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This antibody recognizes an extracellular epitope of CD89, a 55-100 kDa glycoprotein serving as a receptor for IgA and expressed mainly on granulocytes, monocytes and macrophages.
This gene is a member of the immunoglobulin gene superfamily and encodes a receptor for the Fc region of IgA. The receptor is a transmembrane glycoprotein present on the surface of myeloid lineage cells such as neutrophils, monocytes, macrophages, and eosinophils, where it mediates immunologic responses to pathogens. It interacts with IgA-opsonized targets and triggers several immunologic defense processes, including phagocytosis, antibody-dependent cell-mediated cytotoxicity, and stimulation of the release of inflammatory mediators. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: CD89; Fc alpha receptor; Fc fragment of IgA, receptor for; IgA Fc receptor; immunoglobulin A Fc receptor; immunoglobulin A Fc receptor transcript variant deltaEC1 delta TM/C; Immunoglobulin alpha Fc receptor
基因别名: CD89; CTB-61M7.2; FcalphaRI; FCAR
UniProt ID: (Human) P24071
Entrez Gene ID: (Cynomolgus monkey) 102145896, (Human) 2204, (Rhesus monkey) 664734
分子生物学功能:
immunoglobulin receptor superfamily