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CRP Antibody (PA5-79070) in IHC (P)
Immunohistochemistry analysis of CRP on paraffin-embedded rat cerebellum tissue. Antigen retrieval was performed using citrate buffer (pH6, epitope retrieval solution) for 20 mins. Sample was blocked using 10% goat serum, incubated with CRP polyclonal antibody (Product# PA5-79070) with a dilution of 2 µg/mL (overnight at 4°C), followed by biotinylated goat anti-rabbit IgG (30 minutes at 37°C). Development w... View More
产品信息
PA5-79070
应用
建议稀释比
已发表文章
产品规格
种属反应
Rat
已发表种属
Human,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
E. coli-derived rat C Reactive Protein recombinant protein (Position: H20-S230).
偶联物
形式
Lyophilized
浓度
500 µg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS with 4mg trehalose
内含物
0.05mg sodium azide
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2746186
产品详细信息
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
靶标信息
CRP (C-reactive protein) is a major cyclic, pentameric acute phase protein compound consisting of five identical, noncovalently bound, nonglycosylated subunits. Eeach subunit is made up of 206 amino acids, and has a molecular weight of 24 kDa. CRP is produced by the liver, and its plasma levels rise dramatically during inflammatory processes occurring in the body. CRP is an initiator of classical complement cascade, binds to several nuclear components (chromatin, histones, etc.), plays an important role in innate immunity, and mediates activities associated with pre-immune nonspecific host resistance. Specifically, there is a 100-1000 fold increase of CRP in response to injury, infection or inflammation. CRP is opsonic, an initiator of the classical complement cascade, and an activator of monocytes/macrophages. CRP also binds to several nuclear components including chromatin, histones and snRNP, suggesting that it may play a role as a scavenger during cell necrosis. CRP is involved in several host defense related functions based on its ability to recognize foreign pathogens and damaged cells of the host, and initiates pathogen elimination by interacting with humoral and cellular effector systems in the blood. Patients with elevated basal levels of CRP have been shown to be an increased risk for hypertension and cardiovascular disease.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: c reactive; C-reactive protein; C-reactive protein member of the pentraxin family; C-reactive protein, member of the pentraxin family; C-reactive protein, petaxin related; CSRP; CYRP; D1S181E; DKFZp686M148; DKFZp686M149; MGC149895; MGC88244; RP11-419N10.4
基因别名: Aa1249; Ab1-341; Ab2-196; Ac1-114; Ac1262; Ac2-069; Ba2-693; Crp; Ptx1
UniProt ID: (Rat) P48199
Entrez Gene ID: (Rat) 25419
response to hypoxia
acute-phase response
complement activation, classical pathway
aging
response to radiation
response to lead ion
positive regulation of gene expression
negative regulation of macrophage derived foam cell differentiation
negative regulation of lipid storage
regulation of low-density lipoprotein particle clearance
response to estradiol
negative regulation of superoxide anion generation
positive regulation of superoxide anion generation
response to testosterone
wound healing
positive regulation of nitric oxide biosynthetic process
response to ethanol
negative regulation of vasodilation
protein polymerization
cellular response to calcium ion
cellular response to interleukin-6
cellular response to nitric oxide
positive regulation of dendrite development
regulation of interleukin-8 secretion
