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CTDSP1 Antibody (MA5-25370) in IHC (P)
Immunohistochemistry was performed on paraffin-embedded human lymphoma tissue. To expose target proteins, 10mM citric buffer, pH6.0, 100°C for 10min was used. Following antigen retrieval, tissues were probed with a CTDSP1 monoclonal antibody (Product # MA5-25370).
产品信息
MA5-25370
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
OTI1B6
抗原
Full length human recombinant protein of CTDSP1 produced in E.coli
偶联物
形式
Liquid
浓度
0.44 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 1% BSA, 50% glycerol
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2724178
靶标信息
CTDSP1 is a class 2C phosphatase with activity dependent on the conserved DxD motif. Expression of CTDSP1 inhibited activated transcription from several promoter-reporter gene constructs, but expression of a mutant lacking phosphatase activity enhanced transcription. Neuronal gene transcription is repressed in nonneuronal cells by the repressor element-1 (RE1)-silencing transcription factor/neuron-restrictive silencer factor (REST/NRSF; 600571) complex. REST/NRSF recruits SCPs to neuronal genes that contain RE1 elements, leading to neuronal gene silencing in nonneuronal cells. Phosphatase-inactive forms of SCP interfere with REST/NRSF function and promote neuronal differentiation of P19 stem cells. Likewise, small interfering RNA directed to the single Drosophila SCP unmasks neuronal gene expression in S2 cells. Thus, SCP activity is an evolutionarily conserved transcriptional regulator that acts globally to silence neuronal genes.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1; CTD; CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1; NLI-IF; NLI-interacting factor 3; Nuclear LIM interactor-interacting factor 3; SCP1; Small C-terminal domain phosphatase 1
基因别名: CTDSP1; NIF3; NLI-IF; NLIIF; SCP1
UniProt ID: (Human) Q9GZU7
Entrez Gene ID: (Human) 58190
