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CaMKII beta/gamma Antibody (PA5-99600) in WB
Western blot analysis of CaMKII beta/gamma in COS7 cell lysate (left lane: treated with blocking peptide). Samples were incubated with CaMKII beta/gamma polyclonal antibody (Product # PA5-99600).
产品信息
PA5-99600
产品规格
种属反应
Human,
Mouse,
Non-human primate
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human CAMK2G(Accession Q13555), corresponding to amino acid residues D505-A555.
偶联物
Unconjugated
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2818533
产品详细信息
Antibody detects endogenous levels of total CaMKII beta/gamma.
靶标信息
The Ca2+/calmodulin-dependent protein kinases (CaM kinases) comprise a structurally related subfamily of serine/threonine kinases which include CaMKI, CaMKII and CaMKIV. CaMKII is an ubiquitously expressed serine/threonine protein kinase that is activated by Ca2+ and calmodulin (CaM) and has been implicated in regulation of the cell cycle and transcription. There are four CaMKII isozymes, designated alpha, beta, gamma and delta, which may or may not be coexpressed in the same tissue type. CaMKIV is stimulated by Ca2+ and CaM but also requires phosphorylation by a CaMK for full activation.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Ca2+/calmodulin-dependent protein kinase II; calcium/calmodulin-dependent protein kinase (CaM kinase) II gamma; calcium/calmodulin-dependent protein kinase II beta; calcium/calmodulin-dependent protein kinase II gamma; Calcium/calmodulin-dependent protein kinase type II subunit beta; Calcium/calmodulin-dependent protein kinase type II subunit gamma; CaM kinase II beta subunit; CaM kinase II subunit beta; CaM kinase II subunit gamma; CaM-kinase II beta chain; CaMK II; caMK-II subunit beta; caMK-II subunit gamma; proline rich calmodulin-dependent protein kinase
基因别名: CAM2; CAMK; CAMK-II; CAMK2; CAMK2B; Camk2d; CAMK2G; CAMKB; CAMKG
UniProt ID: (Human) Q13554, (Human) Q8N4I3, (Mouse) P28652, (Mouse) Q923T9
Entrez Gene ID: (Human) 816, (Human) 818, (Mouse) 12323, (Mouse) 12325
actin binding
protein serine/threonine kinase activity
calmodulin-dependent protein kinase activity
Ras guanyl-nucleotide exchange factor activity
protein binding
calmodulin binding
ATP binding
protein kinase binding
protein homodimerization activity
phospholipase binding
calcium-dependent protein serine/threonine phosphatase activity
nucleotide binding
protein kinase activity
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
non-receptor serine/threonine protein kinase
MAPK cascade
protein phosphorylation
signal transduction
positive regulation of neuron projection development
regulation of skeletal muscle adaptation
positive regulation of phospholipase A2 activity
positive regulation of GTPase activity
protein autophosphorylation
regulation of long-term neuronal synaptic plasticity
cell projection morphogenesis
regulation of synapse structural plasticity
regulation of calcium ion transport
interferon-gamma-mediated signaling pathway
regulation of dendritic spine development
positive regulation of dendritic spine morphogenesis
positive regulation of synapse maturation
regulation of cellular response to heat
G1/S transition of mitotic cell cycle
protein dephosphorylation
calcium ion transport
nervous system development
insulin secretion
cell differentiation
protein oligomerization
regulation of relaxation of cardiac muscle
inhibitory G-protein coupled receptor phosphorylation
phosphorylation
peptidyl-serine phosphorylation
regulation of synaptic transmission, cholinergic
response to cadmium ion
neuromuscular process controlling balance
long-term synaptic potentiation
activation of meiosis involved in egg activation
positive regulation of apoptotic signaling pathway
response to hypoxia
response to oxidative stress
multicellular organism development
