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CITED2 Antibody (PA5-85562) in ICC/IF
CITED2 Polyclonal Antibody detects CITED2 protein at nucleus by immunofluorescent analysis. Sample: HeLa cells were fixed in 4% paraformaldehyde at RT for 15 min. Green: CITED2 protein stained by CITED2 Polyclonal Antibody (Product # PA5-85562) diluted at 1:1,000. Blue: Hoechst 33342 staining.
产品信息
PA5-85562
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant protein encompassing a sequence within the center region of human CITED2.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7, with 20% glycerol
内含物
0.01% thimerosal
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2792702
产品详细信息
Keep as concentrated solution.
Predicted reactivity: Mouse (99%), Rat (100%), Sheep (98%), Bovine (98%).
Positive Control: 293T, HeLa, HepG2.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
靶标信息
The protein encoded by this gene inhibits transactivation of HIF1A-induced genes by competing with binding of HIF1a to p300-CH1. Mutations in this gene are a cause of cardiac septal defects. Three transcript variants encoding the same protein have been found for this gene.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Cbp/p300-interacting transactivator 2; Cbp/p300-interacting transactivator, with Glu/Asp rich carboxy-terminal domain, 2; Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2; melanocyte-specific gene 1-related gene 1; MRG-1; MSG-related protein 1; MSG1-related gene 1; P35srj
基因别名: ASD8; CITED2; MRG-1; MRG1; P35SRJ; VSD2
UniProt ID: (Human) Q99967
Entrez Gene ID: (Human) 10370
RNA polymerase II transcription coactivator activity
RNA polymerase II transcription corepressor activity
chromatin binding
transcription factor activity, sequence-specific DNA binding
transcription coactivator activity
transcription corepressor activity
protein binding
histone acetyltransferase binding
LBD domain binding
transcription cofactor
negative regulation of transcription from RNA polymerase II promoter
response to hypoxia
liver development
outflow tract morphogenesis
regulation of organ formation
transcription, DNA-templated
determination of left/right symmetry
heart development
sex determination
cell proliferation
positive regulation of gene expression
negative regulation of gene expression
positive regulation of cell-cell adhesion
cell differentiation
negative regulation of cell migration
positive regulation of transforming growth factor beta receptor signaling pathway
response to fluid shear stress
positive regulation of peroxisome proliferator activated receptor signaling pathway
adrenal cortex formation
negative regulation of apoptotic process
response to estrogen
positive regulation of cell cycle
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
spleen development
ventricular septum morphogenesis
embryonic heart tube left/right pattern formation
left/right pattern formation
negative regulation of transcription from RNA polymerase II promoter in response to hypoxia
left/right axis specification
nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry
positive regulation of male gonad development
