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CTDSP1 Antibody (PA5-142159) in WB
Western Blot analysis of CTDSP1 in Mouse Testis lysate (35 µg protein in RIPA buffer) using CTDSP1 Polyclonal Antibody, Biotin (Product # PA5-142159) at 0.1 µg/mL incubated for 1 hour. Detected by chemiluminescence, using streptavidin-HRP and using NAP blocker as a substitute for skimmed milk.
产品信息
PA5-142159
产品规格
种属反应
Human,
Mouse
宿主/亚型
Goat
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Peptide with sequence EAKAQDSDKIC.
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Ammonium sulfate precipitation
保存液
TBS, pH 7.3, with 0.5% BSA
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2932817
产品详细信息
Additional Information: This antibody is expected to recognize all three reported isoforms (NP_067021.1; NP_872580.1; NP_001193807.1).
This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:16,000.
靶标信息
CTDSP1 is a class 2C phosphatase with activity dependent on the conserved DxD motif. Expression of CTDSP1 inhibited activated transcription from several promoter-reporter gene constructs, but expression of a mutant lacking phosphatase activity enhanced transcription. Neuronal gene transcription is repressed in nonneuronal cells by the repressor element-1 (RE1)-silencing transcription factor/neuron-restrictive silencer factor (REST/NRSF; 600571) complex. REST/NRSF recruits SCPs to neuronal genes that contain RE1 elements, leading to neuronal gene silencing in nonneuronal cells. Phosphatase-inactive forms of SCP interfere with REST/NRSF function and promote neuronal differentiation of P19 stem cells. Likewise, small interfering RNA directed to the single Drosophila SCP unmasks neuronal gene expression in S2 cells. Thus, SCP activity is an evolutionarily conserved transcriptional regulator that acts globally to silence neuronal genes.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1; CTD; CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1; GIP; Golli-interacting protein; NLI-IF; NLI-interacting factor 3; Nuclear LIM interactor-interacting factor 3; SCP1; Small C-terminal domain phosphatase 1; small CTD phosphatase 1
基因别名: CTDSP1; GIP; NIF3; NLI-IF; NLIIF; SCP1
UniProt ID: (Human) Q9GZU7, (Mouse) P58466
Entrez Gene ID: (Human) 58190, (Mouse) 227292
