Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
产品信息
PA5-32711
产品规格
种属反应
Bat,
Bovine,
Human,
Mouse,
Non-human primate,
Pig,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic 15 amino acid peptide from internal region of human COMT.
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS
内含物
0.1% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2550174
产品详细信息
Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset, Mouse, Rat, Bat, Bovine, Pig (100%) Hamster, Elephant, Panda, Rabbit, Horse (93%).
靶标信息
Catechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. This O-methylation results in one of the major degradative pathways of the catecholamine transmitters. In addition to its role in the metabolism of endogenous substances, COMT is important in the metabolism of catechol drugs used in the treatment of hypertension, asthma, and Parkinson disease. COMT is found in two forms in tissues, a soluble form (S-COMT) and a membrane-bound form (MB-COMT). The differences between S-COMT and MB-COMT reside within the N-termini. Several transcript variants are formed through the use of alternative translation initiation sites and promoters.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
篇参考文献 (0)
您是否在文献中引用过该产品？请点击下方按钮邮件告知我们。
生物信息学
蛋白别名: Catechol O-methyltransferase; catechol-O-methyltransferase 1; catechol-O-methyltransferase isoform; catecholamine-O-methyltransferase; epididymis secretory sperm binding protein Li 98n; OTTHUMP00000197749; OTTHUMP00000197750; testicular tissue protein Li 42
基因别名: COMT; Comt1; D16Wsu103e; D330014B15Rik; HEL-S-98n
UniProt ID: (Human) P21964, (Bovine) A7MBI7, (Mouse) O88587, (Rat) P22734
Entrez Gene ID: (Pig) 100155530, (Human) 1312, (Bovine) 618278, (Mouse) 12846, (Rat) 24267
methylation
neurotransmitter catabolic process
catecholamine catabolic process
female pregnancy
learning
short-term memory
estrogen metabolic process
response to organic cyclic compound
cellular response to phosphate starvation
response to lipopolysaccharide
developmental process
negative regulation of renal sodium excretion
dopamine catabolic process
response to drug
negative regulation of dopamine metabolic process
response to pain
multicellular organismal reproductive process
negative regulation of smooth muscle cell proliferation
positive regulation of homocysteine metabolic process
regulation of sensory perception of pain
catecholamine metabolic process
catechol-containing compound metabolic process
dopamine metabolic process
S-adenosylhomocysteine metabolic process
S-adenosylmethionine metabolic process
