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Proteintech
Foxp3 Monoclonal Antibody (3G3), CoraLite® Plus 488
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FIGURE: 1 / 1
Foxp3 Antibody (CL488-65089100T) in Flow
1X10^6 Mouse splenocytes were surface stained with CoraLite 647-conjugated Anti-Mouse CD4 (GK1.5) (CL647-65104, Clone: GK1.5) and then fixed and permeabilized with Transcription Factor Staining Buffer Kit (PF00011). Cells were then stained with CoraLite 488-conjugated Mouse IgG1 isotype control or 5 µL CoraLite 488-conjugated Anti-Mouse Foxp3 (Product # CL488-65089100T), Clone: 3G3).
Product Details
CL488-65089100T
Applications
Tested Dilution
Publications
Product Specifications
Host/Isotype
Mouse
/ IgG1, kappa
Class
Monoclonal
Type
Antibody
Clone
3G3
Conjugate
Excitation/Emission Max
493/522 nm
Form
Liquid
Concentration
5 µL/Test
Storage conditions
4°C, store in dark
Shipping conditions
Wet ice
Target Information
FOXP3 (Forkhead box protein 3) is a member of the forkhead/winged-helix family of transcriptional regulators, highly conserved across mammals, and essential for normal immune homeostasis. FOXP3 is 381 amino acids long, stably and constitutively expressed at a high level in CD25 + CD4 positive regulatory T cells, a low level in CD4-positive/CD25-negative cells, and is absent in CD4-negative/CD8-positive T cells. FOXP3 may be a master regulatory gene, and a more specific marker of regulatory T cells. Defects in the gene encoding FOXP3 protein cause the scurfy phenotype in mice. In humans FOXP3 defects play a role in IPEX syndrome (immune dysfunction, polyendocrinopathy, enteropathy, X-linked syndrome), also known as X-linked autoimmunity-allergic dysregulation (XLAAD) syndrome. Transcript variants of FOXP3 encoding different isoforms have been identified. In human breast and colon cancer cells, expression of FOXP3 is regulated by p53 in response to the DNA damage.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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