 was used in flow cytometry to define the contribution of CD103+ tumor-infiltrating lymphocytes to high-grade serous epithelial ovarian cancer
Tue Nov 15 00:00:00 EST 2016
T-cell exhaustion, co-stimulation and clinical outcome in autoimmunity and infection.
Nature
McKinney EF,Lee JC,Jayne DR,Lyons PA,Smith KG
17-9969 was used in Flow cytometry/Cell sorting to conclude that T-cell exhaustion plays a central role in determining outcome in autoimmune disease and targeted manipulation of this process could lead to new therapeutic opportunities.
Thu Jul 30 00:00:00 EDT 2015
PD-1/SHP-2 inhibits Tc1/Th1 phenotypic responses and the activation of T cells in the tumor microenvironment.
Cancer research
Li J,Jie HB,Lei Y,Gildener-Leapman N,Trivedi S,Green T,Kane LP,Ferris RL
17-9969 was used in Flow cytometry/Cell sorting to suggest that PD-1 or SHP-2 blockade can restore Th1 immunity and T-cell activation, thereby reversing immunosuppression in the tumour microenvironment.
Sun Feb 01 00:00:00 EST 2015
PD-1+Tim-3+ CD8+ T Lymphocytes Display Varied Degrees of Functional Exhaustion in Patients with Regionally Metastatic Differentiated Thyroid Cancer.
Cancer immunology research
Severson JJ,Serracino HS,Mateescu V,Raeburn CD,McIntyre RC,Sams SB,Haugen BR,French JD
17-9969 was used in Flow cytometry/Cell sorting to determine that the release of PD-1 and Tim-3, and the inhibition of Tregs, may encourage tumour elimination in metastatic differentiated thyroid cancer.
Mon Jun 01 00:00:00 EDT 2015
Monoclonal antibodies specific to human Δ42PD1: A novel immunoregulator potentially involved in HIV-1 and tumor pathogenesis.
mAbs
Cheng L,Tang X,Liu L,Peng J,Nishiura K,Cheung AK,Guo J,Wu X,Tang HY,An M,Zhou J,Cheung KW,Wang H,Guan X,Wu Z,Chen Z
Published figure using CD279 (PD-1) monoclonal antibody (Product # 17-9969-42) in Flow Cytometry
Tue Mar 22 00:00:00 EDT 2016
Follicular regulatory T cells impair follicular T helper cells in HIV and SIV infection.
Nature communications
Miles B,Miller SM,Folkvord JM,Kimball A,Chamanian M,Meditz AL,Arends T,McCarter MD,Levy DN,Rakasz EG,Skinner PJ,Connick E
17-9969 was used in Flow cytometry/Cell sorting to determine TFR contribute to inefficient germinal centre responses and inhibit HIV and SIV clearance.
Tue Oct 20 00:00:00 EDT 2015
Follicular regulatory T cells impair follicular T helper cells in HIV and SIV infection.
Nature communications
Miles B,Miller SM,Folkvord JM,Kimball A,Chamanian M,Meditz AL,Arends T,McCarter MD,Levy DN,Rakasz EG,Skinner PJ,Connick E
17-9969 was used in Flow cytometry/Cell sorting to determine TFR contribute to inefficient germinal centre responses and inhibit HIV and SIV clearance.
Tue Oct 20 00:00:00 EDT 2015
Immunological biomarkers predict HIV-1 viral rebound after treatment interruption.
Nature communications
Hurst J,Hoffmann M,Pace M,Williams JP,Thornhill J,Hamlyn E,Meyerowitz J,Willberg C,Koelsch KK,Robinson N,Brown H,Fisher M,Kinloch S,Cooper DA,Schechter M,Tambussi G,Fidler S,Babiker A,Weber J,Kelleher AD,Phillips RE,Frater J
17-9969 was used in Flow cytometry/Cell sorting to show that immunological biomarkers can predict time to viral rebound after stopping antiretroviral therapy.
Fri Oct 09 00:00:00 EDT 2015
Upregulation of programmed death-1 on T cells and programmed death ligand-1 on monocytes in septic shock patients.
Critical care (London, England)
Zhang Y,Li J,Lou J,Zhou Y,Bo L,Zhu J,Zhu K,Wan X,Cai Z,Deng X
Published figure using CD279 (PD-1) monoclonal antibody (Product # 17-9969-42) in Flow Cytometry
Wed Dec 07 00:00:00 EST 2011
The PD-1/PD-L1 axis modulates the natural killer cell versus multiple myeloma effect: a therapeutic target for CT-011, a novel monoclonal anti-PD-1 antibody.
Blood
Benson DM,Bakan CE,Mishra A,Hofmeister CC,Efebera Y,Becknell B,Baiocchi RA,Zhang J,Yu J,Smith MK,Greenfield CN,Porcu P,Devine SM,Rotem-Yehudar R,Lozanski G,Byrd JC,Caligiuri MA
Published figure using CD279 (PD-1) monoclonal antibody (Product # 17-9969-42) in Flow Cytometry
Thu Sep 30 00:00:00 EDT 2010
NKp80 defines and stimulates a reactive subset of CD8 T cells.
Blood
Kuttruff S,Koch S,Kelp A,Pawelec G,Rammensee HG,Steinle A
17-9969 was used in Flow cytometry/Cell sorting to investigate the role of NKp80 in T cells, showing that it defines and stimulates a reactive subset of CD8 T cells.
Thu Jan 08 00:00:00 EST 2009
PD-1 up-regulation is correlated with HIV-specific memory CD8+ T-cell exhaustion in typical progressors but not in long-term nonprogressors.
Blood
Zhang JY,Zhang Z,Wang X,Fu JL,Yao J,Jiao Y,Chen L,Zhang H,Wei J,Jin L,Shi M,Gao GF,Wu H,Wang FS
Fri Jun 01 00:00:00 EDT 2007
