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产品信息
PA5-19907
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A peptide corresponding to amino acids 200 to 217 of human CIDE-A.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS
内含物
0.02% sodium azide
保存条件
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_11153776
产品详细信息
In Western blot applications, this antibody detects a band at ~23kDa. A suggested positive control is human brain tissue lysate.
PA5-19907 can be used with blocking peptide PEP-0033.
靶标信息
This gene encodes the homolog of the mouse protein Cidea that has been shown to activate apoptosis. This activation of apoptosis is inhibited by the DNA fragmentation factor DFF45 but not by caspase inhibitors. Mice that lack functional Cidea have higher metabolic rates, higher lipolysis in brown adipose tissue and higher core body temperatures when subjected to cold. These mice are also resistant to diet-induced obesity and diabetes. This suggests that in mice this gene product plays a role in thermogenesis and lipolysis. Alternatively spliced transcripts have been identified.
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生物信息学
蛋白别名: Cell death activator CIDE-A; Cell death-inducing DFFA-like effector A; cide a; Lipid transferase CIDEA
基因别名: CIDE-A; CIDEA
UniProt ID: (Human) O60543
Entrez Gene ID: (Human) 1149
temperature homeostasis
transcription, DNA-templated
regulation of transcription, DNA-templated
lipid metabolic process
apoptotic process
cell death
positive regulation of sequestering of triglyceride
lipid storage
negative regulation of transforming growth factor beta receptor signaling pathway
negative regulation of tumor necrosis factor production
response to stilbenoid
regulation of apoptotic process
negative regulation of cytokine secretion
negative regulation of lipid catabolic process
negative regulation of execution phase of apoptosis
regulation of apoptotic DNA fragmentation
