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CITED2 Antibody (PA5-114719) in ICC/IF
Immunocytochemistry analysis of CITED2 in HeLa cells. Samples were treated with PFA, permeabilized in 0.1% Triton X-100, blocked in 10% serum (45 min at 25°C), and incubated with polyclonal antibody (Product # PA5-114719). Secondary staining was applied with mouse anti-beta tubulin (1 hr at 37°, AlexaFluor 594 conjugated goat anti-rabbit IgG (Red), AlexaFluor 488 conjugated goat anti-mouse IgG (Green) and DAPI.
产品信息
PA5-114719
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human CITED2(Accession Q99967), corresponding to amino acid residues Y134-G184.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2899355
产品详细信息
Antibody detects endogenous levels of total CITED2.
靶标信息
The protein encoded by this gene inhibits transactivation of HIF1A-induced genes by competing with binding of HIF1a to p300-CH1. Mutations in this gene are a cause of cardiac septal defects. Three transcript variants encoding the same protein have been found for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Cbp/p300-interacting transactivator 2; Cbp/p300-interacting transactivator, with Glu/Asp rich carboxy-terminal domain, 2; Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2; melanocyte specific gene 2; melanocyte-specific gene 1-related gene 1; MRG-1; MSG-related protein 1; MSG1-related gene 1; P35srj
基因别名: AI835299; ASD8; CITED2; ER154-like; MRG-1; MRG1; Msg2; P35SRJ; VSD2
UniProt ID: (Human) Q99967, (Mouse) O35740
Entrez Gene ID: (Human) 10370, (Rat) 114490, (Mouse) 17684
RNA polymerase II transcription coactivator activity
RNA polymerase II transcription corepressor activity
chromatin binding
transcription factor activity, sequence-specific DNA binding
transcription coactivator activity
transcription corepressor activity
protein binding
histone acetyltransferase binding
LBD domain binding
RNA polymerase II activating transcription factor binding
molecular_function
SMAD binding
transcription cofactor activity
transcription cofactor
negative regulation of transcription from RNA polymerase II promoter
response to hypoxia
liver development
outflow tract morphogenesis
regulation of organ formation
transcription, DNA-templated
determination of left/right symmetry
heart development
sex determination
cell proliferation
positive regulation of gene expression
negative regulation of gene expression
positive regulation of cell-cell adhesion
cell differentiation
negative regulation of cell migration
positive regulation of transforming growth factor beta receptor signaling pathway
response to fluid shear stress
positive regulation of peroxisome proliferator activated receptor signaling pathway
adrenal cortex formation
negative regulation of apoptotic process
response to estrogen
positive regulation of cell cycle
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
spleen development
ventricular septum morphogenesis
embryonic heart tube left/right pattern formation
left/right pattern formation
negative regulation of transcription from RNA polymerase II promoter in response to hypoxia
left/right axis specification
nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry
positive regulation of male gonad development
blood vessel development
vasculogenesis
branching involved in ureteric bud morphogenesis
in utero embryonic development
kidney development
trophectodermal cell differentiation
neural tube formation
neural tube closure
embryonic placenta development
vasculature development
heart looping
morphogenesis of an epithelium
lens morphogenesis in camera-type eye
hematopoietic progenitor cell differentiation
leukocyte differentiation
endocardial cushion development
ventricular septum development
regulation of transcription from RNA polymerase II promoter
transforming growth factor beta receptor signaling pathway
central nervous system development
peripheral nervous system development
cell aging
male gonad development
response to mechanical stimulus
cranial nerve morphogenesis
adrenal gland development
granulocyte differentiation
skeletal muscle cell differentiation
decidualization
thymus development
embryonic camera-type eye morphogenesis
erythrocyte development
embryonic process involved in female pregnancy
bone morphogenesis
cardiac septum morphogenesis
pulmonary artery morphogenesis
cardiac neural crest cell development involved in heart development
determination of heart left/right asymmetry
cellular response to growth factor stimulus
regulation of nucleic acid-templated transcription
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
multicellular organism development
