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PHAP I is implicated in a number of cellular processes, including proliferation, differentiation, caspase-dependent and caspase-independent apoptosis, suppression of transformation (tumor suppressor), inhibition of protein phosphatase 2A, regulation of mRNA trafficking and stability in association with ELAVL1, and inhibition of acetyltransferases as part of the INHAT (inhibitor of histone acetyltransferases) complex. Plays a role in E4F1-mediated transcriptional repression.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Acid nuclear phosphoprotein 32 (leucine rich); acidic (leucine-rich) nuclear phosphoprotein 32 family, member A; Acidic leucine-rich nuclear phosphoprotein 32 family member A; acidic nuclear phosphoprotein 32; acidic nuclear phosphoprotein 32 family, member A; Acidic nuclear phosphoprotein pp32; cerebellar leucine rich acidic nuclear protein; hepatopoietin Cn; inhibitor-1 of protein phosphatase-2A; LANP; Leucine-rich acidic nuclear protein; leucine-rich acidic nuclear protein LANP; Mapmodulin; MGC119787; MGC150373; PHAPI; Potent heat-stable protein phosphatase 2A inhibitor I1PP2A; pp32; Putative HLA-DR-associated protein I; putative human HLA class II associated protein I; vacidic (leucine-rich) nuclear phosphoprotein 32 family, member A
基因别名: Anp32; ANP32A; C15orf1; HPPCn; I1PP2A; LANP; MAPM; PHAP1; PHAPI; PP32; W91701
UniProt ID: (Human) P39687, (Rat) P49911, (Mouse) O35381
Entrez Gene ID: (Human) 8125, (Rat) 25379, (Mouse) 11737
分子生物学功能: chromatin/chromatin-binding, or -regulatory protein