Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
产品信息
MA5-28575
产品规格
种属反应
Human,
Pig
宿主/亚型
Mouse
/ IgG1, kappa
分类
Monoclonal
类型
Antibody
克隆号
1.2B6
抗原
TNF stimulated human endothelial cells
偶联物
激发/发射光谱
568/666 nm
查看光谱
形式
Liquid
浓度
0.05 mg/mL
纯化类型
purified
保存液
PBS, pH 7.1, with proprietary stabilizer
内含物
<0.1% sodium azide
保存条件
4° C, store in dark, DO NOT FREEZE!
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2745534
靶标信息
CD62E represents the 97 kDa type I transmembrane glycoprotein E-selectin, also known as endothelial-leukocyte adhesion molecule-1 (ELAM-1). It is expressed on cytokine-stimulated endothelium, weakly on unactivated endothelium, and is absent on leukocytes. Like other selectins, CD62E is an adhesion molecule that contributes to the initial attachment and rolling of leukocytes on endothelial surfaces, a prerequisite for leukocyte extravasation into tissues.CD62P is a 140 kDa membrane glycoprotein formerly known as platelet activation-dependent granule membrane protein (PADGEM) or GMP-140. It is expressed on platelets, megakaryocytes, and epithelium. It is thought to mediate the adhesive interactions of neutrophils and monocytes with endothelium in inflammatory responses and of activated platelets to neutrophils and monocytes in hemostasis. The monoclonal antibody 1.2B6 recognizes a common epitope shared by CD62E and CD62P.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
How to use the Panel Builder
Watch the video to learn how to use the Invitrogen Flow Cytometry Panel Builder to build your next flow cytometry panel in 5 easy steps.
篇参考文献 (0)
您是否在文献中引用过该产品？请点击下方按钮邮件告知我们。
生物信息学
蛋白别名: CD62 antigen-like family member E; CD62 antigen-like family member P; CD62E; CD62P; CD62P; CD62 homolog; E-selectin; ELAM-1; endothelial adhesion molecule 1; Endothelial leukocyte adhesion molecule 1; GMP-140; Granule membrane protein 140; granule membrane protein 140kDa; granulocyte membrane protein; LECAM-2; LECAM-3; LECAM2; LECAM3; leukocyte endothelial cell adhesion molecule 2; Leukocyte-endothelial cell adhesion molecule 2; Leukocyte-endothelial cell adhesion molecule 3; P-selectin; PADGEM; Platelet activation dependent granule-external membrane protein; platelet alpha-granule membrane protein; RP1-117P20.2; selectin E (endothelial adhesion molecule 1); selectin P (granule membrane protein 140kDa, antigen CD62)
基因别名: CD62; CD62E; CD62P; ELAM; ELAM1; ESEL; GMP140; GMRP; GRMP; LECAM2; LECAM3; PADGEM; PSEL; SELE; SELP
UniProt ID: (Human) P16581, (Pig) P98110, (Human) P16109
Entrez Gene ID: (Human) 6401, (Pig) 397508, (Pig) 397150, (Human) 6403
transmembrane signaling receptor activity
protein binding
sialic acid binding
phospholipase binding
oligosaccharide binding
carbohydrate binding
metal ion binding
lipopolysaccharide binding
glycoprotein binding
heparin binding
fucose binding
glycosphingolipid binding
calcium-dependent protein binding
platelet degranulation
positive regulation of leukocyte migration
regulation of cellular extravasation
inflammatory response
cell adhesion
heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
leukocyte cell-cell adhesion
positive regulation of platelet activation
positive regulation of phosphatidylinositol 3-kinase signaling
response to organic cyclic compound
response to lipopolysaccharide
regulation of integrin activation
calcium-mediated signaling using intracellular calcium source
positive regulation of cell adhesion
defense response to Gram-negative bacterium
leukocyte migration
leukocyte tethering or rolling
positive regulation of receptor internalization
leukocyte migration involved in inflammatory response
activation of phospholipase C activity
calcium-mediated signaling
actin filament-based process
response to tumor necrosis factor
regulation of inflammatory response
response to interleukin-1
positive regulation of leukocyte tethering or rolling
