Abnova

COL1A1 Monoclonal Antibody (3G3)

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COL1A1 Antibody (H00001277-M01) in WB

COL1A1 monoclonal antibody (M01), clone 3G3. Western Blot analysis of COL1A1 expression in NIH/3T3.

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产品信息

H00001277-M01

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1-5 µg/mL

免疫组化（石蜡） (IHC (P))

3 µg/mL

酶联免疫吸附实验 (ELISA)

10 µg/mL

产品规格

种属反应

Human, Mouse

宿主/亚型

Mouse / IgG3, kappa

分类

Monoclonal

类型

Antibody

克隆号

3G3

抗原

COL1A1 (NP_000079.1, 1021 a.a. approximately 1108 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Protein A

保存液

PBS, pH 7.4

内含物

no preservative

保存条件

-20° C, Avoid Freeze/Thaw Cycles

运输条件

Ambient (domestic); Wet ice (international)

产品详细信息

Product may be used with Western Blot (Cell lysate).

Immunogen sequence: EGSPGRDGSP GAKGDRGETG PAGPPGAPGA PGAPGPVGPA GKSGDRGETG PAGPAGPVGP VGARGPAGPQ GPRGDKGETG EQGDRGIK

靶标信息

The protein encoded by this gene is the pro-alpha1 chain of type I collagen whose triple helix comprises two alpha1 chains and one alpha2 chain. Type I is a fibril-forming collagen found in most connective tissues and is abundant in bone, cornea, dermis and tendon. Mutations in this gene are associated with osteogenesis imperfecta types I-IV, Ehlers-Danlos syndrome type VIIA, Ehlers-Danlos syndrome Classical type, Caffey Disease and idiopathic osteoporosis. Reciprocal translocations between chromosomes 17 and 22, where this gene and the gene for platelet-derived growth factor beta are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans, resulting from unregulated expression of the growth factor. Two transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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生物信息学

蛋白别名: alpha-1 type 1 collagen; Alpha-1 type I collagen; alpha1(I) procollagen; COL1A; Collagen 1; collagen alpha 1 chain type I; Collagen alpha-1(I) chain; collagen alpha-1(I) chain preproprotein; Collagen I; collagen of skin, tendon and bone, alpha-1 chain; collagen, type I, alpha 1; Collagen1A1; pro-alpha-1 collagen type 1; procollagen, type I, alpha 1; Type I Collagen; type I proalpha 1; type I procollagen alpha 1 chain

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基因别名: Col1a-1; COL1A1; Cola-1; Cola1; EDSC; Mov-13; Mov13; OI1; OI2; OI3; OI4

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UniProt ID: (Human) P02452, (Mouse) P11087

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Entrez Gene ID: (Human) 1277, (Mouse) 12842

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功能

extracellular matrix structural constituent protein binding identical protein binding metal ion binding platelet-derived growth factor binding extracellular matrix structural protein

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