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CTPS Antibody (PA5-103121) in ICC/IF
Immunofluorescent analysis of CTPS in HeLa cells. Samples were fixed with paraformaldehyde, permeabilized with 0.1% Triton X-100, blocked with 10% serum (45 min at 25°C), incubated with mouse anti-beta tubulin and CTPS polyclonal antibody (Product # PA5-103121) using a dilution of 1:200 (1 hr, 37°C), and followed by goat anti-rabbit IgG Alexa Fluor 594 (red) and goat anti-mouse IgG Alexa Fluor 488 (green).
产品信息
PA5-103121
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human CTPS1(Accession P17812), corresponding to amino acid residues F541-D591.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2852491
产品详细信息
Antibody detects endogenous levels of total CTPS.
靶标信息
There are two genes encoding members of a new family of type II integral membrane proteins. Both are ubiquitously expressed, and tissue-specific alternative mRNA initiation and splicing generate at least two major isoforms of each protein, with the smaller isoforms being truncated at the N-terminus. These proteins are called nesprin-l and -2 for nuclear _envelope _spectrin repeat, as they are characterized by the presence of multiple, clustered spectrin repeats, bipartite nuclear localization sequences and a conserved C-terminal, single transmembrane domain. Transient transfection of EGFP-fusion expression constructs demonstrated their localization to the nuclear membrane with a novel C-terminal, TM-domain-containing sequence essential for perinuclear localization. Nesprin-l is developmentally regulated in both smooth and skeletal muscle and is relocalized from the nuclear envelope to the nucleus and cytoplasm during C2Cl2 myoblast differentiation. Nesprins may function as 'dystrophins of the nucleus' to maintain nuclear organization and structura integrity.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CTP synthase 1; CTP synthetase 1; cytidine 5'-triphosphate synthase; cytidine 5'-triphosphate synthetase; cytidine 5-prime triphosphate synthetase; UTP--ammonia ligase 1
基因别名: CTPS; CTPS1; IMD24
UniProt ID: (Human) P17812, (Mouse) P70698
Entrez Gene ID: (Human) 1503, (Mouse) 51797, (Rat) 313560
nucleobase-containing compound metabolic process
CTP biosynthetic process
glutamine metabolic process
nucleobase-containing small molecule interconversion
T cell proliferation
B cell proliferation
response to drug
'de novo' CTP biosynthetic process
immune system process
pyrimidine nucleotide biosynthetic process
biological_process
