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产品信息
MA5-32571
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
JM10-31
抗原
Synthetic peptide within Human DDIT3 aa 135-169
偶联物
Unconjugated
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
TBS, pH 7.4, with 40% Glycerol, 0.05% BSA
内含物
0.05% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2809848
产品详细信息
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
靶标信息
GADD153 is a small nuclear protein that is capable of dimerizing with transcription factors C/EBP alpha and beta. Once dimerized, this complex inhibits the normal binding and function of C/EBP to classical binding sites. Inversely, the C/EBP GADD153 dimer gains binding activity to other non classical C/EBP stress related targets. Under normal cellular conditions this protein is not expressed in detectable levels, but is highly unregulated during times of cellular/ER stress. Examples of GADD153 inducing stress include: treatment with tunicamycin, nutrient starvation and reducing agents that interfere with the calcium flux across the ER membrane.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: C/EBP homologous protein; C/EBP homoologous protein 10; C/EBP zeta; C/EBP-homologous protein; C/EBP-homologous protein 10; CCAAT/enhancer-binding protein homologous protein; CHOP; CHOP-10; DDIT-3; DNA damage-inducible transcript 3 protein; DNA-damage-inducible transcript 3; Growth arrest and DNA damage-inducible protein GADD153; Growth arrest and DNA-damage-inducible protein GADD153; MGC4154
基因别名: CEBPZ; CHOP; CHOP-10; CHOP10; DDIT3; GADD153
UniProt ID: (Human) P35638, (Mouse) P35639
Entrez Gene ID: (Human) 1649, (Mouse) 13198, (Rat) 29467
transcription regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
transcription corepressor activity
protein binding
transcription factor binding
cAMP response element binding protein binding
protein homodimerization activity
leucine zipper domain binding
transcription regulatory region DNA binding
protein heterodimerization activity
sequence-specific DNA binding
RNA polymerase II transcription factor binding
negative regulation of transcription from RNA polymerase II promoter
blood vessel maturation
transcription, DNA-templated
regulation of transcription, DNA-templated
apoptotic process
ER overload response
response to unfolded protein
cell cycle
cell cycle arrest
Wnt signaling pathway
endoplasmic reticulum unfolded protein response
positive regulation of interleukin-8 production
negative regulation of CREB transcription factor activity
response to endoplasmic reticulum stress
response to starvation
mRNA transcription from RNA polymerase II promoter
positive regulation of apoptotic process
proteasome-mediated ubiquitin-dependent protein catabolic process
negative regulation of DNA binding
negative regulation of sequence-specific DNA binding transcription factor activity
positive regulation of neuron apoptotic process
regulation of transcription involved in anterior/posterior axis specification
cell redox homeostasis
negative regulation of fat cell differentiation
negative regulation of myoblast differentiation
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
release of sequestered calcium ion into cytosol
negative regulation of protein kinase B signaling
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
negative regulation of canonical Wnt signaling pathway
positive regulation of neuron death
negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding
positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
negative regulation of determination of dorsal identity
response to amphetamine
cellular response to DNA damage stimulus
aging
response to nutrient
PERK-mediated unfolded protein response
ATF6-mediated unfolded protein response
response to drug
response to hydrogen peroxide
regulation of DNA-templated transcription in response to stress
embryonic organ development
positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
response to oxidative stress
