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产品信息
PA5-64372
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
偶联物
形式
Liquid
浓度
0.15 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2639777
产品详细信息
Immunogen sequence: THLPAGPAPK VDEDEEALKQ LAEWVS
Highest antigen sequence identity to the following orthologs: Mouse - 46%, Rat - 42%.
靶标信息
Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. When overexpressed, membrane-assembled circular arrays of CHMP4A filaments can promote or stabilize negative curvature and outward budding. Via its interaction with PDCD6IP involved in HIV-1 p6- and p9-dependent virus release.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Charged multivesicular body protein 4a; CHMP4a; chromatin modifying protein 4A; Chromatin-modifying protein 4a; hSnf-1; hVps32-1; SNF7 homolog associated with Alix-2; Snf7 homologue associated with Alix 2; SNF7-1; Vacuolar protein sorting-associated protein 32-1; Vps32-1
基因别名: C14orf123; CDA04; CHMP4; CHMP4A; CHMP4B; HSPC134; SHAX2; SNF7; SNF7-1; VPS32-1; VPS32A
UniProt ID: (Human) Q9BY43
Entrez Gene ID: (Human) 29082
cell separation after cytokinesis
posttranslational protein targeting to membrane
membrane budding
autophagy
nucleus organization
mitotic metaphase plate congression
membrane invagination
endosomal transport
viral life cycle
multivesicular body assembly
viral budding via host ESCRT complex
protein polymerization
protein homooligomerization
membrane tubulation
negative regulation of neuron death
negative regulation of autophagosome assembly
