Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
图: 1 / 1
CD72 Antibody (PA5-97292) in WB
Western blot analysis of CD72 in Daudi cells. Samples were incubated with CD72 Polyclonal antibody (Product # PA5-97292) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 90s.
产品信息
PA5-97292
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 120-359 of human CD72 (NP_0017731)
偶联物
形式
Liquid
浓度
1.28 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2809094
产品详细信息
Immunogen sequence: QVSQQLQQTN RVLEVTNSSL RQQLRLKITQ LGQSAEDLQG SRRELAQSQE ALQVEQRAHQ AAEGQLQACQ ADRQKTKETL QSEEQQRRAL EQKLSNMENR LKPFFTCGSA DTCCPSGWIM HQKSCFYISL TSKNWQESQK QCETLSSKLA TFSEIYPQSH SYYFLNSLLP NGGSGNSYWT GLSSNKDWKL TDDTQRTRTY AQSSKCNKVH KTWSWWTLES ESCRSSLPYI CEMTAFRFPD; Positive Samples: B-cell, Mouse liver, Mouse kidney, Rat liver, Rat kidney; Cellular Location: Membrane, Single-pass type II membrane protein
靶标信息
CD72 is a transmembrane glycoprotein expressed as a homodimer especially in B cells, but also in other antigen presenting cells such as dendritic cells and macrophages. Through one of its immunoreceptor tyrosine-based inhibitory motives (ITIMs), CD72 interacts with tyrosine phosphatase SHP-1, thereby suppressing B cell responsiveness. Binding of CD72 with its ligand CD100 (Sema4D) prevents BCR association and phosphorylation of CD72 and results in dissociation of SHP-1 from CD72, thus enables B cell activation.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: B-cell differentiation antigen CD72; CD72; CD72 antigen; Ly-32; Lyb-2; Lymphocyte antigen 32; RP11-331F9.9
基因别名: CD72; CD72b; CD72c; Ly-19; Ly-32; Ly-m19; Ly32; Lyb-2; LYB2
UniProt ID: (Human) P21854, (Mouse) P21855
Entrez Gene ID: (Human) 971, (Rat) 313498, (Mouse) 12517
