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Invitrogen
CXCL11 Polyclonal Antibody
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FIGURE: 1 / 3
CXCL11 Antibody (PA5-47767) in Neu
Neutralization of CXCL11 in BaF3 mouse pro‚B cell line transfected with human CXCR3. Samples were incubated in CXCL11 polyclonal antibody (Product # PA5-47767). Recombinant MouseCXCL11/I‚TAC chemoattracts the BaF3 mouse pro‚B cell line transfected with human CXCR3 in a dose-dependent manner (orange line). The amount of cells that migrated through to the lower chemotaxis chamber was measured by Resazurin. Chemotaxis elicited by Recombinant Mouse CXCL11/I‚TAC (200 ng/mL) is neutralized (green line) by increasing concentrations of Goat Anti-M... View More
Product Details
PA5-47767
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse
Published species
Human,
Mouse
Host/Isotype
Goat
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
E. coli-derived recombinant mouse CXCL11/I-TAC Phe22-Met100
Conjugate
Form
Lyophilized
Concentration
0.2 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS with 5% trehalose
Contains
No Preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
In sandwich ELISAs, less than 0.2% cross-reactivity with recombinant human CXCL11, recombinant mouse (rm) BLC, rmCRG-2, rmGCP-2, rmMIG, rmPF4, and rmSDF-1 alpha is observed.
Reconstitute at 0.2 mg/mL in sterile PBS.
Endoxin level is <0.10 EU per 1 µg of the antibody by the LAL method.
Target Information
Interferon-inducible T-cell alpha chemoattractant ( I-TAC), belonging to the CXC chemokine family, is expressed in peripheral blood leukocytes, pancreas and liver, thymus, spleen, lung, small intestine, placenta and prostate. Its molecular weight is 8-11 kD. I-TAC is also known as CXCL-11 and IP-9. The cytokine is involved in regulating calcium release and inducing a chemotactic response in activated T-cells and is the dominant ligand for CXC receptor-3. The gene encoding this protein contains 4 exons and at least three polyadenylation signals which might reflect cell-specific regulation of expression. IFN-gamma is a potent inducer of transcription of this gene. It is upregulated in patients with AIDS, dementia and in patients with multiple sclerosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: C Cmotif chemokine; C X C motif chemokine; C-X-C motif chemokine 11; CC motif chemokine; CCmotif chemokine; CXC; CXC motif chemokine; CXCL; I-TAC; Interferon-inducible T-cell alpha chemoattractant; MGC102770; small inducible cytokine subfamily B (Cys-X-Cys), member 11; Small-inducible cytokine B11
Gene Aliases: b-R1; betaR1; Cxc11; Cxcl11; H174; I-tac; Ip9; Itac; Scyb11; Scyb9b
UniProt ID: (Mouse) Q9JHH5
Entrez Gene ID: (Mouse) 56066
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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