Product References
Platelet factors attenuate inflammation and rescue cognition in ageing.
Nature
Schroer AB,Ventura PB,Sucharov J,Misra R,Chui MKK,Bieri G,Horowitz AM,Smith LK,Encabo K,Tenggara I,Couthouis J,Gross JD,Chan JM,Luke A,Villeda SA
Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry
Tue Aug 01 00:00:00 EDT 2023
TGF-β in the microenvironment induces a physiologically occurring immune-suppressive senescent state.
Cell reports
Matsuda S,Revandkar A,Dubash TD,Ravi A,Wittner BS,Lin M,Morris R,Burr R,Guo H,Seeger K,Szabolcs A,Che D,Nieman L,Getz GA,Ting DT,Lawrence MS,Gainor J,Haber DA,Maheswaran S
17-0452-82 was used in Flow Cytometry to investigate whether TGF-β in the hypoxic tumor microenvironment (TME) induces senescence in cancer and how the ensuing senescence-associated secretory phenotype (SASP) remodels the cellular TME to influence immune checkpoint inhibitor (ICI) responses.
Tue Mar 28 00:00:00 EDT 2023
Inactivation of p53 provides a competitive advantage to del(5q) myelodysplastic syndrome hematopoietic stem cells during inflammation.
Haematologica
Muto T,Walker CS,Agarwal P,Vick E,Sampson A,Choi K,Niederkorn M,Ishikawa C,Hueneman K,Varney M,Starczynowski DT
17-0452-82 was used in Flow cytometry/Cell sorting to investigate the effects of inflammation on hematopoietic stem and progenitor cells (HSPC) in the context of myelodysplastic syndromes (MDS), particularly the del(5q) subtype.
Sun Oct 01 00:00:00 EDT 2023
RIPK3 and caspase 8 collaborate to limit herpes simplex encephalitis.
PLoS pathogens
Guo H,Koehler HS,Mocarski ES,Dix RD
17-0452-82 was used in Flow cytometry/Cell sorting to show that kinase-independent induction of inflammation by RIPK3 in collaboration with caspase 8 restricts virus replication within the brain during HSE neuropathogenesis.
Thu Sep 01 00:00:00 EDT 2022
Transient expansion and myofibroblast conversion of adipogenic lineage precursors mediate bone marrow repair after radiation.
JCI insight
Zhong L,Yao L,Holdreith N,Yu W,Gui T,Miao Z,Elkaim Y,Li M,Gong Y,Pacifici M,Maity A,Busch TM,Joeng KS,Cengel K,Seale P,Tong W,Qin L
Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry
Fri Apr 08 00:00:00 EDT 2022
Lenvatinib for effectively treating antiangiogenic drug-resistant nasopharyngeal carcinoma.
Cell death & disease
Sun Q,Wang Y,Ji H,Sun X,Xie S,Chen L,Li S,Zeng W,Chen R,Tang Q,Zuo J,Hou L,Hosaka K,Lu Y,Liu Y,Ye Y,Yang Y
Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry
Fri Aug 19 00:00:00 EDT 2022
Tet-mediated DNA demethylation regulates specification of hematopoietic stem and progenitor cells during mammalian embryogenesis.
Science advances
Ma L,Tang Q,Gao X,Lee J,Lei R,Suzuki M,Zheng D,Ito K,Frenette PS,Dawlaty MM
Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry
Fri Mar 04 00:00:00 EST 2022
Self-Assembly of Immune Signals to Program Innate Immunity through Rational Adjuvant Design.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Bookstaver ML,Zeng Q,Oakes RS,Kapnick SM,Saxena V,Edwards C,Venkataraman N,Black SK,Zeng X,Froimchuk E,Gebhardt T,Bromberg JS,Jewell CM
17-0452-82 was used in Immunohistochemistry to show activating multiple innate immune pathways drives robust responses in infection and cancer.
Mon Nov 14 00:00:00 EST 2022
Keratinocyte-derived defensins activate neutrophil-specific receptors Mrgpra2a/b to prevent skin dysbiosis and bacterial infection.
Immunity
Dong X,Limjunyawong N,Sypek EI,Wang G,Ortines RV,Youn C,Alphonse MP,Dikeman D,Wang Y,Lay M,Kothari R,Vasavda C,Pundir P,Goff L,Miller LS,Lu W,Garza LA,Kim BS,Archer NK,Dong X
17-0452-82 was used in Flow Cytometry to demonstrate the importance of epithelial-neutrophil signaling via the defensin-Mrgpra2 axis in maintaining healthy skin ecology and promoting antibacterial host defense.
Tue Sep 13 00:00:00 EDT 2022
Sphk2 deletion is involved in structural abnormalities and Th17 response but does not aggravate colon inflammation induced by sub-chronic stress.
Scientific reports
Martín-Hernández D,Gutiérrez IL,González-Prieto M,MacDowell KS,Robledo-Montaña J,Tendilla-Beltrán H,Calleja-Rodríguez N,Bris ÁG,Ulecia-Morón C,Moreno B,Caso JR,García-Bueno B,Rodrigues-Mascarenhas S,Marín-Jiménez I,Leza JC,Menchén L
Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry
Tue Mar 08 00:00:00 EST 2022
B cells imprint adoptively transferred CD8+ T cells with enhanced tumor immunity.
Journal for immunotherapy of cancer
Smith AS,Knochelmann HM,Wyatt MM,Rangel Rivera GO,Rivera-Reyes AM,Dwyer CJ,Ware MB,Cole AC,Neskey DM,Rubinstein MP,Liu B,Thaxton JE,Bartee E,Paulos CM
17-0452-82 was used in Flow cytometry/Cell sorting to investigate how tumor-specific murine CD8+ T cells and human tumor infiltrating lymphocytes (TILs) are impacted when expanded ex vivo with the TLR9 agonist CpG.
Sat Jan 01 00:00:00 EST 2022
TRAF6 functions as a tumor suppressor in myeloid malignancies by directly targeting MYC oncogenic activity.
Cell stem cell
Muto T,Guillamot M,Yeung J,Fang J,Bennett J,Nadorp B,Lasry A,Redondo LZ,Choi K,Gong Y,Walker CS,Hueneman K,Bolanos LC,Barreyro L,Lee LH,Greis KD,Vasyliev N,Khodadadi-Jamayran A,Nudler E,Lujambio A,Lowe SW,Aifantis I,Starczynowski DT
17-0452-82 was used in Flow cytometry/Cell sorting to identify signaling states that cooperate with pre-leukemic cells and, notably, the study aimed to uncover the role of the ubiquitin ligase TRAF6 in preventing the transition from a pre-leukemic stage to overt myeloid leukemia by regulating MYC through ubiquitination and acetylation mechanisms.
Thu Feb 03 00:00:00 EST 2022
Aged hematopoietic stem cells are refractory to bloodborne systemic rejuvenation interventions.
The Journal of experimental medicine
Ho TT,Dellorusso PV,Verovskaya EV,Bakker ST,Flach J,Smith LK,Ventura PB,Lansinger OM,Hérault A,Zhang SY,Kang YA,Mitchell CA,Villeda SA,Passegué E
Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry
Mon Jul 05 00:00:00 EDT 2021
Stromal SOX2 Upregulation Promotes Tumorigenesis through the Generation of a SFRP1/2-Expressing Cancer-Associated Fibroblast Population.
Developmental cell
Kasashima H,Duran A,Martinez-Ordoñez A,Nakanishi Y,Kinoshita H,Linares JF,Reina-Campos M,Kudo Y,L'Hermitte A,Yashiro M,Ohira M,Bao F,Tauriello DVF,Batlle E,Diaz-Meco MT,Moscat J
17-0452-82 was used in Immunohistochemistry to explore the transcriptional mechanisms regulating cancer-associated fibroblasts in promoting tumour malignancy.
Mon Jan 11 00:00:00 EST 2021
A rapid CRISPR competitive assay for in vitro and in vivo discovery of potential drug targets affecting the hematopoietic system.
Computational and structural biotechnology journal
Shen Y,Jiang L,Iyer VS,Raposo B,Dubnovitsky A,Boddul SV,Kasza Z,Wermeling F
Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry
Wed Nov 10 00:00:00 EST 2021
Defining the Mechanistic Correlates of Protection Conferred by Whole-Cell Vaccination against Pseudomonas aeruginosa Acute Murine Pneumonia.
Infection and immunity
Sen-Kilic E,Blackwood CB,Huckaby AB,Horspool AM,Weaver KL,Malkowski AC,Witt WT,Bevere JR,Damron FH,Barbier M
Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry
Tue Jan 19 00:00:00 EST 2021
Polyvinyl alcohol hydrolysis rate and molecular weight influence human and murine HSC activity ex vivo.
Stem cell research
Sudo K,Yamazaki S,Wilkinson AC,Nakauchi H,Nakamura Y
Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry
Fri Oct 01 00:00:00 EDT 2021
Impaired HA-specific T follicular helper cell and antibody responses to influenza vaccination are linked to inflammation in humans.
eLife
Hill DL,Whyte CE,Innocentin S,Lee JL,Dooley J,Wang J,James EA,Lee JC,Kwok WW,Zand MS,Liston A,Carr EJ,Linterman MA
Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry
Tue Nov 02 00:00:00 EDT 2021
Metabolic preconditioning in CD4+ T cells restores inducible immune tolerance in lupus-prone mice.
JCI insight
Wilson CS,Stocks BT,Hoopes EM,Rhoads JP,McNew KL,Major AS,Moore DJ
Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry
Fri Oct 08 00:00:00 EDT 2021
The folate cycle enzyme MTHFD2 induces cancer immune evasion through PD-L1 up-regulation.
Nature communications
Shang M,Yang H,Yang R,Chen T,Fu Y,Li Y,Fang X,Zhang K,Zhang J,Li H,Cao X,Gu J,Xiao J,Zhang Q,Liu X,Yu Q,Wang T
Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry
Mon Mar 29 00:00:00 EDT 2021
Type 2 diabetic mice enter a state of spontaneous hibernation-like suspended animation following accumulation of uric acid.
The Journal of biological chemistry
Zhao Y,Cheng R,Zhao Y,Ge W,Yang Y,Ding Z,Xu X,Wang Z,Wu Z,Zhang J
Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry
Fri Oct 01 00:00:00 EDT 2021
Targeting Ovarian Carcinoma with TSP-1:CD47 Antagonist TAX2 Activates Anti-Tumor Immunity.
Cancers
Jeanne A,Sarazin T,Charlé M,Moali C,Fichel C,Boulagnon-Rombi C,Callewaert M,Andry MC,Diesis E,Delolme F,Rioult D,Dedieu S
Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Immunohistochemistry
Thu Oct 07 00:00:00 EDT 2021
Cell-permeable transgelin-2 as a potent therapeutic for dendritic cell-based cancer immunotherapy.
Journal of hematology & oncology
Kim HR,Park JS,Park JH,Yasmin F,Kim CH,Oh SK,Chung IJ,Jun CD
17-0452 was used in Flow cytometry/Cell sorting to indicate that cell-permeable transgelin-2 have a potential clinical value as a cancer immunotherapy based on DCs.
Wed Mar 17 00:00:00 EDT 2021
TNFRSF13B genotypes control immune-mediated pathology by regulating the functions of innate B cells.
JCI insight
de Mattos Barbosa MG,Lefferts AR,Huynh D,Liu H,Zhang Y,Fu B,Barnes J,Samaniego M,Bram RJ,Geha RS,Shikanov A,Prak ETL,Farkash EA,Platt JL,Cascalho M
17-0452-82 was used in Flow Cytometry to conclude that the wide variation in inflammatory reactions associated with TNFRSF13B diversity suggests polymorphisms could underlie variation in host defense and explosive inflammatory responses that sometimes enhance morbidity associated with immune responses.
Wed Sep 08 00:00:00 EDT 2021
Myeloid cell subsets that express latency-associated peptide promote cancer growth by modulating T cells.
iScience
Gabriely G,Ma D,Siddiqui S,Sun L,Skillin NP,Abou-El-Hassan H,Moreira TG,Donnelly D,da Cunha AP,Fujiwara M,Walton LR,Patel A,Krishnan R,Levine SS,Healy BC,Rezende RM,Murugaiyan G,Weiner HL
17-0452-82 was used in Flow cytometry/Cell sorting to identify a previously unknown function by which LAPHi MCs promote tumor growth and offer therapeutic intervention to target these cells in cancer.
Fri Nov 19 00:00:00 EST 2021
SARS-CoV-2 mRNA Vaccines Foster Potent Antigen-Specific Germinal Center Responses Associated with Neutralizing Antibody Generation.
Immunity
Lederer K,Castaño D,Gómez Atria D,Oguin TH,Wang S,Manzoni TB,Muramatsu H,Hogan MJ,Amanat F,Cherubin P,Lundgreen KA,Tam YK,Fan SHY,Eisenlohr LC,Maillard I,Weissman D,Bates P,Krammer F,Sempowski GD,Pardi N,Locci M
Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry
Tue Dec 15 00:00:00 EST 2020
Adaptive response to inflammation contributes to sustained myelopoiesis and confers a competitive advantage in myelodysplastic syndrome HSCs.
Nature immunology
Muto T,Walker CS,Choi K,Hueneman K,Smith MA,Gul Z,Garcia-Manero G,Ma A,Zheng Y,Starczynowski DT
17-0452 was used in Flow cytometry/Cell sorting to show that chronic inflammation is a determinant for the competitive advantage of myelodysplastic syndrome (MDS) hematopoietic stem and progenitor cells (HSPCs) and for disease progression.
Fri May 01 00:00:00 EDT 2020
Deregulated Notch and Wnt signaling activates early-stage myeloid regeneration pathways in leukemia.
The Journal of experimental medicine
Kang YA,Pietras EM,Passegué E
Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry
Mon Mar 02 00:00:00 EST 2020
Reprogrammed mRNA translation drives resistance to therapeutic targeting of ribosome biogenesis.
The EMBO journal
Kusnadi EP,Trigos AS,Cullinane C,Goode DL,Larsson O,Devlin JR,Chan KT,De Souza DP,McConville MJ,McArthur GA,Thomas G,Sanij E,Poortinga G,Hannan RD,Hannan KM,Kang J,Pearson RB
17-0452 was used in Flow cytometry/Cell sorting to identify key molecular mechanisms underpinning the response of blood cancers to selective inhibition of ribosome biogenesis and define metabolic vulnerabilities that will facilitate the rational design of more effective regimens for Pol I-directed therapies.
Mon Nov 02 00:00:00 EST 2020
MOSPD2 is a therapeutic target for the treatment of CNS inflammation.
Clinical and experimental immunology
Yacov N,Kafri P,Salem Y,Propheta-Meiran O,Feldman B,Breitbart E,Mendel I
17-0452 was used in Flow cytometry/Cell sorting to study the therapeutic potential of MOSPD2 in central nervous system disease.
Sat Aug 01 00:00:00 EDT 2020
High-fat diet induced central adiposity (visceral fat) is associated with increased fibrosis and decreased immune cellularity of the mesenteric lymph node in mice.
European journal of nutrition
Magnuson AM,Regan DP,Booth AD,Fouts JK,Solt CM,Hill JL,Dow SW,Foster MT
17-0452-82 was used in Flow Cytometry to investigate if lymph nodes are inherently distinct and differentially respond to diet-induced obesity much like the adipose depots they reside in.
Mon Jun 01 00:00:00 EDT 2020
Generation and characterization of the Eµ-Irf8 mouse model.
Cancer genetics
Qiu Z,Holder KN,Lin AP,Myers J,Jiang S,Gorena KM,Kinney MC,Aguiar RCT
17-0452-82 was used in Flow Cytometry to investigate the role of IRF8 in B- cell lymphoma biology using a transgenic mouse model.
Wed Jul 01 00:00:00 EDT 2020
The lysophospholipase D enzyme Gdpd3 is required to maintain chronic myelogenous leukaemia stem cells.
Nature communications
Naka K,Ochiai R,Matsubara E,Kondo C,Yang KM,Hoshii T,Araki M,Araki K,Sotomaru Y,Sasaki K,Mitani K,Kim DW,Ooshima A,Kim SJ
Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry
Thu Sep 17 00:00:00 EDT 2020
Myeloid Cell CK2 Regulates Inflammation and Resistance to Bacterial Infection.
Frontiers in immunology
Larson SR,Bortell N,Illies A,Crisler WJ,Matsuda JL,Lenz LL
Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry
Tue Jul 27 00:00:00 EDT 2021
Shp1 Loss Enhances Macrophage Effector Function and Promotes Anti-Tumor Immunity.
Frontiers in immunology
Myers DR,Abram CL,Wildes D,Belwafa A,Welsh AMN,Schulze CJ,Choy TJ,Nguyen T,Omaque N,Hu Y,Singh M,Hansen R,Goldsmith MA,Quintana E,Smith JAM,Lowell CA
Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry
Mon Jun 14 00:00:00 EDT 2021
G protein-coupled receptor 68 increases the number of B lymphocytes.
American journal of blood research
He X,Feng S,Hawkins C,Lawley L,Fan W,Xu Y,Zha XM,Fang J
17-0452 was used in Flow cytometry/Cell sorting to indicate that Gpr68 expression is upregulated in hematopoietic cells upon aging and during hematopoietic regeneration that ends up with increased number of B lymphocytes.
Mon Sep 28 00:00:00 EDT 2020
Analysis of Myeloid Cells in Mouse Tissues with Flow Cytometry.
STAR protocols
Liu Z,Gu Y,Shin A,Zhang S,Ginhoux F
Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry
Fri Jun 19 00:00:00 EDT 2020
TNFAIP3 Plays a Role in Aging of the Hematopoietic System.
Frontiers in immunology
Smith MA,Culver-Cochran AE,Adelman ER,Rhyasen GW,Ma A,Figueroa ME,Starczynowski DT
17-0452-82 was used in Flow Cytometry to find that the expression of A20 is significantly reduced in aged hematopoietic stem and progenitor cells (HSPC) as compared to young HSPC.
Wed Apr 28 00:00:00 EDT 2021
Modest Declines in Proteome Quality Impair Hematopoietic Stem Cell Self-Renewal.
Cell reports
Hidalgo San Jose L,Sunshine MJ,Dillingham CH,Chua BA,Kruta M,Hong Y,Hatters DM,Signer RAJ
17-0452 was used in Flow cytometry/Cell sorting to show that hematopoietic stem cells (HSCs) are dependent on low protein synthesis to maintain proteostasis, which promotes their self-renewal.
Tue Jan 07 00:00:00 EST 2020
Glucocorticoids Promote the Onset of Acute Experimental Colitis and Cancer by Upregulating mTOR Signaling in Intestinal Epithelial Cells.
Cancers
Zhang Z,Dong L,Jia A,Chen X,Yang Q,Wang Y,Wang Y,Liu R,Cao Y,He Y,Bi Y,Liu G
17-0452 was used in Flow cytometry/Cell sorting to indicate that glucocorticoid-induced mTOR signaling in epithelial cells is required in the early stages of acute ulcerative colitis by modulating the dynamics of innate immune cell recruitment and activation.
Sat Apr 11 00:00:00 EDT 2020
Diverse CD8 T Cell Responses to Viral Infection Revealed by the Collaborative Cross.
Cell reports
Martin MD,Sompallae R,Winborn CS,Harty JT,Badovinac VP
17-0452 was used in Flow cytometry/Cell sorting to advance the utility of the Collaborative Cross (CC) as a tool to analyze the immune response to viral infection.
Tue Apr 14 00:00:00 EDT 2020
Retroviral Overexpression of CXCR4 on Murine B-1a Cells and Adoptive Transfer for Targeted B-1a Cell Migration to the Bone Marrow and IgM Production.
Journal of visualized experiments : JoVE
Upadhye A,Marshall M,Garmey JC,Bender TP,McNamara C
17-0452 was used in Flow cytometry/Cell sorting to describe a method to target B-1a cell migration to the bone marrow by retroviral-mediated overexpression of the C-X-C motif chemokine receptor 4 (CXCR4).
Sun May 31 00:00:00 EDT 2020
Crucial Roles of the RIP Homotypic Interaction Motifs of RIPK3 in RIPK1-Dependent Cell Death and Lymphoproliferative Disease.
Cell reports
Zhang H,Wu X,Li X,Li M,Li F,Wang L,Zhang X,Zhang Y,Luo Y,Wang H,Jiang Y,Zhang H
17-0452 was used in Flow cytometry/Cell sorting to reveal a previously unidentified physiological function of RHIM of RIPK3 in regulating RIPK1-dependent cell death and lymphoproliferative disease.
Tue May 19 00:00:00 EDT 2020
Id1 and Id3 Maintain Steady-State Hematopoiesis by Promoting Sinusoidal Endothelial Cell Survival and Regeneration.
Cell reports
Gadomski S,Singh SK,Singh S,Sarkar T,Klarmann KD,Berenschot M,Seaman S,Jakubison B,Gudmundsson KO,Lockett S,Keller JR
17-0452 was used in Flow cytometry/Cell sorting to investigate the effects of loss of ld genes on adult endothelial cell.
Tue Apr 28 00:00:00 EDT 2020
Targeted selection of HIV-specific antibody mutations by engineering B cell maturation.
Science (New York, N.Y.)
Saunders KO,Wiehe K,Tian M,Acharya P,Bradley T,Alam SM,Go EP,Scearce R,Sutherland L,Henderson R,Hsu AL,Borgnia MJ,Chen H,Lu X,Wu NR,Watts B,Jiang C,Easterhoff D,Cheng HL,McGovern K,Waddicor P,Chapdelaine-Williams A,Eaton A,Zhang J,Rountree W,Verkoczy L,Tomai M,Lewis MG,Desaire HR,Edwards RJ,Cain DW,Bonsignori M,Montefiori D,Alt FW,Haynes BF
17-0452-82 was used in Flow Cytometry to study the efficacy of vaccinations with immunogens which bind to bnAb B cell precursors in initiating bnAB B cell development.
Fri Dec 06 00:00:00 EST 2019
Ptpn21 Controls Hematopoietic Stem Cell Homeostasis and Biomechanics.
Cell stem cell
Ni F,Yu WM,Wang X,Fay ME,Young KM,Qiu Y,Lam WA,Sulchek TA,Cheng T,Scadden DT,Qu CK
17-0452 was used in Flow cytometry/Cell sorting to show that Ptpn21 maintains cellular mechanics, which is correlated with its important functions in HSC niche retention and preservation of hematopoietic regeneration capacity.
Thu Apr 04 00:00:00 EDT 2019
Cohesin-mediated NF-κB signaling limits hematopoietic stem cell self-renewal in aging and inflammation.
The Journal of experimental medicine
Chen Z,Amro EM,Becker F,Hölzer M,Rasa SMM,Njeru SN,Han B,Di Sanzo S,Chen Y,Tang D,Tao S,Haenold R,Groth M,Romanov VS,Kirkpatrick JM,Kraus JM,Kestler HA,Marz M,Ori A,Neri F,Morita Y,Rudolph KL
17-0452 was used in Flow cytometry/Cell sorting to determine hematopoietic stem cell function is limited by Rad21/cohesin-mediated NF-kB signaling during aging.
Mon Jan 07 00:00:00 EST 2019
Tpl2 Protects Against Fulminant Hepatitis Through Mobilization of Myeloid-Derived Suppressor Cells.
Frontiers in immunology
Xu J,Pei S,Wang Y,Liu J,Qian Y,Huang M,Zhang Y,Xiao Y
Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry
Wed Oct 14 00:00:00 EDT 2020
Bacteroides fragilis polysaccharide A induces IL-10 secreting B and T cells that prevent viral encephalitis.
Nature communications
Ramakrishna C,Kujawski M,Chu H,Li L,Mazmanian SK,Cantin EM
Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry
Tue May 14 00:00:00 EDT 2019
Bacteroides fragilis polysaccharide A induces IL-10 secreting B and T cells that prevent viral encephalitis.
Nature communications
Ramakrishna C,Kujawski M,Chu H,Li L,Mazmanian SK,Cantin EM
Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry
Tue May 14 00:00:00 EDT 2019
The Hematopoietic Oxidase NOX2 Regulates Self-Renewal of Leukemic Stem Cells.
Cell reports
Adane B,Ye H,Khan N,Pei S,Minhajuddin M,Stevens BM,Jones CL,D'Alessandro A,Reisz JA,Zaberezhnyy V,Gasparetto M,Ho TC,Kelly KK,Myers JR,Ashton JM,Siegenthaler J,Kume T,Campbell EL,Pollyea DA,Becker MW,Jordan CT
Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry
Tue Apr 02 00:00:00 EDT 2019
Nidogen-1 Contributes to the Interaction Network Involved in Pro-B Cell Retention in the Peri-sinusoidal Hematopoietic Stem Cell Niche.
Cell reports
Balzano M,De Grandis M,Vu Manh TP,Chasson L,Bardin F,Farina A,Sergé A,Bidaut G,Charbord P,Hérault L,Bailly AL,Cartier-Michaud A,Boned A,Dalod M,Duprez E,Genever P,Coles M,Bajenoff M,Xerri L,Aurrand-Lions M,Schiff C,Mancini SJC
17-0452 was used in Flow cytometry/Cell sorting to study pro-B cells in their support of stroll cells and their interaction network allowing their retention.
Tue Mar 19 00:00:00 EDT 2019
Modulation of autoimmune pathogenesis by T cell-triggered inflammatory cell death.
Nature communications
Sasaki K,Himeno A,Nakagawa T,Sasaki Y,Kiyonari H,Iwai K
17-0452-82 was used in Flow Cytometry to show that T cell-mediated killing and sequential autoinflammation are common and crucial for pathogenic diversity during T cell-mediated autoimmune responses.
Wed Aug 28 00:00:00 EDT 2019
Adrenergic nerve degeneration in bone marrow drives aging of the hematopoietic stem cell niche.
Nature medicine
Maryanovich M,Zahalka AH,Pierce H,Pinho S,Nakahara F,Asada N,Wei Q,Wang X,Ciero P,Xu J,Leftin A,Frenette PS
Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry
Fri Jun 01 00:00:00 EDT 2018
Mitophagy in Intestinal Epithelial Cells Triggers Adaptive Immunity during Tumorigenesis.
Cell
Ziegler PK,Bollrath J,Pallangyo CK,Matsutani T,Canli Ö,De Oliveira T,Diamanti MA,Müller N,Gamrekelashvili J,Putoczki T,Horst D,Mankan AK,Öner MG,Müller S,Müller-Höcker J,Kirchner T,Slotta-Huspenina J,Taketo MM,Reinheckel T,Dröse S,Larner AC,Wels WS,Ernst M,Greten TF,Arkan MC,Korn T,Wirth D,Greten FR
Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry
Thu Jun 28 00:00:00 EDT 2018
Cbl Ubiquitin Ligases Control B Cell Exit from the Germinal-Center Reaction.
Immunity
Li X,Gadzinsky A,Gong L,Tong H,Calderon V,Li Y,Kitamura D,Klein U,Langdon WY,Hou F,Zou YR,Gu H
17-0452-82 was used in Flow Cytometry to show that deleting E3 ubiquitin ligases Cbl and Cbl-b (Cbls) in GC B cells results in the early exit of high-affinity antigen-specific B cells from the GC reaction and thus impaired clonal expansion.
Tue Mar 20 00:00:00 EDT 2018
Loss of pleckstrin-2 reverts lethality and vascular occlusions in JAK2V617F-positive myeloproliferative neoplasms.
The Journal of clinical investigation
Zhao B,Mei Y,Cao L,Zhang J,Sumagin R,Yang J,Gao J,Schipma MJ,Wang Y,Thorsheim C,Zhao L,Stalker T,Stein B,Wen QJ,Crispino JD,Abrams CS,Ji P
17-0452 was used in Flow cytometry/Cell sorting to identify pleckstrin-2 as an effector of the JAK2/STAT5 pathway and a key factor in the pathogenesis of JAK2V617F-induced myeloproliferative neoplasms.
Tue Jan 02 00:00:00 EST 2018
Proapoptotic BIM Impacts B Lymphoid Homeostasis by Limiting the Survival of Mature B Cells in a Cell-Autonomous Manner.
Frontiers in immunology
Liu R,King A,Bouillet P,Tarlinton DM,Strasser A,Heierhorst J
Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry
Wed May 01 00:00:00 EDT 2019
Host Tumor Suppressor p18INK4c Functions as a Potent Cell-Intrinsic Inhibitor of Murine Gammaherpesvirus 68 Reactivation and Pathogenesis.
Journal of virology
Niemeyer BF,Oko LM,Medina EM,Oldenburg DG,White DW,Cool CD,Clambey ET,van Dyk LF
Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry
Thu Mar 15 00:00:00 EDT 2018
Inactivation of mTORC1 Signaling in Osterix-Expressing Cells Impairs B-cell Differentiation.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Wang Y,Xiao M,Tao C,Chen J,Wang Z,Yang J,Chen Z,Zou Z,Liu A,Cai D,Jiang Y,Ding C,Li M,Bai X
Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry
Sun Apr 01 00:00:00 EDT 2018
Bone marrow‑derived mesenchymal stem cell‑conditioned medium attenuates tubulointerstitial fibrosis by inhibiting monocyte mobilization in an irreversible model of unilateral ureteral obstruction.
Molecular medicine reports
Zheng J,Wang Q,Leng W,Sun X,Peng J
17-0452-82 was used in Flow Cytometry to identify a potential mechanism of MSC‚CM in ameliorating the UUO‚kidney.
Fri Jun 01 00:00:00 EDT 2018
Tanshinone IIA and Astragaloside IV promote the angiogenesis of mesenchymal stem cell-derived endothelial cell-like cells via upregulation of Cx37, Cx40 and Cx43.
Experimental and therapeutic medicine
Li Z,Zhang S,Cao L,Li W,Ye YC,Shi ZX,Wang ZR,Sun LX,Wang JW,Jia LT,Wang W
Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry
Thu Feb 01 00:00:00 EST 2018
miR-143/145 differentially regulate hematopoietic stem and progenitor activity through suppression of canonical TGFβ signaling.
Nature communications
Lam J,van den Bosch M,Wegrzyn J,Parker J,Ibrahim R,Slowski K,Chang L,Martinez-Høyer S,Condorelli G,Boldin M,Deng Y,Umlandt P,Fuller M,Karsan A
Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry
Wed Jun 20 00:00:00 EDT 2018
Dysregulated TRAF3 and BCL2 Expression Promotes Multiple Classes of Mature Non-hodgkin B Cell Lymphoma in Mice.
Frontiers in immunology
Perez-Chacon G,Adrados M,Vallejo-Cremades MT,Lefebvre S,Reed JC,Zapata JM
Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry
Fri Oct 25 00:00:00 EDT 2019
ATF3 Sustains IL-22-Induced STAT3 Phosphorylation to Maintain Mucosal Immunity Through Inhibiting Phosphatases.
Frontiers in immunology
Glal D,Sudhakar JN,Lu HH,Liu MC,Chiang HY,Liu YC,Cheng CF,Shui JW
Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry
Thu Sep 26 00:00:00 EDT 2019
Orally administered heat-killed Lactobacillus paracasei MCC1849 enhances antigen-specific IgA secretion and induces follicular helper T cells in mice.
PloS one
Arai S,Iwabuchi N,Takahashi S,Xiao JZ,Abe F,Hachimura S
17-0452 was used in Flow cytometry/Cell sorting to investigate the effects of orally administered heat-killed MCC1849 on IgA production in the intestine and on Tfh cell induction in vivo.
Wed Jan 02 00:00:00 EST 2019
EDAG promotes the expansion and survival of human CD34+ cells.
PloS one
Zhao K,Zheng WW,Dong XM,Yin RH,Gao R,Li X,Liu JF,Zhan YQ,Yu M,Chen H,Ge CH,Ning HM,Yang XM,Li CY
17-0452 was used in Flow cytometry/Cell sorting to provide novel insight into EDAG in regulation of expansion and survival of human hematopoietic stem/progenitor cells.
Tue Feb 06 00:00:00 EST 2018
Adipose tissue extrinsic factor: Obesity-induced inflammation and the role of the visceral lymph node.
Physiology & behavior
Magnuson AM,Fouts JK,Regan DP,Booth AD,Dow SW,Foster MT
17-0452-82 was used in Flow cytometry/Cell sorting to elucidate how the lymphatic system may contribute to the comorbidities associated with visceral adipose tissue accumulation.
Fri Jun 01 00:00:00 EDT 2018
The creatine kinase pathway is a metabolic vulnerability in EVI1-positive acute myeloid leukemia.
Nature medicine
Fenouille N,Bassil CF,Ben-Sahra I,Benajiba L,Alexe G,Ramos A,Pikman Y,Conway AS,Burgess MR,Li Q,Luciano F,Auberger P,Galinsky I,DeAngelo DJ,Stone RM,Zhang Y,Perkins AS,Shannon K,Hemann MT,Puissant A,Stegmaier K
17-0452 was used in Flow cytometry/Cell sorting to investigate the effect of MECOM on cellular metabolism.
Wed Mar 01 00:00:00 EST 2017
Inflammasome-driven catecholamine catabolism in macrophages blunts lipolysis during ageing.
Nature
Camell CD,Sander J,Spadaro O,Lee A,Nguyen KY,Wing A,Goldberg EL,Youm YH,Brown CW,Elsworth J,Rodeheffer MS,Schultze JL,Dixit VD
17-0452 was used in Flow cytometry/Cell sorting to show that adipose tissue macrophages regulate the age-related reduction in adipocyte lipolysis in mice by lowering the bioavailability of noradrenaline.
Thu Oct 05 00:00:00 EDT 2017
Antibody Tumor Targeting Is Enhanced by CD27 Agonists through Myeloid Recruitment.
Cancer cell
Turaj AH,Hussain K,Cox KL,Rose-Zerilli MJJ,Testa J,Dahal LN,Chan HTC,James S,Field VL,Carter MJ,Kim HJ,West JJ,Thomas LJ,He LZ,Keler T,Johnson PWM,Al-Shamkhani A,Thirdborough SM,Beers SA,Cragg MS,Glennie MJ,Lim SH
17-0452 was used in Flow cytometry/Cell sorting to demonstrate the therapeutic advantage of using an immunomodulatory mAb to regulate lymphoid cells, which then recruit and activate myeloid cells for enhanced killing of mAb-opsonized tumors.
Mon Dec 11 00:00:00 EST 2017
Antibody Tumor Targeting Is Enhanced by CD27 Agonists through Myeloid Recruitment.
Cancer cell
Turaj AH,Hussain K,Cox KL,Rose-Zerilli MJJ,Testa J,Dahal LN,Chan HTC,James S,Field VL,Carter MJ,Kim HJ,West JJ,Thomas LJ,He LZ,Keler T,Johnson PWM,Al-Shamkhani A,Thirdborough SM,Beers SA,Cragg MS,Glennie MJ,Lim SH
17-0452 was used in Flow cytometry/Cell sorting to demonstrate the therapeutic advantage of using an immunomodulatory mAb to regulate lymphoid cells, which then recruit and activate myeloid cells for enhanced killing of mAb-opsonized tumors.
Mon Dec 11 00:00:00 EST 2017
Ubiquitination of hnRNPA1 by TRAF6 links chronic innate immune signaling with myelodysplasia.
Nature immunology
Fang J,Bolanos LC,Choi K,Liu X,Christie S,Akunuru S,Kumar R,Wang D,Chen X,Greis KD,Stoilov P,Filippi MD,Maciejewski JP,Garcia-Manero G,Weirauch MT,Salomonis N,Geiger H,Zheng Y,Starczynowski DT
17-0452 was used in Flow cytometry/Cell sorting to examine the significance of ubiquitin signalling in coordinating RNA processing by Toll-like receptor pathways during an immune response and in premalignant haematologic diseases.
Wed Feb 01 00:00:00 EST 2017
Differential cytokine contributions of perivascular haematopoietic stem cell niches.
Nature cell biology
Asada N,Kunisaki Y,Pierce H,Wang Z,Fernandez NF,Birbrair A,Ma'ayan A,Frenette PS
Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry
Wed Mar 01 00:00:00 EST 2017
Epithelial Fli1 deficiency drives systemic autoimmunity and fibrosis: Possible roles in scleroderma.
The Journal of experimental medicine
Takahashi T,Asano Y,Sugawara K,Yamashita T,Nakamura K,Saigusa R,Ichimura Y,Toyama T,Taniguchi T,Akamata K,Noda S,Yoshizaki A,Tsuruta D,Trojanowska M,Sato S
Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry
Mon Apr 03 00:00:00 EDT 2017
Peptidylarginine deiminase 2 is required for tumor necrosis factor alpha-induced citrullination and arthritis, but not neutrophil extracellular trap formation.
Journal of autoimmunity
Bawadekar M,Shim D,Johnson CJ,Warner TF,Rebernick R,Damgaard D,Nielsen CH,Pruijn GJM,Nett JE,Shelef MA
17-0452 was used in Flow cytometry/Cell sorting to identify the roles of peptidylarginine deiminase 2 and peptidylarginine deiminase 4 in citrullination, NETosis and arthritis.
Thu Jun 01 00:00:00 EDT 2017
Diet-induced obesity causes visceral, but not subcutaneous, lymph node hyperplasia via increases in specific immune cell populations.
Cell proliferation
Magnuson AM,Regan DP,Fouts JK,Booth AD,Dow SW,Foster MT
17-0452 was used in Flow cytometry/Cell sorting to investigate whether secondary lymphatics within visceral adiposity contribute to disease risk.
Sun Oct 01 00:00:00 EDT 2017
ORMDL3 Facilitates the Survival of Splenic B Cells via an ATF6α-Endoplasmic Reticulum Stress-Beclin1 Autophagy Regulatory Pathway.
Journal of immunology (Baltimore, Md. : 1950)
Dang J,Bian X,Ma X,Li J,Long F,Shan S,Yuan Q,Xin Q,Li Y,Gao F,Gong Y,Liu Q
17-0452 was used in Flow cytometry/Cell sorting to study the upregulation of orosomucoid-like 3 in both patients with systemic lupus erythematosus and lupus mice compared with controls.
Fri Sep 01 00:00:00 EDT 2017
Loss of IP3 Receptor-Mediated Ca2+ Release in Mouse B Cells Results in Abnormal B Cell Development and Function.
Journal of immunology (Baltimore, Md. : 1950)
Tang H,Wang H,Lin Q,Fan F,Zhang F,Peng X,Fang X,Liu J,Ouyang K
17-0452 was used in Flow cytometry/Cell sorting to determine the function of 1,4,5-trisphosphate receptor-mediated Ca2+ release in B cells.
Sat Jul 15 00:00:00 EDT 2017
ADAR1 deletion induces NFκB and interferon signaling dependent liver inflammation and fibrosis.
RNA biology
Ben-Shoshan SO,Kagan P,Sultan M,Barabash Z,Dor C,Jacob-Hirsch J,Harmelin A,Pappo O,Marcu-Malina V,Ben-Ari Z,Amariglio N,Rechavi G,Goldstein I,Safran M
17-0452 was used in Flow cytometry/Cell sorting to study the regulatory role of ADAR1 in hepatic immune homeostasis.
Thu May 04 00:00:00 EDT 2017
IL-2/Anti-IL-2 Complex Attenuates Inflammation and BBB Disruption in Mice Subjected to Traumatic Brain Injury.
Frontiers in neurology
Gao W,Li F,Zhou Z,Xu X,Wu Y,Zhou S,Yin D,Sun D,Xiong J,Jiang R,Zhang J
17-0452 was used in Flow cytometry/Cell sorting to suggest that IL-2C treatment can alleviate inflammation and maintain blood vessel stability after traumatic brain injury.
Thu Oct 01 00:00:00 EDT 2020
EZH2 enables germinal centre formation through epigenetic silencing of CDKN1A and an Rb-E2F1 feedback loop.
Nature communications
Béguelin W,Rivas MA,Calvo Fernández MT,Teater M,Purwada A,Redmond D,Shen H,Challman MF,Elemento O,Singh A,Melnick AM
Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry
Thu Oct 12 00:00:00 EDT 2017
DNA-binding of the Tet-transactivator curtails antigen-induced lymphocyte activation in mice.
Nature communications
Ottina E,Peperzak V,Schoeler K,Carrington E,Sgonc R,Pellegrini M,Preston S,Herold MJ,Strasser A,Villunger A
Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry
Wed Oct 18 00:00:00 EDT 2017
The Interleukin (IL)-1R1 pathway is a critical negative regulator of PyMT-mediated mammary tumorigenesis and pulmonary metastasis.
Oncoimmunology
Dagenais M,Dupaul-Chicoine J,Douglas T,Champagne C,Morizot A,Saleh M
Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry
Tue Jan 12 00:00:00 EST 2021
Irgm1 coordinately regulates autoimmunity and host defense at select mucosal surfaces.
JCI insight
Azzam KM,Madenspacher JH,Cain DW,Lai L,Gowdy KM,Rai P,Janardhan K,Clayton N,Cunningham W,Jensen H,Patel PS,Kearney JF,Taylor GA,Fessler MB
Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry
Thu Aug 17 00:00:00 EDT 2017
Multiple functional therapeutic effects of TnP: A small stable synthetic peptide derived from fish venom in a mouse model of multiple sclerosis.
PloS one
Komegae EN,Souza TA,Grund LZ,Lima C,Lopes-Ferreira M
Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry
Thu Aug 17 00:00:00 EDT 2017
Recipient bone marrow assimilates the myeloid/lymphoid reconstitution of distinct fetal hematopoietic stem cells.
Oncotarget
Guo XL,Chu L,Ke F,Mu LL,Li Z,Cai JJ,Li HF,Hong DL
17-0452 was used in Flow cytometry/Cell sorting to show that the recipient bone marrow microenvironment could determine the developmental lineage-trends of fetal liver hematopoietic stem and progenitor cells.
Tue Dec 12 00:00:00 EST 2017
Epigenetic Memory Underlies Cell-Autonomous Heterogeneous Behavior of Hematopoietic Stem Cells.
Cell
Yu VWC,Yusuf RZ,Oki T,Wu J,Saez B,Wang X,Cook C,Baryawno N,Ziller MJ,Lee E,Gu H,Meissner A,Lin CP,Kharchenko PV,Scadden DT
17-0452 was used in Flow cytometry/Cell sorting to define the extent of, and molecular basis for, haematopoetic stem cell heterogeneity using a multi-fluorescent mouse model.
Thu Nov 17 00:00:00 EST 2016
Dendritic cell sphingosine-1-phosphate lyase regulates thymic egress.
The Journal of experimental medicine
Zamora-Pineda J,Kumar A,Suh JH,Zhang M,Saba JD
17-0452 was used in Flow cytometry/Cell sorting to investigate the role of dendritic cell sphingosine-1-phosphate lyase in thymic egress.
Mon Nov 14 00:00:00 EST 2016
Monocyte Adhesion and Plaque Recruitment During Atherosclerosis Development Is Regulated by the Adapter Protein Chat-H/SHEP1.
Arteriosclerosis, thrombosis, and vascular biology
Herbin O,Regelmann AG,Ramkhelawon B,Weinstein EG,Moore KJ,Alexandropoulos K
17-0452 was used in Flow cytometry/Cell sorting to analyse the role of Chat-H in atherosclerosis development, showing that monocyte adhesion and plaque recruitment is regulated by Chat-H/SHEP1.
Thu Sep 01 00:00:00 EDT 2016
The 4E-BP-eIF4E axis promotes rapamycin-sensitive growth and proliferation in lymphocytes.
Science signaling
So L,Lee J,Palafox M,Mallya S,Woxland CG,Arguello M,Truitt ML,Sonenberg N,Ruggero D,Fruman DA
17-0452 was used in Flow cytometry/Cell sorting to investigate the mechanism by which rapamycin leads to selective immunosupression of lymphocytes, showing that the 4E-BP-efF4E axis promotes growth and proliferation of lymphocytes and is uniquely sensitive to rapamycin in these cells.
Tue May 31 00:00:00 EDT 2016
CD4 T Helper Cells Instruct Lymphopenia-Induced Memory-Like CD8 T Cells for Control of Acute LCMV Infection.
Frontiers in immunology
Schmitt ME,Sitte S,Voehringer D
17-0452 was used in Flow cytometry/Cell sorting to determine whether memory-like T cells can efficiently respond to foreign antigen and participate in antiviral immunity.
Wed Nov 20 00:00:00 EST 2019
Adipose tissue adaptive response to trans-10,cis-12-conjugated linoleic acid engages alternatively activated M2 macrophages.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Pini M,Touch S,Poirier H,Dalmas E,Niot I,Rouault C,Druart C,Delzenne N,Clément K,André S,Guerre-Millo M
17-0452 was used in Flow cytometry/Cell sorting to reveal a striking resilience of white adipose tissue after a short-term metabolic injury induced by t10,c12-CLA, which relies on alternatively activated M2 macrophage engagement.
Fri Jan 01 00:00:00 EST 2016
Resident T Cells Are Unable To Control Herpes Simplex Virus-1 Activity in the Brain Ependymal Region during Latency.
Journal of immunology (Baltimore, Md. : 1950)
Menendez CM,Jinkins JK,Carr DJ
Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry
Mon Aug 15 00:00:00 EDT 2016
Caspase-12, but Not Caspase-11, Inhibits Obesity and Insulin Resistance.
Journal of immunology (Baltimore, Md. : 1950)
Skeldon AM,Morizot A,Douglas T,Santoro N,Kursawe R,Kozlitina J,Caprio S,Mehal WZ,Saleh M
17-0452 was used in Flow cytometry/Cell sorting to investigate a role for caspase-11 and caspase-12 in obesity and insulin resistance.
Fri Jan 01 00:00:00 EST 2016
Type I IFN Does Not Promote Susceptibility to Foodborne Listeria monocytogenes.
Journal of immunology (Baltimore, Md. : 1950)
Pitts MG,Myers-Morales T,D'Orazio SE
17-0452 was used in an ELISA assay to investigate whether type I IFN promotes susceptibility to foodborne Listeria monocytogenes.
Fri Apr 01 00:00:00 EDT 2016
Type I IFN Does Not Promote Susceptibility to Foodborne Listeria monocytogenes.
Journal of immunology (Baltimore, Md. : 1950)
Pitts MG,Myers-Morales T,D'Orazio SE
17-0452 was used in an ELISA assay to investigate whether type I IFN promotes susceptibility to foodborne Listeria monocytogenes.
Fri Apr 01 00:00:00 EDT 2016
Transcriptional regulation of the proto-oncogene Zfp521 by SPI1 (PU.1) and HOXC13.
Genesis (New York, N.Y. : 2000)
Yu M,Al-Dallal S,Al-Haj L,Panjwani S,McCartney AS,Edwards SM,Manjunath P,Walker C,Awgulewitsch A,Hentges KE
17-0452 was used in Flow cytometry/Cell sorting to study the regulatory factors controlling the mouse zinc-finger gene Zfp521; a B-cell proto-oncogene.
Sat Oct 01 00:00:00 EDT 2016
Murine iPSC-Derived Macrophages as a Tool for Disease Modeling of Hereditary Pulmonary Alveolar Proteinosis due to Csf2rb Deficiency.
Stem cell reports
Mucci A,Kunkiel J,Suzuki T,Brennig S,Glage S,Kühnel MP,Ackermann M,Happle C,Kuhn A,Schambach A,Trapnell BC,Hansen G,Moritz T,Lachmann N
Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry
Tue Aug 09 00:00:00 EDT 2016
Sequencing and cloning of antigen-specific antibodies from mouse memory B cells.
Nature protocols
von Boehmer L,Liu C,Ackerman S,Gitlin AD,Wang Q,Gazumyan A,Nussenzweig MC
17-0452-82 was used in Flow cytometry/Cell sorting to sequence and clone the variable antibody region of single antigen-specific mouse memory B cells for antibody production.
Sat Oct 01 00:00:00 EDT 2016
CXCL16-positive dendritic cells enhance invariant natural killer T cell-dependent IFNγ production and tumor control.
Oncoimmunology
Veinotte L,Gebremeskel S,Johnston B
17-0452 was used in Flow cytometry/Cell sorting to study the co-stimulatory role of CXCR6/CXCL16 interactions in glycolipid-dependent invariant natural killer T (iNKT) cell activation and tumour control, showing that CXCL16-positive dendritic cells enhance iNKT cell-dependent IFNγ production and tumor control.
Wed Jun 01 00:00:00 EDT 2016
miR-22 has a potent anti-tumour role with therapeutic potential in acute myeloid leukaemia.
Nature communications
Jiang X,Hu C,Arnovitz S,Bugno J,Yu M,Zuo Z,Chen P,Huang H,Ulrich B,Gurbuxani S,Weng H,Strong J,Wang Y,Li Y,Salat J,Li S,Elkahloun AG,Yang Y,Neilly MB,Larson RA,Le Beau MM,Herold T,Bohlander SK,Liu PP,Zhang J,Li Z,He C,Jin J,Hong S,Chen J
17-0452 was used in Flow cytometry/Cell sorting to investigate the anti-tumourigenic role of miR-22, showing that it has an anti-tumour role in acute myeloid leukaemia.
Tue Apr 26 00:00:00 EDT 2016
Alkylator-Induced and Patient-Derived Xenograft Mouse Models of Therapy-Related Myeloid Neoplasms Model Clinical Disease and Suggest the Presence of Multiple Cell Subpopulations with Leukemia Stem Cell Activity.
PloS one
Jonas BA,Johnson C,Gratzinger D,Majeti R
17-0452 was used in Flow cytometry/Cell sorting to report several new t-AML/MDS mouse models that could potentially be used to further define disease pathogenesis and test novel therapeutics.
Wed Jul 26 00:00:00 EDT 2017
Reprogramming mouse fibroblasts into engraftable myeloerythroid and lymphoid progenitors.
Nature communications
Cheng H,Ang HY,A El Farran C,Li P,Fang HT,Liu TM,Kong SL,Chin ML,Ling WY,Lim EK,Li H,Huber T,Loh KM,Loh YH,Lim B
17-0452 was used in Flow cytometry/Cell sorting to demonstrate how it is possible to reprogram mouse embryonic fibroblasts into engraftable blood progenitors.
Mon Nov 21 00:00:00 EST 2016
Heme Oxygenase-1-Expressing Dendritic Cells Promote Foxp3+ Regulatory T Cell Differentiation and Induce Less Severe Airway Inflammation in Murine Models.
PloS one
Wong TH,Chen HA,Gau RJ,Yen JH,Suen JL
17-0452 was used in Flow cytometry/Cell sorting to study the role of heme oxygenase-1 in dendritic cell-mediated T cell differentiation.
Mon Jul 10 00:00:00 EDT 2017
Peroxisomal lipid synthesis regulates inflammation by sustaining neutrophil membrane phospholipid composition and viability.
Cell metabolism
Lodhi IJ,Wei X,Yin L,Feng C,Adak S,Abou-Ezzi G,Hsu FF,Link DC,Semenkovich CF
17-0452 was used in Flow cytometry/Cell sorting to investigate the immunometabolism pathway by which peroxisomal lipid synthesis regulates neutrophil development and inflammation.
Tue Jan 06 00:00:00 EST 2015
Aging-associated inflammation promotes selection for adaptive oncogenic events in B cell progenitors.
The Journal of clinical investigation
Henry CJ,Casás-Selves M,Kim J,Zaberezhnyy V,Aghili L,Daniel AE,Jimenez L,Azam T,McNamee EN,Clambey ET,Klawitter J,Serkova NJ,Tan AC,Dinarello CA,DeGregori J
Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry
Tue Dec 01 00:00:00 EST 2015
Apoptotic cells trigger a membrane-initiated pathway to increase ABCA1.
The Journal of clinical investigation
Fond AM,Lee CS,Schulman IG,Kiss RS,Ravichandran KS
17-0452 was used in Flow cytometry/Cell sorting to identify a membrane-initiated pathway that is triggered by apoptotic cells to enhance ABCA1 within engulfing phagocytes.
Wed Jul 01 00:00:00 EDT 2015
BAFF activation of the ERK5 MAP kinase pathway regulates B cell survival.
The Journal of experimental medicine
Jacque E,Schweighoffer E,Tybulewicz VL,Ley SC
17-0452 was used in Flow cytometry/Cell sorting to reveal a potentially critical role for the MEK5-ERK5 MAP kinase signalling pathway in BAFF-induced mature B cell survival and homeostatic maintenance of B2 cell numbers.
Mon Jun 01 00:00:00 EDT 2015
Tamm-Horsfall Protein Regulates Granulopoiesis and Systemic Neutrophil Homeostasis.
Journal of the American Society of Nephrology : JASN
Micanovic R,Chitteti BR,Dagher PC,Srour EF,Khan S,Hato T,Lyle A,Tong Y,Wu XR,El-Achkar TM
17-0452 was used in Flow cytometry/Cell sorting to show that Tamm-Horsfall protein deficiency in mice causes systemic neutrophilia through enhanced granulopoiesis in the bone marrow.
Tue Sep 01 00:00:00 EDT 2015
Bcl6 middle domain repressor function is required for T follicular helper cell differentiation and utilizes the corepressor MTA3.
Proceedings of the National Academy of Sciences of the United States of America
Nance JP,Bélanger S,Johnston RJ,Hu JK,Takemori T,Crotty S
17-0452 was used in Immunohistochemistry to discover that Bcl6 middle domain mediated repression is important for control of CD4 T-cell fate and function.
Tue Oct 27 00:00:00 EDT 2015
Mitochondrial ATP transporter Ant2 depletion impairs erythropoiesis and B lymphopoiesis.
Cell death and differentiation
Cho J,Seo J,Lim CH,Yang L,Shiratsuchi T,Lee MH,Chowdhury RR,Kasahara H,Kim JS,Oh SP,Lee YJ,Terada N
Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry
Tue Sep 01 00:00:00 EDT 2015
Natural IgM is produced by CD5- plasma cells that occupy a distinct survival niche in bone marrow.
Journal of immunology (Baltimore, Md. : 1950)
Reynolds AE,Kuraoka M,Kelsoe G
17-0452 was used in Flow cytometry/Cell sorting to investigate the origin of natural IgM, showing that it is produced by CD5- plasma cells that occupy a distinct survival niche in bone marrow.
Thu Jan 01 00:00:00 EST 2015
Core fucosylation of IgG B cell receptor is required for antigen recognition and antibody production.
Journal of immunology (Baltimore, Md. : 1950)
Li W,Yu R,Ma B,Yang Y,Jiao X,Liu Y,Cao H,Dong W,Liu L,Ma K,Fukuda T,Liu Q,Ma T,Wang Z,Gu J,Zhang J,Taniguchi N
17-0452 was used in Flow cytometry/Cell sorting to investigate core fucosylation of IgG B cell receptor's role in antigen recognition and antibody production.
Sun Mar 15 00:00:00 EDT 2015
MHC-mismatched mixed chimerism mediates thymic deletion of cross-reactive autoreactive T cells and prevents insulitis in nonobese diabetic mice.
Journal of immunology (Baltimore, Md. : 1950)
Racine JJ,Zhang M,Wang M,Morales W,Shen C,Zeng D
17-0452 was used in Flow cytometry/Cell sorting to investigate whether mismatched MHC class II in mixed chimeras mediates deletion of cross-reactive autoreactive thymocytes.
Thu Jan 01 00:00:00 EST 2015
The Inflammatory Caspases-1 and -11 Mediate the Pathogenesis of Dermatitis in Sharpin-Deficient Mice.
Journal of immunology (Baltimore, Md. : 1950)
Douglas T,Champagne C,Morizot A,Lapointe JM,Saleh M
17-0452 was used in Flow cytometry/Cell sorting to implicate the inflammasome as an important initiating signal in skin disease pathogenesis.
Tue Sep 01 00:00:00 EDT 2015
Endothelial Gata5 transcription factor regulates blood pressure.
Nature communications
Messaoudi S,He Y,Gutsol A,Wight A,Hébert RL,Vilmundarson RO,Makrigiannis AP,Chalmers J,Hamet P,Tremblay J,McPherson R,Stewart AFR,Touyz RM,Nemer M
Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry
Mon Nov 30 00:00:00 EST 2015
Disruption of p21-activated kinase 1 gene diminishes atherosclerosis in apolipoprotein E-deficient mice.
Nature communications
Singh NK,Kotla S,Dyukova E,Traylor JG,Orr AW,Chernoff J,Marion TN,Rao GN
Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry
Wed Jun 24 00:00:00 EDT 2015
TGF-β3-expressing CD4+CD25(-)LAG3+ regulatory T cells control humoral immune responses.
Nature communications
Okamura T,Sumitomo S,Morita K,Iwasaki Y,Inoue M,Nakachi S,Komai T,Shoda H,Miyazaki J,Fujio K,Yamamoto K
17-0452 was used in Flow cytometry/Cell sorting to investigate the role of GF-β3-expressing CD4+CD25(-)LAG3+ Tregs in humoral immune responses.
Thu Feb 19 00:00:00 EST 2015
Standard sub-thermoneutral caging temperature influences radiosensitivity of hematopoietic stem and progenitor cells.
PloS one
Povinelli BJ,Kokolus KM,Eng JW,Dougher CW,Curtin L,Capitano ML,Sailsbury-Ruf CT,Repasky EA,Nemeth MJ
17-0452 was used in Flow cytometry/Cell sorting to demonstrate that chronic stress of laboratory mice increases the resistance of hematopoietic stem and progenitor cells to irradiation-induced apoptosis.
Tue Feb 09 00:00:00 EST 2016
CD4+ T cells promote the transition from hypertrophy to heart failure during chronic pressure overload.
Circulation
Laroumanie F,Douin-Echinard V,Pozzo J,Lairez O,Tortosa F,Vinel C,Delage C,Calise D,Dutaur M,Parini A,Pizzinat N
17-0452 was used in Flow cytometry/Cell sorting to investigate the involvement of T cells in the progression to heart failure using a transverse aortic constriction (TAC) model.
Tue May 27 00:00:00 EDT 2014
α-1-Antitrypsin (AAT)-modified donor cells suppress GVHD but enhance the GVL effect: a role for mitochondrial bioenergetics.
Blood
Marcondes AM,Karoopongse E,Lesnikova M,Margineantu D,Welte T,Dinarello CA,Hockenbery D,Janciauskiene S,Deeg HJ
17-0452 was used in Flow cytometry/Cell sorting to investigate the role of α-1-antitrypsin in graft-versus-host disease, showing that α-1-Antitrypsin-modified donor cells suppress graft-versus-host disease but enhance the graft-versus-leukemia effect.
Thu Oct 30 00:00:00 EDT 2014
Peptidylarginine deiminase 4 contributes to tumor necrosis factor α-induced inflammatory arthritis.
Arthritis & rheumatology (Hoboken, N.J.)
Shelef MA,Sokolove J,Lahey LJ,Wagner CA,Sackmann EK,Warner TF,Wang Y,Beebe DJ,Robinson WH,Huttenlocher A
17-0452 was used in Flow cytometry/Cell sorting to investigate whether TNFα and PAD4 may synergistically exacerbate autoantibody production and inflammatory arthritis, showing that PAD4 contributes to TNFα-induced inflammatory arthritis.
Sun Jun 01 00:00:00 EDT 2014
Diet-induced obesity promotes myelopoiesis in hematopoietic stem cells.
Molecular metabolism
Singer K,DelProposto J,Morris DL,Zamarron B,Mergian T,Maley N,Cho KW,Geletka L,Subbaiah P,Muir L,Martinez-Santibanez G,Lumeng CN
17-0452 was used in Flow cytometry/Cell sorting to demonstrate how metabolic signals potentiate leukocyte production and dietary priming of haematopoietic progenitors contributes to adipose tissue inflammation.
Mon Sep 01 00:00:00 EDT 2014
CD41 is a reliable identification and activation marker for murine basophils in the steady state and during helminth and malarial infections.
European journal of immunology
Bakocevic N,Claser C,Yoshikawa S,Jones LA,Chew S,Goh CC,Malleret B,Larbi A,Ginhoux F,de Lafaille MC,Karasuyama H,Renia L,Ng LG
17-0452 was used in Flow cytometry/Cell sorting to study the CD41 expression within basophils from the blood during both steady state and malarial inections within mice.
Sun Jun 01 00:00:00 EDT 2014
Transcription elongation factor ELL2 drives Ig secretory-specific mRNA production and the unfolded protein response.
Journal of immunology (Baltimore, Md. : 1950)
Park KS,Bayles I,Szlachta-McGinn A,Paul J,Boiko J,Santos P,Liu J,Wang Z,Borghesi L,Milcarek C
Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry
Sat Nov 01 00:00:00 EDT 2014
IκBε is a key regulator of B cell expansion by providing negative feedback on cRel and RelA in a stimulus-specific manner.
Journal of immunology (Baltimore, Md. : 1950)
Alves BN,Tsui R,Almaden J,Shokhirev MN,Davis-Turak J,Fujimoto J,Birnbaum H,Ponomarenko J,Hoffmann A
Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry
Tue Apr 01 00:00:00 EDT 2014
Eosinophils regulate peripheral B cell numbers in both mice and humans.
Journal of immunology (Baltimore, Md. : 1950)
Wong TW,Doyle AD,Lee JJ,Jelinek DF
17-0452 was used in Flow cytometry/Cell sorting to assess the effect of eosinophils on B cell survival, proliferation, and Ig secretion.
Tue Apr 15 00:00:00 EDT 2014
A TNF-α-CCL20-CCR6 axis regulates Nod1-induced B cell responses.
Journal of immunology (Baltimore, Md. : 1950)
Paradis M,Mindt BC,Duerr CU,Rojas OL,Ng D,Boulianne B,McCarthy DD,Yu MD,Summers deLuca LE,Ward LA,Waldron JB,Philpott DJ,Gommerman JL,Fritz JH
17-0452 was used in Flow cytometry/Cell sorting to reveal a novel mechanism of B cells during inflammation and shed light on how B cells participate in innate immune responses to microbial stimulation.
Sat Mar 15 00:00:00 EDT 2014
Relapsing-remitting central nervous system autoimmunity mediated by GFAP-specific CD8 T cells.
Journal of immunology (Baltimore, Md. : 1950)
Sasaki K,Bean A,Shah S,Schutten E,Huseby PG,Peters B,Shen ZT,Vanguri V,Liggitt D,Huseby ES
17-0452 was used in Immunohistochemistry to investigate the mechanism by which CD8 T cells mediate relapsing-remitting inflammatory CNS autoimmunity.
Tue Apr 01 00:00:00 EDT 2014
TRAF6 is a critical regulator of LMP1 functions in vivo.
International immunology
Arcipowski KM,Stunz LL,Bishop GA
17-0452 was used in Flow cytometry/Cell sorting to investigate TRAF6 as a critical regulator of LMP1 versus CD40 specific B-cell functions in TRAF6-deficient mice.
Sat Mar 01 00:00:00 EST 2014
Rhof promotes murine marginal zone B cell development.
Nagoya journal of medical science
Kishimoto M,Matsuda T,Yanase S,Katsumi A,Suzuki N,Ikejiri M,Takagi A,Ikawa M,Kojima T,Kunishima S,Kiyoi H,Naoe T,Matsushita T,Maruyama M
Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry
Fri Aug 01 00:00:00 EDT 2014
B-cell-intrinsic hepatitis C virus expression leads to B-cell-lymphomagenesis and induction of NF-κB signalling.
PloS one
Kasama Y,Mizukami T,Kusunoki H,Peveling-Oberhag J,Nishito Y,Ozawa M,Kohara M,Mizuochi T,Tsukiyama-Kohara K
Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry
Mon Dec 22 00:00:00 EST 2014
Self DNA from lymphocytes that have undergone activation-induced cell death enhances murine B cell proliferation and antibody production.
PloS one
Lu Q,Wang JY,Wang L,Jiang X,Chu Y
17-0452 was used in Flow cytometry/Cell sorting to study how self DNA can act as a damage-associated molecular pattern which promotes B cell activation and differentiation in autoimmune disease.
Wed Jun 24 00:00:00 EDT 2015
Long-term prevention of chronic allograft rejection by regulatory T-cell immunotherapy involves host Foxp3-expressing T cells.
Blood
Pasquet L,Douet JY,Sparwasser T,Romagnoli P,van Meerwijk JP
17-0452 was used in Flow cytometry/Cell sorting to assess if persistence of administered regulatory T cells is required for long-term maintenance of tolerance to allografts.
Thu May 23 00:00:00 EDT 2013
MHC class II-dependent B cell APC function is required for induction of CNS autoimmunity independent of myelin-specific antibodies.
The Journal of experimental medicine
Molnarfi N,Schulze-Topphoff U,Weber MS,Patarroyo JC,Prod'homme T,Varrin-Doyer M,Shetty A,Linington C,Slavin AJ,Hidalgo J,Jenne DE,Wekerle H,Sobel RA,Bernard CC,Shlomchik MJ,Zamvil SS
17-0452 was used in Flow cytometry/Cell sorting to investigate the contribution of B cells to antigen presentation and pathogenic T cell activation in the multiple sclerosis model experimental autoimmune encephalomyelitis.
Mon Dec 16 00:00:00 EST 2013
A type I IFN-Flt3 ligand axis augments plasmacytoid dendritic cell development from common lymphoid progenitors.
The Journal of experimental medicine
Chen YL,Chen TT,Pai LM,Wesoly J,Bluyssen HA,Lee CK
17-0452 was used in Flow cytometry/Cell sorting to define a critical role for the FL/IFN-I/Flt3 axis in plasmacytoid dendritic cell differentiation from common lymphoid progenitors.
Mon Nov 18 00:00:00 EST 2013
VBP15, a novel anti-inflammatory and membrane-stabilizer, improves muscular dystrophy without side effects.
EMBO molecular medicine
Heier CR,Damsker JM,Yu Q,Dillingham BC,Huynh T,Van der Meulen JH,Sali A,Miller BK,Phadke A,Scheffer L,Quinn J,Tatem K,Jordan S,Dadgar S,Rodriguez OC,Albanese C,Calhoun M,Gordish-Dressman H,Jaiswal JK,Connor EM,McCall JM,Hoffman EP,Reeves EK,Nagaraju K
17-0452 was used in Flow cytometry/Cell sorting to demonstrate successful improvement of dystrophy independent of hormonal, growth, or immunosuppressive effects, indicating VBP15 merits clinical investigation for Duchenne muscular dystrophy.
Tue Oct 01 00:00:00 EDT 2013
Reciprocal effects of rab7 deletion in activated and neglected T cells.
Autophagy
Roy SG,Stevens MW,So L,Edinger AL
Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry
Mon Jul 01 00:00:00 EDT 2013
Lipidoid Nanoparticles Containing PD-L1 siRNA Delivered In Vivo Enter Kupffer Cells and Enhance NK and CD8(+) T Cell-mediated Hepatic Antiviral Immunity.
Molecular therapy. Nucleic acids
Dolina JS,Sung SS,Novobrantseva TI,Nguyen TM,Hahn YS
17-0452 was used in Flow cytometry/Cell sorting to demonstrate that PD-L1 knockdown on KCs is central in determining the outcome of liver viral infections, and they represent a new class of gene therapy.
Tue Feb 19 00:00:00 EST 2013
(18)F-FDG-PET/CT imaging in an IL-6- and MYC-driven mouse model of human multiple myeloma affords objective evaluation of plasma cell tumor progression and therapeutic response to the proteasome inhibitor ixazomib.
Blood cancer journal
Duncan K,Rosean TR,Tompkins VS,Olivier A,Sompallae R,Zhan F,Tricot G,Acevedo MR,Ponto LL,Walsh SA,Tygrett LT,Berger AJ,Waldschmidt T,Morse HC,Sunderland JJ,Janz S
17-0452 was used in Flow cytometry/Cell sorting to demonstrate the utility of (18)F-fluorodeoxyglucose positron emission tomography and computed tomography for assessing IL-6 and MYC-driven plasma cell tumour development.
Fri Nov 29 00:00:00 EST 2013
Genome-wide mouse mutagenesis reveals CD45-mediated T cell function as critical in protective immunity to HSV-1.
PLoS pathogens
Caignard G,Leiva-Torres GA,Leney-Greene M,Charbonneau B,Dumaine A,Fodil-Cornu N,Pyzik M,Cingolani P,Schwartzentruber J,Dupaul-Chicoine J,Guo H,Saleh M,Veillette A,Lathrop M,Blanchette M,Majewski J,Pearson A,Vidal SM
17-0452 was used in Flow cytometry/Cell sorting to identify host factors involved in HSV-1 and herpes simplex encephalitis susceptibility in an in vivo HSV-1 infectious model.
Sun Sep 01 00:00:00 EDT 2013
Cellular-FLIP, Raji isoform (c-FLIP R) modulates cell death induction upon T-cell activation and infection.
European journal of immunology
Telieps T,Ewald F,Gereke M,Annemann M,Rauter Y,Schuster M,Ueffing N,von Smolinski D,Gruber AD,Bruder D,Schmitz I
17-0452 was used in Flow cytometry/Cell sorting to study the induction of endogenous murine cellular-FLIPR in activated lymphocytes.
Sat Jun 01 00:00:00 EDT 2013
Antioxidant treatment regulates the humoral immune response during acute viral infection.
Journal of virology
Crump KE,Langston PK,Rajkarnikar S,Grayson JM
17-0452 was used in Flow cytometry/Cell sorting to show that antioxidant treatment regulates the humoral immune response during acute viral infection.
Fri Mar 01 00:00:00 EST 2013
Arrayed lentiviral barcoding for quantification analysis of hematopoietic dynamics.
Stem cells (Dayton, Ohio)
Grosselin J,Sii-Felice K,Payen E,Chretien S,Tronik-Le Roux D,Leboulch P
17-0452-82 was used in Flow Cytometry to demonstrate arrayed lentiviral barcoding as a versatile and powerful approach to deconvolute cell dynamics in vivo with applications in hematology, embryology, and cancer biology.
Tue Oct 01 00:00:00 EDT 2013
Thymic damage, impaired negative selection, and development of chronic graft-versus-host disease caused by donor CD4+ and CD8+ T cells.
Journal of immunology (Baltimore, Md. : 1950)
Wu T,Young JS,Johnston H,Ni X,Deng R,Racine J,Wang M,Wang A,Todorov I,Wang J,Zeng D
17-0452 was used in Flow cytometry/Cell sorting to evaluate the contribution of T cells to the induction of chronic graft-versus-host disease.
Mon Jul 01 00:00:00 EDT 2013
AID-expressing germinal center B cells cluster normally within lymph node follicles in the absence of FDC-M1+ CD35+ follicular dendritic cells but dissipate prematurely.
Journal of immunology (Baltimore, Md. : 1950)
Boulianne B,Le MX,Ward LA,Meng L,Haddad D,Li C,Martin A,Gommerman JL
17-0452 was used in Flow cytometry/Cell sorting to provide a spatial-temporal analysis of Ag-specific B cell activation and AID expression in the context of a peripheral lymph node that lacks FDC-M1(+) CD35(+) FDC and other LT-sensitive cell types.
Fri Nov 01 00:00:00 EDT 2013
CD30 is required for activation of a unique subset of interleukin-17A-producing γδ T cells in innate immunity against Mycobacterium bovis Bacillus Calmette-Guerin infection.
Infection and immunity
Guo Y,Sun X,Shibata K,Yamada H,Muta H,Podack ER,Yoshikai Y
17-0452 was used in Flow cytometry/Cell sorting to demonstrate the involvement of CD30 signalling in the production of IL-17A by γδ T cells following BCG infection.
Tue Oct 01 00:00:00 EDT 2013
Myeloid dendritic cells (DCs) of mice susceptible to paracoccidioidomycosis suppress T cell responses whereas myeloid and plasmacytoid DCs from resistant mice induce effector and regulatory T cells.
Infection and immunity
Pina A,de Araujo EF,Felonato M,Loures FV,Feriotti C,Bernardino S,Barbuto JA,Calich VL
17-0452 was used in Flow cytometry/Cell sorting to highlight the deleterious effect of excessive innate proinflammatory reaction and provide new evidence for the importance of immunomodulation during pulmonary paracoccidioidomycosis.
Mon Apr 01 00:00:00 EDT 2013
Neuronal and nonneuronal cholinergic structures in the mouse gastrointestinal tract and spleen.
The Journal of comparative neurology
Gautron L,Rutkowski JM,Burton MD,Wei W,Wan Y,Elmquist JK
17-0452-82 was used in Immunohistochemistry to describe a variety of cholinergic neuronal and non-neuronal cells that modulate gastrointestinal and splenic immunity.
Fri Nov 01 00:00:00 EDT 2013
TDP2-dependent non-homologous end-joining protects against topoisomerase II-induced DNA breaks and genome instability in cells and in vivo.
PLoS genetics
Gómez-Herreros F,Romero-Granados R,Zeng Z,Alvarez-Quilón A,Quintero C,Ju L,Umans L,Vermeire L,Huylebroeck D,Caldecott KW,Cortés-Ledesma F
Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry
Thu Jun 13 00:00:00 EDT 2013
Up-regulation of a HOXA-PBX3 homeobox-gene signature following down-regulation of miR-181 is associated with adverse prognosis in patients with cytogenetically abnormal AML.
Blood
Li Z,Huang H,Li Y,Jiang X,Chen P,Arnovitz S,Radmacher MD,Maharry K,Elkahloun A,Yang X,He C,He M,Zhang Z,Dohner K,Neilly MB,Price C,Lussier YA,Zhang Y,Larson RA,Le Beau MM,Caligiuri MA,Bullinger L,Valk PJ,Delwel R,Lowenberg B,Liu PP,Marcucci G,Bloomfield CD,Rowley JD,Chen J
17-0452 was used in Flow cytometry/Cell sorting to study the prognostic impact of the four members of the miR-181 family in patients with CA-AML.
Thu Mar 08 00:00:00 EST 2012
Biphenotypic B-lymphoid/myeloid cells expressing low levels of Pax5: potential targets of BAL development.
Blood
Simmons S,Knoll M,Drewell C,Wolf I,Mollenkopf HJ,Bouquet C,Melchers F
17-0452 was used in Flow cytometry/Cell sorting to investigate how variation in Pax5 expression influences hematopoietic development, showing that biphenotypic B-lymphoid/myeloid cells expressing low levels of Pax5 could be targets for BAL.
Thu Nov 01 00:00:00 EDT 2012
IKKα-mediated signaling circuitry regulates early B lymphopoiesis during hematopoiesis.
Blood
Balkhi MY,Willette-Brown J,Zhu F,Chen Z,Liu S,Guttridge DC,Karin M,Hu Y
17-0452-82 was used in Flow Cytometry to demonstrate that IKKα regulates B-lineage commitment via combined canonical and noncanonical NF-κB transcriptional activities to target Pax5 expression during hematopoiesis.
Thu Jun 07 00:00:00 EDT 2012
Mechanisms of indirect acute lung injury: a novel role for the coinhibitory receptor, programmed death-1.
Annals of surgery
Monaghan SF,Thakkar RK,Heffernan DS,Huang X,Chung CS,Lomas-Neira J,Cioffi WG,Ayala A
17-0452 was used in Flow cytometry/Cell sorting to investigate how PD-1 expression contributes to mortality after the induction of indirect-acute lung injury.
Sun Jan 01 00:00:00 EST 2012
MyD88 signaling in B cells regulates the production of Th1-dependent antibodies to AAV.
Molecular therapy : the journal of the American Society of Gene Therapy
Sudres M,Ciré S,Vasseur V,Brault L,Da Rocha S,Boisgérault F,Le Bec C,Gross DA,Blouin V,Ryffel B,Galy A
17-0452 was used in Flow cytometry/Cell sorting to discover that MyD88 signalling in B cells, but not T cells, was sufficient to produce Th1-dependent IgGs.
Wed Aug 01 00:00:00 EDT 2012
Critical role of B cell lymphoma 10 in BAFF-regulated NF-κB activation and survival of anergic B cells.
Journal of immunology (Baltimore, Md. : 1950)
Yu M,Chen Y,He Y,Podd A,Fu G,Wright JA,Kleiman E,Khan WN,Wen R,Wang D
Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry
Sat Dec 01 00:00:00 EST 2012
Activation-induced cytidine deaminase-initiated off-target DNA breaks are detected and resolved during S phase.
Journal of immunology (Baltimore, Md. : 1950)
Hasham MG,Snow KJ,Donghia NM,Branca JA,Lessard MD,Stavnezer J,Shopland LS,Mills KD
Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry
Sat Sep 01 00:00:00 EDT 2012
TRAF binding is required for a distinct subset of in vivo B cell functions of the oncoprotein LMP1.
Journal of immunology (Baltimore, Md. : 1950)
Arcipowski KM,Bishop GA
17-0452 was used in Flow cytometry/Cell sorting to investigate whether the mechanism of action of TRAF proteins for LMP1 in vivo functions requires direct association.
Sat Dec 01 00:00:00 EST 2012
Th17 effector cells support B cell responses outside of germinal centres.
PloS one
Patakas A,Benson RA,Withers DR,Conigliaro P,McInnes IB,Brewer JM,Garside P
17-0452 was used in Flow cytometry/Cell sorting to investigate the role of Th17 cells in the development of a humoral immune response using T and B cell receptor transgenic mice.
Thu Jun 20 00:00:00 EDT 2013
Impact of enzymatic tissue disintegration on the level of surface molecule expression and immune cell function.
European journal of microbiology & immunology
Autengruber A,Gereke M,Hansen G,Hennig C,Bruder D
17-0452 was used in Flow cytometry/Cell sorting to indicate that enzymatic tissue disintegration can have profound effects on the expression of a variety of cell-surface molecules.
Fri Jun 01 00:00:00 EDT 2012
Induction of IL-10-producing CD1dhighCD5+ regulatory B cells following Babesia microti-infection.
PloS one
Jeong YI,Hong SH,Cho SH,Lee WJ,Lee SE
17-0452 was used in Flow cytometry/Cell sorting to demonstrate the expansion of Bregs following infection by an intraerythrocytic protozoan parasite.
Tue Apr 02 00:00:00 EDT 2013
Nuclear export of the NF-κB inhibitor IκBα is required for proper B cell and secondary lymphoid tissue formation.
Immunity
Wuerzberger-Davis SM,Chen Y,Yang DT,Kearns JD,Bates PW,Lynch C,Ladell NC,Yu M,Podd A,Zeng H,Huang TT,Wen R,Hoffmann A,Wang D,Miyamoto S
Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry
Fri Feb 25 00:00:00 EST 2011
Deletion of genes encoding PU.1 and Spi-B in B cells impairs differentiation and induces pre-B cell acute lymphoblastic leukemia.
Blood
Sokalski KM,Li SK,Welch I,Cadieux-Pitre HA,Gruca MR,DeKoter RP
17-0452 was used in Flow cytometry/Cell sorting to investigate the impairment of differentiation of B cells and induction of pre-B cell acute lymphoblastic leukemia through the deletion of genes encoding PU.1 and Spi-1 in B cells.
Thu Sep 08 00:00:00 EDT 2011
Microbiota-induced tertiary lymphoid tissues aggravate inflammatory disease in the absence of RORgamma t and LTi cells.
The Journal of experimental medicine
Lochner M,Ohnmacht C,Presley L,Bruhns P,Si-Tahar M,Sawa S,Eberl G
17-0452 was used in Immunofluorescence to investigate potential for intestinal immunodeficiency compensation by increased lymphoid tissue genesis.
Mon Jan 17 00:00:00 EST 2011
Sensitized phenotypic screening identifies gene dosage sensitive region on chromosome 11 that predisposes to disease in mice.
EMBO molecular medicine
Ermakova O,Piszczek L,Luciani L,Cavalli FM,Ferreira T,Farley D,Rizzo S,Paolicelli RC,Al-Banchaabouchi M,Nerlov C,Moriggl R,Luscombe NM,Gross C
17-0452 was used in Flow cytometry/Cell sorting to validate sensitised phenotypic screening of segmental aneuploidy lines as a strategy for systematically identifying disease susceptibility genes in mice.
Sat Jan 01 00:00:00 EST 2011
Validation of MdmX as a therapeutic target for reactivating p53 in tumors.
Genes & development
Garcia D,Warr MR,Martins CP,Brown Swigart L,Passegué E,Evan GI
17-0452 was used in Flow cytometry/Cell sorting to determine the effects of systemic MdmX inhibition in normal tissues and in tumours.
Mon Aug 15 00:00:00 EDT 2011
Mn(III) meso-tetrakis-(N-ethylpyridinium-2-yl) porphyrin mitigates total body irradiation-induced long-term bone marrow suppression.
Free radical biology & medicine
Li H,Wang Y,Pazhanisamy SK,Shao L,Batinic-Haberle I,Meng A,Zhou D
17-0452 was used in Flow cytometry/Cell sorting to demonstrate that MnTE can mitigate TBI-induced long-term BM suppression by inhibiting IR-induced HSC senescence through the ROS-p16 pathway.
Fri Jul 01 00:00:00 EDT 2011
Role of central leptin signaling in the starvation-induced alteration of B-cell development.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Tanaka M,Suganami T,Kim-Saijo M,Toda C,Tsuiji M,Ochi K,Kamei Y,Minokoshi Y,Ogawa Y
17-0452 was used in Flow cytometry/Cell sorting to show that the alteration of B-cell development in the bone marrow of fasted and obese mice can be reversed by central leptin administration.
Wed Jun 08 00:00:00 EDT 2011
Factor VIII delivered by haematopoietic stem cell-derived B cells corrects the phenotype of haemophilia A mice.
Thrombosis and haemostasis
Ramezani A,Zweier-Renn LA,Hawley RG
17-0452 was used in Flow cytometry/Cell sorting to provide evidence for B cell-directed protein delivery as a potential clinical approach to treat haemophilia A and other similar disorders.
Fri Apr 01 00:00:00 EDT 2011
Enhanced Toll-like receptor (TLR) responses of TNFR-associated factor 3 (TRAF3)-deficient B lymphocytes.
Journal of leukocyte biology
Xie P,Poovassery J,Stunz LL,Smith SM,Schultz ML,Carlin LE,Bishop GA
17-0452 was used in Flow cytometry/Cell sorting to show TRAF3 plays varied and cell type-specific, biological roles in TLR responses.
Thu Dec 01 00:00:00 EST 2011
Distinct developmental requirements for isolated lymphoid follicle formation in the small and large intestine: RANKL is essential only in the small intestine.
The American journal of pathology
Knoop KA,Butler BR,Kumar N,Newberry RD,Williams IR
17-0452 was used in Immunofluorescence to study the role of RANKL in the development of cryptopatches and isolated lymphoid follicles within intestinal lymphoid tissues.
Sat Oct 01 00:00:00 EDT 2011
Analysis of the role of IL-21 in development of murine B cell progenitors in the bone marrow.
Journal of immunology (Baltimore, Md. : 1950)
Simard N,Konforte D,Tran AH,Esufali J,Leonard WJ,Paige CJ
17-0452 was used in Flow cytometry/Cell sorting to provide evidence that IL-21R is functional in B cell progenitors and indicate that IL-21 regulates B cell development.
Sun May 01 00:00:00 EDT 2011
Negative selection by IgM superantigen defines a B cell central tolerance compartment and reveals mutations allowing escape.
Journal of immunology (Baltimore, Md. : 1950)
Duong BH,Ota T,Aoki-Ota M,Cooper AB,Ait-Azzouzene D,Vela JL,Gavin AL,Nemazee D
17-0452 was used in Flow cytometry/Cell sorting to demonstrate the usefulness of reconstituted IgM(b) superantigen hosts in revealing pathways involved in central tolerance.
Thu Dec 01 00:00:00 EST 2011
Lung CD103+ dendritic cells efficiently transport influenza virus to the lymph node and load viral antigen onto MHC class I for presentation to CD8 T cells.
Journal of immunology (Baltimore, Md. : 1950)
Ho AW,Prabhu N,Betts RJ,Ge MQ,Dai X,Hutchinson PE,Lew FC,Wong KL,Hanson BJ,Macary PA,Kemeny DM
17-0452 was used in Flow cytometry/Cell sorting to show that CD11b(low/neg)CD103(+) dendritic cells are functionally specialized for the transport of Ag from the lung to the lymph node.
Thu Dec 01 00:00:00 EST 2011
Sertoli cell-specific deletion of the androgen receptor compromises testicular immune privilege in mice.
Biology of reproduction
Meng J,Greenlee AR,Taub CJ,Braun RE
17-0452 was used in Flow cytometry/Cell sorting to show that Sertoli cell-specific Ar ablation leads to defective tight junction ultrastructure and elevated IgG in mouse testes.
Mon Aug 01 00:00:00 EDT 2011
Sertoli cell-specific deletion of the androgen receptor compromises testicular immune privilege in mice.
Biology of reproduction
Meng J,Greenlee AR,Taub CJ,Braun RE
17-0452 was used in Flow cytometry/Cell sorting to show that Sertoli cell-specific Ar ablation leads to defective tight junction ultrastructure and elevated IgG in mouse testes.
Mon Aug 01 00:00:00 EDT 2011
Memory T cells persisting in the brain following MCMV infection induce long-term microglial activation via interferon-γ.
Journal of neurovirology
Mutnal MB,Hu S,Little MR,Lokensgard JR
17-0452 was used in Flow cytometry/Cell sorting to study the migration, persistence, and effects of antigen-specific CD8 T cells in the brain in response to murine cytomegalovirus brain infection.
Sat Oct 01 00:00:00 EDT 2011
PAD4-mediated neutrophil extracellular trap formation is not required for immunity against influenza infection.
PloS one
Hemmers S,Teijaro JR,Arandjelovic S,Mowen KA
Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry
Tue Nov 15 00:00:00 EST 2011
The death effector domain protein PEA-15 negatively regulates T-cell receptor signaling.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Pastorino S,Renganathan H,Caliva MJ,Filbert EL,Opoku-Ansah J,Sulzmaier FJ,Gawecka JE,Werlen G,Shaw AS,Ramos JW
17-0452 was used in Flow cytometry/Cell sorting to investigate the physiological function of PEA-15, showing that it negatively regulates T-cell receptor signalling.
Sun Aug 01 00:00:00 EDT 2010
Peripheral B cell tolerance and function in transgenic mice expressing an IgD superantigen.
Journal of immunology (Baltimore, Md. : 1950)
Duong BH,Ota T,Aït-Azzouzene D,Aoki-Ota M,Vela JL,Huber C,Walsh K,Gavin AL,Nemazee D
17-0452 was used in Flow cytometry/Cell sorting to generate mice which ubiquitously expressed a membrane-bound IgD-superantigen, to provide a model which should facilitate studies of peripheral B cell tolerance in future.
Thu Apr 15 00:00:00 EDT 2010
The innate immune response to uropathogenic Escherichia coli involves IL-17A in a murine model of urinary tract infection.
Journal of immunology (Baltimore, Md. : 1950)
Sivick KE,Schaller MA,Smith SN,Mobley HL
17-0452 was used in Flow cytometry/Cell sorting to show that IL-17A is a key mediator for the innate immune response to UTIs.
Mon Feb 15 00:00:00 EST 2010
Regulation of follicular B cell differentiation by the related E26 transformation-specific transcription factors PU.1, Spi-B, and Spi-C.
Journal of immunology (Baltimore, Md. : 1950)
DeKoter RP,Geadah M,Khoosal S,Xu LS,Thillainadesan G,Torchia J,Chin SS,Garrett-Sinha LA
17-0452 was used in Flow cytometry/Cell sorting to demonstrate the role of the E26 transformation-specific transcription factors PU.1, Spi-B, and Spi-C in follicular B cell development.
Wed Dec 15 00:00:00 EST 2010
A critical role of TAK1 in B-cell receptor-mediated nuclear factor kappaB activation.
Blood
Schuman J,Chen Y,Podd A,Yu M,Liu HH,Wen R,Chen ZJ,Wang D
Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry
Thu May 07 00:00:00 EDT 2009
Dendritic cells are required for optimal activation of natural killer functions following primary infection with herpes simplex virus type 1.
Journal of virology
Kassim SH,Rajasagi NK,Ritz BW,Pruett SB,Gardner EM,Chervenak R,Jennings SR
17-0452 was used in Flow cytometry/Cell sorting to provide evidence that functional DCs are required for optimal IFN-gamma expression and cytolytic function by NK cells following HSV-1 infection.
Wed Apr 01 00:00:00 EDT 2009
c-Myb is required for pro-B cell differentiation.
Journal of immunology (Baltimore, Md. : 1950)
Fahl SP,Crittenden RB,Allman D,Bender TP
17-0452 was used in Flow cytometry/Cell sorting to demonstrate that c-Myb is absolutely required for the survival and differentiation of CD19(+) B-lineage cells.
Sun Nov 01 00:00:00 EDT 2009
Endogenous IL-21 restricts CD8+ T cell expansion and is not required for tumor immunity.
Journal of immunology (Baltimore, Md. : 1950)
Søndergaard H,Coquet JM,Uldrich AP,McLaughlin N,Godfrey DI,Sivakumar PV,Skak K,Smyth MJ
17-0452 was used in Flow cytometry/Cell sorting to reveal novel immunosuppressive actions of interleukin-21.
Tue Dec 01 00:00:00 EST 2009
E47 controls the developmental integrity and cell cycle quiescence of multipotential hematopoietic progenitors.
Journal of immunology (Baltimore, Md. : 1950)
Yang Q,Kardava L,St Leger A,Martincic K,Varnum-Finney B,Bernstein ID,Milcarek C,Borghesi L
17-0452 was used in Flow cytometry/Cell sorting to show E47 controls the developmental integrity and cell cycle quiescence of hematopoietic progenitors.
Sat Nov 01 00:00:00 EDT 2008
p27 deficiency cooperates with Bcl-2 but not Bax to promote T-cell lymphoma.
PloS one
Cheng N,van de Wetering CI,Knudson CM
Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry
Wed Apr 02 00:00:00 EDT 2008
Silent development of memory progenitor B cells.
Journal of immunology (Baltimore, Md. : 1950)
Aviszus K,Zhang X,Wysocki LJ
17-0452 was used in Immunofluorescence to support a model of memory B cell development in which extensive affinity/specificity maturation can take place within a B cell clone under some circumstances.
Mon Oct 15 00:00:00 EDT 2007
Phospholipase Cgamma2 contributes to light-chain gene activation and receptor editing.
Molecular and cellular biology
Bai L,Chen Y,He Y,Dai X,Lin X,Wen R,Wang D
Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry
Sat Sep 01 00:00:00 EDT 2007
B-1 B lymphocytes require Blimp-1 for immunoglobulin secretion.
The Journal of experimental medicine
Savitsky D,Calame K
17-0452 was used in Flow cytometry/Cell sorting to show that Blimp-1 is not necessary for the formation or self-renewal of B-1 B cells but that Blimp-1 is required for normal immunoglobulin (Ig) secretion by B-1 cells.
Mon Oct 02 00:00:00 EDT 2006
Negative regulation of activation-induced cytidine deaminase in B cells.
Proceedings of the National Academy of Sciences of the United States of America
Muto T,Okazaki IM,Yamada S,Tanaka Y,Kinoshita K,Muramatsu M,Nagaoka H,Honjo T
17-0452 was used in Flow cytometry/Cell sorting to show that abundant activation-induced cytidine deaminase protein accumulated by constitutive expression, is inactivated in B cells.
Tue Feb 21 00:00:00 EST 2006
In vivo ablation of CD11c-positive dendritic cells increases susceptibility to herpes simplex virus type 1 infection and diminishes NK and T-cell responses.
Journal of virology
Kassim SH,Rajasagi NK,Zhao X,Chervenak R,Jennings SR
17-0452 was used in Flow cytometry/Cell sorting to investigate the role of different dendritic cell subsets in response to herpes simplex virus type 1 infection in mice.
Sat Apr 01 00:00:00 EST 2006
Essential role of phospholipase C gamma 2 in early B-cell development and Myc-mediated lymphomagenesis.
Molecular and cellular biology
Wen R,Chen Y,Bai L,Fu G,Schuman J,Dai X,Zeng H,Yang C,Stephan RP,Cleveland JL,Wang D
Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry
Fri Dec 01 00:00:00 EST 2006
A role for brain-derived neurotrophic factor in B cell development.
Journal of neuroimmunology
Schuhmann B,Dietrich A,Sel S,Hahn C,Klingenspor M,Lommatzsch M,Gudermann T,Braun A,Renz H,Nockher WA
Wed Jun 01 00:00:00 EDT 2005
Impaired immune responses and B-cell proliferation in mice lacking the Id3 gene.
Molecular and cellular biology
Pan L,Sato S,Frederick JP,Sun XH,Zhuang Y
Published figure using CD45R (B220) monoclonal antibody (Product # 17-0452-82) in Flow Cytometry
Wed Sep 01 00:00:00 EDT 1999
-RA3-6B2-RE-AV-20170920122035.jpg?time=20220826)
-RA3-6B2-RE-AV-20170920122035.jpg?time=20220826?time=20220826 "CD45R (B220) Antibody (17-0452-82)")
