Target of Interest
Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
产品信息
MA5-16990
产品规格
种属反应
Dog
宿主/亚型
Rat
/ IgG1/IgG2a
分类
Cocktail
类型
Antibody
克隆号
YKIX302.9/YCATE55.9
抗原
Canine Concanavilin A activated T-cell blasts, Canine CD8 alpha chimaeric human IgG1 Fc fusion protein.
偶联物
FITC , PE
形式
Lyophilized
浓度
Conc. Not Determined
纯化类型
purified
保存液
PBS with 1% BSA, 5% sucrose
内含物
0.09% sodium azide
保存条件
4°C, store in dark, DO NOT FREEZE!
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2538463
产品详细信息
MA5-16990 contains a monoclonal mixture of FITC-conjugated CD4 (clone #YKIX 302.9, Rat IgG2a) and RPE-conjugated CD8 (clone #YCATE 55.9, Rat IgG1). This antibody is a dual-color reagent recognizing canine CD4 and CD8 cell surface antigens. Clone YKIX 302.9 recognizes canine CD4, which is expressed by lymphocyte subsets and canine neutrophils. Clone YCATE 55.9 recognizes CD8 alpha, which is expressed by cytotoxic T cells.
Reconstitute with 1 mL of distilled water. After reconstitution, store product undiluted at 4ºC in the dark.
For FACS analysis, use 10 µL of the suggested working dilution to label 1x10^6 cells in 100 µL.
靶标信息
CD4, a single chain transmembrane glycoprotein, is found on a T cell subset (helper/inducer) representing 45% of peripheral blood lymphocytes. It is also present on 80% of thymocytes and at a lower level on monocytes. It is involved in recognition of antigen presented along with MHC class II by APCs. It serves as receptor for HIV. The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen acts as a corepressor with the T-cell receptor on the T lymphocyte to recognize antigens displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. The coreceptor functions as either a homodimer composed of two alpha chains, or as a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
篇参考文献 (0)
您是否在文献中引用过该产品？请点击下方按钮邮件告知我们。
生物信息学
蛋白别名: CD4; CD4 antigen (p55); CD4 antigen p55; CD8 antigen, alpha polypeptide (p32); CD8a; CD8alpha; CD8beta; Leu-2; T-cell surface antigen T4/Leu-3; T-cell surface glycoprotein CD4; T-cell surface glycoprotein CD8 alpha chain
基因别名: CD4; CD8A
UniProt ID: (Dog) P33705, (Dog) P33706
Entrez Gene ID: (Dog) 403931, (Dog) 403157, (Dog) 483076
