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COX1 Antibody (PA5-141177) in WB
Western blot analysis of COX1/Cyclooxygenase 1 in different lysates. Proteins were transferred to a PVDF membrane and blocked with 5% BSA in PBS for 1 hour at room temperature. Samples were incubated in COX1/Cyclooxygenase 1 Polyclonal antibody (Product # PA5-141177) using a dilution of 1:500 in 5% BSA at room temperature for 2 hours followed by Goat Anti-Rabbit IgG - HRP secondary antibody at a dilution of 1:5,000 for 1 hour at room temperature. Positive control: Lane 1: 293T cell lysate, untreated; Lane 2: NIH/3T3 cell lysate, untreated.
产品信息
PA5-141177
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide within Human COX-1 aa 550-599.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4, with 25% glycerol, 0.2% BSA
内含物
0.05% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2932625
靶标信息
PTGS1 (COX1, Cyclooxygenase 1) is the key enzyme in prostaglandin biosynthesis, and acts both as a dioxygenase and as a peroxidase. There are two isozymes of PTGS: a constitutive PTGS1 and an inducible PTGS2, which differ in their regulation of expression and tissue distribution. This gene encodes PTGS1, which regulates angiogenesis in endothelial cells, and is inhibited by nonsteroidal anti-inflammatory drugs such as aspirin. PTGS1 is thought to be involved in cell-cell signaling and maintaining tissue homeostasis. Alternative splicing of this gene generates two transcript variants. The expression of these two transcripts is differentially regulated by relevant cytokines and growth factors.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: COX-1; Cyclooxygenase-1; Cytochrome c oxidase polypeptide I; Cytochrome c oxidase subunit 1; P PGG/HS; PGH synthase 1; Prostaglandin G/H synthase 1; Prostaglandin H2 synthase 1; Prostaglandin-endoperoxide synthase 1; prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
基因别名: COI; Cox-1; Cox-3; COX1; COX3; COXI; MT-CO1; MTCO1; PCOX1; PES-1; PGG/HS; PGHS-1; PGHS1; PHS 1; PHS1; PTGHS; PTGS1
UniProt ID: (Human) P23219, (Mouse) P22437
Entrez Gene ID: (Human) 5742, (Mouse) 19224
prostaglandin biosynthetic process
lipid metabolic process
xenobiotic metabolic process
inflammatory response
response to oxidative stress
aging
learning
memory
regulation of blood pressure
response to organonitrogen compound
negative regulation of norepinephrine secretion
sensory perception of pain
cyclooxygenase pathway
negative regulation of epinephrine secretion
maintenance of blood-brain barrier
regulation of cell proliferation
positive regulation of vasoconstriction
positive regulation of smooth muscle contraction
response to corticosterone
oxidation-reduction process
response to fatty acid
cellular oxidant detoxification
fatty acid metabolic process
fatty acid biosynthetic process
prostaglandin metabolic process
keratinocyte differentiation
