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产品信息
MA5-30306
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
409
抗原
Recombinant Human Fractalkine/CX3CL1 protein (Met1-Arg339)
偶联物
Unconjugated
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
PBS
内含物
no preservative
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2786057
产品详细信息
This product is preservative free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%-0.1%).
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
This antibody has specificity for Human Fractalkine/CX3CL1.
靶标信息
Chemokines are a family of proteins associated with the trafficking of leukocytes in immune surveillance and inflammatory cell recruitment. They are classified based on the positions of key cysteine residues. CX3CL1 is a CX3C chemokine known to induce adhesion and migration of leukocytes mediated by a membrane-bound and soluble form respectively. Recent experiments have shown that CX3CL1 can suppress the production of nitrous oxide, interleukin-6, and TNF-a in activated microglia and neuronal cells, suggesting that it may act as an intrinsic inhibitor against neurotoxicity by activated microglia. Its receptor, CX3CR1, also functions as a co-receptor for HIV-1 and HIV-2 envelope fusion and virus infection, which can be inhibited by CX3CL1.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: C-X3-C motif chemokine 1; chemokine (C-X3-C motif) ligand 1; CX3C membrane-anchored chemokine; Fractalkine; Neurotactin; small inducible cytokine subfamily D (Cys-X3-Cys), member 1 (fractalkine, neurotactin); small inducible cytokine subfamily D (Cys-X3-Cys), member-1; Small-inducible cytokine D1
基因别名: A-152E5.2; ABCD-3; C3Xkine; CX3CL1; CXC3; CXC3C; FKN; fractalkine; neurotactin; NTN; NTT; SCYD1
UniProt ID: (Human) P78423
Entrez Gene ID: (Human) 6376
response to hypoxia
microglial cell activation
positive regulation of neuroblast proliferation
leukocyte migration involved in inflammatory response
monocyte chemotaxis
chemotaxis
defense response
immune response
cell adhesion
G-protein coupled receptor signaling pathway
aging
positive regulation of macrophage chemotaxis
cytokine-mediated signaling pathway
platelet activation
neutrophil chemotaxis
leukocyte chemotaxis
positive regulation of transforming growth factor beta1 production
integrin activation
positive regulation of GTPase activity
positive regulation of angiogenesis
negative regulation of vasoconstriction
macrophage chemotaxis
lymphocyte chemotaxis
positive regulation of smooth muscle cell proliferation
negative regulation of cytokine secretion
positive regulation of inflammatory response
leukocyte adhesive activation
positive regulation of calcium-independent cell-cell adhesion
angiogenesis involved in wound healing
inhibitory postsynaptic potential
chemokine-mediated signaling pathway
positive regulation of ERK1 and ERK2 cascade
cellular response to interferon-gamma
cellular response to interleukin-1
cellular response to tumor necrosis factor
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
