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Proteintech
TYK2 Monoclonal Antibody (1E1A10), CoraLite® 594
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Product Details
CL594-67411
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2b
Class
Monoclonal
Type
Antibody
Clone
1E1A10
Immunogen
TYK2 fusion protein Ag9442
Conjugate
Excitation/Emission Max
593/614 nm
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.3, with 0.5% BSA, 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
-20°C, store in dark
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: RDLGEGHFG KVSLYCYDPT NDGTGEMVAV KALKADCGPQ HRSGWKQEID ILRTLYHEHI IKYKGCCEDQ GEKSLQLVME YVPLGSLRDY LPRHSIGLAQ LLLFAQQICE GMAYLHSQHY IHRDLAARNV LLDNDRLVKI GDFGLAKAVP EGHEYYRVRE DGDSPVFWYA PECLKEYKFY YASDVWSFGV TLYELLTHCD SSQSPPTKFL ELIGIAQGQM TVLRLTELLE RGERLPRPDK CPCEVYHLMK NCWETEASFR PTFENLIPIL KTVHEKYQGQ APSVFSVC
Target Information
Tyrosine Kinase 2 (TYK2) a member of the JAK kinase family, plays both structural and catalytic roles in type I interferon (IFN) signaling. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 4833430L21Rik; AW540162; BRE1; BRE1A; C79397; hBRE1; mKIAA4116; Non-receptor tyrosine-protein kinase TYK2
Gene Aliases: IMD35; JTK1; TYK2
UniProt ID: (Human) P29597
Entrez Gene ID: (Human) 7297
protein phosphorylation
transmembrane receptor protein tyrosine kinase signaling pathway
cell migration
cell differentiation
intracellular signal transduction
peptidyl-tyrosine autophosphorylation
regulation of cell proliferation
innate immune response
type I interferon signaling pathway
regulation of type I interferon-mediated signaling pathway
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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