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CMKLR1 (extracellular) Antibody (ACR-033-200UL) in WB
Western blot analysis of rat cerebellum lysate (lanes 1 and 3) and rat heart membrane (lanes 2 and 4): - 1,2. Anti-Rat CMKLR1 (extracellular) Antibody (1:200), (ACR-033).3,4. Anti-Rat CMKLR1 (extracellular) Antibody , preincubated with Rat CMKLR1 (extracellular) Blocking Peptide (#BLP-CR033).
产品信息
ACR-033-200UL
产品规格
种属反应
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
(C)HSTHPRTDPVGYSRH, corresponding to amino acid residues 201-215 of rat Chemerin receptor 1, 2nd extracellular loop
偶联物
形式
Lyophilized
浓度
0.8 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4, with 1% BSA
内含物
0.05% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
靶标信息
Chemokine-like receptor 1 (CMKLR1) is a receptor for the chemoattractant adipokine chemerin/RARRES2 and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with RARRES2 induces activation of intracellular signaling molecules, such as SKY, MAPK1/3 (ERK1/2), MAPK14/P38MAPK and PI3K leading to multifunctional effects, like, reduction of immune responses, enhancing of adipogenesis and angionesis. Resolvin E1 down-regulates cytokine production in macrophages by reducing the activation of MAPK1/3 (ERK1/2) and NF-kappa-B. CMKLR1 positively regulates adipogenesis and adipocyte metabolism and acts as a coreceptor for several SIV strains (SIVMAC316, SIVMAC239, SIVMACL7E-FR and SIVSM62A), as well as a primary HIV-1 strain (92UG024-2).
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Chemerin-like receptor 1; chemokine receptor-like 1; Chemokine-like receptor 1; G-protein coupled chemoattractant-like receptor; G-protein coupled receptor DEZ
基因别名: Cmklr1; Dez
UniProt ID: (Rat) O35786
Entrez Gene ID: (Rat) 60669
chemotaxis
G-protein coupled receptor signaling pathway
positive regulation of macrophage chemotaxis
negative regulation of NF-kappaB transcription factor activity
negative regulation of interleukin-12 production
positive regulation of fat cell differentiation
regulation of calcium-mediated signaling
chemokine-mediated signaling pathway
