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Immunogen sequence: LDSLTDDSFN QVTQDPIEEA LGLPSSLDSL DQMNQDGGGG DVGNSSASEL VPPPEEAAPT ELSKESTAPA PESITLHDYT TQPASQEQP
DNA helicase that acts as a chromatin remodeling factor and regulates transcription. Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive genes. Involved in both enhancer blocking and epigenetic remodeling at chromatin boundary via its interaction with CTCF. Acts as a suppressor of STAT3 activity by suppressing the LIF-induced STAT3 transcriptional activity. Also acts as a transcription activator via its interaction with ZNF143 by participating in efficient U6 RNA polymerase III transcription.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: ATP-dependent helicase CHD8; axis duplication inhibitor; CHD-8; Chromodomain-helicase-DNA-binding protein 8; duplin; Helicase with SNF2 domain 1
基因别名: AUTS18; CHD8; HELSNF1; KIAA1564
UniProt ID: (Human) Q9HCK8
Entrez Gene ID: (Human) 57680