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Product may be used with Western Blot (Transfected lysate).
The Isotype of this product is composed of an IgG Mixture.
Immunogen sequence: MWKASAGHAV SIAQDDAGAD DWETDPDFVN DVSEKEQRWG AKTVQGSGHQ EHINIHKLRE NVFQEHQTLK EKELETGPKA SHGYGGKFGV EQDRMDKSAV GHEYQSKLSK HCSQVDSVRG FGGKFGVQMD RVDQSAVGFE YQGKTEKHAS QKDYSSGFGG KYGVQADRVD KSAVGFDYQG KTEKHESQRD YSKGFGGKYG IDKDKVDKSA VGFEYQGKTE KHESQKDYVK GFGGKFGVQT DRQDKCALGW DHQEKLQLHE SQKDYSKGFG GKYGVQKDRM DKNASTFEDV TQVSSAYQKT VPVEAVTSKT SNIRANFENL AKEKEQEDRR KAEAERAQRM AKERQEQEEA RRKLEEQARA KTQTPPVSPA PQPTEERLPS SPVYEDAASF KAELSYRGPV SGTEPEPVYS MEAADYREAS SQQGLAYATE AVYESAEAPG HYPAEDSTYD EYENDLGITA VALYDYQAAG DDEISFDPDD IITNIEMIDD GWWRGVCKGR YGLFPANYVE LRQ
Cortactin (Cttn) is a ubiquitous actin-binding protein that was originally identified as a substrate for Src. It contributes to the organization of the actin cytoskeleton and cell shape. Cortactin also plays a role in the formation of lamellipodia and cell migration. It is accumulated in peripheral, actin-enriched structures of cells suggesting that cortactin facilitates actin network formation. Cortactin has four major domains of interest the N-terminal acidic (NTA) and tandem repeats domains and the C-terminal proline-rich and SH3 Domains. NTA associates with the Arp2/3 and WASP complex at F-actin branches. Cortactin is involved in promoting cell motility and invasion, including a critical role in invadopodia, actin rich-subcellular protrusions associated with degradation of the ECM by cancer cells. Cortactin is phosphorylated by src family kinases at Y421, Y466, and Y482 and S405 and S418 that are phosphorylated by Erk family kinases.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: 1110020L01Rik; Amplaxin; ems1 sequence (mammary tumor and squamous cell carcinoma-associated (p80/85 src substrate); FLJ34459; Oncogene EMS1; Oncogene SRC8; Src substrate cortactin; src8
基因别名: CTTN; EMS1
UniProt ID: (Human) Q14247
Entrez Gene ID: (Human) 2017
分子生物学功能:
actin or actin-binding cytoskeletal protein
cytoskeletal protein
non-motor actin binding protein