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CD46 Antibody (MA5-44003) in Flow
Separation of human lymphocytes (red-filled) from erythrocytes (black-dashed) in flow cytometry analysis (surface staining) of human peripheral whole blood stained using anti-human CD46 (MEM-258) purified Monoclonal antibody (Product # MA5-44003), concentration in sample 0.5 µg/mL, GAM APC.
产品信息
MA5-44003
产品规格
种属反应
Bovine,
Human
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
MEM-258
抗原
HPB-ALL human T cell line
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
15mM sodium azide
保存条件
4° C, do not freeze
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2912935
产品详细信息
This antibody recognizes an extracellular epitope on SCR4 (the membrane-proximal SCR) domain of CD46 (Membrane cofactor protein). CD46 is 56-66 kDa dimeric transmembrane protein expressed on T and B lymphocytes, platelets, monocytes, granulocytes, endothelial cells, epithelial cells and fibroblast; it is negative on erythrocytes.
Western Blot: non-reducing conditions.
靶标信息
CD46 (MCP, membrane cofactor protein) is a multifunctional cell surface transmembrane protein that binds and inactivates C3b and C4b complement fragments, regulates T cell-induced inflammatory responses by either inhibiting (CD46-1 isoform) or increasing (CD46-2 isoform) the contact hypersensitivity reaction. CD46 also serves as a receptor for several human pathogens (both bacteria and viruses), and its ligation alteres T lymphocyte polarization toward antigen-presenting cells or target cells, inhibiting lymphocyte function. CD46 is a protector of placental tissue and is also expressed on the inner acrosomal membrane of spermatozoa.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: antigen identified by monoclonal antibody TRA-2-10; brain microvascular membrane cofactor; CD46; CD46 antigen, complement regulatory protein; CD46 molecule, complement regulatory protein; complement membrane cofactor protein; complement regulatory protein; MCP; complement activation regulator; measles virus receptor; Membrane cofactor protein; membrane cofactor protein (CD46, trophoblast-lymphocyte cross-reactive antigen); membrane cofactor protein variant 10; membrane cofactor protein variant 7; membrane cofactor protein variant 8; membrane cofactor protein variant 9; MGC26544; soluble membrane cofactor protein variant 11; soluble membrane cofactor protein variant 12; soluble membrane cofactor protein variant 13; TLX; trophoblast leucocyte common antigen; Trophoblast leukocyte common antigen; trophoblast-lymphocyte cross-reactive antigen
基因别名: AHUS2; CD46; MCP; MIC10; TLX; TRA2.10
UniProt ID: (Human) P15529, (Bovine) Q6VE48
Entrez Gene ID: (Human) 4179, (Bovine) 280851
adaptive immune response
T cell mediated immunity
proteolysis
complement activation, classical pathway
single fertilization
regulation of Notch signaling pathway
positive regulation of gene expression
negative regulation of gene expression
regulation of complement activation
interleukin-10 production
positive regulation of interleukin-10 production
sequestering of extracellular ligand from receptor
positive regulation of T cell proliferation
negative regulation of catalytic activity
positive regulation of memory T cell differentiation
innate immune response
positive regulation of regulatory T cell differentiation
negative regulation of complement activation
viral entry into host cell
positive regulation of transforming growth factor beta production
