Invitrogen

CD41 Monoclonal Antibody (VIPL3), PE

产品信息

MHCD4104

应用

建议稀释比

已发表文章

免疫细胞化学 (ICC/IF)

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流式细胞分析 (Flow)

Assay-Dependent

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产品规格

种属反应

Human

已发表种属

Hamster, Human

宿主/亚型

Mouse / IgG1

分类

Monoclonal

类型

Antibody

克隆号

VIPL3

抗原

Human CD41

偶联物

PE PE PE

激发/发射光谱

565/576 nm 查看光谱

形式

Liquid

纯化类型

purified

保存液

PBS with 4mg/mL BSA

内含物

0.1% sodium azide

保存条件

4° C, store in dark

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_10372510

产品详细信息

R-phycoerythrin (PE) is a stable and highly soluble phycobiliprotein which provides maximal absorbance and fluorescence without susceptibility to internal or external fluorescence quenching, thus providing an exceptional quantum yields and molar extinction coefficients.

靶标信息

CD41 (platelet glycoprotein IIb, ITGA2B) is composed of two subunits -120 kDa a, alpha and 23 kDa b, beta- that interact with CD61 in the presence of calcium to form a functional adhesive protein receptor. CD41 is also involved in blood coagulation by mediating platelet aggregation. Upon blood vessel damage, CD41 binds to a variety of proteins including von Willebrand factor, fibrinogen, fibronectin and vitronectin. CD41 is mainly expressed on megakaryocyte-platelet lineage, but generally belongs to the antigens that are expressed during the early stages of hematopoietic differentiation. Diseases associated with CD41 dysfunction include Glansmann Thrombasthenia, and Platelet type-16 bleeding disorder.

Analyte Specific Reagent

How to use the Panel Builder

Watch the video to learn how to use the Invitrogen Flow Cytometry Panel Builder to build your next flow cytometry panel in 5 easy steps.

Product References

Peristaltic on-chip pump for tunable media circulation and whole blood perfusion in PDMS-free organ-on-chip and Organ-Disc systems.

Lab on a chip

Schneider S,Bubeck M,Rogal J,Weener HJ,Rojas C,Weiss M,Heymann M,van der Meer AD,Loskill P

MHCD4104 was used in Immunocytochemistry-immunoflourescence to present an on-chip pump for Organ-on-chip and Organ-Disc systems, to perfuse media without external pumps or tubing.

Tue Oct 12 00:00:00 EDT 2021

The Phosphatidylinositol 3,4,5-trisphosphate (PI(3,4,5)P3) Binder Rasa3 Regulates Phosphoinositide 3-kinase (PI3K)-dependent Integrin αIIbβ3 Outside-in Signaling.

The Journal of biological chemistry

Battram AM,Durrant TN,Agbani EO,Heesom KJ,Paul DS,Piatt R,Poole AW,Cullen PJ,Bergmeier W,Moore SF,Hers I

MHCD4104 was used in Flow Cytometry to identify Ras/Rap1GAP Rasa3 as a major phosphatidylinositol 3,4,5-trisphosphate-binding protein in human platelets, and a key regulator of integrin αIIbβ3 outside-in signalling.

Fri Feb 03 00:00:00 EST 2017

Case study interpretation: Report from the ICCS Annual Meeting, Seattle, 2014.

Cytometry. Part B, Clinical cytometry

Fromm JR,Tagliente DJ,Shaver AC,Neppalli V,Craig FE

MHCD4104 was used in flow cytometry to discuss how to diagnosis hematolymphoid neoplasms using flow cytometry.

Wed Aug 31 00:00:00 EDT 2016

生物信息学

蛋白别名: alphaIIb protein; CD41; form 1; form 2; GPalpha IIb; GPIIb; Integrin alpha-IIb; integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41); platelet fibrinogen receptor, alpha subunit; platelet glycoprotein IIb of IIb/IIIa complex; Platelet membrane glycoprotein IIb; platelet-specific antigen BAK; protein phosphatase 1, regulatory subunit 93

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基因别名: BDPLT16; BDPLT2; CD41; CD41B; GP2B; GPIIb; GT; GTA; HPA3; ITGA2B; ITGAB; PPP1R93

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UniProt ID: (Human) P08514

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Entrez Gene ID: (Human) 3674

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功能

protein binding identical protein binding metal ion binding extracellular matrix binding fibrinogen binding integrin

参与通路

platelet degranulation positive regulation of leukocyte migration cell adhesion cell-matrix adhesion integrin-mediated signaling pathway extracellular matrix organization platelet aggregation