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CDw293 Antibody (PA5-27712) in IHC (P)
CDw293 Polyclonal Antibody detects BMPR1B protein at cytosol on human hepatoma by immunohistochemical analysis. Sample: Paraffin-embedded human hepatoma. CDw293 Polyclonal Antibody (Product # PA5-27712) dilution: 1:500. Antigen Retrieval: EDTA based buffer, pH 8.0, 15 min.
产品信息
PA5-27712
应用
建议稀释比
已发表文章
产品规格
种属反应
Bovine,
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fragment corresponding to a region within amino acids 238 and 502 of Human BMPR1B
偶联物
形式
Liquid
浓度
0.1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7, with 20% glycerol
内含物
0.025% ProClin 300
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2545188
产品详细信息
Recommended positive controls: 293T, Neuro2A, C8D30, NIH-3T3, human BMPR1B-transfected 293T, Rat2.
Predicted reactivity: Mouse (98%), Rat (98%), Dog (98%), Pig (98%), Chicken (96%), Sheep (98%), Rhesus Monkey (99%), Bovine (99%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
靶标信息
BMPR1B (also known as ALK6, CDw293) is a member of the transmembrane serine/threonine kinase that is the member of the bone morphogenetic protein (BMP) receptor, which is closely related to the activin receptors, ACVR1 and ACVR2. BMPR1B is mainly involved in the endochondral bone formation and embryogenesis. BMPR1B expressed in normal and cancerous prostate tissues and used in the endocrine therapy that given to the prostate cancer patients. BMPR1B receptor trafficking also play a significant role in FOP pathogenesis and used in human T-cell differentiation.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Activin receptor-like kinase 6; ALK-6; BMP type-1B receptor; BMPR-1B; bone morphogenetic protein binding serine/threonine kinase receptor; bone morphogenetic protein receptor IB; bone morphogenetic protein receptor type IB; Bone morphogenetic protein receptor type-1B; bone morphogenetic protein receptor, type IB; CDw293; serine/threonine receptor kinase; Serine/threonine-protein kinase receptor R6; SKR6
基因别名: Acvrlk6; AI385617; ALK-6; ALK6; AMDD; AV355320; BDA1D; BDA2; BMP15; BMPR-1B; BMPR-IB; BMPR1B; BMPRIB; CDw293; CFK-43a; SKR6
UniProt ID: (Human) O00238, (Mouse) P36898
Entrez Gene ID: (Bovine) 407128, (Human) 658, (Mouse) 12167, (Rat) 310914
glycoprotein binding
protein serine/threonine kinase activity
transmembrane receptor protein serine/threonine kinase activity
receptor signaling protein serine/threonine kinase activity
transforming growth factor beta receptor activity, type I
protein binding
ATP binding
SMAD binding
metal ion binding
nucleotide binding
protein kinase activity
transforming growth factor beta-activated receptor activity
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
molecular_function
serine/threonine protein kinase receptor
skeletal system development
cartilage condensation
ovarian cumulus expansion
eye development
chondrocyte development
protein phosphorylation
inflammatory response
dorsal/ventral pattern formation
signal transduction by protein phosphorylation
proteoglycan biosynthetic process
positive regulation of bone mineralization
BMP signaling pathway
retinal ganglion cell axon guidance
positive regulation of chondrocyte differentiation
limb morphogenesis
ovulation cycle
positive regulation of cell differentiation
positive regulation of osteoblast differentiation
positive regulation of transcription from RNA polymerase II promoter
retina development in camera-type eye
endochondral bone morphogenesis
positive regulation of cartilage development
cellular response to BMP stimulus
positive regulation of extrinsic apoptotic signaling pathway via death domain receptors
negative regulation of chondrocyte proliferation
chondrocyte differentiation
estrogen biosynthetic process
transmembrane receptor protein serine/threonine kinase signaling pathway
transforming growth factor beta receptor signaling pathway
phosphorylation
cell differentiation
camera-type eye development
cartilage development
biological_process
