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CYP4A11/CYP4A22 Antibody (MA5-37946) in IHC (P)
Immunohistochemistry analysis of CYP4A11/CYP4A22 in paraffin-embedded mouse kidney. Samples were incubated with CYP4A11/CYP4A22 Monoclonal antibody (Product # MA5-37946) using a dilution of 1:100 (40x lens). Perform microwave antigen retrieval with 10 mM Tris/EDTA buffer pH 9.0 before commencing with IHC staining protocol.
产品信息
MA5-37946
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
ARC2219
抗原
A synthetic peptide corresponding to a sequence within amino acids 50-150 of human Cytochrome P450 4A (CYP4A11) (CYP4A11) (Q02928)
偶联物
形式
Liquid
浓度
0.6 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol, 0.05% BSA
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2897866
产品详细信息
Positive Samples: Mouse liver, Rat liver, Rat kidney
Immunogen sequence: QFPCPPSHWL FGHIQELQQD QELQRIQKWV ETFPSACPHW LWGGKVRVQL YDPDYMKVIL GRSDPKSHGS YRFLAPWIGY GLLLLNGQTW FQHRRMLTPA F
靶标信息
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and hydroxylates medium-chain fatty acids such as laurate and myristate.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 20-HETE synthase; 20-hydroxyeicosatetraenoic acid synthase; alkane-1 monooxygenase; CYP4AII; CYPIVA11; CYPIVA2; Cytochrome P-450 K-2; Cytochrome P-450HK-omega; Cytochrome P450 4A11; Cytochrome P450 4A2; Cytochrome P450 K-5; cytochrome P450, family 4, subfamily A, polypeptide 11; cytochrome P450, subfamily 4A, polypeptide 11; cytochrome P450, subfamily IVA, polypeptide 11; Cytochrome P450-LA-omega 2; Cytochrome P450HL-omega; Fatty acid omega-hydroxylase; Lauric acid omega-hydroxylase; Long-chain fatty acid omega-monooxygenase; P-450 HK omega; P-450 IV4AII; P-450 K-2; P450 K-5; P450-HL-omega; P450-LA-omega 2; P450HL-omega
基因别名: CP4Y; Cyp4a-2; CYP4A11; CYP4A2; CYP4AII
UniProt ID: (Human) Q02928, (Rat) P20816
Entrez Gene ID: (Human) 1579, (Rat) 24306
monooxygenase activity
iron ion binding
arachidonic acid epoxygenase activity
alkane 1-monooxygenase activity
oxygen binding
heme binding
leukotriene-B4 20-monooxygenase activity
fatty acid binding
arachidonic acid monooxygenase activity
arachidonic acid 11,12-epoxygenase activity
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
arachidonic acid binding
arachidonic acid omega-hydroxylase activity
oxygenase
long-chain fatty acid metabolic process
renal water homeostasis
pressure natriuresis
fatty acid metabolic process
leukotriene metabolic process
arachidonic acid metabolic process
epoxygenase P450 pathway
positive regulation of icosanoid secretion
leukotriene B4 catabolic process
sodium ion homeostasis
oxidation-reduction process
omega-hydroxylase P450 pathway
kidney development
response to hormone
response to drug
linoleic acid metabolic process
icosanoid biosynthetic process
lauric acid metabolic process
