Invitrogen

CDK9 Polyclonal Antibody

高级验证

This Antibody was verified by Knockdown to ensure that the antibody binds to the antigen stated.

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说明书
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产品信息

PA5-19674

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:250-1:500
-

免疫细胞化学 (ICC/IF)

1 µg/mL
-
产品规格

种属反应

Human, Mouse, Xenopus

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Synthetic peptide conjugated to KLH derived from within residues 150 - 250 of Human Cdk9.
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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.4 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.4, with 1% BSA

内含物

0.02% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_10978653

产品详细信息

This antibody is predicted to react with mouse, rat, chicken and cow based on sequence homology.

靶标信息

CDK9 is a serine/threonine kinase which when complexed with CyclinT1 forms an active holoenzyme complex. This complex plays a key role in regulating the eukaryotic cell cycle. CDK9 is coexpressed and copurified with CyclinT1. CDK9 regulates cytokine inducible transcription networks by facilitating promoter recognition of target transcription factors. CDK9 promotes RNA synthesis in genetic programs for cell growth, differentiation, and viral pathogenesis. The CDK9/cyclin-K complex also has kinase activity towards CTD of RNAPII and can substitute for CDK9/cyclin-T P-TEFb in vitro. Chronic activation of CDK9 causes cardiac myocyte enlargement leading to cardiac hypertrophy and confers a predisposition to heart failure.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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生物信息学

蛋白别名: C-2K; CDC2-related kinase; Cell division cycle 2-like protein kinase 4; Cell division protein kinase 9; Cyclin-dependent kinase 9; RP11-228B15.5; serine/threonine protein kinase PITALRE; Serine/threonine-protein kinase PITALRE; Tat-associated kinase complex catalytic subunit

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基因别名: C-2k; CDC2L4; CDK9; CTK1; PITALRE; TAK

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UniProt ID: (Human) P50750, (Mouse) Q99J95

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Entrez Gene ID: (Human) 1025, (Mouse) 107951

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功能
RNA polymerase II core promoter sequence-specific DNA binding transcription coactivator binding DNA binding chromatin binding protein kinase activity protein serine/threonine kinase activity cyclin-dependent protein serine/threonine kinase activity protein binding ATP binding RNA polymerase II carboxy-terminal domain kinase activity kinase activity 7SK snRNA binding nucleotide binding transcription factor binding transferase activity transferase activity, transferring phosphorus-containing groups snRNA binding transcription regulatory region DNA binding non-receptor serine/threonine protein kinase
参与通路
DNA repair regulation of DNA repair transcription from RNA polymerase II promoter transcription initiation from RNA polymerase II promoter transcription elongation from RNA polymerase II promoter protein phosphorylation regulation of mitotic cell cycle cell proliferation positive regulation of cardiac muscle hypertrophy regulation of histone modification replication fork processing positive regulation of histone phosphorylation response to drug snRNA transcription from RNA polymerase II promoter positive regulation of transcription from RNA polymerase II promoter positive regulation of viral transcription regulation of muscle cell differentiation negative regulation of cell cycle arrest cellular response to cytokine stimulus negative regulation of mRNA polyadenylation positive regulation of mRNA 3'-UTR binding positive regulation of histone H2B ubiquitination transcription, DNA-templated regulation of transcription, DNA-templated cellular response to DNA damage stimulus phosphorylation replication fork arrest
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