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CRF1, Corticotropin-Releasing Factor Receptor 1 Antibody (7TM0212N-IC) in ICC/IF
Immunocytochemical identification of Corticotropin-Releasing Factor Receptor 1 in HEK293 cells. HEK293 cells stably expressing the Corticotropin-Releasing Factor Receptor 1 (CRF1) were either not exposed or exposed to 100 nM CRF for 30 min and immunocytochemically stained with anti-CRF1 antibody (7TM0212N-IC) at a dilution of 1:200. Note, CRF1 receptors were confined to the plasma membrane in untreated cell... View More
产品信息
7TM0212N-IC
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthetic peptide presents the carboxyl - terminal tail of human CRF1.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
Dulbecco's PBS, pH 7.4
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice (domestic); Dry ice (international)
靶标信息
Corticotropin-releasing factor receptor 1 (CRFR1/CRHR1), a Corticotropin-Releasing Factor Receptor, is involved in mediating the stress response and anxiety-related behaviors. Mutations of the receptor reduce anxiety-related behaviors and may be involved in the pathogenesis of Cushing disease. Multiple isoforms of CRFR1 are produced by alternative splicing. CRFR1 has been reported to be expressed in the pituitary, adrenal gland, brain, colon, ovary, placenta, testis, white blood cells, and skin. ESTs have been isolated from human brain, eye, colon, and embryo libraries.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Corticotropin-releasing factor receptor 1; corticotropin-releasing factor type 1 receptor; Corticotropin-releasing hormone receptor 1; Crf receptor 1; Crf type 1; CRF-R-1; Crf1 receptor; CRH receptor 1; CRH-R-1; CRH-R1h; CRHR1f; seven transmembrane helix receptor
基因别名: CRF-R; CRF-R-1; CRF-R1; CRF1; CRFR; CRFR-1; CRFR1; CRH-R-1; CRH-R1; CRHR; CRHR1; CRHR1L
UniProt ID: (Human) P34998
Entrez Gene ID: (Human) 1394
immune response
cell surface receptor signaling pathway
activation of adenylate cyclase activity
female pregnancy
parturition
regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway
positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway
corticotropin secretion
cellular response to corticotropin-releasing hormone stimulus
negative regulation of voltage-gated calcium channel activity
regulation of corticosterone secretion
