Bethyl Laboratories

CSK Polyclonal Antibody

查看其他26个CSK抗体

产品信息

A304-231A-T

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:1,000

-

免疫沉淀 (IP)

Assay-dependent

-

产品规格

种属反应

Human, Mouse

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Between 400 and 450

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Antigen affinity chromatography

保存液

TBS, pH 7.0 to 8.0

内含物

0.09% sodium azide

保存条件

4° C

运输条件

Wet ice

产品详细信息

The recommended shelf life for this product is 1 year from date of receipt.

靶标信息

CSK is a tyrosine kinase that has been shown to downregulate the activity of SRC oncoprotein through phosphorylation of its carboxy terminus. Since cell transformation by SRC is caused by various mechanisms that interfere with this phosphorylation, the CSK gene might function as an antioncogene. CSK plays an important role in the regulation of cell growth, differentiation, migration, and immune responses. CSK phosphorylates tyrosine residues located in the C-terminal tails of Src-family kinases including LCK, SRC, HCK, FYN, LYN, CSK, and YES1. CSK is expressed ubiquitously as a protein of approximately 50 KDa in cytosol, but a fraction distributes to lipid rafts due to interaction with the lipid raft-associated protein PAG (Csk-binding protein).

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: C-Src kinase; MGC117393; p50CSK; Protein-tyrosine kinase CYL; Protein-tyrosine kinase MPK-2; Tyrosine-protein kinase CSK

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基因别名: AW212630; CSK; p50CSK

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UniProt ID: (Human) P41240, (Mouse) P41241

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Entrez Gene ID: (Human) 1445, (Mouse) 12988

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protein tyrosine kinase activity non-membrane spanning protein tyrosine kinase activity receptor binding protein binding ATP binding protein C-terminus binding kinase activity protein phosphatase binding protein kinase A catalytic subunit binding identical protein binding metal ion binding proline-rich region binding

参与通路

regulation of cytokine production adaptive immune response protein phosphorylation transmembrane receptor protein tyrosine kinase signaling pathway epidermal growth factor receptor signaling pathway central nervous system development brain development negative regulation of cell proliferation negative regulation of low-density lipoprotein particle clearance cell migration cell differentiation T cell costimulation negative regulation of interleukin-6 production negative regulation of kinase activity adherens junction organization peptidyl-tyrosine autophosphorylation regulation of cell proliferation negative regulation of Golgi to plasma membrane protein transport positive regulation of MAP kinase activity innate immune response negative regulation of bone resorption oligodendrocyte differentiation negative regulation of phagocytosis T cell receptor signaling pathway regulation of Fc receptor mediated stimulatory signaling pathway negative regulation of ERK1 and ERK2 cascade cellular response to peptide hormone stimulus