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CHRM3 Antibody (AMR-006-200UL) in IHC (F)
Expression of CHRM3 in mouse cortex. Immunohistochemical staining of perfusion-fixed frozen mouse brain sections with Anti-CHRM3 Antibody (#AMR-006), (1:200), followed by goat Anti-rabbit-AlexaFluor-488. A. CHRM3 immunoreactivity (green) appears in neurons (arrows). B. Pre-incubation of the Antibody with CHRM3 Blocking Peptide (#BLP-MR006), suppressed staining. Cell nuclei are stained with DAPI (blue).
产品信息
AMR-006-200UL
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
(C)TLAKRFALKTRSQITKRKR, corresponding to amino residues 461-479 of rat M3, 3rd intracellular loop
偶联物
Unconjugated
形式
Lyophilized
浓度
0.8 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4, with 1% BSA
内含物
0.05% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
靶标信息
The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The muscarinic cholinergic receptor 3 controls smooth muscle contraction and its stimulation causes secretion of glandular tissue.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: acetylcholine receptor; acetylcholine receptor, muscarinic 3; AChR M3; cholinergic receptor; cholinergic receptor, muscarinic 3; cholinergic receptor, muscarinic 3, cardiac; m3 muscarinic receptor; Mm3 mAChR; muscarinic acetylcholine receptor 3; Muscarinic acetylcholine receptor M3
基因别名: Chrm-3; CHRM3; EGBRS; HM3; M3; M3R; PBS
UniProt ID: (Human) P20309, (Mouse) Q9ERZ3, (Rat) P08483
Entrez Gene ID: (Human) 1131, (Mouse) 12671, (Rat) 24260
regulation of vascular smooth muscle contraction
cellular protein modification process
smooth muscle contraction
signal transduction
G-protein coupled receptor signaling pathway
adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway
phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway
G-protein coupled acetylcholine receptor signaling pathway
synaptic transmission, cholinergic
nervous system development
cell proliferation
positive regulation of smooth muscle contraction
saliva secretion
chemical synaptic transmission
digestion
sensory perception of chemical stimulus
regulation of vasoconstriction
