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This antibody recognizes an extracellular epitope of murine CD49e, a 135 kDa protein serving as VLA-5 alpha chain, expressed on thymocytes, activated T cells, splenic B cells, and mast cells.
The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes the integrin alpha 5 chain. Alpha chain 5 undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 to form a fibronectin receptor. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: CD49 antigen-like family member E; CD49e; fibronectin receptor alpha polypeptide; Fibronectin receptor subunit alpha; Integrin alpha-5; Integrin alpha-F; VLA-5
基因别名: Cd49e; Fnra; Itga5; VLA5
UniProt ID: (Mouse) P11688
Entrez Gene ID: (Mouse) 16402