Invitrogen

CD49f Polyclonal Antibody

高级验证

This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated.

查看其他37个CD49f (Integrin alpha 6)抗体

说明书

实验方案

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说明书

实验方案

技术支持

高级验证 (2)

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CD49f Antibody (PA5-82466)

Relative expression in western blot: Antibody specificity was demonstrated by detection of known differential basal expression of the target across tissue/cell models. Expression of CD49f was observed specifically in A-431 cells and in MCF-7 cells using anti-CD49f Polyclonal Antibody (Product #PA5-82466) in western blot. The relative expression levels of CD49f within each cell line is shown using RNA-Seq. {... View More

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CD49f Antibody — Relative expression in western blot: Antibody specificity was demonstrated by detection of known differential basal expression of the target across tissue/cell models. Expression of CD49f was observed specifically in A-431 cells and in MCF-7 cells using anti-CD49f Polyclonal Antibody (Product #PA5-82466) in western blot. The relative expression levels of CD49f within each cell line is shown using RNA-Seq. {RE}

产品信息

PA5-82466

应用

建议稀释比

已发表文章

免疫印迹 (WB)

0.04-0.4 µg/mL

免疫组化 (IHC)

1:200-1:500

产品规格

种属反应

Human

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Recombinant protein corresponding to Human ITGA6. Recombinant protein control fragment (Product #RP-88618).

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.08 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.2, with 40% glycerol

内含物

0.02% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Wet ice

RRID

AB_2789624

产品详细信息

Immunogen sequence: APYDDLGKVF IYHGSANGIN TKPTQVLKGI SPYFGYSIAG NMDLDRNSYP DVAVGSLSDS VTIFRSRPVI NIQKTITVTP NRIDLRQKTA CGAPSGICLQ VKSCFEYTAN PAGYNPSISI VGTLEAEKER RKSGLSS

靶标信息

CDf (Integrin alpha-6, ITGA6) is the integrin alpha chain alpha 6 protein. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. For example, alpha 6 may combine with beta 4 in the integrin referred to as TSP180, or with beta 1 in the integrin VLA-6. Integrins are known to participate in cell adhesion as well as cell-surface mediated signaling. Two transcript variants encoding different isoforms have been found for CDf. Functionally, integrins are cell surface receptors that interact with the extracellular matrix and mediate intracellular signals that affect cellular shape, mobility, and progression through the cell cycle in response to the extracellular matrix. Integrin receptors are composed of alpha and beta subunits, and form structural and functional linkages between the ECM (extra-cellular matrix) and intracellular cytoskeletal linker proteins. Signaling mediated by Intergrin/ECM interactions are also integrated with cellular responses to growth factor signaling to regulate cellular proliferation, cytoskeletal reorganization and other responses necessary for cellular survival. CDf is predominantly expressed by epithelia, and plays a critical structural role in the hemidesmosome. More than 18 alpha and 8 beta subunits with numerous splice variant isoforms have been identified in mammals. Certain integrins can also bind to soluble ligands or to counter-receptors on adjacent cells, such as the intracellular adhesion molecules (ICAMs), resulting in aggregation of cells.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: CD49 antigen-like family member F; CD49f; DKFZp686J01244; FLJ18737; integrin alpha 6; Integrin alpha-6; integrin alpha6B; integrin, alpha 6; VLA-6

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基因别名: CD49f; ITGA6; ITGA6B; VLA-6

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UniProt ID: (Human) P23229

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Entrez Gene ID: (Human) 3655

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功能

integrin binding protein binding insulin-like growth factor I binding neuregulin binding metal ion binding cadherin binding involved in cell-cell adhesion integrin

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