Invitrogen

COL1A1 Monoclonal Antibody (C3)

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COL1A1 Antibody (MA5-43886) in WB

Western blot analysis of COL1A1 in Lane 1: human placenta lysate; Lane 2: human Cartilage lysate. Samples were incubated in monoclonal COL1A1 antibody (Product # MA5-43886) using a dilution of 0.4 μg/mL, followed by HRP-Linked Caprine Anti-Mouse IgG at a dilution of 0.2 µg/mL.

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产品信息

MA5-43886

应用

建议稀释比

已发表文章

免疫印迹 (WB)

0.5-2 µg/mL

产品规格

种属反应

Human

宿主/亚型

Mouse / IgG1, kappa

分类

Monoclonal

类型

Antibody

克隆号

抗原

Recombinant COL1a1 (Arg253-Ala471) expressed in E.coli

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Protein A/G

保存液

PBS with 50% glycerol

内含物

0.05% ProClin 300

保存条件

-20°C

运输条件

Wet ice

RRID

AB_2912818

靶标信息

The protein encoded by this gene is the pro-alpha1 chain of type I collagen whose triple helix comprises two alpha1 chains and one alpha2 chain. Type I is a fibril-forming collagen found in most connective tissues and is abundant in bone, cornea, dermis and tendon. Mutations in this gene are associated with osteogenesis imperfecta types I-IV, Ehlers-Danlos syndrome type VIIA, Ehlers-Danlos syndrome Classical type, Caffey Disease and idiopathic osteoporosis. Reciprocal translocations between chromosomes 17 and 22, where this gene and the gene for platelet-derived growth factor beta are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans, resulting from unregulated expression of the growth factor. Two transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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生物信息学

蛋白别名: Alpha-1 type I collagen; alpha1(I) procollagen; COL1A; Collagen 1; collagen alpha 1 chain type I; Collagen alpha-1(I) chain; collagen alpha-1(I) chain preproprotein; Collagen I; collagen of skin, tendon and bone, alpha-1 chain; collagen, type I, alpha 1; Collagen1A1; pro-alpha-1 collagen type 1; Type I Collagen; type I proalpha 1; type I procollagen alpha 1 chain

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基因别名: COL1A1; EDSC; OI1; OI2; OI3; OI4

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UniProt ID: (Human) P02452

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Entrez Gene ID: (Human) 1277

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功能

extracellular matrix structural constituent protein binding identical protein binding metal ion binding platelet-derived growth factor binding extracellular matrix structural protein

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