Invitrogen

CLOCK Recombinant Rabbit Monoclonal Antibody (ARC1819)

高级验证

This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated.

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说明书
实验方案
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产品信息

MA5-38168

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:500-1:2,000
-
产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

Expression System

HEK293 cells

分类

Recombinant Monoclonal

类型

Antibody

克隆号

ARC1819

抗原

A synthetic peptide corresponding to a sequence within amino acids 100-200 of human CLOCK (NP_0048891)
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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.4 mg/mL

纯化类型

Affinity chromatography

保存液

PBS, pH 7.3, with 0.05% BSA, 50% glycerol

内含物

0.02% sodium azide

保存条件

-20° C, Avoid Freeze/Thaw Cycles

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_2898085

产品详细信息

Positive Samples: HeLa, 293T, NIH/3T3, SH-SY5Y, Mouse lung, Rat brain

Immunogen sequence: WKPTFLSNEE FTQLMLEALD GFFLAIMTDG SIIYVSESVT SLLEHLPSDL VDQSIFNFIP EGEHSEVYKI LSTHLLESDS LTPEYLKSKN QLEFCCHMLR G

靶标信息

This gene encodes a protein that belongs to the basic helix-loop-helix (bHLH) family of transcription factors. Polymorphisms within the encoded protein have been associated with circadian rhythm sleep disorders. A similar protein in mice is a circadian regulator that acts as a transcription factor and forms a heterodimer with aryl hydrocarbon receptor nuclear translocator-like to activate transcription of mouse period 1.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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生物信息学

蛋白别名: bHLHe8; circadian locomoter output cycles kaput; circadian locomoter output cycles kaput protein; Circadian locomoter output cycles protein kaput; Class E basic helix-loop-helix protein 8; clock homolog; hCLOCK; mCLOCK; rCLOCK

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基因别名: 5330400M04Rik; BHLHE8; CLOCK; KAT13D; KIAA0334

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UniProt ID: (Human) O15516, (Mouse) O08785, (Rat) Q9WVS9

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Entrez Gene ID: (Human) 9575, (Mouse) 12753, (Rat) 60447

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功能
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding core promoter sequence-specific DNA binding core promoter binding transcriptional activator activity, RNA polymerase II transcription factor binding DNA binding transcription factor activity, sequence-specific DNA binding histone acetyltransferase activity protein binding chromatin DNA binding sequence-specific DNA binding protein dimerization activity E-box binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding signal transducer activity transcription factor binding transferase activity transferase activity, transferring acyl groups
参与通路
DNA damage checkpoint transcription, DNA-templated regulation of transcription, DNA-templated transcription from RNA polymerase II promoter cellular response to DNA damage stimulus signal transduction spermatogenesis circadian rhythm histone acetylation circadian regulation of gene expression regulation of hair cycle proteasome-mediated ubiquitin-dependent protein catabolic process negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter rhythmic process positive regulation of inflammatory response regulation of insulin secretion positive regulation of NF-kappaB transcription factor activity response to redox state cellular response to ionizing radiation regulation of type B pancreatic cell development negative regulation of glucocorticoid receptor signaling pathway regulation of transcription from RNA polymerase II promoter photoperiodism entrainment of circadian clock
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