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CHMP1B Antibody (PA5-100437) in ICC/IF
Immunofluorescent analysis of CHMP1B in HeLa cells. Samples were fixed with paraformaldehyde, permeabilized with 0.1% Triton X-100, blocked with 10% serum (45 min at 25°C), incubated with mouse anti-beta tubulin and CHMP1B polyclonal antibody (Product # PA5-100437) using a dilution of 1:200 (1 hr, 37°C), and followed by goat anti-rabbit IgG Alexa Fluor 594 (red) and goat anti-mouse IgG Alexa Fluor 488 (green).
产品信息
PA5-100437
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human CHMP1B(Accession Q7LBR1), corresponding to amino acid residues T144-R194.
偶联物
Unconjugated
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2849948
产品详细信息
Antibody detects endogenous levels of total CHMP1B.
靶标信息
CHMP1B belongs to the chromatin-modifying protein/charged multivesicular body protein (CHMP) family. These proteins are components of ESCRT-III (endosomal sorting complex required for transport III), a complex involved in degradation of surface receptor proteins and formation of endocytic multivesicular bodies (MVBs). Some CHMPs have both nuclear and cytoplasmic/vesicular distributions, and one such CHMP, CHMP1A, is required for both MVB formation and regulation of cell cycle progression (Tsang et al., 2006 ).
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Charged multivesicular body protein 1b; charged multivesicular body protein 1b-1; Charged multivesicular body protein 1B1; CHMP1.5; CHMP1b; CHMP1b-1; chromatin modifying protein 1B; Chromatin-modifying protein 1b; Chromatin-modifying protein 1b-1; vacuolar protein sorting 46-2; Vacuolar protein sorting-associated protein 46-2; Vps46-2
基因别名: 2810405I11Rik; C10orf2; C18-ORF2; C18orf2; CHMP1.5; CHMP1B; Chmp1b1; hVps46-2; Vps46-2; Vps46B
UniProt ID: (Human) Q7LBR1, (Mouse) Q99LU0
Entrez Gene ID: (Human) 57132, (Rat) 689364, (Mouse) 67064
cell separation after cytokinesis
nucleus organization
vacuolar transport
mitotic metaphase plate congression
regulation of centrosome duplication
protein transport
multivesicular body assembly
viral budding via host ESCRT complex
establishment of protein localization
cell division
regulation of mitotic spindle assembly
ESCRT III complex disassembly
transport
cell cycle
