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产品信息
CAMKII-321AP
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide taken within amino acid region 350-400 on human CAMKII gamma protein.
偶联物
形式
Liquid
浓度
0.5-1.5 mg/mL
纯化类型
Affinity chromatography
保存液
proprietary buffer, pH 7.4-7.8, with 30% glycerol, 0.5% BSA
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in dendritic spine and synapse formation, neuronal plasticity and regulation of sarcoplasmic reticulum Ca(2+) transport in skeletal muscle. In neurons, plays an essential structural role in the reorganization of the actin cytoskeleton during plasticity by binding and bundling actin filaments in a kinase-independent manner. This structural function is required for correct targeting of CaMK2A, which acts downstream of NMDAR to promote dendritic spine and synapse formation and maintain synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning. In developing hippocampal neurons, promotes arborization of the dendritic tree and in mature neurons, promotes dendritic remodeling. Participates in the modulation of skeletal muscle function in response to exercise. In slow-twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca(2+) transport and in fast-twitch muscle participates in the control of Ca(2+) release from the SR through phosphorylation of triadin, a ryanodine receptor-coupling factor, and phospholamban (PLN/PLB), an endogenous inhibitor of SERCA2A/ATP2A2.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Ca2+/calmodulin-dependent protein kinase II; calcium/calmodulin-dependent protein kinase (CaM kinase) II gamma; calcium/calmodulin-dependent protein kinase II gamma; calcium/calmodulin-dependent protein kinase type II gamma chain; Calcium/calmodulin-dependent protein kinase type II subunit gamma; CaM kinase II subunit gamma; caM-kinase II gamma chain; CAM2; CaMK II; caMK-II subunit gamma; CAMK2; CAMK2B; CAMK2D; CAMKB; CAMKD
基因别名: CAMK; CAMK-II; CAMK2G; CAMKG
UniProt ID: (Human) Q13282, (Mouse) Q923T9, (Rat) P11730
Entrez Gene ID: (Human) 818, (Mouse) 12325, (Rat) 171140
protein serine/threonine kinase activity
calmodulin-dependent protein kinase activity
calcium-dependent protein serine/threonine phosphatase activity
Ras guanyl-nucleotide exchange factor activity
protein binding
calmodulin binding
ATP binding
protein homodimerization activity
nucleotide binding
protein kinase activity
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
non-receptor serine/threonine protein kinase
G1/S transition of mitotic cell cycle
MAPK cascade
protein dephosphorylation
calcium ion transport
nervous system development
regulation of skeletal muscle adaptation
insulin secretion
cell differentiation
positive regulation of GTPase activity
protein autophosphorylation
protein oligomerization
regulation of calcium ion transport
interferon-gamma-mediated signaling pathway
regulation of cellular response to heat
regulation of relaxation of cardiac muscle
response to hypoxia
protein phosphorylation
response to oxidative stress
multicellular organism development
phosphorylation
regulation of long-term neuronal synaptic plasticity
