Invitrogen

CD4 Monoclonal Antibody (RPA-T4), FITC, eBioscience™

高级验证

This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated.

47 篇参考文献

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说明书

实验方案

技术支持

说明书

实验方案

技术支持

抗体检测数据 (2)
高级验证 (1)

图: 1 / 3

CD4 Antibody (11-0049-42) in Flow

Staining of human peripheral blood mononuclear cells with CD45 Pacific Blue, CD3 APC, CD8 PerCP and CD4 FITC. As expected based on known relative expression patterns, CD4 clone RPA-T4 stains a subset of lymphocytes (pink) and monocytes (orange), but not granulocytes (blue).

Product Image Gallery

CD4 Antibody — Staining of human peripheral blood mononuclear cells with CD45 Pacific Blue, CD3 APC, CD8 PerCP and CD4 FITC. As expected based on known relative expression patterns, CD4 clone RPA-T4 stains a subset of lymphocytes (pink) and monocytes (orange), but not granulocytes (blue). {RE}

产品信息

11-0049-42

应用

建议稀释比

已发表文章

免疫组化 (IHC)

查看1篇已发表文章 1篇已发表文章

流式细胞分析 (Flow)

5 µL (1 µg)/test

查看46篇已发表文章 46篇已发表文章

产品规格

种属反应

Human

已发表种属

Human, Mouse

宿主/亚型

Mouse / IgG1, kappa

分类

Monoclonal

类型

Antibody

克隆号

RPA-T4

偶联物

FITC FITC FITC

激发/发射光谱

498/517 nm 查看光谱

形式

Liquid

浓度

5 µL/Test

纯化类型

Affinity chromatography

保存液

PBS, pH 7.2, with 0.2% BSA

内含物

0.09% sodium azide

保存条件

4° C, store in dark, DO NOT FREEZE!

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_1659694

产品详细信息

Description: The RPA-T4 monoclonal antibody reacts with human CD4, a 59 kDa cell surface receptor expressed by a majority of thymocytes, subpopulation of mature T cells (T-helper cells) and in low levels on monocytes. CD4 is a receptor for the human immunodeficiency virus (HIV). RPA-T4 blocks HIV binding and mixed lymphocyte reaction. The RPA-T4 antibody recognizes a different epitope than the OKT4 monoclonal antibody, and these antibodies do not cross-block binding to each other's respective epitopes.

Applications Reported: This RPA-T4 antibody has been reported for use in flow cytometric analysis.

Applications Tested: This RPA-T4 antibody has been pre-titrated and tested by flow cytometric analysis of normal human peripheral blood cells. This can be used at 5 µL (1 µg) per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test.

Excitation: 488 nm; Emission: 520 nm; Laser: Blue Laser.

Filtration: 0.2 µm post-manufacturing filtered.

靶标信息

The CD4 antigen is involved in the recognition of MHC class II molecules and is a co-receptor for HIV. CD4 is primarily expressed in a subset of T-lymphocytes, also referred to as T helper cells, but may also be expressed by other cells in the immune system, such as monocytes, macrophages, and dendritic cells. At the tissue level, CD4 expression may be detected in thymus, lymph nodes, tonsils, and spleen, and also in specific regions of the brain, gut, and other non-lymphoid tissues. CD4 functions to initiate or augment the early phase of T-cell activation through its association with the T-cell receptor complex and protein tyrosine kinase, Lck. It may also function as an important mediator of direct neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcripts have been identified in this gene [RefSeq, July 2017].

仅用于科研。不用于诊断过程。未经明确授权不得转售。

How to use the Panel Builder

Watch the video to learn how to use the Invitrogen Flow Cytometry Panel Builder to build your next flow cytometry panel in 5 easy steps.

Product References

WT1 Pulsed Human CD141+ Dendritic Cell Vaccine Has High Potential in Solid Tumor-Targeted Immunotherapy.

International journal of molecular sciences

Cho SY,Jeong SM,Jeon YJ,Yang SJ,Hwang JE,Yoo BM,Kim HS

11-0049-42 was used in Flow cytometry/Cell sorting to develop a DC vaccine named CellgramDC-WT1 (CDW).

Thu Jan 12 00:00:00 EST 2023

Pump-less, recirculating organ-on-a-chip (rOoC) platform.

Lab on a chip

Busek M,Aizenshtadt A,Koch T,Frank A,Delon L,Martinez MA,Golovin A,Dumas C,Stokowiec J,Gruenzner S,Melum E,Krauss S

11-0049-42 was used in Flow cytometry/Cell sorting to show the possibility to circulate immune cells in the microfluidic channels that retain viability without being trapped or activated.

Tue Feb 14 00:00:00 EST 2023

Plasmid-Based Donor Templates for Nonviral CRISPR/Cas9-Mediated Gene Knock-In in Human T Cells.

Current protocols

Senger K,Akhmetzyanova I,Haley B,Rutz S,Oh SA

11-0049-42 was used in Flow Cytometry /test) to report a simple and efficient method for nonviral CRISPR/Cas9-based gene knock-in utilizing plasmid-based donor DNA templates.

Thu Sep 01 00:00:00 EDT 2022

MBL Binding with AhR Controls Th17 Immunity in Silicosis-Associated Lung Inflammation and Fibrosis.

Journal of inflammation research

Liu Y,Zhao N,Xu Q,Deng F,Wang P,Dong L,Lu X,Xia L,Wang M,Chen Z,Zhou J,Zuo D

11-0049-42 was used in Flow cytometry/Cell sorting to suggest that MBL limited the Th17 immunity via controlling the AhR/STAT3 pathway, thus providing new insight into silicosis and other inflammatory diseases in patients with MBL deficiency.

Fri Aug 05 00:00:00 EDT 2022

The Composition of Adipose-Derived Regenerative Cells Isolated from Lipoaspirate Using a Point of Care System Does Not Depend on the Subject's Individual Age, Sex, Body Mass Index and Ethnicity.

Cells

Schmitz C,Alt C,Azares AR,Pearce DA,Facile TR,Furia JP,Maffulli N,Huang C,Alt EU

11-0049-42 was used in Flow cytometry/Cell sorting to show that key characteristics of unmodified, autologous, adipose-derived regenerative cells (UA-ADRCs) can be independent of the subject's age, sex, BMI and ethnicity.

Wed Dec 21 00:00:00 EST 2022

Soluble fibrinogen‑like protein 2 levels are decreased in patients with ischemic heart failure and associated with cardiac function.

Molecular medicine reports

You Y,Huang S,Liu H,Fan C,Liu K,Wang Z

11-0049-42 was used in Flow Cytometry to determine serum soluble fibrinogen‚like protein 2 levels in patients with ischemic heart failure.

Sun Aug 01 00:00:00 EDT 2021

Taurine promotes the production of CD4⁺CD25⁺FOXP3⁺ Treg cells through regulating IL-35/STAT1 pathway in a mouse allergic rhinitis model.

Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology

Zhou J,Lu Y,Wu W,Feng Y

11-0049-42 was used in Flow Cytometry to show that the restoration of Treg populations by taurine normalizes the inflammatory response, reduces AR symptomology, and reduces histopathologic signs of AR.

Sat Jun 19 00:00:00 EDT 2021

Propionic Acid Shapes the Multiple Sclerosis Disease Course by an Immunomodulatory Mechanism.

Cell

Duscha A,Gisevius B,Hirschberg S,Yissachar N,Stangl GI,Dawin E,Bader V,Haase S,Kaisler J,David C,Schneider R,Troisi R,Zent D,Hegelmaier T,Dokalis N,Gerstein S,Del Mare-Roumani S,Amidror S,Staszewski O,Poschmann G,Stühler K,Hirche F,Balogh A,Kempa S,Träger P,Zaiss MM,Holm JB,Massa MG,Nielsen HB,Faissner A,Lukas C,Gatermann SG,Scholz M,Przuntek H,Prinz M,Forslund SK,Winklhofer KF,Müller DN,Linker RA,Gold R,Haghikia A

11-0049 was used in Flow cytometry/Cell sorting to investigate propionic acid (PA) in multiple sclerosis (MS), an autoimmune and neurodegenerative disease.

Thu Mar 19 00:00:00 EDT 2020

γδ T-cell Receptors Derived from Breast Cancer-Infiltrating T Lymphocytes Mediate Antitumor Reactivity.

Cancer immunology research

Janssen A,Villacorta Hidalgo J,Beringer DX,van Dooremalen S,Fernando F,van Diest E,Terrizi AR,Bronsert P,Kock S,Schmitt-Gräff A,Werner M,Heise K,Follo M,Straetemans T,Sebestyen Z,Chudakov DM,Kasatskaya SA,Frenkel FE,Ravens S,Spierings E,Prinz I,Küppers R,Malkovsky M,Fisch P,Kuball J

11-0049 was used in Flow cytometry/Cell sorting to describe molecular and functional analyses of T-cell receptors from tumor-infiltrating T lymphocytes that were in direct contact with tumor cells in breast cancer lesions from archival material.

Wed Apr 01 00:00:00 EDT 2020

Aberrant Th2 Immune Responses Are Associated With a Reduced Frequency of IL-35-Induced Regulatory T Cells After Allergen Exposure in Patients With Allergic Asthma.

Allergy, asthma & immunology research

Wang W,Wei C,Cheng Z,Yang J

11-0049 was used in Flow cytometry/Cell sorting to investigate whether Interleukin (IL)-35-induced regulatory T cells involve in the immunoregulation of allergic asthmatic individuals after specific allergen exposure.

Sun Nov 01 00:00:00 EDT 2020

Selective Killing of Activated T Cells by 5-Aminolevulinic Acid Mediated Photodynamic Effect: Potential Improvement of Extracorporeal Photopheresis.

Cancers

Darvekar S,Juzenas P,Oksvold M,Kleinauskas A,Holien T,Christensen E,Stokke T,Sioud M,Peng Q

11-0049-42 was used in Flow Cytometry to explore the possibility of targeting activated human blood T cells ex vivo, using the concept of photodynamic therapy (PDT) with 5-aminolevulinic acid (ALA), a precursor of an endogenously synthesized photosensitizer protoporphyrin IX (PpIX) in combination with blue light.

Thu Feb 06 00:00:00 EST 2020

Immune characterization of metastatic colorectal cancer patients post reovirus administration.

BMC cancer

Parakrama R,Fogel E,Chandy C,Augustine T,Coffey M,Tesfa L,Goel S,Maitra R

11-0049 was used in Flow cytometry/Cell sorting to evaluate the nature of immune response by determining the cytokine expression pattern in peripheral circulation along with the distribution of antigen presenting cells (APCs) and activated T lymphocytes.

Thu Jun 18 00:00:00 EDT 2020

Immune Suppressive Effects of Plasma-Derived Exosome Populations in Head and Neck Cancer.

Cancers

Beccard IJ,Hofmann L,Schroeder JC,Ludwig S,Laban S,Brunner C,Lotfi R,Hoffmann TK,Jackson EK,Schuler PJ,Theodoraki MN

11-0049 was used in Flow cytometry/Cell sorting to show the potential role of exosomes as liquid biomarkers for disease stage and level of immune suppression.

Tue Jul 21 00:00:00 EDT 2020

Th2 Biased Immunity With Altered B Cell Profiles in Circulation of Patients With Sporotrichosis Caused by Sporothrix globosa.

Frontiers in immunology

Zu J,Yao L,Song Y,Cui Y,Guan M,Chen R,Zhen Y,Li S

11-0049 was used in Flow cytometry/Cell sorting to shed light on the potential involvement of peripheral T and B cell immunity against this mycotic infection.

Mon May 31 00:00:00 EDT 2021

Niraparib activates interferon signaling and potentiates anti-PD-1 antibody efficacy in tumor models.

Scientific reports

Wang Z,Sun K,Xiao Y,Feng B,Mikule K,Ma X,Feng N,Vellano CP,Federico L,Marszalek JR,Mills GB,Hanke J,Ramaswamy S,Wang J

11-0049 was used in Flow cytometry/Cell sorting to investigate the therapeutic potential of combining niraparib with anti-P-1 immune checkpoint inhibitors in preclinical tumour models.

Tue Feb 12 00:00:00 EST 2019

CD4⁺CD45RA^-FOXP3^low Regulatory T Cells as Potential Biomarkers of Disease Activity in Systemic Lupus Erythematosus Brazilian Patients.

BioMed research international

Silva-Neta HL,Brelaz-de-Castro MCA,Chagas MBO,Mariz HA,de Arruda RG,de Vasconcelos VF,Pereira MC,Romano A,Pitta IR,Marques CDL,Duarte ALBP,Rêgo MJBM,Pitta MGR

11-0049 was used in Flow cytometry/Cell sorting to demonstrate Foxp3+nontreg cells as new biomarkers in the search of an effective therapeutic strategy in SLE.

Fri Jan 11 00:00:00 EST 2019

Mesenchymal stromal cells from myelodysplastic and acute myeloid leukemia patients display in vitro reduced proliferative potential and similar capacity to support leukemia cell survival.

Stem cell research & therapy

Corradi G,Baldazzi C,Očadlíková D,Marconi G,Parisi S,Testoni N,Finelli C,Cavo M,Curti A,Ciciarello M

11-0049 was used in Flow cytometry/Cell sorting to compare mesenchymal stromal cells isolated from healthy, myelodysplastic syndrome, and acute myeloid leukaemia subjects to investigate MSC alterations and to emphasise putative common and/or diverse features.

Thu Oct 25 00:00:00 EDT 2018

PD1 is expressed on exhausted T cells as well as virus specific memory CD8+ T cells in the bone marrow of myeloma patients.

Oncotarget

Sponaas AM,Yang R,Rustad EH,Standal T,Thoresen AS,Dao Vo C,Waage A,Slørdahl TS,Børset M,Sundan A

11-0049 was used in Flow cytometry to study the expression of PD-1 on exhausted T cells as well as virus specific memory CD8+ T cells in the bone marrow of myeloma patients.

Fri Aug 10 00:00:00 EDT 2018

Comparison between 8-methoxypsoralen and 5-aminolevulinic acid in killing T cells of photopheresis patients ex vivo.

Lasers in surgery and medicine

Holien T,Gederaas OA,Darvekar SR,Christensen E,Peng Q

11-0049-42 was used in Flow cytometry/Cell sorting to suggest that 5-ALA/UV-A may have the potential for improving the efficacy of ECP.

Sun Jul 01 00:00:00 EDT 2018

ATP Release from Chemotherapy-Treated Dying Leukemia Cells Elicits an Immune Suppressive Effect by Increasing Regulatory T Cells and Tolerogenic Dendritic Cells.

Frontiers in immunology

Lecciso M,Ocadlikova D,Sangaletti S,Trabanelli S,De Marchi E,Orioli E,Pegoraro A,Portararo P,Jandus C,Bontadini A,Redavid A,Salvestrini V,Romero P,Colombo MP,Di Virgilio F,Cavo M,Adinolfi E,Curti A

11-0049 was used in Flow cytometry/Cell sorting to study the effect of ATP release in acute myeloid lymphoma on the generation of an immune suppressive microenvironment.

Thu Mar 31 00:00:00 EDT 2022

Tolerogenic dendritic cells generated with dexamethasone and vitamin D3 regulate rheumatoid arthritis CD4⁺ T cells partly via transforming growth factor-β1.

Clinical and experimental immunology

Anderson AE,Swan DJ,Wong OY,Buck M,Eltherington O,Harry RA,Patterson AM,Pratt AG,Reynolds G,Doran JP,Kirby JA,Isaacs JD,Hilkens CM

11-0049 was used in Flow cytometry/Cell sorting to establish a method to generate stable tolDC by pharmacological modulation of human monocyte-derived DC.

Sun Jan 01 00:00:00 EST 2017

Heterologous Immunity between Adenoviruses and Hepatitis C Virus: A New Paradigm in HCV Immunity and Vaccines.

PloS one

Singh S,Vedi S,Samrat SK,Li W,Kumar R,Agrawal B

11-0049 was used in Flow cytometry/Cell sorting to investigate the potential of a previously uncharacterized property of natural human adenovirus infection to dictate, modulate and/or alter the course of HCV infection upon exposure.

Tue Jul 19 00:00:00 EDT 2016

Pathological Roles of Interleukin-22 in the Development of Recurrent Hepatitis C after Liver Transplantation.

PloS one

Gao Y,Ren H,Meng F,Li J,Cheung E,Li H,Zhao J,Liu H,Liu Z,Zhang M

11-0049 was used in Flow cytometry/Cell sorting to investigate the role of interleukin-22-producing CD4 positive cells in the pathogenesis of Hepatitis C Virus recurrence after Orthotopic Liver Transplantation.

Fri Mar 24 00:00:00 EDT 2017

Antitumor immunity triggered by melphalan is potentiated by melanoma cell surface-associated calreticulin.

Cancer research

Dudek-Perić AM,Ferreira GB,Muchowicz A,Wouters J,Prada N,Martin S,Kiviluoto S,Winiarska M,Boon L,Mathieu C,van den Oord J,Stas M,Gougeon ML,Golab J,Garg AD,Agostinis P

11-0049 was used in Flow cytometry/Cell sorting to illustrate how melphalan triggers inflammatory cell death that can be leveraged by immunomodulators.

Wed Apr 15 00:00:00 EDT 2015

PD-1+Tim-3+ CD8+ T Lymphocytes Display Varied Degrees of Functional Exhaustion in Patients with Regionally Metastatic Differentiated Thyroid Cancer.

Cancer immunology research

Severson JJ,Serracino HS,Mateescu V,Raeburn CD,McIntyre RC,Sams SB,Haugen BR,French JD

11-0049 was used in Flow cytometry/Cell sorting to determine that the release of PD-1 and Tim-3, and the inhibition of Tregs, may encourage tumour elimination in metastatic differentiated thyroid cancer.

Mon Jun 01 00:00:00 EDT 2015

Levels and function of regulatory T cells in patients with polymorphic light eruption: relation to photohardening.

The British journal of dermatology

Schweintzger N,Gruber-Wackernagel A,Reginato E,Bambach I,Quehenberger F,Byrne SN,Wolf P

11-0049 was used in Flow cytometry/Cell sorting to investigate how a UV-induced increase in the number of Tregs may be a mechanism by which the immune system counteracts susceptibility to PLE.

Sat Aug 01 00:00:00 EDT 2015

CARD9-Dependent Neutrophil Recruitment Protects against Fungal Invasion of the Central Nervous System.

PLoS pathogens

Drummond RA,Collar AL,Swamydas M,Rodriguez CA,Lim JK,Mendez LM,Fink DL,Hsu AP,Zhai B,Karauzum H,Mikelis CM,Rose SR,Ferre EM,Yockey L,Lemberg K,Kuehn HS,Rosenzweig SD,Lin X,Chittiboina P,Datta SK,Belhorn TH,Weimer ET,Hernandez ML,Hohl TM,Kuhns DB,Lionakis MS

11-0049 was used in Flow cytometry/Cell sorting to highlight the role of CARD9-dependant neutrophil trafficking into the CNS and provide insight into the CNS fungal susceptibility of CARD9-deficient humans.

Tue Dec 01 00:00:00 EST 2015

The immunosuppressive enzyme IL4I1 promotes FoxP3(+) regulatory T lymphocyte differentiation.

European journal of immunology

Cousin C,Aubatin A,Le Gouvello S,Apetoh L,Castellano F,Molinier-Frenkel V

11-0049 was used in Flow cytometry/Cell sorting to study the effect of IL4I1 on naive CD4+ T cell differentiation.

Mon Jun 01 00:00:00 EDT 2015

Synovial Regulatory T Cells Occupy a Discrete TCR Niche in Human Arthritis and Require Local Signals To Stabilize FOXP3 Protein Expression.

Journal of immunology (Baltimore, Md. : 1950)

Bending D,Giannakopoulou E,Lom H,Wedderburn LR

11-0049 was used in Flow cytometry/Cell sorting to identify a unique population of Treg cells which arise from separate lineages to conventional T cells in response to chronic inflammatory conditions.

Tue Dec 15 00:00:00 EST 2015

Fractalkine receptor chemokine (CX3CR1) influences on cervical and lumbar disc herniation.

Indian journal of orthopaedics

Oh IS,Suh DW,Park SR,Ha KY

11-0049 was used in Flow cytometry/Cell sorting to clarify the role of CX3CL1 and CX3CR1 in spinal herniated nucleus pulposus.

Wed May 27 00:00:00 EDT 2015

Severe impairment of regulatory T-cells and Th1-lymphocyte polarization in patients with Gaucher disease.

JIMD reports

Sotiropoulos C,Theodorou G,Repa C,Marinakis T,Verigou E,Solomou E,Karakantza M,Symeonidis A

11-0049 was used in Flow cytometry/Cell sorting to investigate peripheral blood T-lymphocyte subpopulations and intracellular expression of various interleukins and interferons in type I Gaucher disease patients.

Tue Mar 17 00:00:00 EDT 2015

A phase I dose-escalation clinical trial of a peptide-based human papillomavirus therapeutic vaccine with Candida skin test reagent as a novel vaccine adjuvant for treating women with biopsy-proven cervical intraepithelial neoplasia 2/3.

Oncoimmunology

Greenfield WW,Stratton SL,Myrick RS,Vaughn R,Donnalley LM,Coleman HN,Mercado M,Moerman-Herzog AM,Spencer HJ,Andrews-Collins NR,Hitt WC,Low GM,Manning NA,McKelvey SS,Smith D,Smith MV,Phillips AM,Quick CM,Jeffus SK,Hutchins LF,Nakagawa M

11-0049 was used in Flow cytometry/Cell sorting to demonstrate the safety of a human papillomavirus therapeutic vaccine, PepCan.

Thu Oct 01 00:00:00 EDT 2015

The disturbance of TH17-Treg cell balance in adenomyosis.

Fertility and sterility

Gui T,Chen C,Zhang Z,Tang W,Qian R,Ma X,Cao P,Wan G

11-0049 was used in Flow cytometry/Cell sorting to investigate the balance between Treg and T(H)17 cells in peripheral blood and uteri of women with adenomyosis.

Sat Feb 01 00:00:00 EST 2014

Hypomethylation at the regulatory T cell-specific demethylated region in CD25hi T cells is decoupled from FOXP3 expression at the inflamed site in childhood arthritis.

Journal of immunology (Baltimore, Md. : 1950)

Bending D,Pesenacker AM,Ursu S,Wu Q,Lom H,Thirugnanabalan B,Wedderburn LR

11-0049 was used in Flow cytometry/Cell sorting to study dissociation of CD25 and FOXP3 in CD4+ T cells at the site of inflammation in patients with juvenile arthritis..

Mon Sep 15 00:00:00 EDT 2014

NOD-Rag2null IL-2Rγnull mice: an alternative to NOG mice for generation of humanized mice.

Experimental animals

Katano I,Ito R,Kamisako T,Eto T,Ogura T,Kawai K,Suemizu H,Takahashi T,Kawakami Y,Ito M

11-0049 was used in Flow cytometry/Cell sorting to evaluate the usefulness of NR2G mice as humanised mice by comparing human cell engraftment and differentiation among NOG, NR2G, and NOD-scid mice after HSC transplantation.

Mon Feb 09 00:00:00 EST 2015

Fully human antagonistic antibodies against CCR4 potently inhibit cell signaling and chemotaxis.

PloS one

Hagemann UB,Gunnarsson L,Géraudie S,Scheffler U,Griep RA,Reiersen H,Duncan AR,Kiprijanov SM

11-0049 was used in Flow cytometry/Cell sorting to demonstrate a significant survival benefit for animals treated with newly selected anti-CCR4 antibodies.

Fri Nov 13 00:00:00 EST 2015

Autologous Graft versus Host Disease: An Emerging Complication in Patients with Multiple Myeloma.

Bone marrow research

Batra A,Cottler-Fox M,Harville T,Rhodes-Clark BS,Makhoul I,Nakagawa M

11-0049 was used in Flow cytometry/Cell sorting to compare expression of cell surface molecules on hematopoietic progenitor cell products between healthy individuals and sufferers of autologous graft versus host disease.

Fri May 30 00:00:00 EDT 2014

ROS-induced autophagy in cancer cells assists in evasion from determinants of immunogenic cell death.

Autophagy

Garg AD,Dudek AM,Ferreira GB,Verfaillie T,Vandenabeele P,Krysko DV,Mathieu C,Agostinis P

11-0049 was used in Flow cytometry/Cell sorting to unravel a role for ROS-induced autophagy in weakening functional interaction between dying cancer cells and the immune system.

Sun Sep 01 00:00:00 EDT 2013

Ribavirin Does Not Impair the Suppressive Activity of Foxp3(+)CD4(+)CD25(+) Regulatory T Cells.

Immune network

Lee J,Choi YS,Shin EC

11-0049 was used in Flow cytometry/Cell sorting to demonstrate that ribavirin did not attenuate the suppressive activity of Foxp3(+)CD4(+)CD25(+) Treg cells.

Fri Feb 01 00:00:00 EST 2013

High CCR6/CCR7 expression and Foxp3+ Treg cell number are positively related to the progression of laryngeal squamous cell carcinoma.

Oncology reports

Chen B,Zhang D,Zhou J,Li Q,Zhou L,Li SM,Zhu L,Chou KY,Zhou L,Tao L,Lu LM

11-0049 was used in Flow cytometry/Cell sorting to evaluate the expression and clinical significance of CCR6, CCR7, their ligands and CD4+CD25+Foxp3+ regulatory T cells in LSCC and LNs.

Sun Sep 01 00:00:00 EDT 2013

Programmed death-1+ T cells and regulatory T cells are enriched in tumor-involved lymph nodes and associated with aggressive features in papillary thyroid cancer.

The Journal of clinical endocrinology and metabolism

French JD,Kotnis GR,Said S,Raeburn CD,McIntyre RC,Klopper JP,Haugen BR

11-0049 was used in Flow cytometry/Cell sorting to characterise the CD4(+) T cell response to metastatic PTC.

Fri Jun 01 00:00:00 EDT 2012

Antigen-specific IL-2 secretion correlates with NK cell responses after immunization of Tanzanian children with the RTS,S/AS01 malaria vaccine.

Journal of immunology (Baltimore, Md. : 1950)

Horowitz A,Hafalla JC,King E,Lusingu J,Dekker D,Leach A,Moris P,Cohen J,Vekemans J,Villafana T,Corran PH,Bejon P,Drakeley CJ,von Seidlein L,Riley EM

11-0049 was used in Flow cytometry/Cell sorting to analyse immune cell responses to RTS,S and P. falciparum circumsporozoite protein component antigens in Tanzanian children.

Tue May 15 00:00:00 EDT 2012

Anticardiac myosin immunity and chronic allograft vasculopathy in heart transplant recipients.

Journal of immunology (Baltimore, Md. : 1950)

Kalache S,Dinavahi R,Pinney S,Mehrotra A,Cunningham MW,Heeger PS

11-0049 was used in Flow cytometry/Cell sorting to investigate the pathogenesis of chronic allograft vasculopathy in heart transplant failure.

Fri Jul 15 00:00:00 EDT 2011

Lymphotoxin signals from positively selected thymocytes regulate the terminal differentiation of medullary thymic epithelial cells.

Journal of immunology (Baltimore, Md. : 1950)

White AJ,Nakamura K,Jenkinson WE,Saini M,Sinclair C,Seddon B,Narendran P,Pfeffer K,Nitta T,Takahama Y,Caamano JH,Lane PJ,Jenkinson EJ,Anderson G

11-0049 was used in Immunofluorescence to explore the mechanisms behind Aire(+) medullary thymic epithelial cell development.

Fri Oct 15 00:00:00 EDT 2010

Expression and function of PDCD1 at the human maternal-fetal interface.

Biology of reproduction

Taglauer ES,Trikhacheva AS,Slusser JG,Petroff MG

11-0049 was used in Flow cytometry/Cell sorting to examine whether human maternal T cells express PDCD1.

Mon Sep 01 00:00:00 EDT 2008

Shared MHC class II-dependent melanoma ribosomal protein L8 identified by phage display.

Cancer research

Swoboda RK,Somasundaram R,Caputo L,Ochoa EM,Gimotty PA,Marincola FM,Van Belle P,Barth S,Elder D,Guerry D,Czerniecki B,Schuchter L,Vonderheide RH,Herlyn D