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CXCL13 Antibody (PA5-122275) in IHC (P)
Immunohistochemistry of CXCL13 in paraffin-embedded human amygdalitis tissue. Samples were incubated in polyclonal CXCL13 antibody (Product # PA5-122275) using a dilution of 20 µg/mL, followed by HRP-Linked Caprine Anti-Rabbit IgG at a dilution of 2 µg/mL and DAB.
产品信息
PA5-122275
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Val23-Arg94 (Accession Q53X90), with N-terminal His Tag
偶联物
形式
Liquid
浓度
0.8 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS with 50% glycerol
内含物
0.05% ProClin 300
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2915847
靶标信息
CXCL13, also known as BCA-1 and Angie, is a small chemokine strongly expressed in the secondary lymphoid organs. It preferentially promotes the migration of B lymphocytes (both B-1 and B-2) to the follicles of the spleen, lymph nodes, and Peyer's patches. It is produced by macrophages, and in mouse the highest constitutive producers include large peritoneal macrophages, Kuppfer cells and lung macrophages (both CD11c+ and CD11c-). The cellular ligand for CXCL13 is CXCR5 also known as BLR-1 (Burkitt’s Lymphoma Receptor 1). CXCR5 is expressed on B cells, Tfh cells and, to a lower degree, some memory T cell populations. CXCL13 plays an important role in the development of chronic lymphocytic leukemia (CCL). CXCL13 is also a plasma biomarker for germinal center activity and generation of broadly neutralizing antibodies against HIV.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Angie; B cell-attracting chemokine 1; B lymphocyte chemoattractant; B-cell chemoattractant; B-cell-attracting chemokine 1; B-cell-homing chemokine (ligand for Burkitt's lymphoma receptor-1); B-lymphocyte chemoattractant; BCA-1; C Cmotif chemokine; C X C motif chemokine; C-X-C motif chemokine 13; CC motif chemokine; CCmotif chemokine; chem; chemokine (C-X-C motif) ligand 13 (B-cell chemoattractant); CXC; CXC chemokine BLC; CXC motif chemokine; CXC motif chemokine 13; CXCL; small inducible cytokine B subfamily (Cys-X-Cys motif), member 13 (B-cell chemoattractant); Small-inducible cytokine B13
基因别名: ANGIE; ANGIE2; BCA-1; BCA1; BLC; BLR1L; CXCL13; SCYB13
UniProt ID: (Human) O43927
Entrez Gene ID: (Human) 10563
germinal center formation
lymphocyte chemotaxis across high endothelial venule
chronic inflammatory response
regulation of humoral immune response
inflammatory response
immune response
cell surface receptor signaling pathway
G-protein coupled receptor signaling pathway
positive regulation of cytosolic calcium ion concentration
cell-cell signaling
positive regulation of T cell chemotaxis
response to lipopolysaccharide
positive regulation of integrin activation
positive regulation of cell-cell adhesion mediated by integrin
B cell chemotaxis
endothelial cell chemotaxis to fibroblast growth factor
B cell chemotaxis across high endothelial venule
regulation of cell proliferation
defense response to bacterium
regulation of angiogenesis
lymph node development
chemokine-mediated signaling pathway
activation of GTPase activity
negative regulation of endothelial cell chemotaxis to fibroblast growth factor
