Product References
Engineering second-generation TCR-T cells by site-specific integration of TRAF-binding motifs into the CD247 locus.
Journal for immunotherapy of cancer
Lah S,Kim S,Kang I,Kim H,Hupperetz C,Jung H,Choi HR,Lee YH,Jang HK,Bae S,Kim CH
14-0037-82 was used in Flow cytometry/Cell sorting to find that the basic-rich motif (BRM) in the 4-1BB ICD was responsible for the undesirable outcomes, and that fusion of minimal tumor necrosis factor receptor-associated factor (TRAF)-binding motifs at the C-terminus of CD3ζ (zBBΔBRM) was sufficient to recruit TRAF2, the key adaptor molecule in 4-1BB signaling, while retaining the expression and proximal signaling of the transgenic TCR.
Sat Apr 01 00:00:00 EDT 2023
Dynamic S-acylation of the ER-resident protein stromal interaction molecule 1 (STIM1) is required for store-operated Ca2+ entry.
The Journal of biological chemistry
Kodakandla G,West SJ,Wang Q,Tewari R,Zhu MX,Akimzhanov AM,Boehning D
14-0037-82 was used in Flow cytometry/Cell sorting to investigate if stimulus-dependent S-acylation of calcium release-activated calcium channel components Orai1 and STIM1 is a critical mechanism facilitating the CRAC channel assembly and function.
Thu Sep 01 00:00:00 EDT 2022
S-acylation of Orai1 regulates store-operated Ca2+ entry.
Journal of cell science
West SJ,Kodakandla G,Wang Q,Tewari R,Zhu MX,Boehning D,Akimzhanov AM
14-0037-82 was used in flow cytometry to conclude that store depletion-induced S-acylation of Orai1 is necessary for recruitment to ER-PM junctions, subsequent binding to STIM1 and channel activation.
Tue Mar 01 00:00:00 EST 2022
PRDM1/BLIMP1 induces cancer immune evasion by modulating the USP22-SPI1-PD-L1 axis in hepatocellular carcinoma cells.
Nature communications
Li Q,Zhang L,You W,Xu J,Dai J,Hua D,Zhang R,Yao F,Zhou S,Huang W,Dai Y,Zhang Y,Baheti T,Qian X,Pu L,Xu J,Xia Y,Zhang C,Tang J,Wang X
14-0037-82 was used in Flow cytometry/Cell sorting to demonstrate that the PRDM1-USP22-SPI1 axis regulates PD-L1 levels, resulting in infiltrated CD8+ T cell exhaustion.
Mon Dec 12 00:00:00 EST 2022
Cavβ1 regulates T cell expansion and apoptosis independently of voltage-gated Ca2+ channel function.
Nature communications
Erdogmus S,Concepcion AR,Yamashita M,Sidhu I,Tao AY,Li W,Rocha PP,Huang B,Garippa R,Lee B,Lee A,Hell JW,Lewis RS,Prakriya M,Feske S
14-0037-82 was used in Functional assays to demonstrate that although CaVβ1 regulates T cell function, these effects are independent of VGCC channel activity.
Tue Apr 19 00:00:00 EDT 2022
T cell receptor-dependent S-acylation of ZAP-70 controls activation of T cells.
The Journal of biological chemistry
Tewari R,Shayahati B,Fan Y,Akimzhanov AM
14-0037-82 was used in Flow Cytometry to characterise lipidation (S-acylation) of the ZAP-70 tyrosine kinase using Acyl-Biotin Exchange assay, a technique that selectively captures S-acylated proteins.
Thu Aug 26 00:00:00 EDT 2021
CD40 Pathway and IL-2 Expression Mediate the Differential Outcome of Colorectal Cancer Patients with Different CSF1R c.1085 Genotypes.
International journal of molecular sciences
Yeh YM,Lin PC,Su WC,Shen MR
14-0037-82 was used in Immunohistochemistry to study the expression of genes involved in immune response from 66 primary tumor samples of colorectal cancer patients and compared the difference between patients with different colony-stimulating factor 1 receptor (CSF1R) c.1085 genotypes.
Mon Nov 22 00:00:00 EST 2021
Engineering advanced logic and distributed computing in human CAR immune cells.
Nature communications
Cho JH,Okuma A,Sofjan K,Lee S,Collins JJ,Wong WW
14-0037-82 was used in Cell Culture to engineer a chimeric antigen receptor model with computation features and multiple immune cell types.
Thu Feb 04 00:00:00 EST 2021
Positive feedback between the T cell kinase Zap70 and its substrate LAT acts as a clustering-dependent signaling switch.
Cell reports
Dine E,Reed EH,Toettcher JE
14-0037-82 was used in flow cytometry to investigate protein clustering in T cell signalling between Zap70 and LAT.
Tue Jun 22 00:00:00 EDT 2021
Electroporation of NKG2D RNA CAR Improves Vγ9Vδ2 T Cell Responses against Human Solid Tumor Xenografts.
Molecular therapy oncolytics
Ang WX,Ng YY,Xiao L,Chen C,Li Z,Chi Z,Tay JC,Tan WK,Zeng J,Toh HC,Wang S
14-0037 was used in Flow cytometry/Cell sorting to suggest clinical potential for RNA CAR-modified Vγ9Vδ2 T cells to treat a wide variety of NKG2D ligand-expressing cancers.
Fri Jun 26 00:00:00 EDT 2020
Increased Protein Stability and Interleukin-2 Production of a LATG131D Variant With Possible Implications for T Cell Anergy.
Frontiers in cell and developmental biology
Arbulo-Echevarria MM,Vico-Barranco I,Narbona-Sánchez I,García-Cózar F,Miazek A,Aguado E
14-0037-82 was used in ELISA to demonstrate the properties of the LAT mutant, LATG131D, and it's role in T cell anergy.
Tue Oct 13 00:00:00 EDT 2020
Activation of Human Vδ2+ γδ T Cells by Staphylococcus aureus Promotes Enhanced Anti-Staphylococcal Adaptive Immunity.
Journal of immunology (Baltimore, Md. : 1950)
Cooper AJR,Lalor SJ,McLoughlin RM
14-0037-82 was used in Flow Cytometry to study the capacity of human Vδ2+ γδ T cells for rapid activation in response to S. aureus.
Sat Aug 15 00:00:00 EDT 2020
TIGIT is upregulated by HIV-1 infection and marks a highly functional adaptive and mature subset of natural killer cells.
AIDS (London, England)
Vendrame E,Seiler C,Ranganath T,Zhao NQ,Vergara R,Alary M,Labbé AC,Guédou F,Poudrier J,Holmes S,Roger M,Blish CA
14-0037-82 was used in In vitro Assay to investigate the mechanisms that govern natural killer (NK)-cell responses to HIV.
Fri May 01 00:00:00 EDT 2020
Repositioning liothyronine for cancer immunotherapy by blocking the interaction of immune checkpoint TIGIT/PVR.
Cell communication and signaling : CCS
Zhou X,Du J,Wang H,Chen C,Jiao L,Cheng X,Zhou X,Chen S,Gou S,Zhao W,Zhai W,Chen J,Gao Y
14-0037 was used in Flow cytometry/Cell sorting to discover how liothyronine could serve as a potential candidate for cancer immunotherapy by blocking the immune checkpoint TIGIT/PVR.
Mon Sep 07 00:00:00 EDT 2020
TGF-β Enhances the Anti-inflammatory Effect of Tumor- Infiltrating CD33+11b+HLA-DR Myeloid-Derived Suppressor Cells in Gastric Cancer: A Possible Relation to MicroRNA-494.
Asian Pacific journal of cancer prevention : APJCP
Moaaz M,Lotfy H,Elsherbini B,Motawea MA,Fadali G
14-0037-82 was used in T-Cell Activation to address the effect of recombinant (rTGF-β) on the anti-inflammatory activity of MDSCs in GC and its possible association with micro-RNA-494 expression in tumor tissue.
Sun Nov 01 00:00:00 EDT 2020
Nuclear pore blockade reveals that HIV-1 completes reverse transcription and uncoating in the nucleus.
Nature microbiology
Dharan A,Bachmann N,Talley S,Zwikelmaier V,Campbell EM
14-0037-82 was used in Cell Culture to define the spatio-temporal staging of critical steps of HIV-1 infection and provide an experimental system to separate and thereby define the cytoplasmic and nuclear stages of infection by other viruses.
Tue Sep 01 00:00:00 EDT 2020
Human pDCs Are Superior to cDC2s in Attracting Cytolytic Lymphocytes in Melanoma Patients Receiving DC Vaccination.
Cell reports
van Beek JJP,Flórez-Grau G,Gorris MAJ,Mathan TSM,Schreibelt G,Bol KF,Textor J,de Vries IJM
14-0037 was used in Flow cytometry/Cell sorting to show that pDCs and cDC2s display a striking difference in chemokine secretion, which correlates with the recruitment of distinct types of immune effector cells.
Tue Jan 28 00:00:00 EST 2020
Evaluation of Single-Cell Cytokine Secretion and Cell-Cell Interactions with a Hierarchical Loading Microwell Chip.
Cell reports
Zhou Y,Shao N,Bessa de Castro R,Zhang P,Ma Y,Liu X,Huang F,Wang RF,Qin L
14-0037-82 was used in T-Cell Activation to develop a hierarchical loading microwell chip (HL-Chip) that is capable of efficiently aligning multiple cells of different types and/or microbeads as desired in a highthroughput manner.
Tue Apr 28 00:00:00 EDT 2020
Adaptive plasticity of IL-10+ and IL-35+ Treg cells cooperatively promotes tumor T cell exhaustion.
Nature immunology
Sawant DV,Yano H,Chikina M,Zhang Q,Liao M,Liu C,Callahan DJ,Sun Z,Sun T,Tabib T,Pennathur A,Corry DB,Luketich JD,Lafyatis R,Chen W,Poholek AC,Bruno TC,Workman CJ,Vignali DAA
14-0037-82 was used in T-Cell Activation to reveal previously unappreciated cooperative roles for Treg cell-derived IL-10 and IL-35 in promoting BLIMP1-dependent exhaustion of CD8+ TILs that limits effective anti-tumor immunity.
Sat Jun 01 00:00:00 EDT 2019
Loss of ARPC1B impairs cytotoxic T lymphocyte maintenance and cytolytic activity.
The Journal of clinical investigation
Randzavola LO,Strege K,Juzans M,Asano Y,Stinchcombe JC,Gawden-Bone CM,Seaman MN,Kuijpers TW,Griffiths GM
14-0037-82 was used in flow cytometry experiments to show that loss of actin-related protein complex 1B led to loss of CD8 cytotoxic T lymphocytes cytotoxicity, with the defect arising at 2 different levels.
Mon Dec 02 00:00:00 EST 2019
Immunodeficiency and EBV-induced lymphoproliferation caused by 4-1BB deficiency.
The Journal of allergy and clinical immunology
Alosaimi MF,Hoenig M,Jaber F,Platt CD,Jones J,Wallace J,Debatin KM,Schulz A,Jacobsen E,Möller P,Shamseldin HE,Abdulwahab F,Ibrahim N,Alardati H,Almuhizi F,Abosoudah IF,Basha TA,Chou J,Alkuraya FS,Geha RS
14-0037-82 was used in Flow Cytometry to investigate the genetic basis of recurrent sinopulmonary infections, persistent EBV viremia, and EBV-induced lymphoproliferation in 2 unrelated patients.
Thu Aug 01 00:00:00 EDT 2019
Cutting Edge: IL-17B Uses IL-17RA and IL-17RB to Induce Type 2 Inflammation from Human Lymphocytes.
Journal of immunology (Baltimore, Md. : 1950)
Ramirez-Carrozzi V,Ota N,Sambandam A,Wong K,Hackney J,Martinez-Martin N,Ouyang W,Pappu R
14-0037 was used in Flow cytometry/Cell sorting to demonstrate that in the human immune system, the cytokine IL-17B is functionally similar to IL-25 as it elicits type 2 cytokine secretion and, therefore, acts as a novel component in the regulation of human type 2 immunity.
Mon Apr 01 00:00:00 EDT 2019
Targeting immunotherapy for bladder cancer by using anti-CD3 × CD155 bispecific antibody.
Journal of Cancer
Ma W,Ma J,Lei T,Zhao M,Zhang M
14-0037 was used in Synthesis Substrate to show that CD155 is an effective target for the CD155-positive bladder cancer.
Wed Sep 30 00:00:00 EDT 2020
Synthetic TRuC receptors engaging the complete T cell receptor for potent anti-tumor response.
Nature communications
Baeuerle PA,Ding J,Patel E,Thorausch N,Horton H,Gierut J,Scarfo I,Choudhary R,Kiner O,Krishnamurthy J,Le B,Morath A,Baldeviano GC,Quinn J,Tavares P,Wei Q,Weiler S,Maus MV,Getts D,Schamel WW,Hofmeister R
14-0037-82 was used in Western Blot to report that T cell receptor fusion constructs (TRuCs) comprising an antibody-based binding domain fused to T cell receptor (TCR) subunits can effectively reprogram an intact TCR complex to recognize tumor surface antigens.
Tue May 07 00:00:00 EDT 2019
Suppression of R5-type of HIV-1 in CD4+ NKT cells by Vδ1+ T cells activated by flavonoid glycosides, hesperidin and linarin.
Scientific reports
Yonekawa M,Shimizu M,Kaneko A,Matsumura J,Takahashi H
14-0037 was used in an ELISA assay to establish transfectants expressing T cell receptors (TCRs) either for Vγ1 and Vδ1 (1C116) or for Vγ2 and Vδ2 (2C21) using the TCR-deficient Jurkat T cell line J.RT3-T3.5.
Fri May 17 00:00:00 EDT 2019
Leptin induces TNFα-dependent inflammation in acquired generalized lipodystrophy and combined Crohn's disease.
Nature communications
Ziegler JF,Böttcher C,Letizia M,Yerinde C,Wu H,Freise I,Rodriguez-Sillke Y,Stoyanova AK,Kreis ME,Asbach P,Kunkel D,Priller J,Anagnostopoulos I,Kühl AA,Miehle K,Stumvoll M,Tran F,Fredrich B,Forster M,Franke A,Bojarski C,Glauben R,Löscher BS,Siegmund B,Weidinger C
14-0037-82 was used in Flow Cytometry to describe a patient with the unique combination of acquired generalized lipodystrophy and Crohn's disease featuring a lack of adipose tissue, leptin deficiency and intestinal inflammation.
Tue Dec 10 00:00:00 EST 2019
NK cells specifically TCR-dressed to kill cancer cells.
EBioMedicine
Mensali N,Dillard P,Hebeisen M,Lorenz S,Theodossiou T,Myhre MR,Fåne A,Gaudernack G,Kvalheim G,Myklebust JH,Inderberg EM,Wälchli S
14-0037-82 was used in Cell Culture to suggest that an NK cell line could be the basis for an off-the-shelf TCR-based cancer immunotherapy solution.
Fri Feb 01 00:00:00 EST 2019
Efficient identification of neoantigen-specific T-cell responses in advanced human ovarian cancer.
Journal for immunotherapy of cancer
Liu S,Matsuzaki J,Wei L,Tsuji T,Battaglia S,Hu Q,Cortes E,Wong L,Yan L,Long M,Miliotto A,Bateman NW,Lele SB,Chodon T,Koya RC,Yao S,Zhu Q,Conrads TP,Wang J,Maxwell GL,Lugade AA,Odunsi K
14-0037-82 was used in Functional assay to investigate identify neoantigen-specific T-cell responses in epithelial ovarian cancer (EOC).
Thu Jun 20 00:00:00 EDT 2019
Peripheral blood CD4+ T cell populations by CD25 and Foxp3 expression as a potential biomarker: reflecting inflammatory activity in chronic obstructive pulmonary disease.
International journal of chronic obstructive pulmonary disease
Meng ZJ,Wu JH,Zhou M,Sun SW,Miao SY,Han HL,Chen L,Xiong XZ
14-0037 was used in in vitro experiments to explore whether peripheral CD4+ T cell populations based on CD25 and Foxp3 expression could serve as an indicator for COPD inflammatory activity.
Fri Feb 07 00:00:00 EST 2020
Immunosuppression by monocytic myeloid-derived suppressor cells in patients with pancreatic ductal carcinoma is orchestrated by STAT3.
Journal for immunotherapy of cancer
Trovato R,Fiore A,Sartori S,Canè S,Giugno R,Cascione L,Paiella S,Salvia R,De Sanctis F,Poffe O,Anselmi C,Hofer F,Sartoris S,Piro G,Carbone C,Corbo V,Lawlor R,Solito S,Pinton L,Mandruzzato S,Bassi C,Scarpa A,Bronte V,Ugel S
14-0037 was used in Flow cytometry/Cell sorting to report that PDAC patients show increased levels of both circulating and tumor-infiltrating MDSC-like cells.
Wed Sep 18 00:00:00 EDT 2019
The multi-functionality of N-809, a novel fusion protein encompassing anti-PD-L1 and the IL-15 superagonist fusion complex.
Oncoimmunology
Jochems C,Tritsch SR,Knudson KM,Gameiro SR,Smalley Rumfield C,Pellom ST,Morillon YM,Newman R,Marcus W,Szeto C,Rabizadeh S,Wong HC,Soon-Shiong P,Schlom J
14-0037 was used in Functional assays to study the multi-functionality of N-809 as a novel agent against cancer.
Tue Sep 07 00:00:00 EDT 2021
Intrahepatic macrophage populations in the pathophysiology of primary sclerosing cholangitis.
JHEP reports : innovation in hepatology
Chen YY,Arndtz K,Webb G,Corrigan M,Akiror S,Liaskou E,Woodward P,Adams DH,Weston CJ,Hirschfield GM
14-0037 was used in Flow cytometry/Cell sorting to show CD68+CD206+ macrophages occur in greater frequency with higher expression of TGR-5 in primary sclerosing cholangitis.
Fri Nov 01 00:00:00 EDT 2019
Antisense oligonucleotide targeting CD39 improves anti-tumor T cell immunity.
Journal for immunotherapy of cancer
Kashyap AS,Thelemann T,Klar R,Kallert SM,Festag J,Buchi M,Hinterwimmer L,Schell M,Michel S,Jaschinski F,Zippelius A
14-0037-82 was used in Flow Cytometry to targeting of CD39 by ASOs represents a promising state-of-the art therapeutic approach to improve immune responses against tumors.
Tue Mar 12 00:00:00 EDT 2019
Stimulation of Mononuclear Cells Through Toll-Like Receptor 9 Induces Release of Microvesicles Expressing Double-Stranded DNA and Galectin 3-Binding Protein in an Interferon-α-Dependent Manner.
Frontiers in immunology
Rasmussen NS,Nielsen CT,Jacobsen S,Nielsen CH
14-0037 was used in Flow cytometry/Cell sorting to investigate the roles of Toll-like receptors (TLRs), interferon(IFN)-α, and T cells in generation of microvesicles (MVs) that expressing the type I IFN-inducible protein galectin-3 binding protein (G3BP) in healthy subjects.
Thu Oct 29 00:00:00 EDT 2020
"Waltz" of Cell Membrane-Coated Nanoparticles on Lipid Bilayers: Tracking Single Particle Rotation in Ligand-Receptor Binding.
ACS nano
Yu Y,Gao Y,Yu Y
14-0037 was used in Flow cytometry to demonstrate the promise of using combined rotational and translational single particle tracking to resolve biological interactions that could be "hidden" in translational measurements alone.
Wed Dec 26 00:00:00 EST 2018
Adoptive Immunotherapy Using PRAME-Specific T Cells in Medulloblastoma.
Cancer research
Orlando D,Miele E,De Angelis B,Guercio M,Boffa I,Sinibaldi M,Po A,Caruana I,Abballe L,Carai A,Caruso S,Camera A,Moseley A,Hagedoorn RS,Heemskerk MHM,Giangaspero F,Mastronuzzi A,Ferretti E,Locatelli F,Quintarelli C
14-0037 was used in Flow cytometry/Cell sorting to indicate genetic modification with PRAME-specific T cells could treat patients with HLA-A*02+ medulloblastoma.
Fri Jun 15 00:00:00 EDT 2018
Combined Immunodeficiency in Patients With Trichohepatoenteric Syndrome.
Frontiers in immunology
Vély F,Barlogis V,Marinier E,Coste ME,Dubern B,Dugelay E,Lemale J,Martinez-Vinson C,Peretti N,Perry A,Bourgeois P,Badens C,Goulet O,Hugot JP,Farnarier C,Fabre A
14-0037 was used in Flow cytometry/Cell sorting to suggest how an immunological screening of patients with clinical features of SD/THE could facilitate both diagnosis and therapeutic management of these patients.
Thu Jul 11 00:00:00 EDT 2019
A Stretch of Negatively Charged Amino Acids of Linker for Activation of T-Cell Adaptor Has a Dual Role in T-Cell Antigen Receptor Intracellular Signaling.
Frontiers in immunology
Arbulo-Echevarria MM,Narbona-Sánchez I,Fernandez-Ponce CM,Vico-Barranco I,Rueda-Ygueravide MD,Dustin ML,Miazek A,Duran-Ruiz MC,García-Cózar F,Aguado E
14-0037 was used in Functional assays to identify that linker for activation of T cells-Lck interaction constitutes a key element regulating proximal intracellular signals coming from the TCR/CD3 complex.
Tue Mar 05 00:00:00 EST 2019
A mutation in the progesterone receptor predisposes to HEV infection in HIV-positive patients.
Liver international : official journal of the International Association for the Study of the Liver
Debes JD,Pas SD,Groothuismink ZMA,van der Ende ME,de Man RA,Boonstra A
14-0037 was used in Flow cytometry/Cell sorting to compare the presence of SNP PROGINS, IL-10 and IL-12 in the HIV-positive serum vs healthy control serum.
Tue May 01 00:00:00 EDT 2018
TCF1 expression marks self-renewing human CD8+ T cells.
Blood advances
Kratchmarov R,Magun AM,Reiner SL
14-0037 was used in Flow cytometry/Cell sorting to show analyses of TCF1 expression from patient specimens may become a useful biomarker for adaptive immune function in response to vaccination, infection, autoimmunity, and cancer.
Tue Jul 24 00:00:00 EDT 2018
Functional and phenotypical analysis of IL-6-secreting CD4+ T cells in human adipose tissue.
European journal of immunology
de Jong AJ,Pollastro S,Kwekkeboom JC,Andersen SN,Dorjée AL,Bakker AM,Alzaid F,Soprani A,Nelissen RGHH,Mullers JB,Venteclef N,de Vries N,Kloppenburg M,Toes REM,Ioan-Facsinay A
14-0037 was used in Functional assays to analyse the function and phenotype of IL-6-secreting CD4+ T cells in human adipose tissue.
Thu Mar 01 00:00:00 EST 2018
Multiple Homozygous Variants in the STING-Encoding TMEM173 Gene in HIV Long-Term Nonprogressors.
Journal of immunology (Baltimore, Md. : 1950)
Nissen SK,Pedersen JG,Helleberg M,Kjær K,Thavachelvam K,Obel N,Tolstrup M,Jakobsen MR,Mogensen TH
14-0037 was used in Functional assays to examine the presence and possible immunological role of multiple homozygous single-nucleotide polymorphisms in the stimulator of IFN genes (STING) encoding gene TMEM173 involved in IFN induction and T cell proliferation in HIV LTNP patients.
Tue May 15 00:00:00 EDT 2018
STAT5B: A Differential Regulator of the Life and Death of CD4+ Effector Memory T Cells.
Journal of immunology (Baltimore, Md. : 1950)
Majri SS,Fritz JM,Villarino AV,Zheng L,Kanellopoulou C,Chaigne-Delalande B,Grönholm J,Niemela JE,Afzali B,Biancalana M,Pittaluga S,Sun A,Cohen JL,Holland SM,O'Shea JJ,Uzel G,Lenardo MJ
14-0037 was used in Flow cytometry/Cell sorting to show that STAT5B, a transcription factor downstream of multiple cytokines involved in RICD, is essential for triggering apoptosis of mouse and human TEM cells, and that altered STAT5B transcriptional activity drives immunodeficiency and dysfunction.
Mon Jan 01 00:00:00 EST 2018
Cytokine-induced alterations of BAMBI mediate the reciprocal regulation of human Th17/Treg cells in response to cigarette smoke extract.
International journal of molecular medicine
Liu HJ,Chen G,Chen L,Zhou M,Xiong XZ,Meng ZJ,Sun SW,Tao XN
14-0037 was used in Functional assays to characterise BMP and activin membrane-bound inhibitor expression in human CD4+ cells, as well as immune imbalance during activation and cigarette smoke exposure.
Sat Dec 01 00:00:00 EST 2018
Targeting bladder cancer using activated T cells armed with bispecific antibodies.
Oncology reports
Ma J,Ge J,Xue X,Xiu W,Ma P,Sun X,Zhang M
14-0037 was used in Flow cytometry/Cell sorting to investigate the use of activated T cells as a targeted immunotherapy for bladder cancer.
Thu Mar 01 00:00:00 EST 2018
The inhibitory checkpoint, PD-L2, is a target for effector T cells: Novel possibilities for immune therapy.
Oncoimmunology
Ahmad SM,Martinenaite E,Holmström M,Jørgensen MA,Met Ö,Nastasi C,Klausen U,Donia M,Pedersen LM,Munksgaard L,Ødum N,Woetmann A,Svane IM,Andersen MH
14-0037 was used in Magnetic cell separation to investigate whether PD-L2 might represent a natural target that induces specific T cells.
Tue Jan 12 00:00:00 EST 2021
Improved migration of tumor ascites lymphocytes to ovarian cancer microenvironment by CXCR2 transduction.
Oncoimmunology
Idorn M,Olsen M,Halldórsdóttir HR,Skadborg SK,Pedersen M,Høgdall C,Høgdall E,Met Ö,Thor Straten P
14-0037 was used in Functional assays to study whether T cells expressing chemokine receptors matching chemokine expression in the tumour microenvironment would improve homing to immunosuppressive tumour sites.
Tue Jan 12 00:00:00 EST 2021
Choice of costimulatory domains and of cytokines determines CAR T-cell activity in neuroblastoma.
Oncoimmunology
Quintarelli C,Orlando D,Boffa I,Guercio M,Polito VA,Petretto A,Lavarello C,Sinibaldi M,Weber G,Del Bufalo F,Giorda E,Scarsella M,Petrini S,Pagliara D,Locatelli F,De Angelis B,Caruana I
14-0037 was used in Flow cytometry/Cell sorting to demonstrate that activation of the suicide gene iC9, included in our construct without significantly impairing neither CAR expression nor anti-tumor activity, leads to a prompt induction of apoptosis of GD2.CAR T cells.
Tue Jan 12 00:00:00 EST 2021
Filamin A Phosphorylation at Serine 2152 by the Serine/Threonine Kinase Ndr2 Controls TCR-Induced LFA-1 Activation in T Cells.
Frontiers in immunology
Waldt N,Seifert A,Demiray YE,Devroe E,Turk BE,Reichardt P,Mix C,Reinhold A,Freund C,Müller AJ,Schraven B,Stork O,Kliche S
14-0037-82 was used in T-Cell Activation, Flow Cytometry to investigate the role of serine/threonine kinase Ndr2 in T-cell activation.
Fri Oct 25 00:00:00 EDT 2019
Filamin A Phosphorylation at Serine 2152 by the Serine/Threonine Kinase Ndr2 Controls TCR-Induced LFA-1 Activation in T Cells.
Frontiers in immunology
Waldt N,Seifert A,Demiray YE,Devroe E,Turk BE,Reichardt P,Mix C,Reinhold A,Freund C,Müller AJ,Schraven B,Stork O,Kliche S
14-0037-82 was used in T-Cell Activation, Flow Cytometry to investigate the role of serine/threonine kinase Ndr2 in T-cell activation.
Fri Oct 25 00:00:00 EDT 2019
Discovery and preclinical characterization of the antagonist anti-PD-L1 monoclonal antibody LY3300054.
Journal for immunotherapy of cancer
Li Y,Carpenito C,Wang G,Surguladze D,Forest A,Malabunga M,Murphy M,Zhang Y,Sonyi A,Chin D,Burtrum D,Inigo I,Pennello A,Shen L,Malherbe L,Chen X,Hall G,Haidar JN,Ludwig DL,Novosiadly RD,Kalos M
14-0037-82 was used in Functional assay to evaluate the functional activity and potency of a newly discovered antagonist anti-PD-L1 monoclonal antibody LY3300054.
Mon Apr 30 00:00:00 EDT 2018
CD226 opposes TIGIT to disrupt Tregs in melanoma.
JCI insight
Fourcade J,Sun Z,Chauvin JM,Ka M,Davar D,Pagliano O,Wang H,Saada S,Menna C,Amin R,Sander C,Kirkwood JM,Korman AJ,Zarour HM
14-0037 was used in Flow cytometry/Cell sorting to study if a high TIGIT/CD226 ratio in Tregs regulate their suppressive function and stability in melanoma.
Thu Jul 26 00:00:00 EDT 2018
Antigen presentation profiling reveals recognition of lymphoma immunoglobulin neoantigens.
Nature
Khodadoust MS,Olsson N,Wagar LE,Haabeth OA,Chen B,Swaminathan K,Rawson K,Liu CL,Steiner D,Lund P,Rao S,Zhang L,Marceau C,Stehr H,Newman AM,Czerwinski DK,Carlton VE,Moorhead M,Faham M,Kohrt HE,Carette J,Green MR,Davis MM,Levy R,Elias JE,Alizadeh AA
14-0037 was used in Flow cytometry/Cell sorting to demonstrate that an integrative approach combining major histocompatibility complex isolation, peptide identification, and exome sequencing is an effective platform to uncover tumour neoantigens.
Thu Mar 30 00:00:00 EDT 2017
A cycle of Zap70 kinase activation and release from the TCR amplifies and disperses antigenic stimuli.
Nature immunology
Katz ZB,Novotná L,Blount A,Lillemeier BF
14-0037 was used in Flow cytometry/Cell sorting to describe a cycle of recruitment, activation and release for Zap70 kinases at phosphorylated T-cell antigen receptors.
Sun Jan 01 00:00:00 EST 2017
A cycle of Zap70 kinase activation and release from the TCR amplifies and disperses antigenic stimuli.
Nature immunology
Katz ZB,Novotná L,Blount A,Lillemeier BF
14-0037 was used in Flow cytometry/Cell sorting to describe a cycle of recruitment, activation and release for Zap70 kinases at phosphorylated T-cell antigen receptors.
Sun Jan 01 00:00:00 EST 2017
Prolonged immunomodulation in inflammatory arthritis using the selective Kv1.3 channel blocker HsTX1[R14A] and its PEGylated analog.
Clinical immunology (Orlando, Fla.)
Tanner MR,Tajhya RB,Huq R,Gehrmann EJ,Rodarte KE,Atik MA,Norton RS,Pennington MW,Beeton C
14-0037 was used in Flow cytometry/Cell sorting to indicate that HsTX1[R14A] and PEG-HsTX1[R14A] are effective in a model of rheumatoid arthritis and are therefore potential therapeutics for effector memory T lymphocyte-mediated autoimmune diseases.
Sat Jul 01 00:00:00 EDT 2017
An Analysis of Trafficking Receptors Shows that CD44 and P-Selectin Glycoprotein Ligand-1 Collectively Control the Migration of Activated Human T-Cells.
Frontiers in immunology
Ali AJ,Abuelela AF,Merzaban JS
14-0037 was used in Functional assays to analyse E-selectin ligands expressed on activated human T-cells.
Wed Nov 20 00:00:00 EST 2019
Dexamethasone and Monophosphoryl Lipid A Induce a Distinctive Profile on Monocyte-Derived Dendritic Cells through Transcriptional Modulation of Genes Associated With Essential Processes of the Immune Response.
Frontiers in immunology
García-González PA,Schinnerling K,Sepúlveda-Gutiérrez A,Maggi J,Mehdi AM,Nel HJ,Pesce B,Larrondo ML,Aravena O,Molina MC,Catalán D,Thomas R,Verdugo RA,Aguillón JC
14-0037 was used in Flow cytometry/Cell sorting to study the transcriptional profile of monocyte-derived dendritic cells from healthy subjects to identify molecular regulators and pathways associated with the induction of tolerogenic properties in tolerogenic dendritic cells.
Wed Nov 20 00:00:00 EST 2019
Activity of lenalidomide in mantle cell lymphoma can be explained by NK cell-mediated cytotoxicity.
British journal of haematology
Hagner PR,Chiu H,Ortiz M,Apollonio B,Wang M,Couto S,Waldman MF,Flynt E,Ramsay AG,Trotter M,Gandhi AK,Chopra R,Thakurta A
14-0037 was used in Flow cytometry/Cell sorting to provide the first insight into the clinical activity of lenalidomide against MCL, revealing a predominately immune-mediated MOA.
Wed Nov 01 00:00:00 EDT 2017
Hepatitis C virus infection inhibits a Src-kinase regulatory phosphatase and reduces T cell activation in vivo.
PLoS pathogens
Bhattarai N,McLinden JH,Xiang J,Mathahs MM,Schmidt WN,Kaufman TM,Stapleton JT
14-0037 was used in Functional assays to investigate the significance of virus genome-derived small RNAs in hepatitis C virus infection.
Wed Feb 01 00:00:00 EST 2017
Role of regulatory T cells in acute myeloid leukemia patients undergoing relapse-preventive immunotherapy.
Cancer immunology, immunotherapy : CII
Sander FE,Nilsson M,Rydström A,Aurelius J,Riise RE,Movitz C,Bernson E,Kiffin R,Ståhlberg A,Brune M,Foà R,Hellstrand K,Thorén FB,Martner A
14-0037 was used in Flow cytometry/Cell sorting to define the features, function and dynamics of Foxp3+CD25highCD4+ Tregs during immunotherapy and to determine the potential impact of Tregs on relapse risk and survival.
Wed Nov 01 00:00:00 EDT 2017
HLA-B*14:02-Restricted Env-Specific CD8+ T-Cell Activity Has Highly Potent Antiviral Efficacy Associated with Immune Control of HIV Infection.
Journal of virology
Leitman EM,Willberg CB,Tsai MH,Chen H,Buus S,Chen F,Riddell L,Haas D,Fellay J,Goedert JJ,Piechocka-Trocha A,Walker BD,Martin J,Deeks S,Wolinsky SM,Martinson J,Martin M,Qi Y,Sáez-Cirión A,Yang OO,Matthews PC,Carrington M,Goulder PJR
14-0037 was used in Flow cytometry/Cell sorting to indicate that, although Gag-specific CTL may usually have greater anti-HIV efficacy than Env responses, factors independent of protein specificity, including functional avidity, may carry greater weight in mediating effective control of HIV.
Wed Nov 15 00:00:00 EST 2017
FcγRIIIa Signaling Modulates Endosomal TLR Responses in Human CD4+ T Cells.
Journal of immunology (Baltimore, Md. : 1950)
Chauhan AK
14-0037 was used in T-Cell Activation to identify a role for FcγRIIIa-pSyk cosignaling in modulating NA-TLR responses in human CD4+ T cells by affecting the amounts and cellular distribution.
Thu Jun 15 00:00:00 EDT 2017
CXCL4 Exposure Potentiates TLR-Driven Polarization of Human Monocyte-Derived Dendritic Cells and Increases Stimulation of T Cells.
Journal of immunology (Baltimore, Md. : 1950)
Silva-Cardoso SC,Affandi AJ,Spel L,Cossu M,van Roon JAG,Boes M,Radstake TRDJ
14-0037 was used in Flow cytometry/Cell sorting to study the effect of CXCL4 on the phenotype and function of monocyte derived dendritic cells.
Sat Jul 01 00:00:00 EDT 2017
Inhibiting Oxidative Phosphorylation In Vivo Restrains Th17 Effector Responses and Ameliorates Murine Colitis.
Journal of immunology (Baltimore, Md. : 1950)
Franchi L,Monteleone I,Hao LY,Spahr MA,Zhao W,Liu X,Demock K,Kulkarni A,Lesch CA,Sanchez B,Carter L,Marafini I,Hu X,Mashadova O,Yuan M,Asara JM,Singh H,Lyssiotis CA,Monteleone G,Opipari AW,Glick GD
14-0037 was used in Flow cytometry/Cell sorting to highlight the importance of analysing metabolism in effector lymphocytes within in vivo inflammatory contexts.
Sat Apr 01 00:00:00 EDT 2017
D120 and K152 within the PH Domain of T Cell Adapter SKAP55 Regulate Plasma Membrane Targeting of SKAP55 and LFA-1 Affinity Modulation in Human T Lymphocytes.
Molecular and cellular biology
Witte A,Meineke B,Sticht J,Philipsen L,Kuropka B,Müller AJ,Freund C,Schraven B,Kliche S
14-0037 was used in in vitro experiments to gain an understanding of how Src kinase-associated phosphoprotein (SKAP55) controls TCR-mediated β2-integrin lymphocyte function-associated antigen 1 (LFA-1) activation.
Sat Apr 01 00:00:00 EDT 2017
siRNA‑mediated knockdown of T‑bet and RORγt contributes to decreased inflammation in pre‑eclampsia.
Molecular medicine reports
Wang J,Wen ZQ,Cheng XY,Mei TY,Chen ZF,Su LX
14-0037-82 was used in Sample Preparation to determine whether a decrease in the expression of T‚bet can restore immune balance and alleviate the systemic inflammatory response present in preeclampsia.
Wed Nov 01 00:00:00 EDT 2017
A 3D microfluidic model for preclinical evaluation of TCR-engineered T cells against solid tumors.
JCI insight
Pavesi A,Tan AT,Koh S,Chia A,Colombo M,Antonecchia E,Miccolis C,Ceccarello E,Adriani G,Raimondi MT,Kamm RD,Bertoletti A
14-0037 was used in Flow cytometry/Cell sorting to show that our microdevice platform enables us to decipher the factors that can alter T cell function in 3D and can be used in theraputics for immunotherapy configuration.
Thu Jun 15 00:00:00 EDT 2017
Constitutive and activation-dependent phosphorylation of lymphocyte phosphatase-associated phosphoprotein (LPAP).
PloS one
Kruglova NA,Meshkova TD,Kopylov AT,Mazurov DV,Filatov AV
14-0037 was used in Functional assays to investigate the function of lymphocyte phosphatase-associated phosphoprotein.
Fri Oct 13 00:00:00 EDT 2017
A Proteomic Survey Indicates Sortilin as a Secondary Substrate of the ER Translocation Inhibitor Cyclotriazadisulfonamide (CADA).
Molecular & cellular proteomics : MCP
Van Puyenbroeck V,Claeys E,Schols D,Bell TW,Vermeire K
14-0037 was used in Flow cytometry/Cell sorting to demonstrate that a small signal peptide-binding drug is able to down-modulate the expression of human CD4 and sortilin, apparently with low impact on the cellular proteome.
Wed Feb 01 00:00:00 EST 2017
Differential immunomodulation in human monocytes versus macrophages by filarial cystatin.
PloS one
Venugopal G,Mueller M,Hartmann S,Steinfelder S
14-0037 was used in Flow cytometry/Cell sorting to indicate that filarial nematodes differentially trigger and exploit various signalling pathways to induce immunomodulation in different myeloid cell subsets.
Tue Dec 26 00:00:00 EST 2017
Down-regulation of microRNA-451a facilitates the activation and proliferation of CD4+ T cells by targeting Myc in patients with dilated cardiomyopathy.
The Journal of biological chemistry
Zeng Z,Wang K,Li Y,Xia N,Nie S,Lv B,Zhang M,Tu X,Li Q,Tang T,Cheng X
14-0037-82 was used in Flow Cytometry to study the relationship between the dysregulation of microRNAs and CD4+ T cell activation in dilated cardiomyopathy.
Fri Apr 07 00:00:00 EDT 2017
Down-regulation of microRNA-451a facilitates the activation and proliferation of CD4+ T cells by targeting Myc in patients with dilated cardiomyopathy.
The Journal of biological chemistry
Zeng Z,Wang K,Li Y,Xia N,Nie S,Lv B,Zhang M,Tu X,Li Q,Tang T,Cheng X
14-0037-82 was used in Flow Cytometry to study the relationship between the dysregulation of microRNAs and CD4+ T cell activation in dilated cardiomyopathy.
Fri Apr 07 00:00:00 EDT 2017
NOD1 modulates IL-10 signalling in human dendritic cells.
Scientific reports
Neuper T,Ellwanger K,Schwarz H,Kufer TA,Duschl A,Horejs-Hoeck J
14-0037 was used in Functional assays to investigate the regulatory role that NOD1 plays by modulating IL-10 signalling in human dendritic cells during anti-inflammatory immune responses.
Fri Apr 21 00:00:00 EDT 2017
Expression and role of interleukin-9 in Vogt-Koyanagi-Harada disease.
Molecular vision
Peng Z,Jiang S,Wu M,Zhou X,Wang Q
14-0037 was used in an ELISA assay to investigate whether interleukin-9 plays a role in the development of Vogt-Koyanagi-Harada disease.
Fri Apr 13 00:00:00 EDT 2018
Clonal selection in the human Vδ1 T cell repertoire indicates γδ TCR-dependent adaptive immune surveillance.
Nature communications
Davey MS,Willcox CR,Joyce SP,Ladell K,Kasatskaya SA,McLaren JE,Hunter S,Salim M,Mohammed F,Price DA,Chudakov DM,Willcox BE
14-0037 was used in Magnetic cell separation to define the Vδ2(neg) T cell repertoire from human peripheral blood, focusing on the predominant Vδ1 subset.
Wed Mar 01 00:00:00 EST 2017
5T4-specific chimeric antigen receptor modification promotes the immune efficacy of cytokine-induced killer cells against nasopharyngeal carcinoma stem cell-like cells.
Scientific reports
Guo X,Zheng H,Luo W,Zhang Q,Liu J,Yao K
14-0037 was used in Flow cytometry/Cell sorting to identify appropriate tumour-associated antigens predominantly expressed on nasopharyngeal carcinoma stem cells and determine their suitability for chimeric antigen receptor-engineered cytokine induced killer cell therapy against NPC.
Fri Jul 07 00:00:00 EDT 2017
Th2/1 Hybrid Cells Occurring in Murine and Human Strongyloidiasis Share Effector Functions of Th1 Cells.
Frontiers in cellular and infection microbiology
Bock CN,Babu S,Breloer M,Rajamanickam A,Boothra Y,Brunn ML,Kühl AA,Merle R,Löhning M,Hartmann S,Rausch S
14-0037 was used in Flow cytometry/Cell sorting to assess the T helper cell phenotypes in threadworm-infected patients and experimental murine infections with focus on CD4+ T cells co-expressing markers of Th2 and Th1 differentiation.
Mon Feb 26 00:00:00 EST 2018
Functional characterization of T-cells from palatine tonsils in patients with chronic tonsillitis.
PloS one
Geißler K,Markwart R,Requardt RP,Weigel C,Schubert K,Scherag A,Rubio I,Guntinas-Lichius O
14-0037 was used in Flow cytometry/Cell sorting to analyse and characterise the response of tonsillar T-cells from chronic tonsillitis to antigenic stimulation.
Mon Oct 16 00:00:00 EDT 2017
A human tissue-based functional assay platform to evaluate the immune function impact of small molecule inhibitors that target the immune system.
PloS one
St Pierre C,Guo J,Shin JD,Engstrom LW,Lee HH,Herbert A,Surdi L,Baker J,Salmon M,Shah S,Ellis JM,Houshyar H,Crackower MA,Kleinschek MA,Jones DC,Hicks A,Zaller DM,Alves SE,Ramadas RA
14-0037 was used in Flow cytometry/Cell sorting to present a novel, human-tissue based functional assay platform which evaluates the immune system impact of pharmacological modulators, with the aim of providing a better understanding of drug impacts in vivo.
Wed Sep 27 00:00:00 EDT 2017
Src-family kinases negatively regulate NFAT signaling in resting human T cells.
PloS one
Baer A,Colon-Moran W,Xiang J,Stapleton JT,Bhattarai N
14-0037-82 was used in Western Blot to identify a novel role of Src-family of tyrosine kinases in preventing aberrant NFAT1 activation in resting T cells, and suggest that maintaining this pool of active SFKs in therapeutic T cells may increase the efficacy of T cell therapies.
Mon Nov 20 00:00:00 EST 2017
Differential effects of α4β7 and GPR15 on homing of effector and regulatory T cells from patients with UC to the inflamed gut in vivo.
Gut
Fischer A,Zundler S,Atreya R,Rath T,Voskens C,Hirschmann S,López-Posadas R,Watson A,Becker C,Schuler G,Neufert C,Atreya I,Neurath MF
14-0037 was used in Functional assays to analyse the homing of effector and regulatory T-cells to the inflamed gut via α4β7 and GPR15.
Sat Oct 01 00:00:00 EDT 2016
A DOCK8-WIP-WASp complex links T cell receptors to the actin cytoskeleton.
The Journal of clinical investigation
Janssen E,Tohme M,Hedayat M,Leick M,Kumari S,Ramesh N,Massaad MJ,Ullas S,Azcutia V,Goodnow CC,Randall KL,Qiao Q,Wu H,Al-Herz W,Cox D,Hartwig J,Irvine DJ,Luscinskas FW,Geha RS
14-0037 was used in Functional assays to show that Wiskott-Adrich syndrome and dedicator of cytokinesis (DOCK8) deficiency have common pathogenic mechanisms, with the DOCK9-WIP-WASp linking T-cell receptors with the actin cytoskeleton.
Mon Oct 03 00:00:00 EDT 2016
Control of Foxp3 stability through modulation of TET activity.
The Journal of experimental medicine
Yue X,Trifari S,Äijö T,Tsagaratou A,Pastor WA,Zepeda-Martínez JA,Lio CW,Li X,Huang Y,Vijayanand P,Lähdesmäki H,Rao A
14-0037 was used in Immuno-assay to investigate the role of TET proteins in regulating Foxp3.
Mon Mar 07 00:00:00 EST 2016
IL15 Agonists Overcome the Immunosuppressive Effects of MEK Inhibitors.
Cancer research
Allegrezza MJ,Rutkowski MR,Stephen TL,Svoronos N,Tesone AJ,Perales-Puchalt A,Nguyen JM,Sarmin F,Sheen MR,Jeng EK,Tchou J,Wong HC,Fiering SN,Conejo-Garcia JR
14-0037 was used in Functional assays to identify a clinically actionable approach to overcome the T-cell-suppressive effects of MEK inhibitors and illustrate how to reconcile the deficiencies of signal transduction inhibitors.
Sun May 01 00:00:00 EDT 2016
Rational design of a Kv1.3 channel-blocking antibody as a selective immunosuppressant.
Proceedings of the National Academy of Sciences of the United States of America
Wang RE,Wang Y,Zhang Y,Gabrelow C,Zhang Y,Chi V,Fu Q,Luo X,Wang D,Joseph S,Johnson K,Chatterjee AK,Wright TM,Nguyen-Tran VT,Teijaro J,Theofilopoulos AN,Schultz PG,Wang F
14-0037 was used in Functional assays to develop a Kv1.3 channel-blocking antibody.
Tue Oct 11 00:00:00 EDT 2016
Synergistic COX2 Induction by IFNγ and TNFα Self-Limits Type-1 Immunity in the Human Tumor Microenvironment.
Cancer immunology research
Wong JL,Obermajer N,Odunsi K,Edwards RP,Kalinski P
14-0037 was used in Functional assays to investigate the role of COX2 in the antitumour response.
Fri Apr 01 00:00:00 EDT 2016
Patients with MS under daclizumab therapy mount normal immune responses to influenza vaccination.
Neurology(R) neuroimmunology & neuroinflammation
Lin YC,Winokur P,Blake A,Wu T,Manischewitz J,King LR,Romm E,Golding H,Bielekova B
14-0037 was used in Flow cytometry/Cell sorting to explore the effect of Daclizumab-treatment on the activation of CD8(+) T cells and B cells and the development of immune responses to the influenza vaccine.
Mon Feb 01 00:00:00 EST 2016
The adhesion molecule PECAM-1 enhances the TGF-β-mediated inhibition of T cell function.
Science signaling
Newman DK,Fu G,Adams T,Cui W,Arumugam V,Bluemn T,Riese MJ
14-0037 was used in Functional assays to investigate the role of PECAM-1 in T cell function.
Tue Mar 08 00:00:00 EST 2016
Receptor-Targeted Nipah Virus Glycoproteins Improve Cell-Type Selective Gene Delivery and Reveal a Preference for Membrane-Proximal Cell Attachment.
PLoS pathogens
Bender RR,Muth A,Schneider IC,Friedel T,Hartmann J,Plückthun A,Maisner A,Buchholz CJ
14-0037 was used in Functional assays to demonstrate that pseudotyping of lentiviral vectors (LVs) with receptor-targeted Nipah virus glycoproteins is an effective LV gene delivery strategy to specific cells.
Wed Jun 01 00:00:00 EDT 2016
Human Galectin-9 Is a Potent Mediator of HIV Transcription and Reactivation.
PLoS pathogens
Abdel-Mohsen M,Chavez L,Tandon R,Chew GM,Deng X,Danesh A,Keating S,Lanteri M,Samuels ML,Hoh R,Sacha JB,Norris PJ,Niki T,Shikuma CM,Hirashima M,Deeks SG,Ndhlovu LC,Pillai SK
14-0037 was used in Functional assays to investigate whether galectin-9 modulates HIV transcription, showing that it is a potent mediator of HIV transcription and reactivation.
Wed Jun 01 00:00:00 EDT 2016
A Small Molecule, Which Competes with MAdCAM-1, Activates Integrin α4β7 and Fails to Prevent Mucosal Transmission of SHIV-SF162P3.
PLoS pathogens
Arrode-Brusés G,Goode D,Kleinbeck K,Wilk J,Frank I,Byrareddy S,Arthos J,Grasperge B,Blanchard J,Zydowsky T,Gettie A,Martinelli E
14-0037 was used in Functional assays to investigate host and viral characteristics that facilitate HIV acquisition and systemic expansion.
Wed Jun 01 00:00:00 EDT 2016
A Small Molecule, Which Competes with MAdCAM-1, Activates Integrin α4β7 and Fails to Prevent Mucosal Transmission of SHIV-SF162P3.
PLoS pathogens
Arrode-Brusés G,Goode D,Kleinbeck K,Wilk J,Frank I,Byrareddy S,Arthos J,Grasperge B,Blanchard J,Zydowsky T,Gettie A,Martinelli E
14-0037 was used in Functional assays to investigate host and viral characteristics that facilitate HIV acquisition and systemic expansion.
Wed Jun 01 00:00:00 EDT 2016
Genetically modified human CD4(+) T cells can be evaluated in vivo without lethal graft-versus-host disease.
Immunology
Ali R,Babad J,Follenzi A,Gebe JA,Brehm MA,Nepom GT,Shultz LD,Greiner DL,DiLorenzo TP
14-0037 was used in Binding experiments to modify human primary CD4(+) T cells by lentiviral transduction to express a human TCR that recognizes a pancreatic beta cell-derived peptide in the context of HLA-DR4.
Mon Aug 01 00:00:00 EDT 2016
Granulocyte colony-stimulating factor impairs CD8(+) T cell functionality by interfering with central activation elements.
Clinical and experimental immunology
Bunse CE,Tischer S,Lahrberg J,Oelke M,Figueiredo C,Blasczyk R,Eiz-Vesper B
14-0037 was used in Flow cytometry/Cell sorting to show that G-CSF directly influences the effector function of cytotoxic CD8(+) T cells and affects various elements of T cell activation.
Fri Jul 01 00:00:00 EDT 2016
HCV core protein inhibits polarization and activity of both M1 and M2 macrophages through the TLR2 signaling pathway.
Scientific reports
Zhang Q,Wang Y,Zhai N,Song H,Li H,Yang Y,Li T,Guo X,Chi B,Niu J,Crispe IN,Su L,Tu Z
14-0037 was used in Functional assays to demonstrate that HCVc inhibits monocyte-derived macrophage polarization via TLR2 signaling.
Thu Oct 27 00:00:00 EDT 2016
Functional differences in hepatitis C virus nonstructural (NS) 3/4A- and 5A-specific T cell responses.
Scientific reports
Holmström F,Chen M,Balasiddaiah A,Sällberg M,Ahlén G,Frelin L
14-0037 was used in Functional assays to characterise the functional differences in the T-cell responses to hepatitis C virus nonstructural 3/4A and NS5A.
Wed May 04 00:00:00 EDT 2016
Validation and Optimization of an Ex Vivo Assay of Intestinal Mucosal Biopsies in Crohn's Disease: Reflects Inflammation and Drug Effects.
PloS one
Vadstrup K,Galsgaard ED,Gerwien J,Vester-Andersen MK,Pedersen JS,Rasmussen J,Neermark S,Kiszka-Kanowitz M,Jensen T,Bendtsen F
14-0037 was used in Functional assays to optimise and validate a known human explant method to test drug candidates and pathophysiological conditions in Crohn''s Disease intestinal biopsies.
Mon Jul 10 00:00:00 EDT 2017
Follicular Lymphoma Tregs Have a Distinct Transcription Profile Impacting Their Migration and Retention in the Malignant Lymph Node.
PloS one
Nedelkovska H,Rosenberg AF,Hilchey SP,Hyrien O,Burack WR,Quataert SA,Baker CM,Azadniv M,Welle SL,Ansell SM,Kim M,Bernstein SH
14-0037 was used in Functional assays to study the unique number, phenotype, and function of follicular lymphoma nodal regulatory T cells.
Mon Jul 10 00:00:00 EDT 2017
IL-7 Induces SAMHD1 Phosphorylation in CD4+ T Lymphocytes, Improving Early Steps of HIV-1 Life Cycle.
Cell reports
Coiras M,Bermejo M,Descours B,Mateos E,García-Pérez J,López-Huertas MR,Lederman MM,Benkirane M,Alcamí J
14-0037 was used in Functional assays to investigate the mechanisms involved in the establishment of latent HIV-1 virus reservoirs.
Tue Mar 08 00:00:00 EST 2016
Calcium influx through CRAC channels controls actin organization and dynamics at the immune synapse.
eLife
Hartzell CA,Jankowska KI,Burkhardt JK,Lewis RS
14-0037 was used in Functional assays to investigate the role of Ca(2+) influx in actin dynamics at the immunological synapse.
Thu Jul 21 00:00:00 EDT 2016
Human TRAV1-2-negative MR1-restricted T cells detect S. pyogenes and alternatives to MAIT riboflavin-based antigens.
Nature communications
Meermeier EW,Laugel BF,Sewell AK,Corbett AJ,Rossjohn J,McCluskey J,Harriff MJ,Franks T,Gold MC,Lewinsohn DM
14-0037 was used in Functional assays to investigate an MR1-restricted clone that expresses the TRAV12-2 TCRα.
Tue Aug 16 00:00:00 EDT 2016
Increased Th17 cells and IL-17A exist in patients with B cell acute lymphoblastic leukemia and promote proliferation and resistance to daunorubicin through activation of Akt signaling.
Journal of translational medicine
Bi L,Wu J,Ye A,Wu J,Yu K,Zhang S,Han Y
14-0037 was used in Functional assays to investigate the role of Th17 cells in the pathophysiology of B-cell acute lymphoblastic leukemia.
Thu May 12 00:00:00 EDT 2016
Combining FoxP3 and Helios with GARP/LAP markers can identify expanded Treg subsets in cancer patients.
Oncotarget
Abd Al Samid M,Chaudhary B,Khaled YS,Ammori BJ,Elkord E
14-0037 was used in in vitro experiments to demonstrate that studying a combination of Treg-specific markers could be used to more accurately determine expanded Treg subsets and to understand their contribution in cancer settings.
Tue Mar 22 00:00:00 EDT 2016
Human naïve regulatory T-cells feature high steady-state turnover and are maintained by IL-7.
Oncotarget
Silva SL,Albuquerque AS,Serra-Caetano A,Foxall RB,Pires AR,Matoso P,Fernandes SM,Ferreira J,Cheynier R,Victorino RM,Caramalho I,Barata JT,Sousa AE
14-0037 was used in Functional assays to investigate the mechanisms underlying naïve-Treg maintenance throughout life.
Tue Mar 15 00:00:00 EDT 2016
Implication of combined PD-L1/PD-1 blockade with cytokine-induced killer cells as a synergistic immunotherapy for gastrointestinal cancer.
Oncotarget
Dai C,Lin F,Geng R,Ge X,Tang W,Chang J,Wu Z,Liu X,Lin Y,Zhang Z,Li J
14-0037 was used in Functional assays to provide preclinical proof-of-concept for simultaneous PD-L1/PD-1 pathways blockade along with CIK infusion as a novel immunotherapy for unresectable cancers.
Tue Mar 01 00:00:00 EST 2016
Treg activation defect in type 1 diabetes: correction with TNFR2 agonism.
Clinical & translational immunology
Okubo Y,Torrey H,Butterworth J,Zheng H,Faustman DL
14-0037 was used in Functional assays to investigate the role of Tregs in type 1 diabetes.
Fri Jan 01 00:00:00 EST 2016
Golgi self-correction generates bioequivalent glycans to preserve cellular homeostasis.
eLife
Mkhikian H,Mortales CL,Zhou RW,Khachikyan K,Wu G,Haslam SM,Kavarian P,Dell A,Demetriou M
14-0037 was used in Flow cytometry/Cell sorting to demonstrate the functional equivalency of structurally dissimilar N-glycans and suggest a Golgi self-correcting feature that sustains cellular homeostasis.
Wed Jun 08 00:00:00 EDT 2016
Monocyte-derived inflammatory Langerhans cells and dermal dendritic cells mediate psoriasis-like inflammation.
Nature communications
Singh TP,Zhang HH,Borek I,Wolf P,Hedrick MN,Singh SP,Kelsall BL,Clausen BE,Farber JM
14-0037-82 was used in Flow Cytometry to show that dendritic cells are required for psoriasis-like changes in mouse skin induced by the local injection of IL-23.
Fri Dec 16 00:00:00 EST 2016
Control of signaling-mediated clearance of apoptotic cells by the tumor suppressor p53.
Science (New York, N.Y.)
Yoon KW,Byun S,Kwon E,Hwang SY,Chu K,Hiraki M,Jo SH,Weins A,Hakroush S,Cebulla A,Sykes DB,Greka A,Mundel P,Fisher DE,Mandinova A,Lee SW
14-0037 was used in an ELISA assay to reveal that p53-induced expression of death domain 1α regulates the efficient clearance of dead cells and proper immune tolerance.
Fri Jul 31 00:00:00 EDT 2015
Fatal autoimmunity in mice reconstituted with human hematopoietic stem cells encoding defective FOXP3.
Blood
Goettel JA,Biswas S,Lexmond WS,Yeste A,Passerini L,Patel B,Yang S,Sun J,Ouahed J,Shouval DS,McCann KJ,Horwitz BH,Mathis D,Milford EL,Notarangelo LD,Roncarolo MG,Fiebiger E,Marasco WA,Bacchetta R,Quintana FJ,Pai SY,Klein C,Muise AM,Snapper SB
14-0037 was used in Functional assays to develop mouse stains that express human leukocyte antigen DR1 rather than murine MHC class II, displaying fatal autoimmunity following reconstituted with human hematopoietic stem cells encoding defective FOXP3.
Thu Jun 18 00:00:00 EDT 2015
Dual-Affinity Re-Targeting proteins direct T cell-mediated cytolysis of latently HIV-infected cells.
The Journal of clinical investigation
Sung JA,Pickeral J,Liu L,Stanfield-Oakley SA,Lam CY,Garrido C,Pollara J,LaBranche C,Bonsignori M,Moody MA,Yang Y,Parks R,Archin N,Allard B,Kirchherr J,Kuruc JD,Gay CL,Cohen MS,Ochsenbauer C,Soderberg K,Liao HX,Montefiori D,Moore P,Johnson S,Koenig S,Haynes BF,Nordstrom JL,Margolis DM,Ferrari G
14-0037 was used in Functional assays to develop an immunotherapeutic modality aimed to improve T cell-mediated clearance of HIV-1-infected cells.
Mon Nov 02 00:00:00 EST 2015
TIGIT and PD-1 impair tumor antigen-specific CD8⁺ T cells in melanoma patients.
The Journal of clinical investigation
Chauvin JM,Pagliano O,Fourcade J,Sun Z,Wang H,Sander C,Kirkwood JM,Chen TH,Maurer M,Korman AJ,Zarour HM
14-0037 was used in Functional assays to evaluate the expression and regulatory function of T cell Ig and ITIM domain, TIGIT, on tumour antigen-specific T cells in advanced melanoma.
Fri May 01 00:00:00 EDT 2015
Inflammatory IL-15 is required for optimal memory T cell responses.
The Journal of clinical investigation
Richer MJ,Pewe LL,Hancox LS,Hartwig SM,Varga SM,Harty JT
14-0037 was used in Functional assays to demonstrate that inflammatory signals are critical for the rapid proliferation of memory CD8+ T cells following infection, using murine models of viral infection and antigen exposure.
Tue Sep 01 00:00:00 EDT 2015
Human NK cell repertoire diversity reflects immune experience and correlates with viral susceptibility.
Science translational medicine
Strauss-Albee DM,Fukuyama J,Liang EC,Yao Y,Jarrell JA,Drake AL,Kinuthia J,Montgomery RR,John-Stewart G,Holmes S,Blish CA
14-0037 was used in Functional assays to reveal the functional and clinical significance of diversity within the human natural killer cell repertoire.
Wed Jul 22 00:00:00 EDT 2015
TLR5 Ligand-Secreting T Cells Reshape the Tumor Microenvironment and Enhance Antitumor Activity.
Cancer research
Geng D,Kaczanowska S,Tsai A,Younger K,Ochoa A,Rapoport AP,Ostrand-Rosenberg S,Davila E
14-0037 was used in Functional assays to investigate how TLR ligands can act as immune adjuvants, showing that TLR5 ligand-secreting cells reshape tumour microenvironment and enhance auti-tumour activity.
Fri May 15 00:00:00 EDT 2015
Chemotherapy-Derived Inflammatory Responses Accelerate the Formation of Immunosuppressive Myeloid Cells in the Tissue Microenvironment of Human Pancreatic Cancer.
Cancer research
Takeuchi S,Baghdadi M,Tsuchikawa T,Wada H,Nakamura T,Abe H,Nakanishi S,Usui Y,Higuchi K,Takahashi M,Inoko K,Sato S,Takano H,Shichinohe T,Seino K,Hirano S
14-0037 was used in Functional assays to investigate the relationship between chemotherapy and modulation of pancreatic ductal adenocarcinoma-induced tumour microenvironment.
Wed Jul 01 00:00:00 EDT 2015
Mutations in early follicular lymphoma progenitors are associated with suppressed antigen presentation.
Proceedings of the National Academy of Sciences of the United States of America
Green MR,Kihira S,Liu CL,Nair RV,Salari R,Gentles AJ,Irish J,Stehr H,Vicente-Dueñas C,Romero-Camarero I,Sanchez-Garcia I,Plevritis SK,Arber DA,Batzoglou S,Levy R,Alizadeh AA
14-0037 was used in Flow cytometry/Cell sorting to suggest a role for the CREBBP in contributing to immune evasion via decreased antigen presentation in follicular lymphomas.
Tue Mar 10 00:00:00 EDT 2015
PD-1+Tim-3+ CD8+ T Lymphocytes Display Varied Degrees of Functional Exhaustion in Patients with Regionally Metastatic Differentiated Thyroid Cancer.
Cancer immunology research
Severson JJ,Serracino HS,Mateescu V,Raeburn CD,McIntyre RC,Sams SB,Haugen BR,French JD
14-0037 was used in Functional assays to determine that the release of PD-1 and Tim-3, and the inhibition of Tregs, may encourage tumour elimination in metastatic differentiated thyroid cancer.
Mon Jun 01 00:00:00 EDT 2015
Adenosine Receptor 2A Blockade Increases the Efficacy of Anti-PD-1 through Enhanced Antitumor T-cell Responses.
Cancer immunology research
Beavis PA,Milenkovski N,Henderson MA,John LB,Allard B,Loi S,Kershaw MH,Stagg J,Darcy PK
14-0037 was used in Functional assays to determine whether blockade of A2A receptors could enhance the efficacy of anti-PD-1 mAb.
Fri May 01 00:00:00 EDT 2015
The catalytic activity of the kinase ZAP-70 mediates basal signaling and negative feedback of the T cell receptor pathway.
Science signaling
Goodfellow HS,Frushicheva MP,Ji Q,Cheng DA,Kadlecek TA,Cantor AJ,Kuriyan J,Chakraborty AK,Salomon A,Weiss A
14-0037 was used in Functional assays to study the contribution of ZAP-70 catalytic activity to the temporal dynamics of phosphorylation leading to T cell activation.
Tue May 19 00:00:00 EDT 2015
c-CBL E3 ubiquitin ligase is overexpressed in cutaneous T-cell lymphoma: its inhibition promotes activation-induced cell death.
The Journal of investigative dermatology
Wu J,Salva KA,Wood GS
14-0037 was used in Functional assays to identify the mechanism that renders T-cell receptor signalling defective in cutaneous T-cell lymphoma patients, characterized by resistance to apoptosis in T-cells.
Sun Mar 01 00:00:00 EST 2015
Conserved Motifs within Hepatitis C Virus Envelope (E2) RNA and Protein Independently Inhibit T Cell Activation.
PLoS pathogens
Bhattarai N,McLinden JH,Xiang J,Kaufman TM,Stapleton JT
14-0037 was used in Functional assays to demonstrate that HCV particles deliver viral RNA and E2 protein to T-cells, which inhibit proximal and distal TCR signaling.
Tue Sep 01 00:00:00 EDT 2015
Broadening the repertoire of melanoma-associated T-cell epitopes.
Cancer immunology, immunotherapy : CII
Frøsig TM,Lyngaa R,Met Ö,Larsen SK,Donia M,Svane IM,Thor Straten P,Hadrup SR
14-0037 was used in Flow cytometry/Cell sorting to identify novel melanoma-associated T-cell epitopes, restricted to human leukocyte antigen (HLA)-A1, -A3, -A11 and -B7.
Fri May 01 00:00:00 EDT 2015
Increased Levels of Macrophage Inflammatory Proteins Result in Resistance to R5-Tropic HIV-1 in a Subset of Elite Controllers.
Journal of virology
Walker WE,Kurscheid S,Joshi S,Lopez CA,Goh G,Choi M,Barakat L,Francis J,Fisher A,Kozal M,Zapata H,Shaw A,Lifton R,Sutton RE,Fikrig E
14-0037 was used in Flow cytometry/Cell sorting to examine CD4(+) T cell resistance to HIV in a group of elite controllers.
Fri May 01 00:00:00 EDT 2015
Bone marrow-derived mesenchymal stromal cells harness purinergenic signaling to tolerize human Th1 cells in vivo.
Stem cells (Dayton, Ohio)
Amarnath S,Foley JE,Farthing DE,Gress RE,Laurence A,Eckhaus MA,Métais JY,Rose JJ,Hakim FT,Felizardo TC,Cheng AV,Robey PG,Stroncek DE,Sabatino M,Battiwalla M,Ito S,Fowler DH,Barrett AJ
14-0037 was used in Functional assays to investigate the mechanism of BMSC in treatment of alloimmune and autoimmune conditions, showing that they harness purinergenic signaling to tolerize human Th1 cells.
Wed Apr 01 00:00:00 EDT 2015
Autoregulatory function of interleukin-10-producing pre-naïve B cells is defective in systemic lupus erythematosus.
Arthritis research & therapy
Sim JH,Kim HR,Chang SH,Kim IJ,Lipsky PE,Lee J
14-0037 was used in Functional assays to determine that IL-10 can regulate the immune capacity of pre-naïve B cells and their ability to enhance the development of autoimmunity.
Sat Jul 25 00:00:00 EDT 2015
Blocking GluR2-GAPDH ameliorates experimental autoimmune encephalomyelitis.
Annals of clinical and translational neurology
Zhai D,Lee FH,D'Souza C,Su P,Zhang S,Jia Z,Zhang L,Wong AH,Liu F
14-0037 was used in Flow cytometry/Cell sorting to investigate how the GluR2 -GAPDH complex represents a novel therapeutic target for the development of medications for MS that work through a different mechanism than existing treatments.
Wed Apr 01 00:00:00 EDT 2015
Mature cystic fibrosis airway neutrophils suppress T cell function: evidence for a role of arginase 1 but not programmed death-ligand 1.
Journal of immunology (Baltimore, Md. : 1950)
Ingersoll SA,Laval J,Forrest OA,Preininger M,Brown MR,Arafat D,Gibson G,Tangpricha V,Tirouvanziam R
14-0037 was used in Flow cytometry/Cell sorting to study how Arg1 and PD-L1 are dynamically modulated upon polymorphonuclear neutrophil migration into human airways.
Mon Jun 01 00:00:00 EDT 2015
Activated human valvular interstitial cells sustain interleukin-17 production to recruit neutrophils in infective endocarditis.
Infection and immunity
Yeh CY,Shun CT,Kuo YM,Jung CJ,Hsieh SC,Chiu YL,Chen JW,Hsu RB,Yang CJ,Chia JS
14-0037 was used in Functional assays to assess the role of activated valvular interstitial cells in valvular damage.
Mon Jun 01 00:00:00 EDT 2015
Integrative analysis of T cell motility from multi-channel microscopy data using TIAM.
Journal of immunological methods
Mayya V,Neiswanger W,Medina R,Wiggins CH,Dustin ML
14-0037 was used in Immunofluorescence to develop the novel cellular tracking software TIAM (Tool for Integrative Analysis of Motility), for use in the study of T cell mobility.
Thu Jan 01 00:00:00 EST 2015
South African HIV-1 subtype C transmitted variants with a specific V2 motif show higher dependence on α4β7 for replication.
Retrovirology
Richardson SI,Gray ES,Mkhize NN,Sheward DJ,Lambson BE,Wibmer CK,Masson L,Werner L,Garrett N,Passmore JA,Karim QA,Karim SS,Williamson C,Moore PL,Morris L
14-0037 was used in Functional assays to evaluate the role of α4β7 in HIV infection and the contribution of viral and host factors.
Wed Jun 24 00:00:00 EDT 2015
The human complement inhibitor Sushi Domain-Containing Protein 4 (SUSD4) expression in tumor cells and infiltrating T cells is associated with better prognosis of breast cancer patients.
BMC cancer
Englund E,Reitsma B,King BC,Escudero-Esparza A,Owen S,Orimo A,Okroj M,Anagnostaki L,Jiang WG,Jirström K,Blom AM
14-0037 was used in Immunofluorescence to indicate that SUSD4 expression in breast cancer cells and T-cells infiltrating the tumor-associated stroma is useful for breast cancer prognosis.
Mon Oct 19 00:00:00 EDT 2015
Ex vivo expansion of human T cells for adoptive immunotherapy using the novel Xeno-free CTS Immune Cell Serum Replacement.
Clinical & translational immunology
Smith C,Økern G,Rehan S,Beagley L,Lee SK,Aarvak T,Schjetne KW,Khanna R
14-0037 was used in Functional assays to describe a novel xeno-free serum replacement with defined components that can be reproducibly used for the production of clinical grade T-cell therapies.
Thu Jan 01 00:00:00 EST 2015
In-vitro Optimization of Nanoparticle-Cell Labeling Protocols for In-vivo Cell Tracking Applications.
Scientific reports
Betzer O,Meir R,Dreifuss T,Shamalov K,Motiei M,Shwartz A,Baranes K,Cohen CJ,Shraga-Heled N,Ofir R,Yadid G,Popovtzer R
14-0037 was used in Flow cytometry/Cell sorting to examine possible variations in gold nanoparticle uptake, resulting from different incubation period and concentrations in different cell-lines.
Wed Oct 28 00:00:00 EDT 2015
Tryptophan 2,3-dioxygenase (TDO)-reactive T cells differ in their functional characteristics in health and cancer.
Oncoimmunology
Hjortsø MD,Larsen SK,Kongsted P,Met Ö,Frøsig TM,Andersen GH,Ahmad SM,Svane IM,Becker JC,Straten PT,Andersen MH
14-0037 was used in Functional assays to investigate the role of tryptophan-2,3-dioxygenase in cancer.
Thu Jan 01 00:00:00 EST 2015
Molecular difference between WASP and N-WASP critical for chemotaxis of T-cells towards SDF-1α.
Scientific reports
Jain N,Thanabalu T
14-0037 was used in Immunofluorescence to suggest that formation of SQSTM1/p62-bodies and activation of NFE2L2 by omega-3 polyunsaturated fatty acids leads to inflammatory tolerance.
Wed Oct 14 00:00:00 EDT 2015
IL-12 secreting tumor-targeted chimeric antigen receptor T cells eradicate ovarian tumors in vivo.
Oncoimmunology
Koneru M,Purdon TJ,Spriggs D,Koneru S,Brentjens RJ
14-0037 was used in Flow cytometry/Cell sorting to study IL-12 secreting CAR T cells in ovarian cancer, an elimination gene has been included to allow for deletion of CAR T cells in the context of unforeseen or off-tumor on-target toxicity.
Sun Mar 01 00:00:00 EST 2015
The Macrophage Galactose-Type C-Type Lectin (MGL) Modulates Regulatory T Cell Functions.
PloS one
Zizzari IG,Martufi P,Battisti F,Rahimi H,Caponnetto S,Bellati F,Nuti M,Rughetti A,Napoletano C
14-0037 was used in Functional assays to investigate the role of macrophage galactose- type C-type lectin as a regulatory T-cell immunomodulator and its potential therapeutic applications.
Mon Apr 11 00:00:00 EDT 2016
Direct tumor recognition by a human CD4(+) T-cell subset potently mediates tumor growth inhibition and orchestrates anti-tumor immune responses.
Scientific reports
Matsuzaki J,Tsuji T,Luescher IF,Shiku H,Mineno J,Okamoto S,Old LJ,Shrikant P,Gnjatic S,Odunsi K
14-0037 was used in Flow cytometry/Cell sorting to provide mechanistic insights into the role of tumour-recognising CD4(+) T cells in tumour immunity.
Thu Oct 08 00:00:00 EDT 2015
Comparative transcriptional and functional profiling defines conserved programs of intestinal DC differentiation in humans and mice.
Nature immunology
Watchmaker PB,Lahl K,Lee M,Baumjohann D,Morton J,Kim SJ,Zeng R,Dent A,Ansel KM,Diamond B,Hadeiba H,Butcher EC
14-0037 was used in Flow cytometry/Cell sorting to characterise human gut dendritic cell populations, and define their relationship to previously studied human and mouse dendritic cells.
Wed Jan 01 00:00:00 EST 2014
Recombinant IgG2a Fc (M045) multimers effectively suppress experimental autoimmune myasthenia gravis.
Journal of autoimmunity
Thiruppathi M,Sheng JR,Li L,Prabhakar BS,Meriggioli MN
14-0037 was used in Functional assays to investigate the mechanism of action of intravenous immune globulin therapy in myasthenia gravis.
Fri Aug 01 00:00:00 EDT 2014
Inhibition of the immunoproteasome ameliorates experimental autoimmune encephalomyelitis.
EMBO molecular medicine
Basler M,Mundt S,Muchamuel T,Moll C,Jiang J,Groettrup M,Kirk CJ
14-0037 was used in Functional assays to investigate the therapeutic efficacy of an immunoproteasome inhibitor, ONX 0914, in two different mouse models of multiple sclerosis.
Sat Feb 01 00:00:00 EST 2014
Adenosine triphosphate acts as a paracrine signaling molecule to reduce the motility of T cells.
The EMBO journal
Wang CM,Ploia C,Anselmi F,Sarukhan A,Viola A
14-0037 was used in Flow cytometry/Cell sorting to investigate ATP paracrine signalling in T lymphocytes and determine its impact on T-cell physiology.
Tue Jun 17 00:00:00 EDT 2014
Long-lasting disease stabilization in the absence of toxicity in metastatic lung cancer patients vaccinated with an epitope derived from indoleamine 2,3 dioxygenase.
Clinical cancer research : an official journal of the American Association for Cancer Research
Iversen TZ,Engell-Noerregaard L,Ellebaek E,Andersen R,Larsen SK,Bjoern J,Zeyher C,Gouttefangeas C,Thomsen BM,Holm B,Thor Straten P,Mellemgaard A,Andersen MH,Svane IM
14-0037-82 was used in Flow Cytometry to investigate targeting of indoleamine-2,3-dioxygenase enzyme using a synthetic peptide vaccine to treat metastatic non–small cell lung cancer.
Wed Jan 01 00:00:00 EST 2014
T-cell responses to oncogenic merkel cell polyomavirus proteins distinguish patients with merkel cell carcinoma from healthy donors.
Clinical cancer research : an official journal of the American Association for Cancer Research
Lyngaa R,Pedersen NW,Schrama D,Thrue CA,Ibrani D,Met O,Thor Straten P,Nghiem P,Becker JC,Hadrup SR
14-0037 was used in Flow cytometry/Cell sorting to investigate the association between Merkel cell carcinoma and the Merkel cell polyomavirus by detecting MCPyV-derived CD8 T-cell epitopes.
Tue Apr 01 00:00:00 EDT 2014
Prevailing role of contact guidance in intrastromal T-cell trapping in human pancreatic cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research
Hartmann N,Giese NA,Giese T,Poschke I,Offringa R,Werner J,Ryschich E
14-0037 was used in Flow cytometry/Cell sorting to analyse how chemokines and extracellular matrix collagen interact in mediating T-cell infiltration in pancreatic ductal adenocarcinoma.
Tue Jul 01 00:00:00 EDT 2014
Prevailing role of contact guidance in intrastromal T-cell trapping in human pancreatic cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research
Hartmann N,Giese NA,Giese T,Poschke I,Offringa R,Werner J,Ryschich E
14-0037 was used in Flow cytometry/Cell sorting to analyse how chemokines and extracellular matrix collagen interact in mediating T-cell infiltration in pancreatic ductal adenocarcinoma.
Tue Jul 01 00:00:00 EDT 2014
Exposure to a histone deacetylase inhibitor has detrimental effects on human lymphocyte viability and function.
Cancer immunology research
Wong DJ,Rao A,Avramis E,Matsunaga DR,Komatsubara KM,Atefi MS,Escuin-Ordinas H,Chodon T,Koya RC,Ribas A,Comin-Anduix B
14-0037 was used in Functional assays to investigate the effects of a pan-histone deacetylase inhibitors on human lymphocytes and melanoma cell lines.
Thu May 01 00:00:00 EDT 2014
Genuine Immunomodulation With dSLIM.
Molecular therapy. Nucleic acids
Kapp K,Kleuss C,Schroff M,Wittig B
14-0037 was used in Flow cytometry/Cell sorting to describe the structure and biologic profile of dSLIM, showing that it has immunomodulation properties.
Tue Jun 24 00:00:00 EDT 2014
CD4CD8αα lymphocytes, a novel human regulatory T cell subset induced by colonic bacteria and deficient in patients with inflammatory bowel disease.
PLoS biology
Sarrabayrouse G,Bossard C,Chauvin JM,Jarry A,Meurette G,Quévrain E,Bridonneau C,Preisser L,Asehnoune K,Labarrière N,Altare F,Sokol H,Jotereau F
14-0037 was used in Functional assays to identify a Clostridium-specific IL-10-secreting Treg subset in the human lamina propria and blood that may contribute to the control of colitis.
Tue Apr 01 00:00:00 EDT 2014
Calmodulin and PI(3,4,5)P₃ cooperatively bind to the Itk pleckstrin homology domain to promote efficient calcium signaling and IL-17A production.
Science signaling
Wang X,Boyken SE,Hu J,Xu X,Rimer RP,Shea MA,Shaw AS,Andreotti AH,Huang YH
14-0037 was used in Functional assays to elucidate the roles of calmodulin and the lipid PI(3,4,5)P3 in the regulation of Ca(2+) signalling.
Tue Aug 05 00:00:00 EDT 2014
High CTLA-4 expression on Th17 cells results in increased sensitivity to CTLA-4 coinhibition and resistance to belatacept.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Krummey SM,Cheeseman JA,Conger JA,Jang PS,Mehta AK,Kirk AD,Larsen CP,Ford ML
14-0037 was used in Functional assays to investigate the etiology of belatacept-resistant graft rejection.
Sat Mar 01 00:00:00 EST 2014
Immunomodulatory agents lenalidomide and pomalidomide co-stimulate T cells by inducing degradation of T cell repressors Ikaros and Aiolos via modulation of the E3 ubiquitin ligase complex CRL4(CRBN.).
British journal of haematology
Gandhi AK,Kang J,Havens CG,Conklin T,Ning Y,Wu L,Ito T,Ando H,Waldman MF,Thakurta A,Klippel A,Handa H,Daniel TO,Schafer PH,Chopra R
14-0037 was used in Functional assays to identify the substrates of the E3 ubiquitin ligase complex CRL4(CRBN) that are responsible for T cell co-stimulation.
Sat Mar 01 00:00:00 EST 2014
Histone deacetylase inhibitors impair the elimination of HIV-infected cells by cytotoxic T-lymphocytes.
PLoS pathogens
Jones RB,O'Connor R,Mueller S,Foley M,Szeto GL,Karel D,Lichterfeld M,Kovacs C,Ostrowski MA,Trocha A,Irvine DJ,Walker BD
14-0037 was used in Flow cytometry/Cell sorting to study the impact of three histone deacetylase inhibitors in clinical development on T-cell effector functions.
Fri Aug 01 00:00:00 EDT 2014
Development of virus-specific CD4+ and CD8+ regulatory T cells induced by human herpesvirus 6 infection.
Journal of virology
Wang F,Chi J,Peng G,Zhou F,Wang J,Li L,Feng D,Xie F,Gu B,Qin J,Chen Y,Yao K
14-0037 was used in Functional assays to identify the mechanisms by which human herpesvirus 6 establishes latency and immunosuppression in its host.
Wed Jan 01 00:00:00 EST 2014
A dual-targeting triplebody mediates preferential redirected lysis of antigen double-positive over single-positive leukemic cells.
mAbs
Schubert I,Saul D,Nowecki S,Mackensen A,Fey GH,Oduncu FS
14-0037 was used in Functional assays to investigate the effect of a dual-targeting triplebody on leukemic cells.
Wed Oct 15 00:00:00 EDT 2014
NKG2D- and CD28-mediated costimulation regulate CD8+ T cell chemotaxis through different mechanisms: the role of Cdc42/N-WASp.
Journal of leukocyte biology
Serrano-Pertierra E,Cernuda-Morollón E,López-Larrea C
14-0037 was used in Functional assays to analyse the function of the NKG2D receptor in human CD8(+) T cell chemotaxis toward a CXCL12 gradient.
Sat Mar 01 00:00:00 EST 2014
High IP-10 levels decrease T cell function in HIV-1-infected individuals on ART.
Journal of leukocyte biology
Ramirez LA,Arango TA,Thompson E,Naji M,Tebas P,Boyer JD
14-0037 was used in Flow cytometry/Cell sorting to suggest that IP-10-modulating drugs may potentially enhance T cell responses to vaccination and HIV-1 in HIV+ subjects on ART.
Mon Dec 01 00:00:00 EST 2014
HIF-1α- and hypoxia-dependent immune responses in human CD4+CD25high T cells and T helper 17 cells.
Journal of leukocyte biology
Bollinger T,Gies S,Naujoks J,Feldhoff L,Bollinger A,Solbach W,Rupp J
14-0037 was used in Functional assays to analyse the effect of Hox and HIF-1α on human T(res), n(Treg), and Th17 cells.
Fri Aug 01 00:00:00 EDT 2014
Bispecific anti-CD3 x anti-HER2 antibody mediates T cell cytolytic activity to HER2-positive colorectal cancer in vitro and in vivo.
International journal of oncology
Han H,Ma J,Zhang K,Li W,Liu C,Zhang Y,Zhang G,Ma P,Wang L,Zhang G,Tao H,Gao B
14-0037 was used in Conjugation experiments to investigate whether HER2 can serve as a target for T cell-mediated immunotherapy of human colorectal carcinoma.
Mon Dec 01 00:00:00 EST 2014
The generation of induced pluripotent stem cells for macular degeneration as a drug screening platform: identification of curcumin as a protective agent for retinal pigment epithelial cells against oxidative stress.
Frontiers in aging neuroscience
Chang YC,Chang WC,Hung KH,Yang DM,Cheng YH,Liao YW,Woung LC,Tsai CY,Hsu CC,Lin TC,Liu JH,Chiou SH,Peng CH,Chen SJ
14-0037 was used in Functional assays to conclude that the drug Curcumin can effectively restore the neuronal functions in AMD patient-derived RPE cells and could be used for macular degeneration therapy.
Tue Aug 19 00:00:00 EDT 2014
Dual-specificity phosphatase 14 (DUSP14/MKP6) negatively regulates TCR signaling by inhibiting TAB1 activation.
Journal of immunology (Baltimore, Md. : 1950)
Yang CY,Li JP,Chiu LL,Lan JL,Chen DY,Chuang HC,Huang CY,Tan TH
14-0037 was used in Functional assays to study how DUSP14 negatively regulates TCR signaling and immune responses by inhibiting TAB1 activation.
Sat Feb 15 00:00:00 EST 2014
Akt-dependent enhanced migratory capacity of Th17 cells from children with lupus nephritis.
Journal of immunology (Baltimore, Md. : 1950)
Kshirsagar S,Riedl M,Billing H,Tönshoff B,Thangavadivel S,Steuber C,Staude H,Wechselberger G,Edelbauer M
14-0037 was used in Functional assays to determine that therapeutic modulation of Akt activity could suppress chronic inflammatory processes in children with lupus.
Sat Nov 15 00:00:00 EST 2014
Human Th2 but not Th9 cells release IL-31 in a STAT6/NF-κB-dependent way.
Journal of immunology (Baltimore, Md. : 1950)
Maier E,Werner D,Duschl A,Bohle B,Horejs-Hoeck J
14-0037 was used in Functional assays to investigate IL-31 production in human Th9 cells compared with Th2 cells.
Tue Jul 15 00:00:00 EDT 2014
A truncated human NKG2D splice isoform negatively regulates NKG2D-mediated function.
Journal of immunology (Baltimore, Md. : 1950)
Karimi MA,Aguilar O,Zou B,Bachmann MH,Carlyle JR,Baldwin CL,Kambayashi T
14-0037 was used in Functional assays to characterise a novel splice variant of human NKG2D that encodes a truncated receptor lacking the ligand-binding ectodomain.
Mon Sep 15 00:00:00 EDT 2014
Activation and propagation of tumor-infiltrating lymphocytes on clinical-grade designer artificial antigen-presenting cells for adoptive immunotherapy of melanoma.
Journal of immunotherapy (Hagerstown, Md. : 1997)
Forget MA,Malu S,Liu H,Toth C,Maiti S,Kale C,Haymaker C,Bernatchez C,Huls H,Wang E,Marincola FM,Hwu P,Cooper LJ,Radvanyi LG
14-0037 was used in Functional assays to compare the expansion, activation and differentiation of tumour-infiltrating lymphocytes in response to different developmental cues.
Thu Nov 12 00:00:00 EST 2015
TL1A induces TCR independent IL-6 and TNF-α production and growth of PLZF⁺ leukocytes.
PloS one
Reichwald K,Jørgensen TZ,Tougaard P,Skov S
14-0037 was used in Functional assays to investigate the role of the cytokine TL1A in autoimmune disease, showing that it induces the production of IL-6 and TNF-alpha, suggesting that it could be a possible target for the treatment of autoimmune disease.
Mon Sep 08 00:00:00 EDT 2014
Increased presence of FOXP3+ regulatory T cells in inflamed muscle of patients with active juvenile dermatomyositis compared to peripheral blood.
PloS one
Vercoulen Y,Bellutti Enders F,Meerding J,Plantinga M,Elst EF,Varsani H,van Schieveen C,Bakker MH,Klein M,Scholman RC,Spliet W,Ricotti V,Koenen HJ,de Weger RA,Wedderburn LR,van Royen-Kerkhof A,Prakken BJ
14-0037 was used in Flow cytometry/Cell sorting to explore the number, phenotype and function of regulatory T cells in the blood of juvenile dermatomyostitis patients.
Wed May 13 00:00:00 EDT 2015
Spontaneous presence of FOXO3-specific T cells in cancer patients.
Oncoimmunology
Larsen SK,Ahmad SM,Idorn M,Met Ö,Martinenaite E,Svane IM,Straten PT,Andersen MH
14-0037-82 was used in Flow Cytometry to study the forkhead box O3-specific, cytotoxic CD8+ T cells existent among peripheral-blood mononuclear cells of cancer patients.
Thu Feb 11 00:00:00 EST 2021
Exploring T cell reactivity to gliadin in young children with newly diagnosed celiac disease.
Autoimmune diseases
Liu E,McDaniel K,Case S,Yu L,Gerhartz B,Ostermann N,Fankhauser G,Hungerford V,Zou C,Luyten M,Seidl KJ,Michels AW
14-0037 was used in Functional assays to investigate the peripheral T cell responses to alpha and gamma gliadin epitopes in young children with newly diagnosed and untreated celiac disease.
Fri Apr 11 00:00:00 EDT 2014
Wiskott-Aldrich Syndrome causing mutation, Pro373Ser restricts conformational changes essential for WASP activity in T-cells.
Biochimica et biophysica acta
Jain N,George B,Thanabalu T
14-0037 was used in an ELISA assay to assess the effects of mutations to the Wiskott-Aldrich Syndrome protein on chemotaxis and T-cell activation.
Tue Apr 01 00:00:00 EDT 2014
Building and optimizing a virus-specific T cell receptor library for targeted immunotherapy in viral infections.
Scientific reports
Banu N,Chia A,Ho ZZ,Garcia AT,Paravasivam K,Grotenbreg GM,Bertoletti A,Gehring AJ
14-0037 was used in Functional assays to build a virus-specific TCR library that has potential for therapeutic intervention in chronic viral infection or virus-related cancers.
Tue Feb 25 00:00:00 EST 2014
Dendritic cells loaded with pancreatic Cancer Stem Cells (CSCs) lysates induce antitumor immune killing effect in vitro.
PloS one
Yin T,Shi P,Gou S,Shen Q,Wang C
14-0037 was used in Functional assays to show that Panc-1 CSCs lysate modified dendritic cells induced significant cytotoxic effects of lymphocytes on Panc-1 CSCs and may provide a pancreatic cancer vaccine.
Thu Dec 17 00:00:00 EST 2015
An NCR1-based chimeric receptor endows T-cells with multiple anti-tumor specificities.
Oncotarget
Tal Y,Yaakobi S,Horovitz-Fried M,Safyon E,Rosental B,Porgador A,Cohen CJ
14-0037 was used in Functional assays to generate and evaluate several chimaeric receptors based on a natural killer cell receptor, and assess their antitumour activity when retrovirally expressed in T cells.
Sat Nov 15 00:00:00 EST 2014
Non-overlapping functions of Nck1 and Nck2 adaptor proteins in T cell activation.
Cell communication and signaling : CCS
Ngoenkam J,Paensuwan P,Preechanukul K,Khamsri B,Yiemwattana I,Beck-García E,Minguet S,Schamel WW,Pongcharoen S
14-0037 was used in Functional assays to conclude that Nck1 and Nck2 have non-redundant roles in human T cell activation in contrast to murine T cells.
Wed Mar 26 00:00:00 EDT 2014
Soluble GARP has potent antiinflammatory and immunomodulatory impact on human CD4⁺ T cells.
Blood
Hahn SA,Stahl HF,Becker C,Correll A,Schneider FJ,Tuettenberg A,Jonuleit H
14-0037 was used in Functional assays to analyse the impact of a soluble glycoprotein A repetitions predominant (GARP) protein on human CD4+ T cell differentiation and activation.
Thu Aug 15 00:00:00 EDT 2013
Toward eliminating HLA class I expression to generate universal cells from allogeneic donors.
Blood
Torikai H,Reik A,Soldner F,Warren EH,Yuen C,Zhou Y,Crossland DL,Huls H,Littman N,Zhang Z,Tykodi SS,Kebriaei P,Lee DA,Miller JC,Rebar EJ,Holmes MC,Jaenisch R,Champlin RE,Gregory PD,Cooper LJ
14-0037 was used in Functional assays to develop designer zinc finger nucleases and employ a "hit-and-run" approach to genetic editing for selective elimination of human leukocyte antigen expression.
Thu Aug 22 00:00:00 EDT 2013
Low-dose interleukin-2 therapy restores regulatory T cell homeostasis in patients with chronic graft-versus-host disease.
Science translational medicine
Matsuoka K,Koreth J,Kim HT,Bascug G,McDonough S,Kawano Y,Murase K,Cutler C,Ho VT,Alyea EP,Armand P,Blazar BR,Antin JH,Soiffer RJ,Ritz J
14-0037 was used in Functional assays to define the mechanisms of action of IL-2 therapy for chronic graft-versus-host disease, showing that therapy restores regulatory T cell homeostasis.
Wed Apr 03 00:00:00 EDT 2013
B7-H4Ig inhibits mouse and human T-cell function and treats EAE via IL-10/Treg-dependent mechanisms.
Journal of autoimmunity
Podojil JR,Liu LN,Marshall SA,Chiang MY,Goings GE,Chen L,Langermann S,Miller SD
14-0037 was used in Functional assays to investigate the inhibition of mouse and human T-cell function and treatment of EAE via IL-10/Treg-dependent mechanisms through B7-H4Ig.
Thu Aug 01 00:00:00 EDT 2013
IL-2-inducible T-cell kinase modulates TH2-mediated allergic airway inflammation by suppressing IFN-γ in naive CD4+ T cells.
The Journal of allergy and clinical immunology
Kannan AK,Sahu N,Mohanan S,Mohinta S,August A
14-0037 was used in Functional assays to determine the role of IL-2-inducible T-cell kinase (Itk) in regulating TH cell differentiation in allergic airway inflammation.
Tue Oct 01 00:00:00 EDT 2013
IL-4 confers resistance to IL-27-mediated suppression on CD4+ T cells by impairing signal transducer and activator of transcription 1 signaling.
The Journal of allergy and clinical immunology
Chen Z,Wang S,Erekosima N,Li Y,Hong J,Qi X,Merkel P,Nagabhushanam V,Choo E,Katial R,Alam R,Trikha A,Chu HW,Zhuang Y,Jin M,Bai C,Huang H
14-0037 was used in Neutralization experiments to explore the mechanisms by which CD4(+) T cells from asthmatic patients resist IL-27-mediated inhibition.
Tue Oct 01 00:00:00 EDT 2013
Hypomorphic Janus kinase 3 mutations result in a spectrum of immune defects, including partial maternal T-cell engraftment.
The Journal of allergy and clinical immunology
Cattaneo F,Recher M,Masneri S,Baxi SN,Fiorini C,Antonelli F,Wysocki CA,Calderon JG,Eibel H,Smith AR,Bonilla FA,Tsitsikov E,Giliani S,Notarangelo LD,Pai SY
14-0037 was used in Functional assays to study the molecular, cellular, and humoural immune phenotype and function of 3 patients with hypomorphic Janus kinase 3 mutations.
Mon Apr 01 00:00:00 EDT 2013
Beta-lactam antibiotics modulate T-cell functions and gene expression via covalent binding to cellular albumin.
Proceedings of the National Academy of Sciences of the United States of America
Mor F,Cohen IR
14-0037 was used in Functional assays to investigate the effects of commonly used beta-lactam antibiotics on rodent and human T cells on T-cell-mediated experimental autoimmune diseases.
Tue Feb 19 00:00:00 EST 2013
HHLA2 is a member of the B7 family and inhibits human CD4 and CD8 T-cell function.
Proceedings of the National Academy of Sciences of the United States of America
Zhao R,Chinai JM,Buhl S,Scandiuzzi L,Ray A,Jeon H,Ohaegbulam KC,Ghosh K,Zhao A,Scharff MD,Zang X
14-0037 was used in Flow cytometry/Cell sorting to identify a unique B7 pathway that is able to inhibit human CD4 and CD8 T-cell proliferation and cytokine production.
Tue Jun 11 00:00:00 EDT 2013
Peptide library-based evaluation of T-cell receptor breadth detects defects in global and regulatory activation in human immunologic diseases.
Proceedings of the National Academy of Sciences of the United States of America
Barber JS,Yokomizo LK,Sheikh V,Freeman AF,Garabedian E,van Dijk E,Sokolic R,Candotti F,Weng NP,Sereti I,Milner JD
14-0037 was used in Flow cytometry/Cell sorting to investigate the pathophysiology and functional consequences of abnormal T-cell repertoires and into differentiation of human naive T-cells.
Tue May 14 00:00:00 EDT 2013
A practical approach to immunotherapy of hepatocellular carcinoma using T cells redirected against hepatitis B virus.
Molecular therapy. Nucleic acids
Koh S,Shimasaki N,Suwanarusk R,Ho ZZ,Chia A,Banu N,Howland SW,Ong AS,Gehring AJ,Stauss H,Renia L,Sällberg M,Campana D,Bertoletti A
14-0037 was used in Functional assays to establish a method for targeting HPV-integrated DNA within hepatocytes using T-cell receptor mRNA electroporation, as an alternative immunotherapy of hepatocellular carcinoma.
Tue Aug 13 00:00:00 EDT 2013
Activation of the transcriptional function of the NF-κB protein c-Rel by O-GlcNAc glycosylation.
Science signaling
Ramakrishnan P,Clark PM,Mason DE,Peters EC,Hsieh-Wilson LC,Baltimore D
14-0037 was used in Functional assays to investigate the role of O-GlcNAcylation on NF-κB activity, showing that c-Rel is activated.
Tue Aug 27 00:00:00 EDT 2013
Up-regulation of proliferative and migratory genes in regulatory T cells from patients with metastatic castration-resistant prostate cancer.
International journal of cancer
Huen NY,Pang AL,Tucker JA,Lee TL,Vergati M,Jochems C,Intrivici C,Cereda V,Chan WY,Rennert OM,Madan RA,Gulley JL,Schlom J,Tsang KY
14-0037 was used in Functional assays to perform genome-wide expression analyses to compare gene expression in Tregs isolated from the peripheral blood of healthy donors and patients with metastatic castration-resistant prostate cancer.
Mon Jul 15 00:00:00 EDT 2013
Methylation of FOXP3 in regulatory T cells is related to the severity of coronary artery disease.
Atherosclerosis
Jia L,Zhu L,Wang JZ,Wang XJ,Chen JZ,Song L,Wu YJ,Sun K,Yuan ZY,Hui R
14-0037 was used in Flow cytometry/Cell sorting to demonstrate that reduction in regulatory T-cells is associated with acute coronary syndrome in atherosclerotic patients.
Sat Jun 01 00:00:00 EDT 2013
Mesenchymal stem cells from periapical lesions modulate differentiation and functional properties of monocyte-derived dendritic cells.
European journal of immunology
Dokić J,Tomić S,Marković M,Milosavljević P,Colić M
14-0037 was used in Immunohistochemistry on frozen tissues to investigate whether mesenchymal stem cells from periapical lesions modulate the development and functions of dendritic cells.
Mon Jul 01 00:00:00 EDT 2013
Adipocyte-derived lipids modulate CD4+ T-cell function.
European journal of immunology
Ioan-Facsinay A,Kwekkeboom JC,Westhoff S,Giera M,Rombouts Y,van Harmelen V,Huizinga TW,Deelder A,Kloppenburg M,Toes RE
14-0037 was used in Functional assays to investigate the possibility that human adipocytes modulate CD4(+) T-cell cytokine production and proliferation.
Sat Jun 01 00:00:00 EDT 2013
Phase I trial of a multi-epitope-pulsed dendritic cell vaccine for patients with newly diagnosed glioblastoma.
Cancer immunology, immunotherapy : CII
Phuphanich S,Wheeler CJ,Rudnick JD,Mazer M,Wang H,Nuño MA,Richardson JE,Fan X,Ji J,Chu RM,Bender JG,Hawkins ES,Patil CG,Black KL,Yu JS
14-0037 was used in Flow cytometry/Cell sorting to study how expression of four ICT-107 targeted antigens in the pre-vaccine tumors correlated with prolonged overall survival and PFS in ND-GBM patients.
Tue Jan 01 00:00:00 EST 2013
The zinc-binding region of IL-2 inducible T cell kinase (Itk) is required for interaction with Gα13 and activation of serum response factor.
The international journal of biochemistry & cell biology
Huang W,Morales JL,Gazivoda VP,Lai J,Qi Q,August A
14-0037 was used in Functional assays to reveal a new pathway regulated by Itk in cells, and suggest cross talk between Itk and G-protein signaling downstream of the TcR.
Sat Jun 01 00:00:00 EDT 2013
Fine-tuning of regulatory T cell function: the role of calcium signals and naive regulatory T cells for regulatory T cell deficiency in multiple sclerosis.
Journal of immunology (Baltimore, Md. : 1950)
Schwarz A,Schumacher M,Pfaff D,Schumacher K,Jarius S,Balint B,Wiendl H,Haas J,Wildemann B
14-0037 was used in Functional assays to investigate the mechanisms underlying impaired suppressor functions in Tregs in multiple sclerosis, showing that calcium signals and naive regulatory T cells play a role.
Wed May 15 00:00:00 EDT 2013
GB virus C particles inhibit T cell activation via envelope E2 protein-mediated inhibition of TCR signaling.
Journal of immunology (Baltimore, Md. : 1950)
Bhattarai N,McLinden JH,Xiang J,Landay AL,Chivero ET,Stapleton JT
14-0037 was used in Flow cytometry/Cell sorting to investigate GBV-C reduced global T cell activation via competition between its envelope protein E2 and Lck following TCR engagement.
Sat Jun 15 00:00:00 EDT 2013
Human T cells engineered to express a programmed death 1/28 costimulatory retargeting molecule display enhanced antitumor activity.
Journal of immunology (Baltimore, Md. : 1950)
Ankri C,Shamalov K,Horovitz-Fried M,Mauer S,Cohen CJ
14-0037 was used in Functional assays to indicate that engineering T-cells with a costimulatory retargeting molecule can enhance their antitumor function.
Tue Oct 15 00:00:00 EDT 2013
Nuclear translocation of MEK1 triggers a complex T cell response through the corepressor silencing mediator of retinoid and thyroid hormone receptor.
Journal of immunology (Baltimore, Md. : 1950)
Guo L,Chen C,Liang Q,Karim MZ,Gorska MM,Alam R
14-0037 was used in Functional assays to show that MEK1 translocates to the nucleus following TCR stimulation and interacts with the nuclear co-repressor SMRT in CD4 T cells.
Tue Jan 01 00:00:00 EST 2013
Human neonatal naive CD4+ T cells have enhanced activation-dependent signaling regulated by the microRNA miR-181a.
Journal of immunology (Baltimore, Md. : 1950)
Palin AC,Ramachandran V,Acharya S,Lewis DB
14-0037 was used in Flow cytometry/Cell sorting to investigate the developmental differences in immune function between human neonates and adults, showing that neonatal naive CD4+ T cells have enhanced activation-dependent signalling.
Fri Mar 15 00:00:00 EDT 2013
LAT1 is a critical transporter of essential amino acids for immune reactions in activated human T cells.
Journal of immunology (Baltimore, Md. : 1950)
Hayashi K,Jutabha P,Endou H,Sagara H,Anzai N
14-0037 was used in Functional assays to uncover the previously unknown mechanism by which T cells accelerate essential amino acid uptake upon activation and adapt to essential amino acid starvation.
Tue Oct 15 00:00:00 EDT 2013
Intercellular adhesion molecule 1 mediates migration of Th1 and Th17 cells across human retinal vascular endothelium.
Investigative ophthalmology & visual science
Bharadwaj AS,Schewitz-Bowers LP,Wei L,Lee RW,Smith JR
14-0037 was used in Flow cytometry/Cell sorting to investigate the ability of human Th1- and Th17-polarised cells to cross a simulated human retinal endothelium, and examined the role of IgG superfamily members in this process.
Wed Oct 23 00:00:00 EDT 2013
Enhanced function of redirected human T cells expressing linker for activation of T cells that is resistant to ubiquitylation.
Human gene therapy
Kunii N,Zhao Y,Jiang S,Liu X,Scholler J,Balagopalan L,Samelson LE,Milone MC,June CH
14-0037 was used in Flow cytometry/Cell sorting to investigate how the interruption of LAT ubiquitylation is a promising strategy to augment effector T cell function for adoptive cell therapy.
Tue Jan 01 00:00:00 EST 2013
HER2 as a promising target for cytotoxicity T cells in human melanoma therapy.
PloS one
Ma J,Han H,Liu D,Li W,Feng H,Xue X,Wu X,Niu G,Zhang G,Zhao Y,Liu C,Tao H,Gao B
14-0037 was used in Flow cytometry/Cell sorting to study the expression of HER2 in a number of human melanoma cells and assess the suitability of HER2 as a target for melanoma immunotherapy.
Mon Mar 31 00:00:00 EDT 2014
Anti-KIT designer T cells for the treatment of gastrointestinal stromal tumor.
Journal of translational medicine
Katz SC,Burga RA,Naheed S,Licata LA,Thorn M,Osgood D,Nguyen CT,Espat NJ,Fletcher JA,Junghans RP
14-0037 was used in Flow cytometry/Cell sorting to develop a novel anti-KIT chimeric immune receptor to target KIT+ gastrointestinal stromal tumours using designer T cells.
Thu Feb 21 00:00:00 EST 2013
Impaired functionality of antiviral T cells in G-CSF mobilized stem cell donors: implications for the selection of CTL donor.
PloS one
Bunse CE,Borchers S,Varanasi PR,Tischer S,Figueiredo C,Immenschuh S,Kalinke U,Köhl U,Goudeva L,Maecker-Kolhoff B,Ganser A,Blasczyk R,Weissinger EM,Eiz-Vesper B
14-0037 was used in Flow cytometry/Cell sorting to study factors affecting the efficacy of the adoptive transfer of antiviral T cells after stem cell transplantation.
Mon Sep 08 00:00:00 EDT 2014
Anti-tumor necrosis factor α targets protein kinase B/c-Akt-induced resistance of effector cells to suppression in juvenile idiopathic arthritis.
Arthritis and rheumatism
Wehrens EJ,Vastert SJ,Mijnheer G,Meerding J,Klein M,Wulffraat NM,Prakken BJ,van Wijk F
14-0037-82 was used in Flow Cytometry to determine whether therapeutic strategies that block interleukin-6 or tumour necrosis factor α can improve the responsiveness of Teff cells to suppression in patients with juvenile idiopathic arthritis.
Sun Dec 01 00:00:00 EST 2013
Novel CD47: SIRPα dependent mechanism for the activation of STAT3 in antigen-presenting cell.
PloS one
Toledano N,Gur-Wahnon D,Ben-Yehuda A,Rachmilewitz J
14-0037 was used in an ELISA assay to demonstrate that CD47:SIRPα induces STAT3 phosphorylation that regulates antigen-presenting cell maturation.
Tue May 27 00:00:00 EDT 2014
Cyclotides Suppress Human T-Lymphocyte Proliferation by an Interleukin 2-Dependent Mechanism.
PloS one
Gründemann C,Thell K,Lengen K,Garcia-Käufer M,Huang YH,Huber R,Craik DJ,Schabbauer G,Gruber CW
14-0037 was used in Immuno-assay to indicate that cyclotides interfere with T-cell polyfunctionality and arrest proliferation of immunecompetent cells through inhibition of IL-2.
Tue Oct 10 00:00:00 EDT 2017
CD70-CD27 ligation between neural stem cells and CD4+ T cells induces Fas-FasL-mediated T-cell death.
Stem cell research & therapy
Lee EM,Hurh S,Cho B,Oh KH,Kim SU,Surh CD,Sprent J,Yang J,Kim JY,Ahn C
14-0037 was used in Functional assays to demonstrate CD70-CD27 ligation to be an initiating step for NSC-induced CD4+ T-cell apoptosis.
Tue May 21 00:00:00 EDT 2013
CD137L-stimulated dendritic cells are more potent than conventional dendritic cells at eliciting cytotoxic T-cell responses.
Oncoimmunology
Harfuddin Z,Kwajah S,Chong Nyi Sim A,Macary PA,Schwarz H
14-0037 was used in Flow cytometry/Cell sorting to develop improved dendritic cell-based immunotherapy using CD137 signalling.
Fri Nov 01 00:00:00 EDT 2013
Effects of conventional therapeutic interventions on the number and function of regulatory T cells.
Oncoimmunology
Roselli M,Cereda V,di Bari MG,Formica V,Spila A,Jochems C,Farsaci B,Donahue R,Gulley JL,Schlom J,Guadagni F
14-0037 was used in Flow cytometry/Cell sorting to investigate the number and function of Tregs obtained from the peripheral blood of carcinoma patients before and during chemotherapy.
Tue Oct 01 00:00:00 EDT 2013
LINE-1 retrotransposable element DNA accumulates in HIV-1-infected cells.
Journal of virology
Jones RB,Song H,Xu Y,Garrison KE,Buzdin AA,Anwar N,Hunter DV,Mujib S,Mihajlovic V,Martin E,Lee E,Kuciak M,Raposo RA,Bozorgzad A,Meiklejohn DA,Ndhlovu LC,Nixon DF,Ostrowski MA
14-0037 was used in Functional assays to investigate whether HIV-1 infection compromises cellular control of L1 elements, showing that LINE-1 retrotransposable element DNA accumulates in infected cells.
Sun Dec 01 00:00:00 EST 2013
Activated human nasal epithelial cells modulate specific antibody response against bacterial or viral antigens.
PloS one
Yeh CY,Yeh TH,Jung CJ,Chen PL,Lien HT,Chia JS
14-0037 was used in Flow cytometry/Cell sorting to elucidate the contribution of human nasal epithelial cells (hNECs) to antibody production in patients with chronic rhinosinusitis.
Tue Aug 20 00:00:00 EDT 2013
A foundation for universal T-cell based immunotherapy: T cells engineered to express a CD19-specific chimeric-antigen-receptor and eliminate expression of endogenous TCR.
Blood
Torikai H,Reik A,Liu PQ,Zhou Y,Zhang L,Maiti S,Huls H,Miller JC,Kebriaei P,Rabinovich B,Lee DA,Champlin RE,Bonini C,Naldini L,Rebar EJ,Gregory PD,Holmes MC,Cooper LJ
14-0037 was used in Functional assays to show that these engineered T cells display the expected property of having redirected specificity for CD19 without responding to TCR stimulation.
Thu Jun 14 00:00:00 EDT 2012
DNGR-1 is a specific and universal marker of mouse and human Batf3-dependent dendritic cells in lymphoid and nonlymphoid tissues.
Blood
Poulin LF,Reyal Y,Uronen-Hansson H,Schraml BU,Sancho D,Murphy KM,Håkansson UK,Moita LF,Agace WW,Bonnet D,Reis e Sousa C
14-0037 was used in Flow cytometry/Cell sorting to investigate the presence of unique markers in human dendritic cells, showing that DNGR-1 is a specific marker of mouse and human dendritic cells in lymphoid and nonlymphoid tissues.
Thu Jun 21 00:00:00 EDT 2012
A mutation in the human Uncoordinated 119 gene impairs TCR signaling and is associated with CD4 lymphopenia.
Blood
Gorska MM,Alam R
14-0037 was used in Magnetic cell separation to show that the V22G mutation of Unc119 represents a novel genetic defect in ICL.
Thu Feb 09 00:00:00 EST 2012
Loss of the signaling adaptor TRAF1 causes CD8+ T cell dysregulation during human and murine chronic infection.
The Journal of experimental medicine
Wang C,McPherson AJ,Jones RB,Kawamura KS,Lin GH,Lang PA,Ambagala T,Pellegrini M,Calzascia T,Aidarus N,Elford AR,Yue FY,Kremmer E,Kovacs CM,Benko E,Tremblay C,Routy JP,Bernard NF,Ostrowski MA,Ohashi PS,Watts TH
14-0037 was used in Functional assays to study the role of TRAF1 on the responses of CD8 T cells to chronic HIV infection.
Mon Jan 16 00:00:00 EST 2012
Differential mTOR and ERK pathway utilization by effector CD4 T cells suggests combinatorial drug therapy of arthritis.
Clinical immunology (Orlando, Fla.)
Lin JT,Stein EA,Wong MT,Kalpathy KJ,Su LL,Utz PJ,Robinson WH,Fathman CG
14-0037 was used in Functional assays to evaluate the signalling pathways utilised by naïve and experienced effector CD4 T cells during activation and proliferation.
Wed Feb 01 00:00:00 EST 2012
Phenotypic complexity of T regulatory subsets in patients with B-chronic lymphocytic leukemia.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
Biancotto A,Dagur PK,Fuchs JC,Wiestner A,Bagwell CB,McCoy JP
14-0037 was used in Flow cytometry/Cell sorting to show that T(reg) cells can be divided into multiple complex subsets based on a number of markers.
Wed Feb 01 00:00:00 EST 2012
Transmitted/founder and chronic subtype C HIV-1 use CD4 and CCR5 receptors with equal efficiency and are not inhibited by blocking the integrin α4β7.
PLoS pathogens
Parrish NF,Wilen CB,Banks LB,Iyer SS,Pfaff JM,Salazar-Gonzalez JF,Salazar MG,Decker JM,Parrish EH,Berg A,Hopper J,Hora B,Kumar A,Mahlokozera T,Yuan S,Coleman C,Vermeulen M,Ding H,Ochsenbauer C,Tilton JC,Permar SR,Kappes JC,Betts MR,Busch MP,Gao F,Montefiori D,Haynes BF,Shaw GM,Hahn BH,Doms RW
14-0037 was used in Functional assays to determine that the population bottleneck associated with mucosal HIV-1 acquisition isn't due to the selection of T/F viruses that use α4β7, CD4 or CCR5 more efficiently.
Thu Oct 04 00:00:00 EDT 2012
K12/SECTM1, an interferon-γ regulated molecule, synergizes with CD28 to costimulate human T cell proliferation.
Journal of leukocyte biology
Wang T,Huang C,Lopez-Coral A,Slentz-Kesler KA,Xiao M,Wherry EJ,Kaufman RE
14-0037 was used in Functional assays to study the ability of SECTM1 to stimulate CD27-dependent T cell proliferation and production of INF-gamma.
Thu Mar 01 00:00:00 EST 2012
Inhibition of activation induced CD154 on CD4+ CD25- cells: a valid surrogate for human Treg suppressor function.
Immunology and cell biology
Hill D,Eastaff-Leung N,Bresatz-Atkins S,Warner N,Ruitenberg J,Krumbiegel D,Pederson S,McInnes N,Brown CY,Sadlon T,Barry SC
14-0037 was used in Functional assays to show that a 7-h CD154 expression assay is a rapid, simple and reliable alternative method of determining Treg function, from conventional mixed lymphocyte reaction.
Sat Sep 01 00:00:00 EDT 2012
Trogocytosis is a gateway to characterize functional diversity in melanoma-specific CD8+ T cell clones.
Journal of immunology (Baltimore, Md. : 1950)
Uzana R,Eisenberg G,Sagi Y,Frankenburg S,Merims S,Amariglio N,Yefenof E,Peretz T,Machlenkin A,Lotem M
14-0037 was used in Flow cytometry/Cell sorting to demonstrate a possible contribution of NK, T, and B cell Ag costimulation to T-cell functional diversity.
Sun Jan 15 00:00:00 EST 2012
GB virus C envelope protein E2 inhibits TCR-induced IL-2 production and alters IL-2-signaling pathways.
Journal of immunology (Baltimore, Md. : 1950)
Bhattarai N,McLinden JH,Xiang J,Kaufman TM,Stapleton JT
14-0037 was used in Functional assays to investigate IL-2 release, IL-2R expression, IL-2 signaling, and cell proliferation in tet-off Jurkat cells expressing E2 following activation through the TCR.
Sat Sep 01 00:00:00 EDT 2012
Novel humanized and highly efficient bispecific antibodies mediate killing of prostate stem cell antigen-expressing tumor cells by CD8+ and CD4+ T cells.
Journal of immunology (Baltimore, Md. : 1950)
Feldmann A,Arndt C,Töpfer K,Stamova S,Krone F,Cartellieri M,Koristka S,Michalk I,Lindemann D,Schmitz M,Temme A,Bornhäuser M,Ehninger G,Bachmann M
14-0037 was used in Functional assays to compare a series of murine and humanised anti-CD3-anti-PSCA single-chain bispecific Abs.
Sat Sep 15 00:00:00 EDT 2012
Cytokine secretion by CD4+ T cells at the immunological synapse requires Cdc42-dependent local actin remodeling but not microtubule organizing center polarity.
Journal of immunology (Baltimore, Md. : 1950)
Chemin K,Bohineust A,Dogniaux S,Tourret M,Guégan S,Miro F,Hivroz C
14-0037 was used in Functional assays to investigate how newly synthesised cytokines are routed within T cells and the mechanisms involved in regulating their secretion.
Sat Sep 01 00:00:00 EDT 2012
Production of TNF-α in macrophages activated by T cells, compared with lipopolysaccharide, uses distinct IL-10-dependent regulatory mechanism.
Journal of immunology (Baltimore, Md. : 1950)
Agbanoma G,Li C,Ennis D,Palfreeman AC,Williams LM,Brennan FM
14-0037 was used in Functional assays to compare the mechanisms involved in IL-10-mediated TNF-α regulation in LPS-stimulated macrophages with macrophages stimulated with activated T cells.
Wed Feb 01 00:00:00 EST 2012
TCR-redirected human T cells inhibit hepatitis C virus replication: hepatotoxic potential is linked to antigen specificity and functional avidity.
Journal of immunology (Baltimore, Md. : 1950)
Pasetto A,Frelin L,Aleman S,Holmström F,Brass A,Ahlén G,Brenndörfer ED,Lohmann V,Bartenschlager R,Sällberg M,Bertoletti A,Chen M
14-0037 was used in Functional assays to compare novel hepatitis C virus (HCV) T-cell Receptors (TCRs) that differ in antigen specificity and functional avidity.
Thu Nov 01 00:00:00 EDT 2012
Emergence of peripheral CD3+CD56+ cytokine-induced killer cell in HIV-1-infected Chinese children.
International immunology
Fu GF,Chen X,Hu HY,Yang HT,Xu XQ,Qiu T,Li L,Xu JS,Huan XP,Hou YY
14-0037 was used in Functional assays to quantify cytokine-induced killer cells and their changes in surface cell receptor expression in HIV-1-positive children infected via mother-to-child transmission.
Thu Mar 01 00:00:00 EST 2012
Blood-derived human iPS cells generate optic vesicle-like structures with the capacity to form retinal laminae and develop synapses.
Investigative ophthalmology & visual science
Phillips MJ,Wallace KA,Dickerson SJ,Miller MJ,Verhoeven AD,Martin JM,Wright LS,Shen W,Capowski EE,Percin EF,Perez ET,Zhong X,Canto-Soler MV,Gamm DM
14-0037 was used in Functional assays to determine if human induced pluripotent stem cells derived from blood could produce optic vesicle-like structures with the capacity to stratify and express markers of inter-cellular communication.
Wed Apr 18 00:00:00 EDT 2012
Do plant cyclotides have potential as immunosuppressant peptides?
Journal of natural products
Gründemann C,Koehbach J,Huber R,Gruber CW
14-0037 was used in Functional assays to analyse crude plant extract and observe the antiproliferative effect of a contained cyclotide, kalata B1, on immune cells.
Fri Feb 24 00:00:00 EST 2012
Lymphocyte-polarized dendritic cells are highly effective in inducing tumor-specific CTLs.
Vaccine
Berk E,Muthuswamy R,Kalinski P
14-0037 was used in an ELISA assay to test the feasibility of using lymphocytes to generate mature type-1 polarised dendritic cells in a clinically-compatible process.
Fri Sep 21 00:00:00 EDT 2012
A predictive biomimetic model of cytokine release induced by TGN1412 and other therapeutic monoclonal antibodies.
Journal of immunotoxicology
Dhir V,Fort M,Mahmood A,Higbee R,Warren W,Narayanan P,Wittman V
14-0037 was used in Functional assays to describe a three-dimensional biomimetic vascular test-bed (RL-PTE-100 module) that can be used as an assay for testing therapeutic antibodies.
Tue May 29 00:00:00 EDT 2012
Engagement of T-cell antigen receptor and CD4/CD8 co-receptors induces prolonged STAT activation through autocrine/paracrine stimulation in human primary T cells.
Biochemical and biophysical research communications
Chueh FY,Yu CL
14-0037 was used in Functional assays to determine the extent of STAT protein involvement in T-cell antigen receptor signalling.
Fri Sep 21 00:00:00 EDT 2012
Expression and isotopic labelling of the potassium channel blocker ShK toxin as a thioredoxin fusion protein in bacteria.
Toxicon : official journal of the International Society on Toxinology
Chang SC,Galea CA,Leung EW,Tajhya RB,Beeton C,Pennington MW,Norton RS
14-0037 was used in Functional assays to develop a recombinant peptide expression system to generate isotopically-labelled ShK and various ShK analogues.
Mon Oct 01 00:00:00 EDT 2012
Fermented mistletoe extract as a multimodal antitumoral agent in gliomas.
Evidence-based complementary and alternative medicine : eCAM
Podlech O,Harter PN,Mittelbronn M,Pöschel S,Naumann U
14-0037 was used in Functional assays to investigate the mechanisms responsible for the anti-tumoural effects of mistletoe extracts.
Thu Nov 08 00:00:00 EST 2012
HSP70 enhances immunosuppressive function of CD4(+)CD25(+)FoxP3(+) T regulatory cells and cytotoxicity in CD4(+)CD25(-) T cells.
PloS one
Wachstein J,Tischer S,Figueiredo C,Limbourg A,Falk C,Immenschuh S,Blasczyk R,Eiz-Vesper B
14-0037 was used in Functional assays to show that HSP70 enhances the suppressive capacity of Tregs to neutralize target immune cells.
Wed Jul 17 00:00:00 EDT 2013
Polycomb antagonizes p300/CREB-binding protein-associated factor to silence FOXP3 in a Kruppel-like factor-dependent manner.
The Journal of biological chemistry
Xiong Y,Khanna S,Grzenda AL,Sarmento OF,Svingen PA,Lomberk GA,Urrutia RA,Faubion WA
14-0037 was used in Functional assays to provide insight into chromatin remodeling events key to phenotypic features of distinct T cell populations.
Fri Oct 05 00:00:00 EDT 2012
A cancer vaccine induces expansion of NY-ESO-1-specific regulatory T cells in patients with advanced melanoma.
PloS one
Ebert LM,MacRaild SE,Zanker D,Davis ID,Cebon J,Chen W
14-0037 was used in Functional assays to develop a novel assay to detect antigen-specific Tregs based on down-regulation of surface CD3 following TCR engagement.
Fri Apr 26 00:00:00 EDT 2013
Global activation of CD8+ cytotoxic T lymphocytes correlates with an impairment in regulatory T cells in patients with generalized vitiligo.
PloS one
Lili Y,Yi W,Ji Y,Yue S,Weimin S,Ming L
14-0037 was used in Flow cytometry/Cell sorting to understand the mechanisms of immune tolerance that are impaired in GV patients and may aid in the future development of effective immunotherapy for GV patients.
Tue Oct 09 00:00:00 EDT 2012
Biochemical and functional studies of lymphoid-specific tyrosine phosphatase (Lyp) variants S201F and R266W.
PloS one
Liu J,Chen M,Li R,Yang F,Shi X,Zhu L,Wang HM,Yao W,Liu Q,Meng FG,Sun JP,Pang Q,Yu X
14-0037 was used in Functional assays to investigate the biochemical characters and T cell signalling functions of two uncharacterised Lyp variants S201F and R266W.
Tue Feb 19 00:00:00 EST 2013
Cannabinoid receptor 2-mediated attenuation of CXCR4-tropic HIV infection in primary CD4+ T cells.
PloS one
Costantino CM,Gupta A,Yewdall AW,Dale BM,Devi LA,Chen BK
14-0037 was used in Functional assays to investigate whether drugs targeting cannabinoid receptors modulate chemokine co-receptor function and regulate HIV-1 infectivity.
Mon Aug 20 00:00:00 EDT 2012
Apoptotic effects of antilymphocyte globulins on human pro-inflammatory CD4+CD28- T-cells.
PloS one
Duftner C,Dejaco C,Hengster P,Bijuklic K,Joannidis M,Margreiter R,Schirmer M
14-0037 was used in Functional assays to evaluate the influence of polyclonal antilymphocyte globulins on CD4(+)CD28(-) T-cells in vivo and in vitro.
Mon Nov 19 00:00:00 EST 2012
Interleukin-2 and regulatory T cells in graft-versus-host disease.
The New England journal of medicine
Koreth J,Matsuoka K,Kim HT,McDonough SM,Bindra B,Alyea EP,Armand P,Cutler C,Ho VT,Treister NS,Bienfang DC,Prasad S,Tzachanis D,Joyce RM,Avigan DE,Antin JH,Ritz J,Soiffer RJ
14-0037 was used in Flow cytometry/Cell sorting to assess whether low-dose interleukin-2 could preferentially enhance Treg cells in vivo and suppress clinical manifestations of chronic graft-versus-host disease.
Thu Dec 01 00:00:00 EST 2011
A critical role for STAT3 transcription factor signaling in the development and maintenance of human T cell memory.
Immunity
Siegel AM,Heimall J,Freeman AF,Hsu AP,Brittain E,Brenchley JM,Douek DC,Fahle GH,Cohen JI,Holland SM,Milner JD
14-0037 was used in Functional assays to point to a specific role for STAT3 in human central memory T cell formation and in control of certain chronic viruses.
Wed Nov 23 00:00:00 EST 2011
The transcription factor E4BP4 regulates the production of IL-10 and IL-13 in CD4+ T cells.
Nature immunology
Motomura Y,Kitamura H,Hijikata A,Matsunaga Y,Matsumoto K,Inoue H,Atarashi K,Hori S,Watarai H,Zhu J,Taniguchi M,Kubo M
14-0037 was used in Functional assays to indicate that E4BP4 has multiple functions in controlling the plasticity of IL-13 in Th1 cells, and IL-10 in Th1, Th2, Treg and NKT cells.
Sun May 01 00:00:00 EDT 2011
Follicular lymphoma tumor-infiltrating T-helper (T(H)) cells have the same polyfunctional potential as normal nodal T(H) cells despite skewed differentiation.
Blood
Hilchey SP,Rosenberg AF,Hyrien O,Secor-Socha S,Cochran MR,Brady MT,Wang JC,Sanz I,Burack WR,Quataert SA,Bernstein SH
14-0037 was used in Functional assays to evaluate the potential of FL-infiltrating CD4(+) T-helper cells to elicit antitumour effects.
Thu Sep 29 00:00:00 EDT 2011
Functional human regulatory T cells fail to control autoimmune inflammation due to PKB/c-akt hyperactivation in effector cells.
Blood
Wehrens EJ,Mijnheer G,Duurland CL,Klein M,Meerding J,van Loosdregt J,de Jager W,Sawitzki B,Coffer PJ,Vastert B,Prakken BJ,van Wijk F
14-0037 was used in Flow cytometry/Cell sorting to study Treg function at the site of inflammation in patients with juvenile idiopathic arthritis.
Thu Sep 29 00:00:00 EDT 2011
Low telomerase activity in CD4+ regulatory T cells in patients with severe chronic GVHD after hematopoietic stem cell transplantation.
Blood
Kawano Y,Kim HT,Matsuoka K,Bascug G,McDonough S,Ho VT,Cutler C,Koreth J,Alyea EP,Antin JH,Soiffer RJ,Ritz J
14-0037 was used in Functional assays to examine telomere length and telomerase activity of Treg and conventional CD4(+) T cells in patients surviving >2 years following HSC transplant, showing low telomerase activity.
Thu Nov 03 00:00:00 EDT 2011
In vitro and in vivo model of a novel immunotherapy approach for chronic lymphocytic leukemia by anti-CD23 chimeric antigen receptor.
Blood
Giordano Attianese GM,Marin V,Hoyos V,Savoldo B,Pizzitola I,Tettamanti S,Agostoni V,Parma M,Ponzoni M,Bertilaccio MT,Ghia P,Biondi A,Dotti G,Biagi E
14-0037 was used in Functional assays to suggest that CD23.CAR(+) T cells represent a selective immunotherapy for the elimination of CD23(+) leukemic cells in patients with CLL.
Thu May 05 00:00:00 EDT 2011
NKG2D receptor regulates human effector T-cell cytokine production.
Blood
Barber A,Sentman CL
14-0037 was used in Functional assays to reveal that human effector T cells alter their function depending on which innate receptors are engaged in conjunction with the TCR complex.
Thu Jun 16 00:00:00 EDT 2011
T cell protein tyrosine phosphatase attenuates T cell signaling to maintain tolerance in mice.
The Journal of clinical investigation
Wiede F,Shields BJ,Chew SH,Kyparissoudis K,van Vliet C,Galic S,Tremblay ML,Russell SM,Godfrey DI,Tiganis T
14-0037 was used in Functional assays to investigate the role of T cell protein tyrosine phosphatase in autoimmune diseases.
Thu Dec 01 00:00:00 EST 2011
Heat shock protein 27 differentiates tolerogenic macrophages that may support human breast cancer progression.
Cancer research
Banerjee S,Lin CF,Skinner KA,Schiffhauer LM,Peacock J,Hicks DG,Redmond EM,Morrow D,Huston A,Shayne M,Langstein HN,Miller-Graziano CL,Strickland J,O'Donoghue L,De AK
14-0037 was used in Functional assays to investigate the role of Hsp27 in breast cancer, showing that Hsp27 differentiates tolerogenic macrophages.
Sat Jan 15 00:00:00 EST 2011
The human cytomegalovirus UL11 protein interacts with the receptor tyrosine phosphatase CD45, resulting in functional paralysis of T cells.
PLoS pathogens
Gabaev I,Steinbrück L,Pokoyski C,Pich A,Stanton RJ,Schwinzer R,Schulz TF,Jacobs R,Messerle M,Kay-Fedorov PC
14-0037 was used in Immunoprecipitation to study how pUL11 has immunosuppressive properties, and that disruption of T cell function via inhibition of CD45 is a previously unknown immunomodulatory strategy of CMV.
Thu Dec 01 00:00:00 EST 2011
Atorvastatin upregulates regulatory T cells and reduces clinical disease activity in patients with rheumatoid arthritis.
Journal of lipid research
Tang TT,Song Y,Ding YJ,Liao YH,Yu X,Du R,Xiao H,Yuan J,Zhou ZH,Liao MY,Yao R,Jevallee H,Shi GP,Cheng X
14-0037 was used in Functional assays to reveal that the suppressive function of T(reg) from rheumatoid arthritis patients significantly decreased compared with that of control subjects.
Sun May 01 00:00:00 EDT 2011
Analysis of circulating regulatory T cells in patients with metastatic prostate cancer pre- versus post-vaccination.
Cancer immunology, immunotherapy : CII
Vergati M,Cereda V,Madan RA,Gulley JL,Huen NY,Rogers CJ,Hance KW,Arlen PM,Schlom J,Tsang KY
14-0037 was used in Functional assays to highlight a possible association between improved overall survival and a decrease in Treg function after three monthly vaccinations.
Tue Feb 01 00:00:00 EST 2011
Increased frequency of regulatory T cells accompanies increased immune activation in rectal mucosae of HIV-positive noncontrollers.
Journal of virology
Shaw JM,Hunt PW,Critchfield JW,McConnell DH,Garcia JC,Pollard RB,Somsouk M,Deeks SG,Shacklett BL
14-0037 was used in Functional assays to investigate the role of Tregs in persistent HIV infection, showing that an increased frequency of Tregs accompanies increased immune activation in HIV-positive noncontrollers.
Tue Nov 01 00:00:00 EDT 2011
Engineering T cells specific for a dominant severe acute respiratory syndrome coronavirus CD8 T cell epitope.
Journal of virology
Oh HL,Chia A,Chang CX,Leong HN,Ling KL,Grotenbreg GM,Gehring AJ,Tan YJ,Bertoletti A
14-0037 was used in Functional assays to engineer T cells specific for a dominant SARS coronavirus CD8 T cell epitope, to potentially provide a new avenue for treatment during a SARS outbreak.
Sat Oct 01 00:00:00 EDT 2011
An HIV-1 gp120 envelope human monoclonal antibody that recognizes a C1 conformational epitope mediates potent antibody-dependent cellular cytotoxicity (ADCC) activity and defines a common ADCC epitope in human HIV-1 serum.
Journal of virology
Ferrari G,Pollara J,Kozink D,Harms T,Drinker M,Freel S,Moody MA,Alam SM,Tomaras GD,Ochsenbauer C,Kappes JC,Shaw GM,Hoxie JA,Robinson JE,Haynes BF
14-0037 was used in Functional assays to demonstrate that the epitope defined by MAb A32 is a major target on gp120 for plasma ADCC activity.
Fri Jul 01 00:00:00 EDT 2011
Serine residues in the LAT adaptor are essential for TCR-dependent signal transduction.
Journal of leukocyte biology
Martínez-Florensa M,García-Blesa A,Yélamos J,Muñoz-Suano A,Domínguez-Villar M,Valdor R,Alonso A,García-Cózar F,Aparicio P,Malissen B,Aguado E
14-0037 was used in Functional assays to report that the adaptor LAT contains several conserved serine-based motifs, which are essential for proper signal transduction through the TCR.
Sat Jan 01 00:00:00 EST 2011
Cofilin-mediated F-actin severing is regulated by the Rap GTPase and controls the cytoskeletal dynamics that drive lymphocyte spreading and BCR microcluster formation.
Journal of immunology (Baltimore, Md. : 1950)
Freeman SA,Lei V,Dang-Lawson M,Mizuno K,Roskelley CD,Gold MR
14-0037 was used in Functional assays to identify factors critical for the early cytoskeletal changes and BCR reorganisation that are involved in APC-dependent lymphocyte activation.
Thu Dec 01 00:00:00 EST 2011
Impairment of regulatory capacity of CD4+CD25+ regulatory T cells mediated by dendritic cell polarization and hyperthyroidism in Graves' disease.
Journal of immunology (Baltimore, Md. : 1950)
Mao C,Wang S,Xiao Y,Xu J,Jiang Q,Jin M,Jiang X,Guo H,Ning G,Zhang Y
14-0037 was used in Functional assays to investigate whether dendritic cells are the main cause of defective regulatory T cell activity in Graves' disease patients.
Fri Apr 15 00:00:00 EDT 2011
Enhanced phosphoinositide 3-kinase δ activity is a frequent event in systemic lupus erythematosus that confers resistance to activation-induced T cell death.
Journal of immunology (Baltimore, Md. : 1950)
Suárez-Fueyo A,Barber DF,Martínez-Ara J,Zea-Mendoza AC,Carrera AC
14-0037 was used in in vitro experiments to point to PI3Kδ as a target of clinical interest for SLE.
Thu Sep 01 00:00:00 EDT 2011
Functional gap junctions accumulate at the immunological synapse and contribute to T cell activation.
Journal of immunology (Baltimore, Md. : 1950)
Mendoza-Naranjo A,Bouma G,Pereda C,Ramírez M,Webb KF,Tittarelli A,López MN,Kalergis AM,Thrasher AJ,Becker DL,Salazar-Onfray F
14-0037 was used in Magnetic cell separation to demonstrate the importance of Cx43 in the immune system, and indicate roles for GJ and Hchl in T-cell activation.
Thu Sep 15 00:00:00 EDT 2011
Maturation of human dendritic cells with Saccharomyces cerevisiae (yeast) reduces the number and function of regulatory T cells and enhances the ratio of antigen-specific effectors to regulatory T cells.
Vaccine
Cereda V,Vergati M,Huen NY,di Bari MG,Jochems C,Intrivici C,Gulley JL,Apelian D,Schlom J,Tsang KY
14-0037 was used in Functional assays to assess the contribution of yeast-treated dendritic cells to the induction of regulatory and effector T cells.
Tue Jul 12 00:00:00 EDT 2011
Protein kinase Ctheta is a specific target for inhibition of the HIV type 1 replication in CD4+ T lymphocytes.
The Journal of biological chemistry
López-Huertas MR,Mateos E,Díaz-Gil G,Gómez-Esquer F,Sánchez del Cojo M,Alcamí J,Coiras M
14-0037 was used in Functional assays to analyse the effect of Rottlerin, a dose-dependent PKC inhibitor, on HIV-1 replication in T cells.
Fri Aug 05 00:00:00 EDT 2011
Engineered artificial antigen presenting cells facilitate direct and efficient expansion of tumor infiltrating lymphocytes.
Journal of translational medicine
Ye Q,Loisiou M,Levine BL,Suhoski MM,Riley JL,June CH,Coukos G,Powell DJ
14-0037 was used in Immunofluorescence to investigate how genetically-enhanced aAPCs represent a standardized, "off-the-shelf" platform for the direct ex vivo expansion of TILs of suitable number, phenotype and function for use in adoptive immunotherapy.
Tue Aug 09 00:00:00 EDT 2011
Licensing virus-specific T cells to secrete the neutrophil attracting chemokine CXCL-8 during hepatitis B virus infection.
PloS one
Gehring AJ,Koh S,Chia A,Paramasivam K,Chew VS,Ho ZZ,Lee KH,Maini MK,Madhavan K,Lim SG,Bertoletti A
14-0037 was used in in vitro experiments to investigate whether during different phases of HBV infection, virus-specific T-cells can acquire specific proinflammatory functions.
Fri Dec 30 00:00:00 EST 2011
Predicting cytotoxic T-cell age from multivariate analysis of static and dynamic biomarkers.
Molecular & cellular proteomics : MCP
Rivet CA,Hill AS,Lu H,Kemp ML
14-0037 was used in Functional assays to highlight the information content of both averaged biomarker values and heterogeneity metrics for prediction of cellular age within a T cell population.
Tue Mar 01 00:00:00 EST 2011
SHP2 is a target of the immunosuppressant tautomycetin.
Chemistry & biology
Liu S,Yu Z,Yu X,Huang SX,Luo Y,Wu L,Shen W,Yang Z,Wang L,Gunawan AM,Chan RJ,Shen B,Zhang ZY
14-0037 was used in Functional assays to support the notion that SHP2 is a cellular target for tautomycetin (TTN) and provide a potential mechanism for the immunosuppressive activity of TTN.
Fri Jan 28 00:00:00 EST 2011
IL-7 and IL-21 are superior to IL-2 and IL-15 in promoting human T cell-mediated rejection of systemic lymphoma in immunodeficient mice.
Blood
Markley JC,Sadelain M
14-0037 was used in an ELISA assay to support the use of gamma(c)-cytokines in cancer immunotherapy, and establish multiple T-cell memory phenotypes associated with long-term tumor immunity.
Thu Apr 29 00:00:00 EDT 2010
Selective inhibition of IDO1 effectively regulates mediators of antitumor immunity.
Blood
Liu X,Shin N,Koblish HK,Yang G,Wang Q,Wang K,Leffet L,Hansbury MJ,Thomas B,Rupar M,Waeltz P,Bowman KJ,Polam P,Sparks RB,Yue EW,Li Y,Wynn R,Fridman JS,Burn TC,Combs AP,Newton RC,Scherle PA
14-0037 was used in an ELISA assay to suggest that selective inhibition of IDO1 may represent an attractive cancer therapeutic strategy via up-regulation of cellular immunity.
Thu Apr 29 00:00:00 EDT 2010
Altered regulatory T cell homeostasis in patients with CD4+ lymphopenia following allogeneic hematopoietic stem cell transplantation.
The Journal of clinical investigation
Matsuoka K,Kim HT,McDonough S,Bascug G,Warshauer B,Koreth J,Cutler C,Ho VT,Alyea EP,Antin JH,Soiffer RJ,Ritz J
14-0037 was used in in vitro experiments to indicate that CD4+ lymphopenia is a critical factor in Treg homeostasis and that its imbalance can result in loss of tolerance and clinical disease manifestations.
Sat May 01 00:00:00 EDT 2010
Human cytomegalovirus elicits fetal gammadelta T cell responses in utero.
The Journal of experimental medicine
Vermijlen D,Brouwer M,Donner C,Liesnard C,Tackoen M,Van Rysselberge M,Twité N,Goldman M,Marchant A,Willems F
14-0037 was used in in vitro experiments to indicate that functional fetal gammadelta T cell responses can be generated during development in utero and suggest that this T cell subset could participate in antiviral defense in early life.
Mon Apr 12 00:00:00 EDT 2010
Accumulation of foxp3+ T regulatory cells in draining lymph nodes correlates with disease progression and immune suppression in colorectal cancer patients.
Clinical cancer research : an official journal of the American Association for Cancer Research
Deng L,Zhang H,Luan Y,Zhang J,Xing Q,Dong S,Wu X,Liu M,Wang S
14-0037 was used in Functional assays to reveal the association between the frequency of Tregs in tumour draining lymph nodes and cancer progression.
Sun Aug 15 00:00:00 EDT 2010
T-cell receptor complex is essential for Fas signal transduction.
Proceedings of the National Academy of Sciences of the United States of America
Akimzhanov AM,Wang X,Sun J,Boehning D
14-0037 was used in in vitro experiments to demonstrate the potential for unsintered indium tin oxide to induce immune sensitization.
Tue Aug 24 00:00:00 EDT 2010
NF-kappaB inhibits T-cell activation-induced, p73-dependent cell death by induction of MDM2.
Proceedings of the National Academy of Sciences of the United States of America
Busuttil V,Droin N,McCormick L,Bernassola F,Candi E,Melino G,Green DR
14-0037 was used in Functional assays to demonstrate a pathway for the survival of activated T cells through NF-κB-induced Mdm2.
Tue Oct 19 00:00:00 EDT 2010
Anaphase-promoting complex/cyclosome-Cdh1 coordinates glycolysis and glutaminolysis with transition to S phase in human T lymphocytes.
Proceedings of the National Academy of Sciences of the United States of America
Colombo SL,Palacios-Callender M,Frakich N,De Leon J,Schmitt CA,Boorn L,Davis N,Moncada S
14-0037 was used in Functional assays to explore how the anaphase-promoting complex/cyclosome-Cdh1 controls the proliferative response of human T lymphocytes.
Tue Nov 02 00:00:00 EDT 2010
Fas ligand gene expression is directly regulated by stress-inducible heat shock transcription factor-1.
Cell death and differentiation
Bouchier-Hayes L,McBride S,van Geelen CM,Nance S,Lewis LK,Pinkoski MJ,Beere HM
14-0037 was used in Flow cytometry/Cell sorting to demonstrate the ability of HSF-1 to mediate stress-inducible expression of FasL.
Tue Jun 01 00:00:00 EDT 2010
Enhanced suppressive function of regulatory T cells from patients with immune-mediated diseases following successful ex vivo expansion.
Clinical immunology (Orlando, Fla.)
Cao T,Wenzel SE,Faubion WA,Harriman G,Li L
14-0037 was used in in vitro experiments to demonstrate that CD4(+)CD25(+)Foxp3(+) Treg cells from patients with autoimmune and inflammatory diseases can be successfully purified, activated and expanded, suggesting possible therapeutic potential.
Wed Sep 01 00:00:00 EDT 2010
Role played by the programmed death-1-programmed death ligand pathway during innate immunity against Mycobacterium tuberculosis.
The Journal of infectious diseases
Alvarez IB,Pasquinelli V,Jurado JO,Abbate E,Musella RM,de la Barrera SS,García VE
14-0037-82 was used in Flow Cytometry to describe a novel inhibitory role played by PD-1:PD-L interactions in innate immunity in tuberculosis.
Sun Aug 15 00:00:00 EDT 2010
PD-1 on immature and PD-1 ligands on migratory human Langerhans cells regulate antigen-presenting cell activity.
The Journal of investigative dermatology
Peña-Cruz V,McDonough SM,Diaz-Griffero F,Crum CP,Carrasco RD,Freeman GJ
14-0037 was used in Functional assays to show that PD-1 expressed on immature langerhans cells in situ regulate antigen-presenting cell activity.
Wed Sep 01 00:00:00 EDT 2010
CD137 ligand signaling induces human monocyte to dendritic cell differentiation.
European journal of immunology
Kwajah M M S,Schwarz H
14-0037 was used in Flow cytometry/Cell sorting to deduce that peripheral monocytes can be differentiated into mature inflammatory dendritic cells by the single factor CD137.
Thu Jul 01 00:00:00 EDT 2010
Human adenosine deaminase 2 induces differentiation of monocytes into macrophages and stimulates proliferation of T helper cells and macrophages.
Journal of leukocyte biology
Zavialov AV,Gracia E,Glaichenhaus N,Franco R,Zavialov AV,Lauvau G
14-0037 was used in Flow cytometry/Cell sorting to discover the growth factor-like activity of ADA2.
Sun Aug 01 00:00:00 EDT 2010
Expression of the autoimmune susceptibility gene FcRL3 on human regulatory T cells is associated with dysfunction and high levels of programmed cell death-1.
Journal of immunology (Baltimore, Md. : 1950)
Swainson LA,Mold JE,Bajpai UD,McCune JM
14-0037 was used in Functional assays to suggest that FcRL3 expression is associated with T(reg) dysfunction that may, in turn, contribute to the loss of self-tolerance and the development of autoimmunity.
Thu Apr 01 00:00:00 EDT 2010
Human tumor antigen-specific helper and regulatory T cells share common epitope specificity but exhibit distinct T cell repertoire.
Journal of immunology (Baltimore, Md. : 1950)
Fourcade J,Sun Z,Kudela P,Janjic B,Kirkwood JM,El-Hafnawy T,Zarour HM
14-0037-82 was used in Flow Cytometry to demonstrate that two immunodominant epitopes derived from the tumour antigens NY-ESO-1 and TRAG-3 stimulate both CD4+ T helper and regulatory T cells.
Tue Jun 15 00:00:00 EDT 2010
Genome-wide analysis of allelic expression imbalance in human primary cells by high-throughput transcriptome resequencing.
Human molecular genetics
Heap GA,Yang JH,Downes K,Healy BC,Hunt KA,Bockett N,Franke L,Dubois PC,Mein CA,Dobson RJ,Albert TJ,Rodesch MJ,Clayton DG,Todd JA,van Heel DA,Plagnol V
14-0037 was used in Functional assays to perform deep human transcriptome-wide resequencing (RNA-seq) for ASE analysis and expression quantitative trait locus discovery.
Fri Jan 01 00:00:00 EST 2010
A role for the transcription factor Helios in human CD4(+)CD25(+) regulatory T cells.
Molecular immunology
Getnet D,Grosso JF,Goldberg MV,Harris TJ,Yen HR,Bruno TC,Durham NM,Hipkiss EL,Pyle KJ,Wada S,Pan F,Pardoll DM,Drake CG
14-0037 was used in Magnetic cell separation to investigate possible reasons for the observed upregulation of Helios in regulatory T cells.
Thu Apr 01 00:00:00 EDT 2010
Modulation of cell signaling networks after CTLA4 blockade in patients with metastatic melanoma.
PloS one
Comin-Anduix B,Sazegar H,Chodon T,Matsunaga D,Jalil J,von Euw E,Escuin-Ordinas H,Balderas R,Chmielowski B,Gomez-Navarro J,Koya RC,Ribas A
14-0037 was used in Flow cytometry/Cell sorting to determine that the CTLA4-blockade antibody tremelimumab has downstream signalling effects in T cells and monocytes of patients with metastatic melanoma.
Wed Sep 15 00:00:00 EDT 2010
Androgen-regulated expression of arginase 1, arginase 2 and interleukin-8 in human prostate cancer.
PloS one
Gannon PO,Godin-Ethier J,Hassler M,Delvoye N,Aversa M,Poisson AO,Péant B,Alam Fahmy M,Saad F,Lapointe R,Mes-Masson AM
14-0037 was used in Functional assays to provide the first detailed account of an androgen-regulated immunosuppressive pathway in human PCa through ARG1, ARG2 and IL-8 expression.
Wed Aug 11 00:00:00 EDT 2010
Adhesion and degranulation promoting adapter protein (ADAP) is a central hub for phosphotyrosine-mediated interactions in T cells.
PloS one
Sylvester M,Kliche S,Lange S,Geithner S,Klemm C,Schlosser A,Grossmann A,Stelzl U,Schraven B,Krause E,Freund C
14-0037 was used in Functional assays to indicate that ADAP directly links integrins to modulators of the cytoskeleton independent of SLP-76.
Thu Jul 22 00:00:00 EDT 2010
Polyfunctional T-cell responses are disrupted by the ovarian cancer ascites environment and only partially restored by clinically relevant cytokines.
PloS one
Tran E,Nielsen JS,Wick DA,Ng AV,Johnson LD,Nesslinger NJ,McMurtrie E,Webb JR,Nelson BH
14-0037 was used in Functional assays to evaluate a panel of clinically relevant cytokines for the ability to enhance multiple T-cell effector functions (polyfunctionality) in the native tumor environment.
Wed Dec 22 00:00:00 EST 2010
CD277 is a negative co-stimulatory molecule universally expressed by ovarian cancer microenvironmental cells.
Oncotarget
Cubillos-Ruiz JR,Martinez D,Scarlett UK,Rutkowski MR,Nesbeth YC,Camposeco-Jacobs AL,Conejo-Garcia JR
14-0037 was used in Flow cytometry/Cell sorting to show the major role of CD277 in the orchestration of immunosuppressive networks in ovarian cancer.
Wed Sep 01 00:00:00 EDT 2010
Effects of nilotinib on regulatory T cells: the dose matters.
Molecular cancer
Fei F,Yu Y,Schmitt A,Rojewski MT,Chen B,Greiner J,Götz M,Bunjes D,Schmitt M
14-0037 was used in Functional assays to measure the expression of the transcription factor forkhead box P3 and the glucocorticoid-induced tumor necrosis factor receptor in Tregs.
Fri Jan 29 00:00:00 EST 2010
Inhibition of effector function but not T cell activation and increase in FoxP3 expression in T cells differentiated in the presence of PP14.
PloS one
Ochanuna Z,Geiger-Maor A,Dembinsky-Vaknin A,Karussis D,Tykocinski ML,Rachmilewitz J
14-0037 was used in Functional assays to suggest that PP14 arrests T cells in an activated state that isn't accompanied with the acquisition of effector function, together with promoting the generation of Treg cells.
Thu Sep 23 00:00:00 EDT 2010
Derivation of induced pluripotent stem cells from human peripheral blood T lymphocytes.
PloS one
Brown ME,Rondon E,Rajesh D,Mack A,Lewis R,Feng X,Zitur LJ,Learish RD,Nuwaysir EF
14-0037 was used in Functional assays to describe the generation of T lymphocyte-derived iPSCs from small, clinically advantageous volumes of non-mobilized peripheral blood.
Tue Jun 29 00:00:00 EDT 2010
A role for human skin-resident T cells in wound healing.
The Journal of experimental medicine
Toulon A,Breton L,Taylor KR,Tenenhaus M,Bhavsar D,Lanigan C,Rudolph R,Jameson J,Havran WL
14-0037 was used in Functional assays to demonstrate that human epidermal T cells are able to produce IGF-1 upon activation to promote wound healing.
Mon Apr 13 00:00:00 EDT 2009
Accumulation of raft lipids in T-cell plasma membrane domains engaged in TCR signalling.
The EMBO journal
Zech T,Ejsing CS,Gaus K,de Wet B,Shevchenko A,Simons K,Harder T
14-0037 was used in Magnetic cell separation to determine the molecular lipid composition of immunoisolated T-cell receptor activation domains.
Wed Mar 04 00:00:00 EST 2009
Brx mediates the response of lymphocytes to osmotic stress through the activation of NFAT5.
Science signaling
Kino T,Takatori H,Manoli I,Wang Y,Tiulpakov A,Blackman MR,Su YA,Chrousos GP,DeCherney AH,Segars JH
14-0037 was used in Functional assays to investigate the role of Brx in osmotic stress.
Tue Feb 10 00:00:00 EST 2009
A2A adenosine receptor (AR) activation inhibits pro-inflammatory cytokine production by human CD4+ helper T cells and regulates Helicobacter-induced gastritis and bacterial persistence.
Mucosal immunology
Alam MS,Kurtz CC,Wilson JM,Burnette BR,Wiznerowicz EB,Ross WG,Rieger JM,Figler RA,Linden J,Crowe SE,Ernst PB
14-0037 was used in Functional assays to determine that A(2A) adenosine receptor limits the pro-inflammatory effects of Th cells and favours chronic Helicobacter infection.
Fri May 01 00:00:00 EDT 2009
Parallel multi-time point cell stimulation and lysis on-chip for studying early signaling events in T cell activation.
Lab on a chip
Hirsch AM,Rivet CA,Zhang B,Kemp ML,Lu H
14-0037 was used in Functional assays to test a two-module microfluidic platform for simultaneous multi-time point stimulation and lysis of T-Cells for studying early signaling events in T-cell activation.
Sat Feb 21 00:00:00 EST 2009
CD69 gene is differentially regulated in T and B cells by evolutionarily conserved promoter-distal elements.
Journal of immunology (Baltimore, Md. : 1950)
Vazquez BN,Laguna T,Carabana J,Krangel MS,Lauzurica P
14-0037 was used in Functional assays to investigate the molecular mechanism underlying mouse CD69 gene transcription in vivo in T and B cells, showing it is is differentially regulated.
Sun Nov 15 00:00:00 EST 2009
ESAT-6 inhibits production of IFN-gamma by Mycobacterium tuberculosis-responsive human T cells.
Journal of immunology (Baltimore, Md. : 1950)
Wang X,Barnes PF,Dobos-Elder KM,Townsend JC,Chung YT,Shams H,Weis SE,Samten B
14-0037 was used in an ELISA assay to investigate how ESAT-6 directly inhibits human T cell responses to mycobacterial Ags by affecting TCR signaling pathways downstream of ZAP70.
Sun Mar 15 00:00:00 EDT 2009
Uncoordinated 119 protein controls trafficking of Lck via the Rab11 endosome and is critical for immunological synapse formation.
Journal of immunology (Baltimore, Md. : 1950)
Gorska MM,Liang Q,Karim Z,Alam R
14-0037 was used in Immunofluorescence to demonstrate that Lck is transported to the membrane via the Rab11 endosome, dependent on Uncoordinated 119 protein.
Sat Aug 01 00:00:00 EDT 2009
The adapter protein SLP-76 mediates "outside-in" integrin signaling and function in T cells.
Molecular and cellular biology
Baker RG,Hsu CJ,Lee D,Jordan MS,Maltzman JS,Hammer DA,Baumgart T,Koretzky GA
14-0037 was used in Immunofluorescence to identify the role of the adapter protein SLP-76 in integrin-initiated signalling in T cells, using an inducible in vivo model to control SLP-76 expression.
Thu Oct 01 00:00:00 EDT 2009
Psychosocial adaptation and cellular immunity in breast cancer patients in the weeks after surgery: An exploratory study.
Journal of psychosomatic research
Blomberg BB,Alvarez JP,Diaz A,Romero MG,Lechner SC,Carver CS,Holley H,Antoni MH
14-0037-82 was used in Functional assays to investigate the link between psychosocial adaptation and cellular immunity signalling cytokines in breast cancer patients.
Sun Nov 01 00:00:00 EDT 2009
LXR signaling couples sterol metabolism to proliferation in the acquired immune response.
Cell
Bensinger SJ,Bradley MN,Joseph SB,Zelcer N,Janssen EM,Hausner MA,Shih R,Parks JS,Edwards PA,Jamieson BD,Tontonoz P
14-0037 was used in Flow cytometry/Cell sorting to implicate LXR signaling in a metabolic checkpoint that modulates cell proliferation and immunity.
Fri Jul 11 00:00:00 EDT 2008
High TCL1 expression and intact T-cell receptor signaling define a hyperproliferative subset of T-cell prolymphocytic leukemia.
Blood
Herling M,Patel KA,Teitell MA,Konopleva M,Ravandi F,Kobayashi R,Jones D
14-0037 was used in Functional assays to investigate the role of TCL1 in prolymphocytic leukemia.
Tue Jan 01 00:00:00 EST 2008
PILAR is a novel modulator of human T-cell expansion.
Blood
Huarte E,Cubillos-Ruiz JR,Nesbeth YC,Scarlett UK,Martinez DG,Engle XA,Rigby WF,Pioli PA,Guyre PM,Conejo-Garcia JR
14-0037 was used in Flow cytometry/Cell sorting to identify a novel human transmembrane molecule expressed on T cells that enhances their expansion through CD161.
Fri Aug 15 00:00:00 EDT 2008
Establishment and characterization of a cell based artificial antigen-presenting cell for expansion and activation of CD8+ T cells ex vivo.
Cellular & molecular immunology
Gong W,Ji M,Cao Z,Wang L,Qian Y,Hu M,Qian L,Pan X
14-0037 was used in Functional assays to design an approach for the expansion and activation of CD8+ T cells which may have important therapeutic implications for adoptive immunotherapy.
Fri Feb 01 00:00:00 EST 2008
Establishment and characterization of a cell based artificial antigen-presenting cell for expansion and activation of CD8+ T cells ex vivo.
Cellular & molecular immunology
Gong W,Ji M,Cao Z,Wang L,Qian Y,Hu M,Qian L,Pan X
14-0037 was used in Functional assays to design an approach for the expansion and activation of CD8+ T cells which may have important therapeutic implications for adoptive immunotherapy.
Fri Feb 01 00:00:00 EST 2008
The blood-brain barrier induces differentiation of migrating monocytes into Th17-polarizing dendritic cells.
Brain : a journal of neurology
Ifergan I,Kébir H,Bernard M,Wosik K,Dodelet-Devillers A,Cayrol R,Arbour N,Prat A
14-0037 was used in an ELISA assay to provide evidence that functional perivascular myeloid CNS dendritic cells arise from the migration of CD14+ monocytes across the human blood-brain barrier.
Sat Mar 01 00:00:00 EST 2008
Enhanced functionality of CD4+CD25(high)FoxP3+ regulatory T cells in the peripheral blood of patients with prostate cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research
Yokokawa J,Cereda V,Remondo C,Gulley JL,Arlen PM,Schlom J,Tsang KY
14-0037 was used in Functional assays to compare the levels of Tregs in the peripheral blood of healthy donors and patients with various stages of prostate cancer.
Fri Feb 15 00:00:00 EST 2008
Cell-type-specific tyrosine phosphorylation of the herpes simplex virus tegument protein VP11/12 encoded by gene UL46.
Journal of virology
Zahariadis G,Wagner MJ,Doepker RC,Maciejko JM,Crider CM,Jerome KR,Smiley JR
14-0037 was used in Functional assays to show that HSV-inactivated NK-92 NK cells and Jurkat T cells contain a novel 90-kDa tyrosine-phosphorylated protein identified as the HSV tegument protein VP11/12.
Tue Jul 01 00:00:00 EDT 2008
Antigen presentation by human microvascular endothelial cells triggers ICAM-1-dependent transendothelial protrusion by, and fractalkine-dependent transendothelial migration of, effector memory CD4+ T cells.
Journal of immunology (Baltimore, Md. : 1950)
Manes TD,Pober JS
14-0037 was used in Functional assays to suggest that presentation of Ag by microvascular endothelial cells to circulating CD4(+) effector memory T cells may initiate recall responses in peripheral tissues.
Sun Jun 15 00:00:00 EDT 2008
Functional implications of plasma membrane condensation for T cell activation.
PloS one
Rentero C,Zech T,Quinn CM,Engelhardt K,Williamson D,Grewal T,Jessup W,Harder T,Gaus K
14-0037 was used in Functional assays to investigate the functional significance of plasma membrane condensation following T lymphocyte activation.
Wed May 28 00:00:00 EDT 2008
HIV-induced type I interferon and tryptophan catabolism drive T cell dysfunction despite phenotypic activation.
PloS one
Boasso A,Hardy AW,Anderson SA,Dolan MJ,Shearer GM
14-0037 was used in Functional assays to model HIV-induced T cell dysregulation in relation to the activation and inhibition of T cell proliferative capacity during HIV infection.
Wed Aug 13 00:00:00 EDT 2008
Dysfunctional CD4+,CD25+ regulatory T cells in untreated active systemic lupus erythematosus secondary to interferon-alpha-producing antigen-presenting cells.
Arthritis and rheumatism
Yan B,Ye S,Chen G,Kuang M,Shen N,Chen S
14-0037-82 was used in Functional assay to explore whether there are extrinsic factors that impair the suppressive function of CD4+,CD25+ regulatory T cells in patients with untreated active systemic lupus erythematosus.
Sat Mar 01 00:00:00 EST 2008
Mature antigen-experienced T helper cells synthesize and secrete the B cell chemoattractant CXCL13 in the inflammatory environment of the rheumatoid joint.
Arthritis and rheumatism
Manzo A,Vitolo B,Humby F,Caporali R,Jarrossay D,Dell'accio F,Ciardelli L,Uguccioni M,Montecucco C,Pitzalis C
14-0037-82 was used in Functional assay to investigate the functional involvement of synovial T cells in the ectopic expression of CXCL13 in rheumatoid arthritis.
Sat Nov 01 00:00:00 EDT 2008
Human IL4I1 is a secreted L-phenylalanine oxidase expressed by mature dendritic cells that inhibits T-lymphocyte proliferation.
Blood
Boulland ML,Marquet J,Molinier-Frenkel V,Möller P,Guiter C,Lasoudris F,Copie-Bergman C,Baia M,Gaulard P,Leroy K,Castellano F
14-0037 was used in Magnetic cell separation to characterise the biochemical properties and functions of the human and mouse interleukin-4-induced gene 1 (IL4I1) proteins.
Sun Jul 01 00:00:00 EDT 2007
Increased frequencies of CD4+ CD25(high) regulatory T cells in acute dengue infection.
The Journal of experimental medicine
Lühn K,Simmons CP,Moran E,Dung NT,Chau TN,Quyen NT,Thao le TT,Van Ngoc T,Dung NM,Wills B,Farrar J,McMichael AJ,Dong T,Rowland-Jones S
14-0037 was used in Flow cytometry/Cell sorting to investigate whether a defective population of Tregs can contribute to immunopathology in severe dengue disease.
Mon May 14 00:00:00 EDT 2007
General strategy for decoration of enveloped viruses with functionally active lipid-modified cytokines.
Journal of virology
Kueng HJ,Leb VM,Haiderer D,Raposo G,Thery C,Derdak SV,Schmetterer KG,Neunkirchner A,Sillaber C,Seed B,Pickl WF
14-0037 was used in Functional assays to address the feasibility of designing a system which predicts the decoration of enveloped viruses with functionally active lipid-modified cytokines.
Wed Aug 01 00:00:00 EDT 2007
The immunomodulatory Pseudomonas aeruginosa signalling molecule N-(3-oxododecanoyl)-L-homoserine lactone enters mammalian cells in an unregulated fashion.
Immunology and cell biology
Ritchie AJ,Whittall C,Lazenby JJ,Chhabra SR,Pritchard DI,Cooley MA
14-0037 was used in an ELISA assay to investigate how OdDHL enters mammalian cells by passive mechanisms, and that it does not preferentially associate with the membrane or nucleus upon T-cell receptor ligation.
Fri Feb 15 00:00:00 EST 2008
Beta-agonists modulate T-cell functions via direct actions on type 1 and type 2 cells.
Blood
Loza MJ,Foster S,Peters SP,Penn RB
14-0037 was used in Flow cytometry/Cell sorting to investigate the direct effects of beta2AR activation on T-cell subtypes and suggest a complex role for GPCRs and PKA activity in modulating T-cell functions.
Wed Mar 01 00:00:00 EST 2006
C1q and MBL, components of the innate immune system, influence monocyte cytokine expression.
Journal of leukocyte biology
Fraser DA,Bohlson SS,Jasinskiene N,Rawal N,Palmarini G,Ruiz S,Rochford R,Tenner AJ
14-0037 was used in Flow cytometry/Cell sorting to show that C1q and MBL modulate cytokine production at the mRNA and protein levels.
Sat Jul 01 00:00:00 EDT 2006
Lipid raft targeting of hematopoietic protein tyrosine phosphatase by protein kinase C theta-mediated phosphorylation.
Molecular and cellular biology
Nika K,Charvet C,Williams S,Tautz L,Bruckner S,Rahmouni S,Bottini N,Schoenberger SP,Baier G,Altman A,Mustelin T
14-0037 was used in Functional assays to describe a novel mechanism for the active immune synapse recruitment and activation of the hematopoietic protein tyrosine phosphatase by PKC Theta in TCR signaling.
Wed Mar 01 00:00:00 EST 2006
Between adaptive and innate immunity: TLR4-mediated perforin production by CD28null T-helper cells in ankylosing spondylitis.
Arthritis research & therapy
Raffeiner B,Dejaco C,Duftner C,Kullich W,Goldberger C,Vega SC,Keller M,Grubeck-Loebenstein B,Schirmer M
14-0037 was used in Functional assays to support the hypothesis that CD4+CD28null T cells represent an immunological link between the innate immune system and the adaptive immune system.
Tue Jan 10 00:00:00 EST 2006
IL-8 responsiveness defines a subset of CD8 T cells poised to kill.
Blood
Hess C,Means TK,Autissier P,Woodberry T,Altfeld M,Addo MM,Frahm N,Brander C,Walker BD,Luster AD
14-0037 was used in Flow cytometry/Cell sorting to investigate how CXCR1 identifies a subset of CD8 T cells poised for immediate cytotoxicity and early recruitment into sites of innate immune system activation.
Wed Dec 01 00:00:00 EST 2004
