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Centromere and kinetochore proteins play a critical role in centromere structure, kinetochore formation, and sister chromatid separation. The protein encoded by this gene colocalizes with inner kinetochore plate proteins CENP-A and CENP-C in both interphase and metaphase. It localizes outside of centromeric heterochromatin, where CENP-B is localized, and inside the kinetochore corona, where CENP-E is localized during prometaphase. It is thought that this protein can bind to itself, as well as to CENP-A, CENP-B or CENP-C. Multimers of the protein localize constitutively to the inner kinetochore plate and play an important role in the organization and function of the active centromere-kinetochore complex.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: CENP-H; cenph; centromere autoantigen H; Centromere protein H
基因别名: 1700021I11Rik; 2410018A12Rik; 2610042E16Rik; 2810046K12Rik; AU044255; CENP-H; Cenph; ENP
UniProt ID: (Mouse) Q9QYM8
Entrez Gene ID: (Mouse) 26886