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产品信息
MA5-18049
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG2a
分类
Monoclonal
类型
Antibody
克隆号
44.1
抗原
Partially Purified human neutrophil flavocytochrome b
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein G
保存液
PBS
内含物
0.1% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2539432
产品详细信息
This antibody is specific for human Cytochrome b245 light chain aa 29-33 (TAGRF) and 183-188 (PQVNPI). The immunogen was prepared using partially purified human neutrophil flavocytochrome b (heparin Ultrogel/lectin affinity purification in Triton X-100).
This target has a predicted molecular weight of 21 kDa.
靶标信息
Cytochrome b is comprised of a light chain (alpha) and a heavy chain (beta). This gene encodes the light, alpha subunit which has been proposed as a primary component of the microbicidal oxidase system of phagocytes. Mutations in this gene are associated with autosomal recessive chronic granulomatous disease (CGD), that is characterized by the failure of activated phagocytes to generate superoxide, which is important for the microbicidal activity of these cells.
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生物信息学
蛋白别名: cytochrome b light chain; Cytochrome b(558) alpha chain; cytochrome b(558) alpha-subunit; cytochrome b, alpha polypeptide; Cytochrome b-245 light chain; cytochrome b-245, alpha polypeptide; Cytochrome b558 subunit alpha; flavocytochrome b-558 alpha polypeptide; Neutrophil cytochrome b 22 kDa polypeptide; p22 phagocyte B-cytochrome; p22-phox; p22phox; Superoxide-generating NADPH oxidase light chain subunit
基因别名: CYBA; p22-PHOX
UniProt ID: (Human) P13498
Entrez Gene ID: (Human) 1535
response to reactive oxygen species
positive regulation of endothelial cell proliferation
antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
negative regulation of glomerular filtration by angiotensin
superoxide metabolic process
inflammatory response
smooth muscle hypertrophy
cytochrome complex assembly
positive regulation of cell growth
response to nutrient levels
positive regulation of interleukin-6 production
positive regulation of tumor necrosis factor production
positive regulation of superoxide anion generation
positive regulation of toll-like receptor 2 signaling pathway
response to drug
superoxide anion generation
innate immune response
cell redox homeostasis
respiratory burst
vascular endothelial growth factor receptor signaling pathway
positive regulation of smooth muscle cell proliferation
hydrogen peroxide biosynthetic process
positive regulation of phagocytosis
regulation of release of sequestered calcium ion into cytosol
oxidation-reduction process
positive regulation of mucus secretion
response to interleukin-1
cellular response to amino acid stimulus
cellular response to mechanical stimulus
cellular response to glucose stimulus
cellular response to tumor necrosis factor
cellular response to organic cyclic compound
cellular response to gamma radiation
positive regulation of defense response to bacterium
positive regulation of reactive oxygen species biosynthetic process
