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产品信息
H00001393-D01P
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
CRHBP (NP_001873.2, 1 a.a. approximately 322 a.a) full-length human protein.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Product may be used with Western Blot (Transfected lysate).
The Isotype of this product is composed of an IgG Mixture.
Immunogen sequence: MSPNFKLQCH FILIFLTALR GESRYLELRE AADYDPFLLF SANLKRELAG EQPYRRALRC LDMLSLQGQF TFTADRPQLH CAAFFISEPE EFITIHYDQV SIDCQGGDFL KVFDGWILKG EKFPSSQDHP LPSAERYIDF CESGLSRRSI RSSQNVAMIF FRVHEPGNGF TLTIKTDPNL FPCNVISQTP NGKFTLVVPH QHRNCSFSII YPVVIKISDL TLGHVNGLQL KKSSAGCEGI GDFVELLGGT GLDPSKMTPL ADLCYPFHGP AQMKVGCDNT VVRMVSSGKH VNRVTFEYRQ LEPYELENPN GNSIGEFCLS GL
靶标信息
Response to stress in mammals requires an intact hypothalamic-pituitary-adrenal axis. The proximal part of the response is mediated by secretion of corticotropin-releasing hormone (CRH) by the paraventricular nucleus of the hypothalamus. CRH is a 41 amino acid peptide derived by enzymatic cleavage from a 191 amino acid preprohormone. CRH is produced not only in the hypothalamus but also in peripheral tissues, such as T lymphocytes; it is highly expressed in human placenta. Glucocorticoids stimulate placental CRH synthesis and secretion in primary cultures of human placenta. This stimulation is in contrast to the glucocorticoid suppression of CRH expression in hypothalamus. The gene which encodes CRH maps to human chromosome 8q13. Human plasma contains a CRH-binding protein, CRH-BP (also designated CRF-BP) which inactivates CRH and which may prevent inappropriate pituitary-adrenal stimulation in pregnancy. The gene which encodes CRF-BP maps to human chromosome 5q11.2-q13.3.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: corticotropin releasing hormone-binding protein; Corticotropin-releasing factor-binding protein; Corticotropin-releasing hormone-binding protein; CRF-binding protein; CRF-BP; CRH-BP
基因别名: CRF-BP; CRFBP; CRHBP
UniProt ID: (Human) P24387
Entrez Gene ID: (Human) 1393
synaptic transmission, dopaminergic
maternal aggressive behavior
inflammatory response
signal transduction
female pregnancy
learning or memory
hormone-mediated signaling pathway
cellular response to stress
cellular response to drug
cellular response to potassium ion
hormone metabolic process
regulated exocytosis
behavioral response to ethanol
regulation of corticotropin secretion
negative regulation of corticotropin secretion
cellular response to calcium ion
cellular response to cocaine
cellular response to cAMP
cellular response to tumor necrosis factor
cellular response to estrogen stimulus
cellular response to estradiol stimulus
cellular response to gonadotropin-releasing hormone
negative regulation of corticotropin-releasing hormone receptor activity
regulation of N-methyl-D-aspartate selective glutamate receptor activity
