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Invitrogen
CDK5 Polyclonal Antibody
高级验证
This Antibody was verified by Knockout to ensure that the antibody binds to the antigen stated.
产品信息
PA5-96409
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 1-292 of human CDK5 (NP_004926.1).
偶联物
形式
Liquid
浓度
0.54 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.01% thimerosal
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2808211
产品详细信息
Immunogen sequence: MQKYEKLEKI GEGTYGTVFK AKNRETHEIV ALKRVRLDDD DEGVPSSALR EICLLKELKH KNIVRLHDVL HSDKKLTLVF EFCDQDLKKY FDSCNGDLDP EIVKSFLFQL LKGLGFCHSR NVLHRDLKPQ NLLINRNGEL KLADFGLARA FGIPVRCYSA EVVTLWYRPP DVLFGAKLYS TSIDMWSAGC IFAELANAGR PLFPGNDVDD QLKRIFRLLG TPTEEQWPSM TKLPDYKPYP MYPATTSLVN VVPKLNATGR DLLQNLLKCN PVQRISAEEA LQHPYFSDFC PP
Positive Samples: 293T, HepG2, BT-474, Mouse brain, PC-12, Rat brain; Cellular Location: Cell junction, Cell membrane, Cell projection, Cytoplasm, Nucleus, Perikaryon, Peripheral membrane protein, growth cone, lamellipodium, postsynaptic cell membrane, postsynaptic density, synapse
靶标信息
CDK5 is a member of the Cyclin-Dependent Kinase family that is most abundant in the mammalian brain. Active form of CDK5, which has also been called neuronal cdc2-like kinase, is a heterodimer of CDK5 and a 25 kDa protein which is derived proteolytically from a 35 kDa brain and neuron-specific protein and is essential for the kinase activity of CDK5. CDK5 has emerged as a crucial regulator of neuronal migration in the developing central nervous system. CDK5 phosphorylates a diverse list of substrates, implicating it in the regulation of a range of cellular processes - from adhesion and motility, to synaptic plasticity and drug addiction.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CDK5-SV; Cell division protein kinase 5; CR6 protein kinase; Cyclin-dependent kinase 5; Cyclin-dependent-like kinase 5; protein kinase CDK5 splicing; Serine/threonine-protein kinase PSSALRE; Tau protein kinase II catalytic subunit; TPKII catalytic subunit
基因别名: AW048668; CDK5; CDKN5; Crk6; LIS7; PSSALRE
UniProt ID: (Human) Q00535, (Mouse) P49615, (Rat) Q03114
Entrez Gene ID: (Human) 1020, (Mouse) 12568, (Rat) 140908
p53 binding
protein kinase activity
protein serine/threonine kinase activity
cyclin-dependent protein serine/threonine kinase activity
ErbB-2 class receptor binding
protein binding
ATP binding
cytoskeletal protein binding
kinase activity
protein kinase binding
acetylcholine receptor activator activity
ErbB-3 class receptor binding
ephrin receptor binding
tau-protein kinase activity
nucleotide binding
transferase activity
transferase activity, transferring phosphorus-containing groups
non-receptor serine/threonine protein kinase
neuron migration
synaptic transmission, dopaminergic
intracellular protein transport
nucleocytoplasmic transport
cell cycle
cell-matrix adhesion
chemical synaptic transmission
synapse assembly
skeletal muscle tissue development
motor neuron axon guidance
cell proliferation
visual learning
response to wounding
Schwann cell development
synaptic vesicle exocytosis
regulation of macroautophagy
phosphorylation
peptidyl-serine phosphorylation
peptidyl-threonine phosphorylation
sensory perception of pain
cerebellar cortex formation
hippocampus development
layer formation in cerebral cortex
central nervous system neuron development
corpus callosum development
neuron differentiation
regulation of cell migration
negative regulation of axon extension
cortical actin cytoskeleton organization
neuron projection development
negative regulation of protein ubiquitination
negative regulation of synaptic plasticity
positive regulation of protein binding
receptor catabolic process
serine phosphorylation of STAT3 protein
synaptic transmission, glutamatergic
protein localization to synapse
regulation of apoptotic process
receptor clustering
positive regulation of neuron apoptotic process
negative regulation of cell cycle
positive regulation of protein kinase activity
negative regulation of proteolysis
negative regulation of transcription, DNA-templated
positive regulation of calcium ion-dependent exocytosis
protein autophosphorylation
negative regulation of protein export from nucleus
behavioral response to cocaine
regulation of synaptic plasticity
synaptic vesicle endocytosis
rhythmic process
axon extension
oligodendrocyte differentiation
dendrite morphogenesis
cell division
neuron apoptotic process
excitatory postsynaptic potential
regulation of dendritic spine morphogenesis
calcium ion import
regulation of cell cycle arrest
positive regulation of protein targeting to membrane
negative regulation of neuron death
regulation of signal transduction by p53 class mediator
regulation of synaptic vesicle recycling
positive regulation of actin cytoskeleton reorganization
positive regulation of receptor activity
protein phosphorylation
exocytosis
apoptotic process
nervous system development
axonogenesis
associative learning
cell migration
telencephalon development
cerebellum development
cerebellar cortex development
cerebral cortex development
forebrain development
response to cocaine
regulated exocytosis
neuron projection morphogenesis
regulation of cell cycle
regulation of postsynaptic membrane potential
central nervous system development
